JP2015533156A - 大環状デプシペプチドを製造するための液相プロセスおよび新規中間体 - Google Patents

大環状デプシペプチドを製造するための液相プロセスおよび新規中間体 Download PDF

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Publication number
JP2015533156A
JP2015533156A JP2015536260A JP2015536260A JP2015533156A JP 2015533156 A JP2015533156 A JP 2015533156A JP 2015536260 A JP2015536260 A JP 2015536260A JP 2015536260 A JP2015536260 A JP 2015536260A JP 2015533156 A JP2015533156 A JP 2015533156A
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Japan
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formula
compound
group
prot
amino
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JP2015536260A
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English (en)
Japanese (ja)
Inventor
エースモグル，ムラー
ヘルスターン，ヘリバート
コルマー，フェリックス
シュライバー，ロバート
ステットラー，ハンス
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2015533156A publication Critical patent/JP2015533156A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Analytical Chemistry (AREA)
JP2015536260A 2012-10-09 2013-10-08 大環状デプシペプチドを製造するための液相プロセスおよび新規中間体 Pending JP2015533156A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261711284P 2012-10-09 2012-10-09
US61/711,284 2012-10-09
PCT/IB2013/059196 WO2014057418A2 (en) 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Publications (1)

Publication Number Publication Date
JP2015533156A true JP2015533156A (ja) 2015-11-19

Family

ID=49880854

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015536260A Pending JP2015533156A (ja) 2012-10-09 2013-10-08 大環状デプシペプチドを製造するための液相プロセスおよび新規中間体

Country Status (14)

Country Link
US (2) US9067978B2 (forum.php)
EP (1) EP2906585A2 (forum.php)
JP (1) JP2015533156A (forum.php)
KR (1) KR20150065709A (forum.php)
CN (1) CN104703997A (forum.php)
AR (1) AR092948A1 (forum.php)
AU (1) AU2013328284B2 (forum.php)
BR (1) BR112015007196A2 (forum.php)
CA (1) CA2884393A1 (forum.php)
EA (1) EA201590698A1 (forum.php)
IN (1) IN2015DN01811A (forum.php)
MX (1) MX2015004629A (forum.php)
TW (1) TW201418278A (forum.php)
WO (1) WO2014057418A2 (forum.php)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2016500668A (ja) * 2012-10-09 2016-01-14 ノバルティス アーゲー アルデヒドアセタールをベースとする、大環状デプシペプチドの製造プロセス、および新規中間体
WO2023277186A1 (ja) * 2021-07-02 2023-01-05 ペプチスター株式会社 液相ペプチド合成用担体結合ペプチドの分析方法

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CL2008002394A1 (es) 2007-08-17 2009-05-15 Novartis Ag Depsipeptido ciclico, o derivados, inhibidores de calicreína 7, obtenidos desde chondromyces crocatus, metodo de obtencion y usos terapeuticos.
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
EP3393499B1 (en) 2015-12-21 2022-05-11 Texas Tech University System System and method for solution phase gap peptide synthesis
WO2019217116A1 (en) * 2018-05-06 2019-11-14 Gap Peptides Llc Method for solution-phase peptide synthesis
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
CA3126705A1 (en) 2019-02-01 2020-08-06 Gap Peptides Llc Synthesis strategy for gap protecting group

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JP2010536731A (ja) * 2007-08-17 2010-12-02 ノバルティス アーゲー 環状デプシペプチド類
JP2016500668A (ja) * 2012-10-09 2016-01-14 ノバルティス アーゲー アルデヒドアセタールをベースとする、大環状デプシペプチドの製造プロセス、および新規中間体

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US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
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US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

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JP2010536731A (ja) * 2007-08-17 2010-12-02 ノバルティス アーゲー 環状デプシペプチド類
JP2016500668A (ja) * 2012-10-09 2016-01-14 ノバルティス アーゲー アルデヒドアセタールをベースとする、大環状デプシペプチドの製造プロセス、および新規中間体

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016500668A (ja) * 2012-10-09 2016-01-14 ノバルティス アーゲー アルデヒドアセタールをベースとする、大環状デプシペプチドの製造プロセス、および新規中間体
WO2023277186A1 (ja) * 2021-07-02 2023-01-05 ペプチスター株式会社 液相ペプチド合成用担体結合ペプチドの分析方法

Also Published As

Publication number Publication date
CA2884393A1 (en) 2014-04-17
WO2014057418A2 (en) 2014-04-17
US9493512B2 (en) 2016-11-15
AR092948A1 (es) 2015-05-06
US20140100355A1 (en) 2014-04-10
AU2013328284B2 (en) 2016-07-14
TW201418278A (zh) 2014-05-16
MX2015004629A (es) 2015-07-14
KR20150065709A (ko) 2015-06-15
BR112015007196A2 (pt) 2017-07-04
WO2014057418A3 (en) 2014-07-10
IN2015DN01811A (forum.php) 2015-05-29
EP2906585A2 (en) 2015-08-19
AU2013328284A1 (en) 2015-03-12
EA201590698A1 (ru) 2015-07-30
US20150218224A1 (en) 2015-08-06
US9067978B2 (en) 2015-06-30
CN104703997A (zh) 2015-06-10

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