JP2015534812A - コラーゲン加水分解物及びその使用 - Google Patents
コラーゲン加水分解物及びその使用 Download PDFInfo
- Publication number
- JP2015534812A JP2015534812A JP2015540142A JP2015540142A JP2015534812A JP 2015534812 A JP2015534812 A JP 2015534812A JP 2015540142 A JP2015540142 A JP 2015540142A JP 2015540142 A JP2015540142 A JP 2015540142A JP 2015534812 A JP2015534812 A JP 2015534812A
- Authority
- JP
- Japan
- Prior art keywords
- collagen hydrolyzate
- collagen
- gelatin
- bone
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 title claims abstract description 97
- 108010035532 Collagen Proteins 0.000 title claims abstract description 97
- 229920001436 collagen Polymers 0.000 title claims abstract description 97
- 108010010803 Gelatin Proteins 0.000 claims abstract description 43
- 229920000159 gelatin Polymers 0.000 claims abstract description 43
- 235000019322 gelatine Nutrition 0.000 claims abstract description 43
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 43
- 239000008273 gelatin Substances 0.000 claims abstract description 42
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 28
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 13
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 9
- 230000037180 bone health Effects 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 7
- 230000007071 enzymatic hydrolysis Effects 0.000 claims abstract description 6
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims abstract description 6
- 101710118538 Protease Proteins 0.000 claims description 16
- 235000013406 prebiotics Nutrition 0.000 claims description 13
- 230000007935 neutral effect Effects 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 244000063299 Bacillus subtilis Species 0.000 claims description 8
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 230000015556 catabolic process Effects 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 6
- 238000006731 degradation reaction Methods 0.000 claims description 6
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 6
- 150000004676 glycans Chemical class 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 239000005017 polysaccharide Substances 0.000 claims description 6
- 208000001685 postmenopausal osteoporosis Diseases 0.000 claims description 6
- 230000009435 amidation Effects 0.000 claims description 5
- 238000007112 amidation reaction Methods 0.000 claims description 5
- 159000000007 calcium salts Chemical class 0.000 claims description 5
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 5
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 5
- 229920001542 oligosaccharide Polymers 0.000 claims description 5
- 229920002670 Fructan Polymers 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 229920001202 Inulin Polymers 0.000 claims description 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 3
- 229920001100 Polydextrose Polymers 0.000 claims description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 235000009582 asparagine Nutrition 0.000 claims description 3
- 229960001230 asparagine Drugs 0.000 claims description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 229940029339 inulin Drugs 0.000 claims description 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 235000010755 mineral Nutrition 0.000 claims description 3
- 235000016709 nutrition Nutrition 0.000 claims description 3
- 239000001259 polydextrose Substances 0.000 claims description 3
- 235000013856 polydextrose Nutrition 0.000 claims description 3
- 229940035035 polydextrose Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 239000002970 Calcium lactobionate Substances 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- 230000009471 action Effects 0.000 claims description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 2
- 239000001354 calcium citrate Substances 0.000 claims description 2
- 229960004256 calcium citrate Drugs 0.000 claims description 2
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
- 229960002401 calcium lactate Drugs 0.000 claims description 2
- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 229940050954 calcium lactobionate Drugs 0.000 claims description 2
- 235000019307 calcium lactobionate Nutrition 0.000 claims description 2
- RHEMCSSAABKPLI-SQCCMBKESA-L calcium;(2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate Chemical compound [Ca+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.[O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O RHEMCSSAABKPLI-SQCCMBKESA-L 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- 239000007894 caplet Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 230000000415 inactivating effect Effects 0.000 claims description 2
- 159000000003 magnesium salts Chemical class 0.000 claims description 2
- 239000002207 metabolite Substances 0.000 claims description 2
- 230000035764 nutrition Effects 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 235000019168 vitamin K Nutrition 0.000 claims description 2
- 239000011712 vitamin K Substances 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 229940046010 vitamin k Drugs 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 210000002805 bone matrix Anatomy 0.000 description 10
- 229940088598 enzyme Drugs 0.000 description 10
- 238000003786 synthesis reaction Methods 0.000 description 10
- 102000012422 Collagen Type I Human genes 0.000 description 9
- 108010022452 Collagen Type I Proteins 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 210000000963 osteoblast Anatomy 0.000 description 9
- 230000000638 stimulation Effects 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 230000007062 hydrolysis Effects 0.000 description 7
- 238000006460 hydrolysis reaction Methods 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- 229960005069 calcium Drugs 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 102000004067 Osteocalcin Human genes 0.000 description 5
- 108090000573 Osteocalcin Proteins 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 235000004554 glutamine Nutrition 0.000 description 5
- 239000006041 probiotic Substances 0.000 description 5
- 235000018291 probiotics Nutrition 0.000 description 5
- 230000004936 stimulating effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 108060003393 Granulin Proteins 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000002779 inactivation Effects 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 102000004954 Biglycan Human genes 0.000 description 3
- 108090001138 Biglycan Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 2
- 239000012981 Hank's balanced salt solution Substances 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 2
- 230000037182 bone density Effects 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 2
- 229940107187 fructooligosaccharide Drugs 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 230000000529 probiotic effect Effects 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 230000009103 reabsorption Effects 0.000 description 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 description 2
- 229940095743 selective estrogen receptor modulator Drugs 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000131386 Aspergillus sojae Species 0.000 description 1
- 241000193744 Bacillus amyloliquefaciens Species 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 108010049264 Teriparatide Proteins 0.000 description 1
- 206010044696 Tropical spastic paresis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000004251 balanced diet Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000018678 bone mineralization Effects 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- KIZFHUJKFSNWKO-UHFFFAOYSA-M calcium monohydroxide Chemical compound [Ca]O KIZFHUJKFSNWKO-UHFFFAOYSA-M 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 230000004821 effect on bone Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- NVJUPMZQNWDHTL-MJODAWFJSA-N partricin Chemical compound O1C(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(O[C@@H]2[C@@H]([C@H](N)[C@@H](O)[C@H](C)O2)O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 NVJUPMZQNWDHTL-MJODAWFJSA-N 0.000 description 1
- 229950007355 partricin Drugs 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000003687 soy isoflavones Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 1
- 229960005460 teriparatide Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/342—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of collagen; of gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
Abstract
Description
5重量%〜20重量%の濃度、好ましくは約10重量%の濃度でB型骨ゼラチンの水溶液を生成し、
ゼラチンの量に対して、1重量%〜4重量%の量、好ましくは約2重量%の量で枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを添加し、
40℃〜60℃の温度で、好ましくは、約50℃の温度で、そして5.5〜6.5のpH値で、好ましくは、約6のpH値で、20分間から40分間、好ましくは約30分間、ゼラチンにエンドプロテアーゼを作用させ、そして
エンドプロテアーゼを熱不活性化する
ことを含む。
本願発明によるコラーゲン加分解物の生成(実施例)及び本願発明によらない4つのコラーゲン加水分解物の生成(比較例1〜4)を以下に記載する。
200gウシゼラチンを、1800g蒸留水に、30分間、室温で浸漬した。予め浸漬したゼラチンを58±2℃に加熱し、撹拌しつつ溶解した。pH値を水酸化ナトリウム溶液で6.0±0.2に調節した。2重量%(ゼラチンに対して)の枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを、その後添加した。30分の加水分解継続後、酵素失活のために85℃で加熱した。
200g骨ゼラチンを、1800g蒸留水に、30分間、室温で浸漬した。予め浸漬したゼラチンを49±2℃に加熱し、そして撹拌しつつ溶解し、その後、1.64g CaCl2・2H2Oを添加した。pH値を水酸化ナトリウム溶液で6.0±0.2に調整した。その後、枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを、0.6重量%(ゼラチンに対して)を添加した。30分の加水分解継続後、0.2重量%(ゼラチンに対して)のバチルスアミロリケファシエンス(Bacillus amyloliquefaciens)由来の中性エンドプロテアーゼを添加した。180分の全加水分解継続後、酵素失活のために85℃で溶液を加熱し、そしてその後、乾燥させた。
200g骨ゼラチンを、1800g蒸留水に、30分間、室温で浸漬した。予め浸漬したゼラチンを49±2℃に加熱し、そして撹拌しつつ溶解し、その後、0.4g CaCl2・2H2Oを添加した。pH値を水酸化ナトリウム溶液で6.5±0.2に調整した。その後、枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを、0.6重量%(ゼラチンに対して)を添加した。60分の全加水分解継続後、0.2重量%(ゼラチンに対して)のショウユコウジカビ(Aspergillus sojae)由来のエキソプロテアーゼを添加した。7時間の加水分解継続後、酵素失活のために85℃で溶液を加熱し、そしてその後、乾燥させた。
200gブタ皮膚ゼラチンを、1800g蒸留水に、30分間、室温で浸漬した。予め浸漬したゼラチンを57±2℃に加熱し、撹拌しつつ溶解した。pH値を水酸化ナトリウム溶液で6.0±0.2に調節した。その後、0.3重量%(ゼラチンに対して)の枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを添加した。180分後、酵素失活のために85℃で加熱し、そしてその後、乾燥させた。
200gブタ皮膚ゼラチンを、1800g蒸留水に、30分間、室温で浸漬した。予め浸漬したゼラチンを58±2℃に加熱し、撹拌しつつ溶解した。pH値を水酸化ナトリウム溶液で7.0±0.2に調節した。その後、2重量%(ゼラチンに対して)のバチルスリケニフォルミス(Bacillus licheniformis)由来のアルカリエンドプロテアーゼを添加した。180分後、酵素失活のために85℃で加熱し、そしてその後、乾燥させた。
異なるコラーゲン加水分解物のペプチドの分子量分布を、ゲル浸透クロマトグラフィーで、以下のパラメータを使用して決定した。
固定相:TSK 2000 SW XL(Tosoh Bioscience GmbH)
移動相:0.4mol/l リン酸一ナトリウム pH5.3
流速:0.5ml/分
キャリブレーション標準:規定のI型コラーゲン断片(FILK,Freiberg)
検出:UV検出器 Knauer K‐2501(214nm)
本願発明によるコラーゲン加水分解物の特定の有効性の証拠として、基質の構築及び石灰化に役立つ、基質タンパク質及び酵素の合成に対するそれらの刺激効果を、骨芽細胞を使用してインビトロで研究した。これを、リアルタイムPCR及び半定量分析(全くコラーゲン加水分解物を含まない対照に関して)を用いて、関連するmRNAの発現を決定することによって行った。
Claims (18)
- B型骨ゼラチンの酵素的加水分解により生成されるコラーゲン加水分解物であって、ここで前記コラーゲン加水分解物が、少なくとも50重量%、好ましくは、少なくとも70重量%の、1,500Da〜13,500Daの分子量を有し、そして4,000Da〜8,000Daの範囲、好ましくは、4,500〜6,000の範囲の平均分子量を有するペプチドから形成される、コラーゲン加水分解物。
- 前記骨ゼラチンが、脊椎動物の骨、好ましくは、オセイン由来のコラーゲンのアルカリ分解によって生成される、請求項1に記載のコラーゲン加水分解物。
- 前記骨ゼラチンが5.5未満の等電点を有する、請求項1又は2に記載のコラーゲン加水分解物。
- 前記ペプチドが、15%未満、好ましくは、10%未満のグルタミン残基及び/又はグルタミン酸残基、及びアスパラギン残基及び/又はアスパラギン酸残基の全体のアミド化レベルを有する、請求項1〜3のいずれか1項に記載のコラーゲン加水分解物。
- 前記コラーゲン加水分解物の20重量%の水溶液が、25℃で、5mPa.s超、好ましくは、6mPa.s超の粘度を有する、請求項1〜4のいずれか1項に記載のコラーゲン加水分解物。
- 前記コラーゲン加水分解物が、300ppm未満、好ましくは、100ppm未満のアンモニウム、硫黄及びリン酸塩含量をそれぞれ有する、請求項1〜5のいずれか1項に記載のコラーゲン加水分解物。
- 前記コラーゲン加水分解物が、枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼで前記ゼラチンを加水分解することにより生成される、請求項1〜6のいずれか1項に記載のコラーゲン加水分解物。
- 前記コラーゲン加水分解物が、40℃〜60℃の温度、好ましくは、約50℃の温度で、20分間〜40分間、好ましくは、約30分間、前記エンドプロテアーゼの作用を介して生成される、請求項7に記載のコラーゲン加水分解物。
- 骨の健康を維持し及び/又は改善するための、好ましくは、骨粗鬆症を予防し及び/又は処置するための活性成分としての請求項1〜8のいずれか1項に記載のコラーゲン加水分解物。
- 閉経後骨粗鬆症を予防し及び/又は処置するための活性成分としての請求項9に記載のコラーゲン加水分解物。
- 前記コラーゲン加水分解物が、栄養サプリメントとして、好ましくは、粉末、顆粒、溶液、又は懸濁液の形態で、又は錠剤、カプセル、カプレット又はサチェットの形態で、処方される、請求項9又は10に記載のコラーゲン加水分解物。
- 1g〜15g、好ましくは、2g〜10g、より好ましくは、2g〜7g、そして特に好ましくは、2.5g〜5gの前記コラーゲン加水分解物の1日の経口摂取を提供する、請求項11に記載のコラーゲン加水分解物。
- 請求項1〜12のいずれか1項に記載のコラーゲン加水分解物及び1つ以上のプレバイオティクスを含む栄養サプリメント。
- 前記プレバイオティクスが、オリゴ糖及び/又は多糖類から、好ましくは、イヌリン、フルクタン、ガラクト‐オリゴ糖(GOS)、フルクト‐オリゴ糖(FOS)、難消化性デキストリン、ポリデキストロース及びそれらの混合物から選択される、請求項13に記載の栄養サプリメント。
- 好ましくは、クエン酸カルシウム、乳酸カルシウム、グルコン酸カルシウム、グルコン酸乳酸カルシウム、ラクトビオン酸カルシウム及びそれらの混合物から選択される1つ以上の可溶性カルシウム塩をさらに含む、請求項13又は14に記載の栄養サプリメント。
- ビタミンC、ビタミンD、ビタミンD3、ビタミンE、ビタミンK及びそれらの代謝物から選択される1つ以上のビタミンをさらに含む、請求項13〜15のいずれか1項に記載の栄養サプリメント。
- フッ化塩、カリウム塩及びマグネシウム塩から選択される1つ以上のミネラルをさらに含む、請求項13〜16のいずれか1項に記載の栄養サプリメント。
- 請求項1〜12のいずれか1項に記載のコラーゲン加水分解物を生成するための方法であって、以下のステップ:
5重量%〜20重量%の濃度、好ましくは約10重量%の濃度でB型骨ゼラチンの水溶液を生成し、
ゼラチンの量に対して、1重量%〜4重量%の量、好ましくは、約2重量%の量で枯草菌(Bacillus subtilis)由来の中性エンドプロテアーゼを添加し、
40℃〜60℃の温度で、好ましくは、約50℃の温度で、そして5.5〜6.5のpH値で、好ましくは、約6のpH値で、20分間から40分間、好ましくは約30分間、ゼラチンにエンドプロテアーゼを作用させ、そして
エンドプロテアーゼを熱不活性化する
ことを含む、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102012110612.6 | 2012-11-06 | ||
DE102012110612.6A DE102012110612A1 (de) | 2012-11-06 | 2012-11-06 | Kollagenhydrolysat und dessen Verwendung |
PCT/EP2013/072894 WO2014072235A1 (de) | 2012-11-06 | 2013-11-04 | Kollagenhydrolysat und dessen verwendung |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015534812A true JP2015534812A (ja) | 2015-12-07 |
JP2015534812A5 JP2015534812A5 (ja) | 2016-09-23 |
JP6272891B2 JP6272891B2 (ja) | 2018-01-31 |
Family
ID=49578271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015540142A Active JP6272891B2 (ja) | 2012-11-06 | 2013-11-04 | コラーゲン加水分解物及びその使用 |
Country Status (13)
Country | Link |
---|---|
US (1) | US10364283B2 (ja) |
EP (1) | EP2916855B1 (ja) |
JP (1) | JP6272891B2 (ja) |
CN (1) | CN104768566B (ja) |
AU (1) | AU2013343685B2 (ja) |
BR (1) | BR112015009473B1 (ja) |
CL (1) | CL2015001159A1 (ja) |
DE (1) | DE102012110612A1 (ja) |
ES (1) | ES2587928T3 (ja) |
MX (1) | MX2015005649A (ja) |
PL (1) | PL2916855T3 (ja) |
RU (1) | RU2671401C2 (ja) |
WO (1) | WO2014072235A1 (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102013104897A1 (de) * | 2013-05-13 | 2014-11-13 | Gelita Ag | Wirkstoff zur Behandlung von Sarkopenie |
DE102014117036A1 (de) | 2014-11-20 | 2016-05-25 | RenaCare NEPHROMED GmbH | Zusammensetzung zur Eiweißsubstitution |
DE202014105602U1 (de) | 2014-11-20 | 2015-11-23 | RenaCare NEPHROMED GmbH | Zusammensetzung zur Eiweißsubstitution |
RU2659383C2 (ru) * | 2015-10-20 | 2018-06-29 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Биоактивный гидрогель для регенерации кожи |
GR1009140B (el) * | 2016-01-12 | 2017-10-20 | Σωτηρης Γεωργιου Χορτομαρης | Συμπληρωμα διατροφης με χοιρινο και βοϊο κολλαγονο υδρολυμενο και ζελατινη |
NL2017219B1 (en) * | 2016-07-22 | 2018-01-30 | Rousselot B V | Low cross-linking gelatine |
CN110691604A (zh) * | 2017-03-15 | 2020-01-14 | 罗赛洛公司 | 水解胶原蛋白肽和共生微生物的组合物及其方法 |
CN107083415A (zh) * | 2017-05-27 | 2017-08-22 | 四川汇宇生物技术有限公司 | 一种明胶的生产方法 |
US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
DE102018120420A1 (de) * | 2018-08-22 | 2020-02-27 | Gelita Ag | Proteinriegel |
DE102019202606A1 (de) | 2018-11-06 | 2020-05-07 | Gelita Ag | Rekombinante Herstellung eines Kollagenpeptidpräparates und dessen Verwendung |
DE102019207859A1 (de) | 2018-12-21 | 2020-06-25 | Gelita Ag | Synthetische und rekombinant hergestellte Kollagenpeptide mit biologischer Wirksamkeit |
DE102020210725A1 (de) | 2019-10-31 | 2021-05-06 | Gelita Ag | Ernährungsphysiologisch optimiertes Kollagenpeptid |
DE102019130196A1 (de) * | 2019-11-08 | 2021-05-12 | Gelita Ag | Verfahren zur Herstellung von Kollagenpeptiden aus Knochen, und hergestellte Kollagenpeptide |
US20210145764A1 (en) * | 2019-11-15 | 2021-05-20 | Brigham Young University | Compositions of cannabidiol (cbd), and/or polyphenols, and methods for the prevention and/or treatment of skin, muscle, nerve and inflammatory disorders, and biological factors and functions in mammals |
DE202023107635U1 (de) | 2023-12-22 | 2024-02-08 | RenaCare NEPHROMED GmbH | Zusammensetzung zur Eiweißsubstitution |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03501686A (ja) * | 1988-10-14 | 1991-04-18 | ビーエーエスエフ、コーポレーション | 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法 |
JPH09255588A (ja) * | 1996-03-28 | 1997-09-30 | Snow Brand Milk Prod Co Ltd | 骨強化用医薬、飲食品及び飼料 |
JPH1112192A (ja) * | 1997-06-18 | 1999-01-19 | Zenyaku Kogyo Kk | 骨粗鬆症予防・治療剤 |
WO2008059927A1 (fr) * | 2006-11-15 | 2008-05-22 | Meiji Seika Kaisha, Ltd. | Composition de peptide de collagène et aliment ou boisson la contenant |
WO2012065782A2 (de) * | 2010-11-15 | 2012-05-24 | Gelita Ag | Kollagenhydrolysat für die verwendung zur verbesserung der gesundheit der menschlichen haut, haare und/oder nägel |
WO2012117012A1 (de) * | 2011-03-01 | 2012-09-07 | Gelita Ag | Zusammensetzung für ernährungszwecke |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5120761A (en) * | 1988-10-14 | 1992-06-09 | Finnan Jeffrey L | Method of making a free-flowing spray dried edible powder comprising an oil |
JPH09501678A (ja) * | 1993-08-13 | 1997-02-18 | ベイヤー、コーポレーション | かむ錠剤の芳香増進剤としての加水分解ゼラチン |
FR2720067B1 (fr) | 1994-05-17 | 1996-08-02 | Dielen Lab | Hydrolysat de protéines d'animaux marins, procédé d'obtention et applications. |
AU703137B2 (en) * | 1994-08-23 | 1999-03-18 | Dgf Stoess Ag | Use of tasteless, hydrolyzed collagen and agent containing the same |
US20020025921A1 (en) * | 1999-07-26 | 2002-02-28 | Petito George D. | Composition and method for growing, protecting, and healing tissues and cells |
GB0031065D0 (en) * | 2000-12-20 | 2001-01-31 | Univ Cardiff | Preservation of cells |
GB2418431A (en) * | 2004-09-27 | 2006-03-29 | Multigerm Uk Entpr Ltd | Metabolically active micro organisms and methods for their production |
US7485323B2 (en) * | 2005-05-31 | 2009-02-03 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
JP4975751B2 (ja) | 2005-10-13 | 2012-07-11 | グ、ジェニファー、エル. | ミネラル・コラーゲン・キレートおよびその製造方法と使用方法 |
WO2008075333A2 (en) * | 2006-12-18 | 2008-06-26 | Zeev Pam | Edible compositions for preventing hair loss |
JP2008247809A (ja) | 2007-03-30 | 2008-10-16 | Yaizu Suisankagaku Industry Co Ltd | コラーゲン錠剤 |
FR2927336B1 (fr) * | 2008-02-12 | 2010-05-21 | Cie Des Peches Saint Malo Sant | Hydrolysat de proteines de poissons presentant une activite de stimulation et de maintien du capital osseux, compositions nutraceutiques et pharmacologiques comprenant un tel hydrolysat et procede d'obtention |
DE102009030351A1 (de) | 2009-06-22 | 2010-12-23 | Gelita Ag | Zusammensetzung zur Behandlung von degenerativen Gelenkerkrankungen |
CN102094056B (zh) | 2009-12-14 | 2013-04-03 | 包头东宝生物技术股份有限公司 | 可溶性胶原蛋白的制备方法 |
JP5370225B2 (ja) * | 2010-03-18 | 2013-12-18 | 株式会社デンソーウェーブ | ロボットのアーム連結装置 |
US8603183B2 (en) * | 2011-06-22 | 2013-12-10 | Shinn Jyh Ding | Bilayered bone graft device |
-
2012
- 2012-11-06 DE DE102012110612.6A patent/DE102012110612A1/de not_active Withdrawn
-
2013
- 2013-11-04 ES ES13789518.1T patent/ES2587928T3/es active Active
- 2013-11-04 CN CN201380057628.9A patent/CN104768566B/zh active Active
- 2013-11-04 JP JP2015540142A patent/JP6272891B2/ja active Active
- 2013-11-04 WO PCT/EP2013/072894 patent/WO2014072235A1/de active Application Filing
- 2013-11-04 RU RU2015121573A patent/RU2671401C2/ru active
- 2013-11-04 EP EP13789518.1A patent/EP2916855B1/de active Active
- 2013-11-04 MX MX2015005649A patent/MX2015005649A/es active IP Right Grant
- 2013-11-04 AU AU2013343685A patent/AU2013343685B2/en active Active
- 2013-11-04 BR BR112015009473-2A patent/BR112015009473B1/pt active IP Right Grant
- 2013-11-04 PL PL13789518T patent/PL2916855T3/pl unknown
-
2015
- 2015-04-28 US US14/697,759 patent/US10364283B2/en active Active
- 2015-04-30 CL CL2015001159A patent/CL2015001159A1/es unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03501686A (ja) * | 1988-10-14 | 1991-04-18 | ビーエーエスエフ、コーポレーション | 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法 |
JPH09255588A (ja) * | 1996-03-28 | 1997-09-30 | Snow Brand Milk Prod Co Ltd | 骨強化用医薬、飲食品及び飼料 |
JPH1112192A (ja) * | 1997-06-18 | 1999-01-19 | Zenyaku Kogyo Kk | 骨粗鬆症予防・治療剤 |
WO2008059927A1 (fr) * | 2006-11-15 | 2008-05-22 | Meiji Seika Kaisha, Ltd. | Composition de peptide de collagène et aliment ou boisson la contenant |
WO2012065782A2 (de) * | 2010-11-15 | 2012-05-24 | Gelita Ag | Kollagenhydrolysat für die verwendung zur verbesserung der gesundheit der menschlichen haut, haare und/oder nägel |
WO2012117012A1 (de) * | 2011-03-01 | 2012-09-07 | Gelita Ag | Zusammensetzung für ernährungszwecke |
Also Published As
Publication number | Publication date |
---|---|
MX2015005649A (es) | 2015-08-20 |
AU2013343685A1 (en) | 2015-05-21 |
AU2013343685A8 (en) | 2015-07-02 |
RU2015121573A (ru) | 2016-12-27 |
PL2916855T3 (pl) | 2017-08-31 |
AU2013343685B2 (en) | 2018-03-29 |
ES2587928T3 (es) | 2016-10-27 |
WO2014072235A1 (de) | 2014-05-15 |
JP6272891B2 (ja) | 2018-01-31 |
DE102012110612A1 (de) | 2014-05-08 |
RU2671401C2 (ru) | 2018-10-31 |
CN104768566B (zh) | 2018-06-29 |
US20150232534A1 (en) | 2015-08-20 |
CL2015001159A1 (es) | 2015-08-28 |
CN104768566A (zh) | 2015-07-08 |
US10364283B2 (en) | 2019-07-30 |
BR112015009473B1 (pt) | 2022-10-04 |
EP2916855B1 (de) | 2016-07-27 |
BR112015009473A2 (pt) | 2017-07-04 |
EP2916855A1 (de) | 2015-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6272891B2 (ja) | コラーゲン加水分解物及びその使用 | |
JP5894341B2 (ja) | コラーゲンペプチド、エラスチンペプチドおよびプロテオグリカンを含む組成物 | |
ES2659413T3 (es) | Composición para fines nutricionales | |
US20050009734A1 (en) | Avian sternal cartilage composition and method of administering | |
KR101156703B1 (ko) | 계란유래의 뼈 강화 조성물 | |
US20190292242A1 (en) | Hydrolyzed Jellyfish Collagen Types I, II, and V and Use Thereof | |
KR101513855B1 (ko) | 알긴산을 포함하는 골관절염 예방 또는 치료용 조성물 | |
JP6441825B2 (ja) | フィラーの効能維持用組成物 | |
EP1273239B1 (en) | Uses of a composition comprising partly-hydrolyzed fish gelatin | |
JP4253296B2 (ja) | 健康美容食品 | |
JP2018030880A (ja) | 軟骨形成促進剤 | |
US20210401020A1 (en) | Hafnia alvei formulations | |
JPWO2009057280A1 (ja) | 骨強化用食品素材 | |
MXPA05004994A (es) | Composicion para el tratamiento de enfermedades gastrointestinales. | |
CN103494201B (zh) | L-抗坏血酸棕榈酸酯配伍的骨关节疾病保健品 | |
JP2005281186A (ja) | 創傷治癒剤、腱または靭帯の損傷等に対する改善、治癒促進または予防剤、機能性食品ならびに医薬品 | |
JP2002080340A (ja) | 美容組成物 | |
Sasidharan | Pharmaceutical and Hydrogel Applications of Marine Collagen | |
JP2020110066A (ja) | コンドロイチン硫酸含有ブタ軟骨抽出物を有効成分とする血圧上昇抑制剤およびそれを含有する食品組成物 | |
JP5756498B2 (ja) | 変形性関節症予防治療薬 | |
US20030096741A1 (en) | Enhanced mineral delivery | |
WO2015008836A1 (ja) | 筋萎縮防止及び/又は筋合成促進剤 | |
JP2013224277A (ja) | 経口骨強化組成物及びそれを含有する飲食品、医薬又は飼料 | |
KR20010045055A (ko) | 타우린을 포함하는 경조직 재생촉진제 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160802 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160802 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170425 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170426 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170725 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20171205 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180104 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6272891 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |