JP2016088859A - 外用クリーム - Google Patents
外用クリーム Download PDFInfo
- Publication number
- JP2016088859A JP2016088859A JP2014222565A JP2014222565A JP2016088859A JP 2016088859 A JP2016088859 A JP 2016088859A JP 2014222565 A JP2014222565 A JP 2014222565A JP 2014222565 A JP2014222565 A JP 2014222565A JP 2016088859 A JP2016088859 A JP 2016088859A
- Authority
- JP
- Japan
- Prior art keywords
- fucoidan
- cream
- inflammatory activity
- skin
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000006071 cream Substances 0.000 title claims abstract description 31
- 229920000855 Fucoidan Polymers 0.000 claims abstract description 52
- 239000002994 raw material Substances 0.000 claims abstract description 4
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 claims description 17
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 5
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims description 5
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 5
- 240000001829 Catharanthus roseus Species 0.000 claims description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 27
- 238000000034 method Methods 0.000 abstract description 7
- 238000009835 boiling Methods 0.000 abstract description 6
- 239000012141 concentrate Substances 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 abstract 2
- 229960003720 enoxolone Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 15
- 230000000694 effects Effects 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 6
- 241000199919 Phaeophyceae Species 0.000 description 4
- 239000008278 cosmetic cream Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003906 humectant Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000004264 Petrolatum Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940066842 petrolatum Drugs 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000512259 Ascophyllum nodosum Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 235000019502 Orange oil Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000010502 orange oil Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000003405 preventing effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 230000035943 smell Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 241001261506 Undaria pinnatifida Species 0.000 description 1
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- CNYFJCCVJNARLE-UHFFFAOYSA-L calcium;2-sulfanylacetic acid;2-sulfidoacetate Chemical compound [Ca+2].[O-]C(=O)CS.[O-]C(=O)CS CNYFJCCVJNARLE-UHFFFAOYSA-L 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 229940110859 magnesium chloride / sodium chloride Drugs 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008250 pharmaceutical cream Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000003009 skin protective agent Substances 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【解決手段】クリームは、抗炎症作用の有効成分としてフコイダンとグリチルレチン酸ステアリルとを含んでいる。フコイダンは、原料(モズク)の抽出液を煮沸した濃縮液を使用できる。濃縮液は、クリームとしての粘度を維持できる程度に、可能な限り多く使用する。フコイダンの高い抗炎症作用に加えて、グリチルレチン酸ステアリルによる抗炎症作用も確保できるため、従来にない高い抗炎症作用を得ることができる。フコイダンは、抽出液を煮沸する簡単な方法で濃縮したものを使用できるため、コストも抑制できる。
【選択図】図1
Description
Claims (3)
- クリームベース剤とフコイダンとグリチルレチン酸ステアリルと水とを含んでおり、前記フコイダンはフコース換算で0.2重量%以上含まれている、
外用クリーム。 - 前記フコイダンは、トンガ産のモズクを原料として精製されたものである、
請求項1に記載した外用クリーム。 - 前記グリチルレチン酸ステアリルは0.05〜0.3重量%含まれている、
請求項1又は2に記載した外用クリーム。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014222565A JP6859017B2 (ja) | 2014-10-31 | 2014-10-31 | 外用クリーム及びその製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014222565A JP6859017B2 (ja) | 2014-10-31 | 2014-10-31 | 外用クリーム及びその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016088859A true JP2016088859A (ja) | 2016-05-23 |
JP6859017B2 JP6859017B2 (ja) | 2021-04-14 |
Family
ID=56018706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014222565A Active JP6859017B2 (ja) | 2014-10-31 | 2014-10-31 | 外用クリーム及びその製造方法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6859017B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113520937A (zh) * | 2021-06-28 | 2021-10-22 | 上海化工研究院有限公司 | 一种提高水渗透效率的化妆品组合物 |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0645143A1 (en) * | 1993-09-24 | 1995-03-29 | Kabushiki Kaisha Yakult Honsha | Antiulcer agent and adhesion inhibitor for helicobacter pyroli |
JPH1121247A (ja) * | 1997-06-30 | 1999-01-26 | Lion Corp | 皮膚賦活剤及びアレルギー抑制剤 |
JP2000351790A (ja) * | 1999-06-07 | 2000-12-19 | Yaizu Suisankagaku Industry Co Ltd | フコース含有オリゴ糖又はその組成物の製造法及びフコース含有オリゴ糖又はその組成物 |
JP2001233755A (ja) * | 2000-02-25 | 2001-08-28 | Yakult Honsha Co Ltd | 皮膚外用剤組成物 |
JP2002262788A (ja) * | 2001-03-08 | 2002-09-17 | Kyodo Milk Industry Co Ltd | フコイダンの簡易製造方法 |
JP2003342124A (ja) * | 2002-05-31 | 2003-12-03 | Noevir Co Ltd | 皮膚外用剤 |
JP2004002219A (ja) * | 2002-05-31 | 2004-01-08 | Noevir Co Ltd | 皮膚外用剤 |
JP2006184131A (ja) * | 2004-12-27 | 2006-07-13 | Nippon Meat Packers Inc | フコイダン含量の測定方法及びフコイダン含有食品 |
JP2006298784A (ja) * | 2005-04-18 | 2006-11-02 | Ube Ind Ltd | フコイダン組成物の防腐方法 |
JP2009298738A (ja) * | 2008-06-16 | 2009-12-24 | Tsujido Chemical Corp | 皮膚外用剤 |
JP2010260834A (ja) * | 2009-05-11 | 2010-11-18 | Rohto Pharmaceut Co Ltd | 苦味の低減方法 |
JP2011001276A (ja) * | 2009-06-17 | 2011-01-06 | Satoshi Shinkawa | 痩身方法 |
JP2011026231A (ja) * | 2009-07-24 | 2011-02-10 | Rohto Pharmaceutical Co Ltd | 棒状組成物及び棒状製品 |
JP2013010700A (ja) * | 2011-06-28 | 2013-01-17 | Meiji Univ | ヒアルロニダーゼ阻害剤 |
-
2014
- 2014-10-31 JP JP2014222565A patent/JP6859017B2/ja active Active
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0645143A1 (en) * | 1993-09-24 | 1995-03-29 | Kabushiki Kaisha Yakult Honsha | Antiulcer agent and adhesion inhibitor for helicobacter pyroli |
JPH1121247A (ja) * | 1997-06-30 | 1999-01-26 | Lion Corp | 皮膚賦活剤及びアレルギー抑制剤 |
JP2000351790A (ja) * | 1999-06-07 | 2000-12-19 | Yaizu Suisankagaku Industry Co Ltd | フコース含有オリゴ糖又はその組成物の製造法及びフコース含有オリゴ糖又はその組成物 |
JP2001233755A (ja) * | 2000-02-25 | 2001-08-28 | Yakult Honsha Co Ltd | 皮膚外用剤組成物 |
JP2002262788A (ja) * | 2001-03-08 | 2002-09-17 | Kyodo Milk Industry Co Ltd | フコイダンの簡易製造方法 |
JP2003342124A (ja) * | 2002-05-31 | 2003-12-03 | Noevir Co Ltd | 皮膚外用剤 |
JP2004002219A (ja) * | 2002-05-31 | 2004-01-08 | Noevir Co Ltd | 皮膚外用剤 |
JP2006184131A (ja) * | 2004-12-27 | 2006-07-13 | Nippon Meat Packers Inc | フコイダン含量の測定方法及びフコイダン含有食品 |
JP2006298784A (ja) * | 2005-04-18 | 2006-11-02 | Ube Ind Ltd | フコイダン組成物の防腐方法 |
JP2009298738A (ja) * | 2008-06-16 | 2009-12-24 | Tsujido Chemical Corp | 皮膚外用剤 |
JP2010260834A (ja) * | 2009-05-11 | 2010-11-18 | Rohto Pharmaceut Co Ltd | 苦味の低減方法 |
JP2011001276A (ja) * | 2009-06-17 | 2011-01-06 | Satoshi Shinkawa | 痩身方法 |
JP2011026231A (ja) * | 2009-07-24 | 2011-02-10 | Rohto Pharmaceutical Co Ltd | 棒状組成物及び棒状製品 |
JP2013010700A (ja) * | 2011-06-28 | 2013-01-17 | Meiji Univ | ヒアルロニダーゼ阻害剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113520937A (zh) * | 2021-06-28 | 2021-10-22 | 上海化工研究院有限公司 | 一种提高水渗透效率的化妆品组合物 |
Also Published As
Publication number | Publication date |
---|---|
JP6859017B2 (ja) | 2021-04-14 |
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