JP6501362B2 - エリスロフェロンおよびerfeポリペプチドならびに鉄代謝を調節する方法 - Google Patents
エリスロフェロンおよびerfeポリペプチドならびに鉄代謝を調節する方法 Download PDFInfo
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- JP6501362B2 JP6501362B2 JP2015540784A JP2015540784A JP6501362B2 JP 6501362 B2 JP6501362 B2 JP 6501362B2 JP 2015540784 A JP2015540784 A JP 2015540784A JP 2015540784 A JP2015540784 A JP 2015540784A JP 6501362 B2 JP6501362 B2 JP 6501362B2
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Description
Claims (5)
- 鉄代謝の疾患を治療するための医薬の製造における、ERFEポリペプチドに対する抗体の使用であって、ERFEポリペプチドが、配列番号1−15から選択される少なくとも1つで表されるポリペプチドであり、Xは任意のアミノ酸である、使用。
- 前記鉄代謝の疾患が、鉄過剰疾患、または異常に低レベルのヘプシジンに関連する疾患および/もしくは障害である、請求項1に記載の使用。
- 前記鉄代謝の疾患が、異常に低レベルの鉄および/または異常に高レベルのヘプシジンに関連する疾患である、
請求項1に記載の使用。 - 鉄代謝の疾患が、ヘモクロマトーシス、HFE変異ヘモクロマトーシス、フェロポーチン変異ヘモクロマトーシス、トランスフェリン受容体2変異ヘモクロマトーシス、ヘモジュベリン(hemojuvelin)変異ヘモクロマトーシス、ヘプシジン変異ヘモクロマトーシス、若年性ヘモクロマトーシス、新生児ヘモクロマトーシス、ヘプシジン欠乏症、輸血鉄過剰、サラセミア、中間型サラセミア、αサラセミア、鉄芽球性貧血、ポルフィリン症、晩発性皮膚ポルフィリン症、アフリカ鉄過剰、高フェリチン血症、セルロプラスミン欠乏症、無トランスフェリン血症、先天性赤血球異形成貧血、慢性疾患貧血、炎症性貧血、感染性貧血、低色素性小球性貧血、鉄欠乏症貧血、鉄難治性鉄欠乏症貧血、慢性腎臓疾病の貧血、エリスロポエチン耐性、肥満の鉄欠乏症、ヘプシジンを過剰産生するまたはその過剰産生を誘発する良性もしくは悪性腫瘤、ヘプシジン過剰を伴う状態、フリートライヒ運動失調症、グラシール症候群(gracile syndrome)、ハラーホルデン・スパッツ症候群、ウィルソン病、肺ヘモジデリン沈着症、肝細胞癌、癌、肝炎、肝硬変、異食症、慢性腎不全、インスリン抵抗性、糖尿病、アテローム性動脈硬化症、神経変性障害、多発性硬化症、パーキンソン病、ハンチントン病、およびアルツハイマー病からなる群から選択される、
請求項1に記載の使用。 - 試薬、デバイス、指示書、またはこれらの組み合わせと一緒にパッケージングされた、ERFEポリペプチドに対する少なくとも1つの抗体を含むキットであって、該ERFEポリペプチドは配列番号3−15から選択される少なくとも1つで表され、Xは任意のアミノ酸である、鉄代謝の疾患の診断、治療または監視において使用するための医薬を製造するためのキット。
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PCT/US2013/067771 WO2014071015A1 (en) | 2012-11-01 | 2013-10-31 | Erythroferrone and erfe polypeptides and methods of regulating iron metabolism |
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US (2) | US20160122409A1 (ja) |
EP (1) | EP2914619B1 (ja) |
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BR112018072141B8 (pt) | 2016-04-27 | 2022-12-20 | Badmaev Vladimir | Método para manter homeostase de ferro com shogaóis |
EP3497127A1 (en) * | 2016-08-05 | 2019-06-19 | Silarus Therapeutics, Inc. | Erfe specific antibodies compositions and methods of use |
EP3519432A1 (en) * | 2016-10-03 | 2019-08-07 | Silarus Therapeutics, Inc. | Erfe fusion polypeptides compositions and methods of use |
RU2019132201A (ru) * | 2017-03-13 | 2021-04-14 | ИНТРИНСИК ЛАЙФСАЙЕНСИС ЭлЭлСи | Антитела к человеческому эритроферрону и их применение |
EP3628006A4 (en) * | 2017-05-16 | 2021-07-21 | Generos Biopharma Ltd. | COMPOSITIONS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS |
US11255865B2 (en) | 2017-06-06 | 2022-02-22 | The Regents Of The University Of California | Immunoassay for human erythroferrone |
TW201945026A (zh) * | 2018-01-29 | 2019-12-01 | 美商希拉諾斯醫療公司 | 結合erfe之抗體及使用方法 |
WO2019212364A1 (en) * | 2018-05-01 | 2019-11-07 | Christopher Joseph Pemberton | Test for heart failure |
CA3045370A1 (en) * | 2018-06-08 | 2019-12-08 | Pfizer Inc. | Methods of treating metabolic disease |
JP2022522265A (ja) * | 2019-01-16 | 2022-04-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エリスロフェロンの変異体及びその使用 |
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JP4638350B2 (ja) * | 2002-11-19 | 2011-02-23 | ディーアールジー・インターナショナル,インコーポレイテッド | ヒトまたは動物の組織、血液もしくは体液中のヘプシジンの存在または量を検出する方法 |
GB0423973D0 (en) * | 2004-10-28 | 2004-12-01 | Ares Trading Sa | C1q related points |
WO2006088972A2 (en) * | 2005-02-16 | 2006-08-24 | The General Hospital Corporation | Use of modulatirs of compounds of tgf-beta superfamily to regulate hepcidin-mediated iron metabolism |
AU2008214386B2 (en) * | 2007-02-02 | 2013-09-19 | Amgen Inc | Hepcidin and hepcidin antibodies |
GB0818273D0 (en) * | 2008-10-06 | 2008-11-12 | Cambridge Entpr Ltd | Modulation of cellular activity and differentiation |
US8435941B2 (en) * | 2008-12-05 | 2013-05-07 | The Regents Of The University Of California | Mini-hepcidin peptides and methods of using thereof |
EP2807256A4 (en) * | 2012-01-26 | 2015-10-28 | Univ Johns Hopkins | MYONECTIN (CTRP15), COMPOSITION COMPRISING SAME AND METHODS OF USE |
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AU2013337808A1 (en) | 2015-05-14 |
WO2014071015A1 (en) | 2014-05-08 |
RU2684216C2 (ru) | 2019-04-04 |
AU2013337808B2 (en) | 2017-12-21 |
JP2015536337A (ja) | 2015-12-21 |
CA2890040A1 (en) | 2014-05-08 |
EP2914619B1 (en) | 2019-05-29 |
CN104854130A (zh) | 2015-08-19 |
KR20150077471A (ko) | 2015-07-07 |
US20180355008A1 (en) | 2018-12-13 |
US20160122409A1 (en) | 2016-05-05 |
ES2731609T3 (es) | 2019-11-18 |
BR112015009954A2 (pt) | 2017-08-22 |
EP2914619A1 (en) | 2015-09-09 |
KR102186218B1 (ko) | 2020-12-03 |
RU2015120601A (ru) | 2016-12-20 |
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