IN2015DN01811A - - Google Patents

Info

Publication number
IN2015DN01811A
IN2015DN01811A IN1811DEN2015A IN2015DN01811A IN 2015DN01811 A IN2015DN01811 A IN 2015DN01811A IN 1811DEN2015 A IN1811DEN2015 A IN 1811DEN2015A IN 2015DN01811 A IN2015DN01811 A IN 2015DN01811A
Authority
IN
India
Prior art keywords
manufacture
depsipeptides
symbols
formula
well
Prior art date
Application number
Inventor
Murat Acemoglu
Heribert Hellstern
Felix Kollmer
Robert Schreiber
Hans Stettler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN01811A publication Critical patent/IN2015DN01811A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula (I) wherein the symbols have the meaning defined in the description to new intermediates and their manufacture as well as related invention embodiments.
IN1811DEN2015 2012-10-09 2013-10-08 IN2015DN01811A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261711284P 2012-10-09 2012-10-09
PCT/IB2013/059196 WO2014057418A2 (en) 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Publications (1)

Publication Number Publication Date
IN2015DN01811A true IN2015DN01811A (en) 2015-05-29

Family

ID=49880854

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1811DEN2015 IN2015DN01811A (en) 2012-10-09 2013-10-08

Country Status (14)

Country Link
US (2) US9067978B2 (en)
EP (1) EP2906585A2 (en)
JP (1) JP2015533156A (en)
KR (1) KR20150065709A (en)
CN (1) CN104703997A (en)
AR (1) AR092948A1 (en)
AU (1) AU2013328284B2 (en)
BR (1) BR112015007196A2 (en)
CA (1) CA2884393A1 (en)
EA (1) EA201590698A1 (en)
IN (1) IN2015DN01811A (en)
MX (1) MX2015004629A (en)
TW (1) TW201418278A (en)
WO (1) WO2014057418A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008290567B2 (en) 2007-08-17 2011-05-12 Novartis Ag Cyclic depsipeptides
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (en) 2011-04-20 2013-11-27 Novartis Ag PROCESSES FOR THE ELABORATION OF MACROCICLICAL AND INTERMEDIARY DEPSIPEPTIDES
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
WO2017112809A1 (en) 2015-12-21 2017-06-29 Taxas Tech University System System and method for solution phase gap peptide synthesis
WO2019217116A1 (en) * 2018-05-06 2019-11-14 Gap Peptides Llc Method for solution-phase peptide synthesis
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
EP3917937A4 (en) 2019-02-01 2022-11-23 Sederma Synthesis strategy for gap protecting group
JP7162853B1 (en) * 2021-07-02 2022-10-31 ペプチスター株式会社 Method for analyzing carrier-bound peptides for liquid-phase peptide synthesis

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DE3043252C2 (en) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclic acetals of N-acylglutamic acid - γ - semialdehydes, processes for their preparation and their use
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (en) 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, extraction process, means with chondrams and mixed culture for chondramide production
DE19828043A1 (en) 1998-06-24 1999-12-30 Bayer Ag Use of cyclooctadepsipeptide derivatives
JP2000154198A (en) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd Solid phase synthesis of cyclic depsipeptide and its intermediate
GB0108234D0 (en) 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
CA2525383C (en) 2003-06-06 2012-03-06 Arexis Ab Use of heterocyclic compounds as scce inhibitors
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
WO2005075667A1 (en) 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
EP1994181A4 (en) 2006-02-27 2010-05-19 Univ Arizona Identification and use of novopeptides for the treatment of cancer
GB0715750D0 (en) 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
JP5401459B2 (en) 2007-08-17 2014-01-29 ノバルティス アーゲー Use of cyclic depsipeptides to inhibit kallikrein 7
AU2008290567B2 (en) * 2007-08-17 2011-05-12 Novartis Ag Cyclic depsipeptides
DE102007052391A1 (en) 2007-10-31 2009-05-07 Henkel Ag & Co. Kgaa Matt wax
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
KR101004362B1 (en) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 TNF-α AND TWEAK COUPLED ANTAGONIST FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
EP2616037A2 (en) 2010-09-14 2013-07-24 Trima - Israel Phramaceutical Products Maabarot Ltd. Foamable topical composition
KR20140003572A (en) 2011-01-24 2014-01-09 안테리오스, 인코퍼레이티드 Nanoparticle compositions
IL293156A (en) 2011-01-24 2022-07-01 Anterios Inc Nanoparticle compositions, formulations thereof, and uses therefor
AR086168A1 (en) * 2011-04-20 2013-11-27 Novartis Ag PROCESSES FOR THE ELABORATION OF MACROCICLICAL AND INTERMEDIARY DEPSIPEPTIDES
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
US9067978B2 (en) 2015-06-30
EP2906585A2 (en) 2015-08-19
WO2014057418A3 (en) 2014-07-10
EA201590698A1 (en) 2015-07-30
MX2015004629A (en) 2015-07-14
BR112015007196A2 (en) 2017-07-04
US9493512B2 (en) 2016-11-15
AU2013328284A1 (en) 2015-03-12
CN104703997A (en) 2015-06-10
AR092948A1 (en) 2015-05-06
KR20150065709A (en) 2015-06-15
US20150218224A1 (en) 2015-08-06
AU2013328284B2 (en) 2016-07-14
TW201418278A (en) 2014-05-16
WO2014057418A2 (en) 2014-04-17
US20140100355A1 (en) 2014-04-10
JP2015533156A (en) 2015-11-19
CA2884393A1 (en) 2014-04-17

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