JP2016027797A5 - - Google Patents
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- JP2016027797A5 JP2016027797A5 JP2015138613A JP2015138613A JP2016027797A5 JP 2016027797 A5 JP2016027797 A5 JP 2016027797A5 JP 2015138613 A JP2015138613 A JP 2015138613A JP 2015138613 A JP2015138613 A JP 2015138613A JP 2016027797 A5 JP2016027797 A5 JP 2016027797A5
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- JP
- Japan
- Prior art keywords
- fibroblasts
- vcam
- protein
- cell culture
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002950 fibroblast Anatomy 0.000 claims 17
- 239000000463 material Substances 0.000 claims 9
- 102100019577 VCAM1 Human genes 0.000 claims 8
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 8
- 238000004113 cell culture Methods 0.000 claims 8
- 210000002064 heart cell Anatomy 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 210000001519 tissues Anatomy 0.000 claims 5
- 210000004413 Myocytes, Cardiac Anatomy 0.000 claims 4
- 210000002317 cardiac myocyte Anatomy 0.000 claims 4
- 230000002107 myocardial Effects 0.000 claims 4
- 230000001737 promoting Effects 0.000 claims 4
- 230000000747 cardiac effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000005012 migration Effects 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Claims (16)
- VCAM-1蛋白質を発現している線維芽細胞からなる、心臓細胞培養材料。
- 心臓組織を構築するための培養に使用されるものである、請求項１に記載の心臓細胞培養材料。
- 前記線維芽細胞が、心臓由来のものである、請求項２に記載の心臓細胞培養材料。
- 前記線維芽細胞が、心外膜由来のものである、請求項２または３に記載の心臓細胞培養材料。
- 請求項１〜４のいずれか１項に記載の心臓細胞培養材料と共に、心臓細胞を培養するステップを含む、人工臓器材料の製造方法。
- VCAM-1蛋白質発現線維芽細胞の、心臓細胞培養材料としての使用。
- 抗VCAM-1抗体を含む、心臓細胞培養材料スクリーニング用試薬。
- 線維芽細胞群を準備するステップ、及び
準備した線維芽細胞群からVCAM-1蛋白質発現線維芽細胞をソーティングするステップ、を含む、心臓細胞培養材料の製造方法。 - 線維芽細胞群を準備するステップ、及び
準備した線維芽細胞群からVCAM-1蛋白質発現線維芽細胞をソーティングするステップ、を含む、心筋組織の製造方法。 - 線維芽細胞群を準備するステップ、及び
準備した線維芽細胞群からVCAM-1蛋白質発現線維芽細胞をソーティングするステップ、を含む、組成物の製造方法。 - 全線維芽細胞中、VCAM-1蛋白質発現線維芽細胞の割合が４０％以上である、組成物。
- 全線維芽細胞中、VCAM-1蛋白質発現線維芽細胞の割合が７０％以上である、請求項１１に記載の組成物。
- 心筋細胞の細胞増殖を促進するため、心筋細胞の遊走を促進するため、及び心筋組織を構築するため、からなる群から選択されるいずれかの目的で用いられる、請求項１１または１２に記載の組成物。
- 請求項１１〜１３のいずれか１項に記載の組成物と、心臓細胞との混合物。
- 請求項１４に記載の混合物の培養物である、心筋組織。
- VCAM-1蛋白質またはこれをコードする遺伝子の、心筋細胞の細胞増殖を促進するため、心筋細胞の遊走を促進するため、及び心筋組織を構築するため、からなる群から選択されるいずれかを目的とする、使用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015138613A JP6241893B2 (ja) | 2014-07-11 | 2015-07-10 | 心臓細胞培養材料 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014142804 | 2014-07-11 | ||
| JP2014142804 | 2014-07-11 | ||
| WOPCT/JP2015/050028 | 2015-01-05 | ||
| PCT/JP2015/050028 WO2016006262A1 (ja) | 2014-07-11 | 2015-01-05 | 心臓細胞培養材料 |
| JP2015138613A JP6241893B2 (ja) | 2014-07-11 | 2015-07-10 | 心臓細胞培養材料 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017208721A Division JP2018029611A (ja) | 2014-07-11 | 2017-10-30 | 心臓細胞培養材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016027797A JP2016027797A (ja) | 2016-02-25 |
| JP2016027797A5 true JP2016027797A5 (ja) | 2017-08-10 |
| JP6241893B2 JP6241893B2 (ja) | 2017-12-06 |
Family
ID=55063910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015138613A Active JP6241893B2 (ja) | 2014-07-11 | 2015-07-10 | 心臓細胞培養材料 |
| JP2017208721A Pending JP2018029611A (ja) | 2014-07-11 | 2017-10-30 | 心臓細胞培養材料 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017208721A Pending JP2018029611A (ja) | 2014-07-11 | 2017-10-30 | 心臓細胞培養材料 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20170112880A1 (ja) |
| EP (1) | EP3168297B1 (ja) |
| JP (2) | JP6241893B2 (ja) |
| KR (1) | KR102263824B1 (ja) |
| CN (2) | CN106661552B (ja) |
| AU (1) | AU2015286462B2 (ja) |
| CA (1) | CA2954743C (ja) |
| WO (1) | WO2016006262A1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109890398B (zh) * | 2017-02-24 | 2024-01-16 | 玛土撤拉有限公司 | 可用于治疗心脏疾病并含有成纤维细胞的注射用组合物以及用于生产用于治疗用途的成纤维细胞的方法 |
| AU2019332400A1 (en) * | 2018-08-29 | 2021-04-01 | Metcela Inc. | Method for producing fibroblast, and G-CSF-positive fibroblast mass |
| KR102200341B1 (ko) * | 2018-12-21 | 2021-01-08 | 고려대학교 산학협력단 | 지방줄기세포 시트를 함유하는 심장조직 모사 심장이식용 시트 및 이의 제조방법 |
| US20220135942A1 (en) | 2019-03-29 | 2022-05-05 | Nagasaki University | Cultured tissue and method for producing same |
| WO2021146994A1 (zh) * | 2020-01-22 | 2021-07-29 | 京东方科技集团股份有限公司 | 间充质干细胞膜片及其用途 |
| CA3174551A1 (en) * | 2020-03-04 | 2021-09-10 | Metcela Inc. | Fibroblast having enhanced erythropoietin production ability |
| KR102283340B1 (ko) * | 2020-03-27 | 2021-07-30 | 서울대학교산학협력단 | 심근 직분화를 위한 심장 모사 세포 배양장치 및 이를 이용한 세포 분화 방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| CA2453438C (en) * | 2001-07-12 | 2016-04-05 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| JP4950659B2 (ja) * | 2003-06-27 | 2012-06-13 | エチコン、インコーポレイテッド | 胎盤組織から由来最多分娩後細胞、及びそれらを作成し使用する方法。 |
| JP4749331B2 (ja) * | 2003-10-07 | 2011-08-17 | 株式会社バイオマスター | 脂肪由来前駆細胞の細胞分化 |
| WO2006078034A1 (ja) * | 2005-01-24 | 2006-07-27 | Japan Health Sciences Foundation | 心筋細胞への分化能を有する細胞 |
| US8933197B2 (en) * | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
| CA2758208A1 (en) * | 2009-04-09 | 2010-10-14 | Jordan Lancaster | Cellular seeding and co-culture of a three dimensional fibroblast construct |
| US20120045487A1 (en) * | 2009-04-29 | 2012-02-23 | The Regents Of The University Of Michigan | Multiphasic microfibers for spatially guided cell growth |
| US8323972B2 (en) * | 2009-09-30 | 2012-12-04 | Advanced Technologies And Regenerative Medicine, Llc | Mammary artery derived cells and methods of use in tissue repair and regeneration |
| WO2012162741A1 (en) * | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
-
2015
- 2015-01-05 CN CN201580037730.1A patent/CN106661552B/zh active Active
- 2015-01-05 AU AU2015286462A patent/AU2015286462B2/en active Active
- 2015-01-05 EP EP15819754.1A patent/EP3168297B1/en active Active
- 2015-01-05 KR KR1020177003798A patent/KR102263824B1/ko active IP Right Grant
- 2015-01-05 CA CA2954743A patent/CA2954743C/en active Active
- 2015-01-05 WO PCT/JP2015/050028 patent/WO2016006262A1/ja active Application Filing
- 2015-01-05 CN CN202010584861.4A patent/CN111876371A/zh active Pending
- 2015-07-10 JP JP2015138613A patent/JP6241893B2/ja active Active
-
2017
- 2017-01-09 US US15/401,832 patent/US20170112880A1/en not_active Abandoned
- 2017-10-30 JP JP2017208721A patent/JP2018029611A/ja active Pending
-
2018
- 2018-08-21 US US16/106,723 patent/US11801267B2/en active Active
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