JP2015536337A5 - - Google Patents

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Publication number

JP2015536337A5

JP2015536337A5 JP2015540784A JP2015540784A JP2015536337A5 JP 2015536337 A5 JP2015536337 A5 JP 2015536337A5 JP 2015540784 A JP2015540784 A JP 2015540784A JP 2015540784 A JP2015540784 A JP 2015540784A JP 2015536337 A5 JP2015536337 A5 JP 2015536337A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

nucleic acid

acid molecule

erfe

Prior art date

2013-10-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 101000938779 Homo sapiens Erythroferrone Proteins 0.000 claims 22
• 102000039446 nucleic acids Human genes 0.000 claims 15
• 108020004707 nucleic acids Proteins 0.000 claims 15
• 150000007523 nucleic acids Chemical class 0.000 claims 15
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 208000007502 anemia Diseases 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 7
• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 6
• 208000018565 Hemochromatosis Diseases 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 6
• 102000018511 hepcidin Human genes 0.000 claims 6
• 229940066919 hepcidin Drugs 0.000 claims 6
• 108060003558 hepcidin Proteins 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 230000035772 mutation Effects 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 230000010438 iron metabolism Effects 0.000 claims 4
• 102100030767 Erythroferrone Human genes 0.000 claims 3
• -1 An antibody Proteins 0.000 claims 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 208000002903 Thalassemia Diseases 0.000 claims 2
• 208000020832 chronic kidney disease Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 201000000359 African iron overload Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010003591 Ataxia Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000017667 Chronic Disease Diseases 0.000 claims 1
• 206010010356 Congenital anomaly Diseases 0.000 claims 1
• 108700037009 Congenital atransferrinemia Proteins 0.000 claims 1
• 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 1
• 208000019505 Deglutition disease Diseases 0.000 claims 1
• 108700000224 Familial apoceruloplasmin deficiency Proteins 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 208000013381 GRACILE syndrome Diseases 0.000 claims 1
• 102000048988 Hemochromatosis Human genes 0.000 claims 1
• 201000000361 Hemochromatosis type 2 Diseases 0.000 claims 1
• 102000000213 Hemojuvelin Human genes 0.000 claims 1
• 108050008605 Hemojuvelin Proteins 0.000 claims 1
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
• 101000835086 Homo sapiens Transferrin receptor protein 2 Proteins 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 208000028958 Hyperferritinemia Diseases 0.000 claims 1
• 208000020075 IRIDA syndrome Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 206010022971 Iron Deficiencies Diseases 0.000 claims 1
• 206010065973 Iron Overload Diseases 0.000 claims 1
• 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 1
• 102100027891 Mitochondrial chaperone BCS1 Human genes 0.000 claims 1
• 208000031790 Neonatal hemochromatosis Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 241000232971 Passer domesticus Species 0.000 claims 1
• 241000097929 Porphyria Species 0.000 claims 1
• 208000010642 Porphyrias Diseases 0.000 claims 1
• 208000031306 Rare hereditary hemochromatosis Diseases 0.000 claims 1
• 108091006976 SLC40A1 Proteins 0.000 claims 1
• 102100026143 Transferrin receptor protein 2 Human genes 0.000 claims 1
• 208000018839 Wilson disease Diseases 0.000 claims 1
• 201000006288 alpha thalassemia Diseases 0.000 claims 1
• 201000007867 atransferrinemia Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 201000008230 cutaneous porphyria Diseases 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000913 erythropoietic effect Effects 0.000 claims 1
• 208000006454 hepatitis Diseases 0.000 claims 1
• 231100000283 hepatitis Toxicity 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 208000006278 hypochromic anemia Diseases 0.000 claims 1
• 208000009300 hypochromic microcytic anemia Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000002458 infectious effect Effects 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 238000012261 overproduction Methods 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 238000011282 treatment Methods 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1