JP2016166203A5 - - Google Patents
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- JP2016166203A5 JP2016166203A5 JP2016045111A JP2016045111A JP2016166203A5 JP 2016166203 A5 JP2016166203 A5 JP 2016166203A5 JP 2016045111 A JP2016045111 A JP 2016045111A JP 2016045111 A JP2016045111 A JP 2016045111A JP 2016166203 A5 JP2016166203 A5 JP 2016166203A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 5
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229940123237 Taxane Drugs 0.000 claims 3
- 229940121647 egfr inhibitor Drugs 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 2
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 2
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 2
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 102000015694 estrogen receptors Human genes 0.000 claims 2
- 108010038795 estrogen receptors Proteins 0.000 claims 2
- 238000002509 fluorescent in situ hybridization Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 2
- 230000004544 DNA amplification Effects 0.000 claims 1
- 101150054472 HER2 gene Proteins 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 102100025803 Progesterone receptor Human genes 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108700020302 erbB-2 Genes Proteins 0.000 claims 1
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical compound [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229950008001 matuzumab Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 229950010203 nimotuzumab Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
- -1 taxanes Substances 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31289510P | 2010-03-11 | 2010-03-11 | |
| US61/312,895 | 2010-03-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Division JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016166203A JP2016166203A (ja) | 2016-09-15 |
| JP2016166203A5 true JP2016166203A5 (cg-RX-API-DMAC7.html) | 2016-10-27 |
| JP6185102B2 JP6185102B2 (ja) | 2017-08-23 |
Family
ID=44513103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Pending JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
| JP2016045111A Expired - Fee Related JP6185102B2 (ja) | 2010-03-11 | 2016-03-09 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557285A Pending JP2013522237A (ja) | 2010-03-11 | 2011-03-11 | トリプルネガティブおよび基底様乳癌の治療におけるｅｒｂｂ３阻害剤の使用 |
Country Status (20)
Families Citing this family (39)
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| KR101598229B1 (ko) | 2007-02-16 | 2016-02-26 | 메리맥 파마슈티컬즈, 인크. | Ｅｒｂｂ3에 대한 항체 및 이의 용도 |
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| SG183532A1 (en) * | 2010-03-11 | 2012-09-27 | Merrimack Pharmaceuticals Inc | Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers |
| PH12013500333A1 (en) | 2010-08-20 | 2013-04-22 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| BR112013022882A2 (pt) * | 2011-03-11 | 2016-12-20 | Merrimack Pharmaceuticals Inc | uso de inibidores de receptores da família egfr no tratamento de cânceres de mama hormônio-refratários |
| SMT201900505T1 (it) | 2011-03-31 | 2019-11-13 | Adc Therapeutics Sa | Anticorpi contro l'antigene 1 associato ai reni e loro frammenti leganti l'antigene |
| JP2014527035A (ja) * | 2011-06-30 | 2014-10-09 | メリマック ファーマシューティカルズ インコーポレーティッド | 婦人科悪性腫瘍を治療するためのパクリタキセルとの組み合わせの抗ＥｒｂＢ３抗体 |
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| JP2022512038A (ja) * | 2018-10-21 | 2022-02-01 | エスエルエスジー リミテッド エルエルシー | トリプルネガティブ乳癌治療のための併用免疫療法 |
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-
2011
- 2011-03-11 SG SG2012063905A patent/SG183532A1/en unknown
- 2011-03-11 PT PT117301127T patent/PT2544680E/pt unknown
- 2011-03-11 AU AU2011224186A patent/AU2011224186C1/en not_active Ceased
- 2011-03-11 EP EP20140196121 patent/EP2859893A1/en not_active Ceased
- 2011-03-11 US US13/583,949 patent/US8895001B2/en not_active Expired - Fee Related
- 2011-03-11 KR KR1020127025753A patent/KR101798679B1/ko not_active Expired - Fee Related
- 2011-03-11 DK DK11730112T patent/DK2544680T3/en active
- 2011-03-11 JP JP2012557285A patent/JP2013522237A/ja active Pending
- 2011-03-11 EP EP11730112.7A patent/EP2544680B1/en not_active Revoked
- 2011-03-11 WO PCT/US2011/028129 patent/WO2011112953A2/en not_active Ceased
- 2011-03-11 NZ NZ602084A patent/NZ602084A/en not_active IP Right Cessation
- 2011-03-11 MX MX2012010226A patent/MX344355B/es active IP Right Grant
- 2011-03-11 CA CA2792327A patent/CA2792327C/en not_active Expired - Fee Related
- 2011-03-11 ES ES11730112.7T patent/ES2535503T3/es active Active
- 2011-03-11 EA EA201201186A patent/EA201201186A1/ru unknown
- 2011-03-11 CN CN201180013330.9A patent/CN102858335B/zh not_active Expired - Fee Related
- 2011-03-11 BR BR112012022802A patent/BR112012022802A2/pt not_active IP Right Cessation
- 2011-03-11 PL PL11730112T patent/PL2544680T3/pl unknown
- 2011-11-03 UA UAA201210790A patent/UA111149C2/uk unknown
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2012
- 2012-08-27 ZA ZA2012/06425A patent/ZA201206425B/en unknown
- 2012-08-30 IL IL221693A patent/IL221693A/en not_active IP Right Cessation
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2014
- 2014-10-20 US US14/518,900 patent/US9518130B2/en not_active Expired - Fee Related
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2016
- 2016-03-09 JP JP2016045111A patent/JP6185102B2/ja not_active Expired - Fee Related
- 2016-11-08 US US15/346,439 patent/US20170291957A1/en not_active Abandoned
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2018
- 2018-05-31 US US15/994,393 patent/US20190119401A1/en not_active Abandoned
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