JP2015536950A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015536950A5 JP2015536950A5 JP2015540834A JP2015540834A JP2015536950A5 JP 2015536950 A5 JP2015536950 A5 JP 2015536950A5 JP 2015540834 A JP2015540834 A JP 2015540834A JP 2015540834 A JP2015540834 A JP 2015540834A JP 2015536950 A5 JP2015536950 A5 JP 2015536950A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- cell lymphoma
- lymphoma
- ibrutinib
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722107P | 2012-11-02 | 2012-11-02 | |
| US61/722,107 | 2012-11-02 | ||
| US201361785868P | 2013-03-14 | 2013-03-14 | |
| US61/785,868 | 2013-03-14 | ||
| PCT/US2013/068132 WO2014071231A1 (en) | 2012-11-02 | 2013-11-01 | Tec family kinase inhibitor adjuvant therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018179447A Division JP2019031506A (ja) | 2012-11-02 | 2018-09-25 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015536950A JP2015536950A (ja) | 2015-12-24 |
| JP2015536950A5 true JP2015536950A5 (https=) | 2016-12-22 |
Family
ID=50628113
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540834A Pending JP2015536950A (ja) | 2012-11-02 | 2013-11-01 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
| JP2018179447A Ceased JP2019031506A (ja) | 2012-11-02 | 2018-09-25 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
| JP2020120047A Pending JP2020183413A (ja) | 2012-11-02 | 2020-07-13 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018179447A Ceased JP2019031506A (ja) | 2012-11-02 | 2018-09-25 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
| JP2020120047A Pending JP2020183413A (ja) | 2012-11-02 | 2020-07-13 | Tecファミリーキナーゼ阻害剤アジュバント療法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9717731B2 (https=) |
| EP (1) | EP2914263A4 (https=) |
| JP (3) | JP2015536950A (https=) |
| KR (1) | KR20150080592A (https=) |
| CN (2) | CN111329989A (https=) |
| AU (3) | AU2013337663A1 (https=) |
| BR (1) | BR112015010059A2 (https=) |
| CA (1) | CA2890111A1 (https=) |
| CL (1) | CL2015001147A1 (https=) |
| CR (1) | CR20150242A (https=) |
| DO (1) | DOP2015000098A (https=) |
| EA (1) | EA201590822A1 (https=) |
| HK (1) | HK1214508A1 (https=) |
| IL (1) | IL238548A0 (https=) |
| MX (2) | MX2015005633A (https=) |
| NI (1) | NI201500062A (https=) |
| PE (1) | PE20151604A1 (https=) |
| PH (1) | PH12015500985A1 (https=) |
| SG (1) | SG11201503459SA (https=) |
| TN (1) | TN2015000170A1 (https=) |
| TW (1) | TW201427664A (https=) |
| WO (1) | WO2014071231A1 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| TWI546290B (zh) | 2008-06-27 | 2016-08-21 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| CN105566229A (zh) | 2010-08-10 | 2016-05-11 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐及其用途和制备方法 |
| DK2632927T3 (en) | 2010-10-26 | 2016-04-11 | Mars Inc | Boronates AS ARGINSASEINHIBITORER |
| EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| MX382354B (es) | 2010-11-01 | 2025-03-13 | Celgene Car Llc | Compuestos heterocíclicos y usos de los mismos. |
| JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | 変異体選択的egfr阻害剤およびその使用 |
| AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
| KR102081042B1 (ko) | 2012-03-15 | 2020-02-26 | 셀젠 카르 엘엘씨 | 상피 성장 인자 수용체 키나제 억제제의 고체 형태 |
| PL2825042T3 (pl) | 2012-03-15 | 2019-02-28 | Celgene Car Llc | Sole inhibitora kinazy receptora czynnika wzrostu naskórka |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| SG11201503459SA (en) | 2012-11-02 | 2015-06-29 | Pharmacyclics Inc | Tec family kinase inhibitor adjuvant therapy |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| AU2014214846A1 (en) | 2013-02-08 | 2015-07-23 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| CA2919996A1 (en) * | 2013-08-02 | 2015-02-05 | Pharmacyclics Llc | Methods for the treatment of solid tumors |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| JP6508785B2 (ja) * | 2013-10-25 | 2019-05-08 | ファーマサイクリックス エルエルシー | ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置 |
| WO2015084892A1 (en) * | 2013-12-02 | 2015-06-11 | Cornell University | Methods for treating b cell proliferative disorders |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2015187848A1 (en) * | 2014-06-04 | 2015-12-10 | Sampath Deepa | Hdac inhibitor and btk inhibitor combinations |
| WO2015192081A1 (en) * | 2014-06-13 | 2015-12-17 | Byrd, John C. | Biomarker for predicting response of cll to treatment with a btk inhibitor |
| WO2016010961A1 (en) * | 2014-07-15 | 2016-01-21 | Abbvie Inc. | Enzyme occupancy assay |
| US10799604B2 (en) | 2014-07-25 | 2020-10-13 | Northeastern University | Biopolymer-nanoparticle composite implant for tumor cell tracking |
| US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| WO2016044774A1 (en) * | 2014-09-18 | 2016-03-24 | Pharmacyclics Llc | Dendritic cell based vaccine with bruton's tyrosine kinase inhibitor |
| WO2016090107A2 (en) * | 2014-12-04 | 2016-06-09 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2016123073A1 (en) | 2015-01-26 | 2016-08-04 | Children's Medical Center Corporation | Treatment of infectious diseases |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11512289B2 (en) | 2015-02-18 | 2022-11-29 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016138542A1 (en) * | 2015-02-28 | 2016-09-01 | Cyprus Therapeutics, Inc. | Methods for inhibiting tumors and drug resistance |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibitor |
| HK1251165A1 (en) | 2015-04-13 | 2019-01-25 | Daiichi Sankyo Company, Limited | Treatment method combining mdm2 inhibitor and btk inhibitor |
| WO2016172342A1 (en) | 2015-04-21 | 2016-10-27 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| WO2016196385A1 (en) | 2015-05-29 | 2016-12-08 | Portola Pharmaceuticals, Inc. | Cerdulatinib for the treatment of b-cell malignancies |
| US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
| JP2018522028A (ja) * | 2015-07-31 | 2018-08-09 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害剤の組み合わせ及びそれらの使用 |
| JP6833816B2 (ja) * | 2015-08-12 | 2021-02-24 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 骨髄腫を治療するためのセルデュラチニブ(cerdulatinib) |
| WO2017075363A1 (en) * | 2015-10-30 | 2017-05-04 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| AU2016363005A1 (en) | 2015-12-04 | 2018-07-05 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating hematological cancers |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| JP7674628B2 (ja) * | 2016-02-19 | 2025-05-12 | イーアイティー・ファーマ・インコーポレイテッド | インターフェロンラムダによるデルタ型肝炎ウイルス感染の処置 |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| EP3318276A1 (en) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| CN106405086A (zh) * | 2016-09-21 | 2017-02-15 | 四川大学华西医院 | 一种肺癌筛查试剂盒 |
| AU2017355544A1 (en) | 2016-11-03 | 2019-05-16 | Juno Therapeutics, Inc. | Combination therapy of a T cell therapy and a BTK inhibitor |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| SMT202100573T1 (it) | 2016-12-22 | 2021-11-12 | Calithera Biosciences Inc | Composizioni e metodi per l'inibizione dell'attivita' dell'arginasi |
| CN108732280B (zh) * | 2017-04-18 | 2022-07-08 | 广东东阳光药业有限公司 | 一种分离检测盐酸达卡他韦及其光学异构体的方法 |
| WO2019014684A1 (en) * | 2017-07-14 | 2019-01-17 | Ohio State Innovation Foundation | EXPANSION OF IMMUNE CELLS WITH INTERLEUKIN-INDUCIBLE T CELL KINASE-INHIBITING COMPOUNDS |
| EP3688007B1 (en) | 2017-09-27 | 2024-07-31 | The University of York | Bioconjugation of polypeptides |
| CZ2017787A3 (cs) | 2017-12-08 | 2019-06-19 | Zentiva, K.S. | Farmaceutické kompozice obsahující ibrutinib |
| US20210121466A1 (en) | 2018-05-03 | 2021-04-29 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| EP3788035B1 (en) | 2018-05-04 | 2024-08-07 | Alexion Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| CN111110685A (zh) * | 2018-10-31 | 2020-05-08 | 正大天晴药业集团股份有限公司 | 一种含伊布替尼的药物组合物及其应用 |
| US20220339156A1 (en) * | 2019-09-09 | 2022-10-27 | The Children's Hospital Of Philadelphia | Compositions and methods for treatment of disorders associated with clec16a dysfunction or loss |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| CN112779285B (zh) * | 2019-11-11 | 2023-01-06 | 百奥赛图(北京)医药科技股份有限公司 | 人源化il-10和il-10ra基因改造动物的构建方法和应用 |
| JP2023511105A (ja) | 2020-01-22 | 2023-03-16 | プリンシピア バイオファーマ インコーポレイテッド | 2-[3-[4-アミノ-3-(2-フルオロ-4-フェノキシ-フェニル)-1h-ピラゾロ[3,4-d]ピリミジン-1-イル]ピペリジン-1-カルボニル]-4-メチル-4-[4-(オキセタン-3-イル)ピペラジン-1-イル]ペンタ-2-エンニトリルの結晶形態 |
| WO2021207716A2 (en) * | 2020-04-10 | 2021-10-14 | Ohio State Innovation Foundation | Methods and composition for treatment of covid-19 illness requiring hospitalization |
| US20230286934A1 (en) * | 2020-06-08 | 2023-09-14 | Icahn School Of Medicine At Mount Sinai | Use of Multi-Kinase Inhibitors to Treat RNA Virus Infections |
| KR20240169633A (ko) * | 2022-04-05 | 2024-12-03 | 코버스 파마슈티칼스, 인크. | Th1 세포 활성을 증가시키기 위한 itk 저해제 |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2025071560A1 (en) * | 2023-09-28 | 2025-04-03 | Rutgers, The State University Of New Jersey | Methods of diagnosing b cell malignancies, detecting b cell malignancy relapse, and treating thereof |
| WO2024206869A2 (en) * | 2023-03-30 | 2024-10-03 | Board Of Regents, The University Of Texas System | Combination of hpk1 inhibitor and axl inhibitor in cancer therapy |
| WO2025085889A1 (en) * | 2023-10-20 | 2025-04-24 | Corvus Pharmaceuticals, Inc. | Interleukin-2-inducible t-cell kinase inhibitors to produce enhanced immune responses |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| JP3416147B2 (ja) | 1996-01-23 | 2003-06-16 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | 活性化tリンパ球におけるリバビリン及びリバビリン類似体によるth1型/th2型サイトカインの発現の調節 |
| EP1254911A1 (en) | 1996-10-16 | 2002-11-06 | ICN Pharmaceuticals, Inc. | Monocyclic L-nucleosides, analogs and uses thereof |
| US7390619B1 (en) | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
| US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| CA2345722A1 (en) | 1998-09-28 | 2000-04-06 | Albert Edge | Determining resistance to treatment for hepatitis c virus |
| US6824768B2 (en) | 1998-12-18 | 2004-11-30 | Schering Corporation | Ribavirin-pegylated interferon alfa induction HCV combination therapy |
| AU4463300A (en) | 1999-04-19 | 2000-11-02 | Schering Corporation | Hcv combination therapy, containing ribavirin in association with antioxidants |
| WO2001032210A2 (en) | 1999-10-29 | 2001-05-10 | Pharmacyclics, Inc. | Compositions for treating atheroma and neoplastic tissue |
| WO2001066132A2 (en) | 2000-03-09 | 2001-09-13 | Schering Corporation | Hiv immune adjuvant therapy |
| AU2001259788A1 (en) | 2000-05-18 | 2001-11-26 | Genetics Institute, Llc | Identification and modulationof of a t helper-1 and t helper-2 cells |
| EP1326594A2 (en) | 2000-10-18 | 2003-07-16 | Schering Corporation | Ribavirin-pegylated interferon alfa hcv combination therapy |
| US20030103938A1 (en) | 2001-05-09 | 2003-06-05 | Alk-Abello A/S | Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio |
| GB0116249D0 (en) | 2001-07-05 | 2001-08-29 | Imp College Innovations Ltd | Methods |
| CN1688340A (zh) | 2002-07-15 | 2005-10-26 | 韦思公司 | 调节t辅助(th)细胞发育和功能的方法和组合物 |
| AU2003300184B8 (en) | 2002-12-30 | 2009-12-03 | 3M Innovative Properties Company | Immunostimulatory combinations |
| WO2004110245A2 (en) | 2003-05-16 | 2004-12-23 | Intermune, Inc. | Combination therapy for cancer treatment |
| EP1670503A4 (en) | 2003-09-30 | 2008-09-24 | Telethon Inst For Child Health | IMMUNOTHERAPY METHOD |
| WO2007052059A2 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Changing th1/th2 balance in split influenza vaccines with adjuvants |
| WO2007059329A2 (en) | 2005-11-16 | 2007-05-24 | Pharmacyclics, Inc. | Methods and compositions for treating cancer |
| GB0605521D0 (en) | 2006-03-18 | 2006-04-26 | Isis Innovation | Adjuvant |
| US20080131398A1 (en) | 2006-08-21 | 2008-06-05 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| BRPI0622054B8 (pt) * | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| US20120065201A1 (en) | 2007-03-28 | 2012-03-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| NZ585500A (en) | 2007-11-12 | 2012-06-29 | Theraclone Sciences Inc | Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus |
| GB0805356D0 (en) | 2008-03-25 | 2008-04-30 | Isis Innovation | Vaccine adjuvant composition |
| CN102036658A (zh) | 2008-05-23 | 2011-04-27 | 香港大学 | 治疗流感的联合疗法 |
| US20110218512A1 (en) | 2008-06-03 | 2011-09-08 | Aethlon Medical, Inc. | Enhanced antiviral therapy methods and devices |
| JP2012503619A (ja) | 2008-09-26 | 2012-02-09 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Hcv感染に対する抗ウイルス治療のための標的としての宿主細胞キナーゼ |
| CA2745284A1 (en) | 2008-12-18 | 2010-06-24 | F. Hoffmann-La Roche Ag | Biomarkers for hcv treatment response |
| WO2010093843A2 (en) | 2009-02-12 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies |
| WO2010123891A1 (en) | 2009-04-20 | 2010-10-28 | Genentech, Inc. | Adjuvant cancer therapy |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| CN107898791A (zh) * | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| GB2481611A (en) | 2010-06-30 | 2012-01-04 | Statoil Asa | Test cell for well fluid assessment |
| RU2013127625A (ru) * | 2010-11-18 | 2014-12-27 | Зе Дженерал Хоспитал Корпорейшен | Новые композиции и применения антигипертензивных средств для терапии рака |
| AU2012275841A1 (en) | 2011-06-27 | 2014-01-16 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
| WO2013036994A1 (en) | 2011-09-16 | 2013-03-21 | Biota Scientific Management Pty Ltd | Compounds for the treatment of hcv |
| CA2853138A1 (en) | 2011-12-05 | 2013-06-13 | Immunomedics, Inc. | Therapeutic use of anti-cd22 antibodies for inducing trogocytosis |
| JO3754B1 (ar) | 2012-06-04 | 2021-01-31 | Pharmacyclics Llc | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
| SG11201503459SA (en) | 2012-11-02 | 2015-06-29 | Pharmacyclics Inc | Tec family kinase inhibitor adjuvant therapy |
-
2013
- 2013-11-01 SG SG11201503459SA patent/SG11201503459SA/en unknown
- 2013-11-01 HK HK16102454.7A patent/HK1214508A1/zh unknown
- 2013-11-01 EA EA201590822A patent/EA201590822A1/ru unknown
- 2013-11-01 EP EP13850097.0A patent/EP2914263A4/en not_active Withdrawn
- 2013-11-01 CN CN202010271248.7A patent/CN111329989A/zh active Pending
- 2013-11-01 PE PE2015000592A patent/PE20151604A1/es not_active Application Discontinuation
- 2013-11-01 KR KR1020157014129A patent/KR20150080592A/ko not_active Withdrawn
- 2013-11-01 TW TW102139881A patent/TW201427664A/zh unknown
- 2013-11-01 MX MX2015005633A patent/MX2015005633A/es unknown
- 2013-11-01 US US14/070,420 patent/US9717731B2/en active Active
- 2013-11-01 WO PCT/US2013/068132 patent/WO2014071231A1/en not_active Ceased
- 2013-11-01 BR BR112015010059A patent/BR112015010059A2/pt not_active Application Discontinuation
- 2013-11-01 JP JP2015540834A patent/JP2015536950A/ja active Pending
- 2013-11-01 CN CN201380065469.7A patent/CN104994858A/zh active Pending
- 2013-11-01 AU AU2013337663A patent/AU2013337663A1/en not_active Abandoned
- 2013-11-01 CA CA2890111A patent/CA2890111A1/en not_active Abandoned
-
2014
- 2014-03-05 US US14/198,559 patent/US20140371241A1/en not_active Abandoned
-
2015
- 2015-04-30 NI NI201500062A patent/NI201500062A/es unknown
- 2015-04-30 IL IL238548A patent/IL238548A0/en unknown
- 2015-04-30 CL CL2015001147A patent/CL2015001147A1/es unknown
- 2015-04-30 DO DO2015000098A patent/DOP2015000098A/es unknown
- 2015-05-04 TN TNP2015000170A patent/TN2015000170A1/fr unknown
- 2015-05-04 MX MX2021003018A patent/MX2021003018A/es unknown
- 2015-05-04 PH PH12015500985A patent/PH12015500985A1/en unknown
- 2015-05-08 CR CR20150242A patent/CR20150242A/es unknown
-
2017
- 2017-07-14 US US15/650,830 patent/US20180071293A1/en not_active Abandoned
-
2018
- 2018-09-21 AU AU2018233032A patent/AU2018233032B2/en not_active Ceased
- 2018-09-25 JP JP2018179447A patent/JP2019031506A/ja not_active Ceased
-
2019
- 2019-05-21 US US16/418,590 patent/US20200147084A1/en not_active Abandoned
-
2020
- 2020-07-13 JP JP2020120047A patent/JP2020183413A/ja active Pending
- 2020-08-21 AU AU2020220205A patent/AU2020220205A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015536950A5 (https=) | ||
| JP2017517520A5 (https=) | ||
| PH12016500575A1 (en) | Inhibitors of bruton`s tyrosine kinase | |
| PH12014501815A1 (en) | Purinone compounds as kinase inhibitors | |
| CN112888458A (zh) | Cldn18的抗体和化疗药物的联合治疗 | |
| JP2008507530A5 (https=) | ||
| PH12015501067A1 (en) | Pyrrolopyrimidine compounds as kinase inhibitors | |
| JP2016506908A5 (https=) | ||
| JP2015134825A5 (https=) | ||
| PH12015500940A1 (en) | Bruton`s tyrosine kinase inhibitors | |
| JP2018508469A5 (https=) | ||
| CN106659757A8 (zh) | 白介素2的超级激动剂、部分激动剂和拮抗剂 | |
| WO2016196776A3 (en) | Inhibitors of bruton's tyrosine kinase | |
| JP2013527232A5 (https=) | ||
| JP2011079858A5 (https=) | ||
| NZ707377A (en) | Combination therapy methods for treating proliferative diseases | |
| HK1222297A1 (zh) | 一种包含ampk激活剂及血清素活性制剂之医药组合物及其用途 | |
| CL2014002557A1 (es) | Compuestos bicíclicos de pirazinona; procedimiento de preparacion; composicion farmaceutica; kit; y uso en el tratamiento y/o prevencion de enfermedades cardiovasculares, cancer, entre otras. | |
| WO2014165412A3 (en) | Methods and compositions for treating cancers having acquired resistance to chemotherapeutic and targeted drugs using carboxyamidotriazole orotate | |
| MX2022001249A (es) | Tratamiento de tumores evasivos inmunitarios. | |
| WO2009140675A3 (en) | Combination therapy with pm00104 and another antitumor agent | |
| RU2015152785A (ru) | Лечение злокачественной опухоли налтрексоном | |
| NZ801252A (en) | Pharmaceutical composition comprising insoluble camptothecin compound-containing nanoparticle for treatment of cancer and combination therapy thereof | |
| IL179075A (en) | Use of random copolymer preparations in the preparation of drugs for the treatment of diseases, the reduction of undesirable immune reactions and the treatment of multiple sclerosis and pharmaceutical preparations containing random copolymer preparations | |
| WO2008088855A3 (en) | Gene polymorphisms as predictors of tumor progression and their use in cancer therapy |