EA201590698A1 - Жидкофазные способы получения макроциклических депсипептидов и новые промежуточные соединения - Google Patents

Жидкофазные способы получения макроциклических депсипептидов и новые промежуточные соединения

Info

Publication number
EA201590698A1
EA201590698A1 EA201590698A EA201590698A EA201590698A1 EA 201590698 A1 EA201590698 A1 EA 201590698A1 EA 201590698 A EA201590698 A EA 201590698A EA 201590698 A EA201590698 A EA 201590698A EA 201590698 A1 EA201590698 A1 EA 201590698A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dipsypeps
liquid
new intermediate
phase methods
intermediate connections
Prior art date
Application number
EA201590698A
Other languages
English (en)
Inventor
Мурат Асемоглу
Хериберт Хелльштерн
Феликс Колльмер
Роберт Шрайбер
Ханс Штеттлер
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201590698A1 publication Critical patent/EA201590698A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Analytical Chemistry (AREA)

Abstract

Изобретение относится к методу или способу получения в жидкой фазе депсипептидов формулы Iгде символы имеют значения, определенные в описании, к новым промежуточным соединениям и их получению, а также к относящимся к ним вариантам осуществления.
EA201590698A 2012-10-09 2013-10-08 Жидкофазные способы получения макроциклических депсипептидов и новые промежуточные соединения EA201590698A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261711284P 2012-10-09 2012-10-09
PCT/IB2013/059196 WO2014057418A2 (en) 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Publications (1)

Publication Number Publication Date
EA201590698A1 true EA201590698A1 (ru) 2015-07-30

Family

ID=49880854

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590698A EA201590698A1 (ru) 2012-10-09 2013-10-08 Жидкофазные способы получения макроциклических депсипептидов и новые промежуточные соединения

Country Status (14)

Country Link
US (2) US9067978B2 (ru)
EP (1) EP2906585A2 (ru)
JP (1) JP2015533156A (ru)
KR (1) KR20150065709A (ru)
CN (1) CN104703997A (ru)
AR (1) AR092948A1 (ru)
AU (1) AU2013328284B2 (ru)
BR (1) BR112015007196A2 (ru)
CA (1) CA2884393A1 (ru)
EA (1) EA201590698A1 (ru)
IN (1) IN2015DN01811A (ru)
MX (1) MX2015004629A (ru)
TW (1) TW201418278A (ru)
WO (1) WO2014057418A2 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5520824B2 (ja) 2007-08-17 2014-06-11 ノバルティス アーゲー 環状デプシペプチド類
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
ES2924473T3 (es) 2015-12-21 2022-10-07 Univ Texas Tech System Sistema y procedimiento de síntesis de péptidos GAP en fase de solución
WO2019217116A1 (en) * 2018-05-06 2019-11-14 Gap Peptides Llc Method for solution-phase peptide synthesis
WO2020159837A1 (en) 2019-02-01 2020-08-06 Gap Peptides Llc Synthesis strategy for gap protecting group
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
JP7162853B1 (ja) * 2021-07-02 2022-10-31 ペプチスター株式会社 液相ペプチド合成用担体結合ペプチドの分析方法

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EP2183270B1 (en) 2007-08-17 2014-12-17 Novartis AG Use of cyclic depsipeptides to inhibit kallikrein 7
JP5520824B2 (ja) * 2007-08-17 2014-06-11 ノバルティス アーゲー 環状デプシペプチド類
DE102007052391A1 (de) 2007-10-31 2009-05-07 Henkel Ag & Co. Kgaa Mattwachs
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US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
WO2014057418A3 (en) 2014-07-10
CN104703997A (zh) 2015-06-10
US9067978B2 (en) 2015-06-30
AR092948A1 (es) 2015-05-06
IN2015DN01811A (ru) 2015-05-29
AU2013328284A1 (en) 2015-03-12
KR20150065709A (ko) 2015-06-15
JP2015533156A (ja) 2015-11-19
EP2906585A2 (en) 2015-08-19
US9493512B2 (en) 2016-11-15
US20140100355A1 (en) 2014-04-10
BR112015007196A2 (pt) 2017-07-04
CA2884393A1 (en) 2014-04-17
TW201418278A (zh) 2014-05-16
US20150218224A1 (en) 2015-08-06
MX2015004629A (es) 2015-07-14
AU2013328284B2 (en) 2016-07-14
WO2014057418A2 (en) 2014-04-17

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