JP2015533810A5 - - Google Patents
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- JP2015533810A5 JP2015533810A5 JP2015533142A JP2015533142A JP2015533810A5 JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5 JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5
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- 150000001875 compounds Chemical class 0.000 claims description 54
- 150000003839 salts Chemical class 0.000 claims description 49
- VVVLTGMSHYUYEA-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NCC(O)=O)=C1 VVVLTGMSHYUYEA-UHFFFAOYSA-N 0.000 claims description 5
- JSESMWCLQOOOCY-UHFFFAOYSA-N 2-(4-methoxyphenyl)-n-(2,4,6-trimethoxyphenyl)ethanesulfonamide Chemical compound C1=CC(OC)=CC=C1CCS(=O)(=O)NC1=C(OC)C=C(OC)C=C1OC JSESMWCLQOOOCY-UHFFFAOYSA-N 0.000 claims description 4
- CHFLIEPNRSVIAP-UHFFFAOYSA-N 4-[2-(3,4-dimethoxyphenyl)ethylsulfanylmethyl]-2-methoxyphenol Chemical compound C1=C(OC)C(OC)=CC=C1CCSCC1=CC=C(O)C(OC)=C1 CHFLIEPNRSVIAP-UHFFFAOYSA-N 0.000 claims description 4
- UQCUBWLMEBNQAC-UHFFFAOYSA-N 4-[2-(3,4-dimethoxyphenyl)ethylsulfonylmethyl]-2-methoxyphenol Chemical compound C1=C(OC)C(OC)=CC=C1CCS(=O)(=O)CC1=CC=C(O)C(OC)=C1 UQCUBWLMEBNQAC-UHFFFAOYSA-N 0.000 claims description 4
- WJKRZBLORMSJFD-UHFFFAOYSA-N 4-methoxy-3-nitro-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNS(=O)(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 WJKRZBLORMSJFD-UHFFFAOYSA-N 0.000 claims description 4
- ACLZWBAKRRRYCE-UHFFFAOYSA-N 4-methoxy-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCC1=C(OC)C=C(OC)C=C1OC ACLZWBAKRRRYCE-UHFFFAOYSA-N 0.000 claims description 4
- RELMLWSUAWYQCN-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]-3-nitrobenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 RELMLWSUAWYQCN-UHFFFAOYSA-N 0.000 claims description 4
- OBJJVDWZGCVDCO-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(OC)C=C1 OBJJVDWZGCVDCO-UHFFFAOYSA-N 0.000 claims description 4
- HKDHSJXMJYCZCI-UHFFFAOYSA-N 4-methyl-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNS(=O)(=O)C1=CC=C(C)C=C1 HKDHSJXMJYCZCI-UHFFFAOYSA-N 0.000 claims description 4
- QIAINPANZBVSKL-UHFFFAOYSA-N n-[2-(4-methoxyphenyl)ethyl]-4-methylbenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(C)C=C1 QIAINPANZBVSKL-UHFFFAOYSA-N 0.000 claims description 4
- HEWJRHOJRHHIMM-UHFFFAOYSA-N 1,3,5-trimethoxy-2-[2-[(4-methoxyphenyl)methylsulfonyl]ethyl]benzene Chemical compound C1=CC(OC)=CC=C1CS(=O)(=O)CCC1=C(OC)C=C(OC)C=C1OC HEWJRHOJRHHIMM-UHFFFAOYSA-N 0.000 claims description 2
- VVNSAGFVOFCHEZ-UHFFFAOYSA-N 1-[2-[(4-chlorophenyl)methylsulfonyl]ethyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1CCS(=O)(=O)CC1=CC=C(Cl)C=C1 VVNSAGFVOFCHEZ-UHFFFAOYSA-N 0.000 claims description 2
- DZPCCAFPSYYZNT-UHFFFAOYSA-N 1-chloro-4-[2-(4-fluorophenyl)ethylsulfanylmethyl]benzene Chemical compound C1=CC(F)=CC=C1CCSCC1=CC=C(Cl)C=C1 DZPCCAFPSYYZNT-UHFFFAOYSA-N 0.000 claims description 2
- LOQFEVOQDUJSGR-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC(Cl)=CC=2)=C1 LOQFEVOQDUJSGR-UHFFFAOYSA-N 0.000 claims description 2
- ARELIXMFRBREQS-UHFFFAOYSA-N 2-(4-fluorophenyl)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC(F)=CC=2)=C1 ARELIXMFRBREQS-UHFFFAOYSA-N 0.000 claims description 2
- REMLYGMYCSCYPB-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-(1h-pyrrol-3-yl)acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C2=CNC=C2)=C1 REMLYGMYCSCYPB-UHFFFAOYSA-N 0.000 claims description 2
- DZEPLHZROPFQIZ-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-methylpropanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C)(C)C(O)=O)=C1 DZEPLHZROPFQIZ-UHFFFAOYSA-N 0.000 claims description 2
- HOKGDMRTJJNKKF-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-phenylacetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC=CC=2)=C1 HOKGDMRTJJNKKF-UHFFFAOYSA-N 0.000 claims description 2
- ZYNDYVNREASBDG-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-3-phenylpropanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(CC=2C=CC=CC=2)C(O)=O)=C1 ZYNDYVNREASBDG-UHFFFAOYSA-N 0.000 claims description 2
- JDNQNGHPXHOJQU-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]propanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C)C(O)=O)=C1 JDNQNGHPXHOJQU-UHFFFAOYSA-N 0.000 claims description 2
- MLVWKTZLSNWMMB-UHFFFAOYSA-N 2-cyclopropyl-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C2CC2)C(O)=O)=C1 MLVWKTZLSNWMMB-UHFFFAOYSA-N 0.000 claims description 2
- ORLOIZRWYPMTFC-UHFFFAOYSA-N 2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]aniline Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(N)=C1 ORLOIZRWYPMTFC-UHFFFAOYSA-N 0.000 claims description 2
- AOLIEXFAJQTCRI-UHFFFAOYSA-N 2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]phenol Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(O)=C1 AOLIEXFAJQTCRI-UHFFFAOYSA-N 0.000 claims description 2
- BGGSAZMFBNCKFE-UHFFFAOYSA-N 4-[2-[(4-chlorophenyl)methylsulfonyl]ethyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CCS(=O)(=O)CC1=CC=C(Cl)C=C1 BGGSAZMFBNCKFE-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 2
- FESUOBZSNMUXOP-UHFFFAOYSA-N n-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)NC1=CC=C(OC)C(N)=C1 FESUOBZSNMUXOP-UHFFFAOYSA-N 0.000 claims description 2
- ITWHXUWPAYKSEL-UHFFFAOYSA-N n-(3-amino-4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propanamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCC(=O)NC1=CC=C(OC)C(N)=C1 ITWHXUWPAYKSEL-UHFFFAOYSA-N 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 13
- 239000011541 reaction mixture Substances 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 229920006395 saturated elastomer Polymers 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 125000002015 acyclic group Chemical group 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 230000003796 beauty Effects 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000005239 aroylamino group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- -1 cyano, carboxy Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- CSXHUONYHRDYGM-UHFFFAOYSA-N 2-(hydroxyamino)-2-oxoacetic acid Chemical compound ONC(=O)C(O)=O CSXHUONYHRDYGM-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241001553014 Myrsine salicina Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 150000001767 cationic compounds Chemical class 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 150000002892 organic cations Chemical class 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- JRTAMQDKIGNMEI-UHFFFAOYSA-N 4-methoxy-3-nitro-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNC(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 JRTAMQDKIGNMEI-UHFFFAOYSA-N 0.000 description 2
- PXESUFRTUNJEIN-UHFFFAOYSA-N 4-methoxy-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzamide Chemical compound C1=CC(OC)=CC=C1C(=O)NCCC1=C(OC)C=C(OC)C=C1OC PXESUFRTUNJEIN-UHFFFAOYSA-N 0.000 description 2
- PVVVTRASHPXKOI-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]-3-nitrobenzamide Chemical compound C1=CC(OC)=CC=C1CCNC(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 PVVVTRASHPXKOI-UHFFFAOYSA-N 0.000 description 2
- LLRIWSIYZIKQEN-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]benzamide Chemical compound C1=CC(OC)=CC=C1CCNC(=O)C1=CC=C(OC)C=C1 LLRIWSIYZIKQEN-UHFFFAOYSA-N 0.000 description 2
- 0 *C(*)C(*)NS(*)(=O)=O Chemical compound *C(*)C(*)NS(*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703368P | 2012-09-20 | 2012-09-20 | |
| US61/703,368 | 2012-09-20 | ||
| PCT/US2013/060294 WO2014047110A2 (en) | 2012-09-20 | 2013-09-18 | Substituted alkyl diaryl derivatives, methods of preparation and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533810A JP2015533810A (ja) | 2015-11-26 |
| JP2015533810A5 true JP2015533810A5 (enExample) | 2016-11-04 |
| JP6348904B2 JP6348904B2 (ja) | 2018-06-27 |
Family
ID=50342061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533142A Active JP6348904B2 (ja) | 2012-09-20 | 2013-09-18 | 置換アルキルジアリール誘導体、その製造方法及び使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10207989B2 (enExample) |
| EP (1) | EP2897599B1 (enExample) |
| JP (1) | JP6348904B2 (enExample) |
| KR (1) | KR101992929B1 (enExample) |
| CN (2) | CN110776447A (enExample) |
| AU (1) | AU2013318206B2 (enExample) |
| CA (1) | CA2885217C (enExample) |
| ES (1) | ES2863538T3 (enExample) |
| IL (1) | IL237699B (enExample) |
| WO (1) | WO2014047110A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| MX342288B (es) | 2010-04-22 | 2016-09-23 | Vertex Pharma | Proceso para producir compuestos de cicloalquilcarboxamido-indol. |
| KR102447581B1 (ko) | 2014-04-15 | 2022-09-28 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물 |
| CN105085436B (zh) | 2014-04-19 | 2019-08-16 | 广东东阳光药业有限公司 | 磺酰胺类衍生物及其在药物上的应用 |
| EP3233072A1 (en) * | 2014-12-16 | 2017-10-25 | Glucox Biotech AB | Compounds for use in the treatment of conditions associated with nadph oxidase |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| US12202790B2 (en) | 2018-05-09 | 2025-01-21 | Glucox Biotech Ab | Sulfonamide derivatives having selective Nox inhibiting activity |
| CR20220316A (es) | 2019-12-06 | 2022-10-07 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| CN115334959A (zh) | 2020-01-31 | 2022-11-11 | 瑞思迈传感器技术有限公司 | 用于呼吸暂停-低通气指数计算的睡眠状态检测 |
| JP2024522292A (ja) | 2021-06-04 | 2024-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド |
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|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
| US5070099A (en) * | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| JP3660395B2 (ja) | 1995-06-22 | 2005-06-15 | 大鵬薬品工業株式会社 | フェニルスルホン誘導体及びその製造方法 |
| GB9717576D0 (en) * | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| ATE284386T1 (de) | 1997-10-03 | 2004-12-15 | Univ Temple | Styrolsulfone als antikrebsmittel |
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| US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
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| IL157540A0 (en) | 2001-02-28 | 2004-03-28 | Univ Temple | N-(aryl)-2-arylethenesulphonamides and therapeutic uses thereof |
| ATE406881T1 (de) | 2001-02-28 | 2008-09-15 | Univ Temple | Verwendung von alpha, beta ungesättigten arylsulfonen zum schutz von zellen und geweben vor toxizität ionischer strahlung |
| MXPA04008356A (es) | 2002-02-28 | 2005-09-12 | Univ Temple | (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas con un grupo amino y en la posicion 4 para tratar trastornos poliferativos. |
| ATE517626T1 (de) | 2002-02-28 | 2011-08-15 | Univ Temple | Aminosubstituierte sulphonanilide und ihre derivate zur behandlung von proliferativen erkrankungen |
| NZ538663A (en) | 2002-08-29 | 2006-02-24 | Univ Temple | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
| EP1549614A4 (en) | 2002-10-03 | 2008-04-16 | Targegen Inc | VASCULATORY AGENTS AND METHODS FOR THEIR APPLICATION |
| HUE032523T2 (en) | 2003-11-14 | 2017-09-28 | Temple Univ - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for the treatment of proliferative disorders |
| ES2609084T3 (es) | 2004-03-16 | 2017-04-18 | Temple University - Of The Commonwealth System Of Higher Education | Derivados de fenoxi y feniltio sustituidos para tratar trastornos proliferativos |
| EP1765804A4 (en) | 2004-06-08 | 2009-11-11 | Univ Temple | HETEROARYLSULFONES AND SULFONAMIDES AND THEIR THERAPEUTIC USES |
| CA2577309C (en) | 2004-06-24 | 2013-10-22 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| AU2006204103B2 (en) | 2005-01-05 | 2011-11-24 | Temple University Of The Commonwealth System Of Higher Education | Treatment of drug-resistant proliferative disorders |
| PT1896401E (pt) * | 2005-02-25 | 2013-07-17 | Univ Temple | Síntese de sulfuretos, sulfonas, sulfóxidos e sulfonamidas não saturados |
| WO2006104668A2 (en) | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| WO2007127366A2 (en) | 2006-04-25 | 2007-11-08 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| JP5278968B2 (ja) | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| CL2007003591A1 (es) | 2006-12-12 | 2008-02-29 | Wyeth Corp | Compuestos derivados de sulfonamida ciclicos, inhibidores de retoma de monoamina; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de disfuncion sexual, trastorno gastrointestinal, trastorno genitourinari |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| US8124605B2 (en) * | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8686190B2 (en) * | 2008-04-10 | 2014-04-01 | The Uab Research Foundation | Bis-aromatic anticancer agents |
| MX2010014172A (es) | 2008-07-03 | 2011-02-22 | Amira Pharmaceuticals Inc | Antagonistas de receptores de prostaglandina d2. |
| EP2226329B1 (en) | 2009-03-02 | 2013-07-10 | Ruhr-Universität Bochum | Metal-containing platensimycin analogues |
| GB0908293D0 (en) | 2009-05-14 | 2009-06-24 | Syngenta Ltd | Herbicidal compounds |
-
2013
- 2013-09-18 US US14/429,223 patent/US10207989B2/en active Active
- 2013-09-18 JP JP2015533142A patent/JP6348904B2/ja active Active
- 2013-09-18 EP EP13839254.3A patent/EP2897599B1/en not_active Not-in-force
- 2013-09-18 KR KR1020157010016A patent/KR101992929B1/ko active Active
- 2013-09-18 ES ES13839254T patent/ES2863538T3/es active Active
- 2013-09-18 WO PCT/US2013/060294 patent/WO2014047110A2/en not_active Ceased
- 2013-09-18 CN CN201910975554.6A patent/CN110776447A/zh active Pending
- 2013-09-18 AU AU2013318206A patent/AU2013318206B2/en active Active
- 2013-09-18 CA CA2885217A patent/CA2885217C/en active Active
- 2013-09-18 CN CN201380056016.8A patent/CN104812382A/zh active Pending
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2015
- 2015-03-12 IL IL237699A patent/IL237699B/en active IP Right Grant
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