RU2684216C2 - Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа - Google Patents

Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа Download PDF

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RU2684216C2
RU2684216C2 RU2015120601A RU2015120601A RU2684216C2 RU 2684216 C2 RU2684216 C2 RU 2684216C2 RU 2015120601 A RU2015120601 A RU 2015120601A RU 2015120601 A RU2015120601 A RU 2015120601A RU 2684216 C2 RU2684216 C2 RU 2684216C2
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erfe
hepcidin
iron
erythroferron
mice
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RU2015120601A
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RU2015120601A (ru
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Томас ГАНЗ
Элизабета НЕМЕТ
Леон КАУТЦ
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Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния
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    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • AHUMAN NECESSITIES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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RU2015120601A 2012-11-01 2013-10-31 Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа RU2684216C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721322P 2012-11-01 2012-11-01
US61/721,322 2012-11-01
PCT/US2013/067771 WO2014071015A1 (en) 2012-11-01 2013-10-31 Erythroferrone and erfe polypeptides and methods of regulating iron metabolism

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RU2015120601A RU2015120601A (ru) 2016-12-20
RU2684216C2 true RU2684216C2 (ru) 2019-04-04

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US (2) US20160122409A1 (enExample)
EP (1) EP2914619B1 (enExample)
JP (1) JP6501362B2 (enExample)
KR (1) KR102186218B1 (enExample)
CN (1) CN104854130A (enExample)
AU (1) AU2013337808B2 (enExample)
BR (1) BR112015009954A2 (enExample)
CA (1) CA2890040A1 (enExample)
ES (1) ES2731609T3 (enExample)
RU (1) RU2684216C2 (enExample)
WO (1) WO2014071015A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3448405B1 (en) 2016-04-27 2024-07-03 Vladimir Badmaev Method maintaining iron homeostasis with shogaols
US20190284274A1 (en) * 2016-08-05 2019-09-19 Silarus Therapeutics, Inc. Erfe specific antibodies compositions and methods of use
EP3519432A1 (en) * 2016-10-03 2019-08-07 Silarus Therapeutics, Inc. Erfe fusion polypeptides compositions and methods of use
IL269318B2 (en) * 2017-03-13 2024-10-01 Intrinsic Lifesciences Llc ANTIBODIES TO HUMAN ERYTHROFERRONE AND USES THEREOF
EP3628006A4 (en) * 2017-05-16 2021-07-21 Generos Biopharma Ltd. COMPOSITIONS AND METHODS OF TREATMENT FOR RHEUMATOID ARTHRITIS
US11255865B2 (en) 2017-06-06 2022-02-22 The Regents Of The University Of California Immunoassay for human erythroferrone
WO2019148186A1 (en) * 2018-01-29 2019-08-01 Silarus Therapeutics, Inc. Antibodies binding erfe and methods of use
WO2019212364A1 (en) * 2018-05-01 2019-11-07 Christopher Joseph Pemberton Test for heart failure
US20210196823A1 (en) * 2018-06-08 2021-07-01 Pfizer Inc. Methods of Treating Metabolic Disease
US20220119516A1 (en) * 2019-01-16 2022-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Variants of erythroferrone and their use
CA3156007A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
WO2024170505A1 (en) 2023-02-13 2024-08-22 Institut National de la Santé et de la Recherche Médicale Methods of treatment of iron overload associated diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006046073A2 (en) * 2004-10-28 2006-05-04 Ares Trading S.A. C1q related protein
RU2359268C2 (ru) * 2002-11-19 2009-06-20 ДиАрДжи ИНТЕРНЭШНЛ, ИНК. Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2597925A1 (en) * 2005-02-16 2006-08-24 The General Hospital Corporation Use of a human hemojuvelin product to regulate hepcidin-mediated iron metabolism
TW201206954A (en) * 2007-02-02 2012-02-16 Amgen Inc Hepcidin, hepcidin antagonists and methods of use
GB0818273D0 (en) * 2008-10-06 2008-11-12 Cambridge Entpr Ltd Modulation of cellular activity and differentiation
WO2010065815A2 (en) * 2008-12-05 2010-06-10 The Regents Of The University Of California Mini-hepcidin peptides and methods of using thereof
WO2013112663A1 (en) * 2012-01-26 2013-08-01 The Johns Hopkins University Myonectin (ctrp15), compositions comprising same, and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2359268C2 (ru) * 2002-11-19 2009-06-20 ДиАрДжи ИНТЕРНЭШНЛ, ИНК. Способ диагностики заболеваний путем скрининга тканей, крови или жидкостей организма животных или человека на предмет обнаружения нефизиологических уровней гепсидина и его терапевтическое применение
WO2006046073A2 (en) * 2004-10-28 2006-05-04 Ares Trading S.A. C1q related protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SELDIN M.M. ET AL. Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, v. 287, n. 15, p.11968-11980. *

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KR20150077471A (ko) 2015-07-07
US20160122409A1 (en) 2016-05-05
JP6501362B2 (ja) 2019-04-17
CN104854130A (zh) 2015-08-19
AU2013337808B2 (en) 2017-12-21
AU2013337808A1 (en) 2015-05-14
EP2914619A1 (en) 2015-09-09
CA2890040A1 (en) 2014-05-08
JP2015536337A (ja) 2015-12-21
BR112015009954A2 (pt) 2017-08-22
KR102186218B1 (ko) 2020-12-03
ES2731609T3 (es) 2019-11-18
EP2914619A4 (en) 2016-05-11
US20180355008A1 (en) 2018-12-13
WO2014071015A1 (en) 2014-05-08
RU2015120601A (ru) 2016-12-20
EP2914619B1 (en) 2019-05-29

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