CN106659757A8 - 白介素2的超级激动剂、部分激动剂和拮抗剂 - Google Patents

白介素2的超级激动剂、部分激动剂和拮抗剂 Download PDF

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CN106659757A8
CN106659757A8 CN201580033661.7A CN201580033661A CN106659757A8 CN 106659757 A8 CN106659757 A8 CN 106659757A8 CN 201580033661 A CN201580033661 A CN 201580033661A CN 106659757 A8 CN106659757 A8 CN 106659757A8
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mutains
agonist
antagonist
interleukin
pharmaceutical composition
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CN201580033661.7A
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CN106659757B (zh
CN106659757A (zh
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K·克里斯多夫·加西亚
休曼·米特拉
沃伦·J·莱昂纳多
亚伦·M·林
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National Institutes of Health NIH
Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

提供了新型人白介素-2(IL-2)突变蛋白或其变体。具体地讲，提供了与野生型IL-2相比具有升高的对IL-2RP受体的结合能力和降低的对IL-2Rγc受体的结合能力的IL-2突变蛋白。例如，此类IL-2突变蛋白在降低或抑制一种或多种IL-2和/或IL-15功能为有用的应用中(例如，在治疗移植物抗宿主病(GVHD)和成人T细胞白血病中)可用作IL-2部分激动剂和拮抗剂。还提供了编码此类IL-2突变蛋白的核酸、制备此类IL-2突变蛋白的方法、包含此类IL-2突变蛋白的药物组合物和使用此类药物组合物的治疗方法。
CN201580033661.7A 2014-04-24 2015-04-24 白介素2的超级激动剂、部分激动剂和拮抗剂 Active CN106659757B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983973P 2014-04-24 2014-04-24
US61/983,973 2014-04-24
PCT/US2015/027635 WO2015164815A1 (en) 2014-04-24 2015-04-24 Superagonists, partial agonists and antagonists of interleukin-2

Publications (3)

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CN106659757A CN106659757A (zh) 2017-05-10
CN106659757A8 true CN106659757A8 (zh) 2017-07-07
CN106659757B CN106659757B (zh) 2022-01-28

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US (4) US10150802B2 (zh)
EP (1) EP3134102B1 (zh)
JP (3) JP6592505B2 (zh)
CN (1) CN106659757B (zh)
CA (1) CA2946398A1 (zh)
WO (1) WO2015164815A1 (zh)

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US20170044229A1 (en) 2017-02-16
US20230002467A1 (en) 2023-01-05
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JP2020023506A (ja) 2020-02-13
WO2015164815A1 (en) 2015-10-29
JP2017518361A (ja) 2017-07-06
US10150802B2 (en) 2018-12-11
US11384131B2 (en) 2022-07-12
JP6592505B2 (ja) 2019-10-16
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EP3134102A1 (en) 2017-03-01
US20190119346A1 (en) 2019-04-25
EP3134102A4 (en) 2017-11-15
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US20210079055A1 (en) 2021-03-18

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