JP2015533084A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015533084A5 JP2015533084A5 JP2015534816A JP2015534816A JP2015533084A5 JP 2015533084 A5 JP2015533084 A5 JP 2015533084A5 JP 2015534816 A JP2015534816 A JP 2015534816A JP 2015534816 A JP2015534816 A JP 2015534816A JP 2015533084 A5 JP2015533084 A5 JP 2015533084A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- marker
- item
- marker gene
- gene set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003550 marker Substances 0.000 claims description 103
- 238000000034 method Methods 0.000 claims description 96
- 206010028980 Neoplasm Diseases 0.000 claims description 65
- 108090000623 proteins and genes Proteins 0.000 claims description 57
- 102000038427 NEDD8-activating enzyme E1 Human genes 0.000 claims description 52
- 108091007790 NEDD8-activating enzyme E1 Proteins 0.000 claims description 52
- 239000003112 inhibitor Substances 0.000 claims description 48
- 201000011510 cancer Diseases 0.000 claims description 46
- 230000014509 gene expression Effects 0.000 claims description 32
- 238000010238 partial least squares regression Methods 0.000 claims description 17
- 230000037361 pathway Effects 0.000 claims description 13
- 230000035945 sensitivity Effects 0.000 claims description 13
- -1 1- Substituted methyl Chemical group 0.000 claims description 10
- 230000002489 hematologic effect Effects 0.000 claims description 10
- 230000019491 signal transduction Effects 0.000 claims description 8
- 206010005003 Bladder cancer Diseases 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 7
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 7
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 7
- 201000004101 esophageal cancer Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 201000002528 pancreatic cancer Diseases 0.000 claims description 7
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 7
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- 201000000849 skin cancer Diseases 0.000 claims description 6
- 201000001441 melanoma Diseases 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 4
- 102000009096 Proto-Oncogene Proteins c-myb Human genes 0.000 claims description 4
- 108010087776 Proto-Oncogene Proteins c-myb Proteins 0.000 claims description 4
- 102000040945 Transcription factor Human genes 0.000 claims description 4
- 108091023040 Transcription factor Proteins 0.000 claims description 4
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims description 4
- 102000019997 adhesion receptor Human genes 0.000 claims description 4
- 108010013985 adhesion receptor Proteins 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 2
- FIYXUOWXHWJDAM-UHFFFAOYSA-N methyl sulfamate Chemical class COS(N)(=O)=O FIYXUOWXHWJDAM-UHFFFAOYSA-N 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- MPUQHZXIXSTTDU-QXGSTGNESA-N sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester Chemical compound C1[C@H](O)[C@H](COS(=O)(=O)N)C[C@H]1N1C2=NC=NC(N[C@@H]3C4=CC=CC=C4CC3)=C2C=C1 MPUQHZXIXSTTDU-QXGSTGNESA-N 0.000 description 3
- 230000008236 biological pathway Effects 0.000 description 2
- 201000010536 head and neck cancer Diseases 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261708349P | 2012-10-01 | 2012-10-01 | |
| US61/708,349 | 2012-10-01 | ||
| PCT/US2013/062902 WO2014055543A2 (en) | 2012-10-01 | 2013-10-01 | Biomarkers and methods to predict response to inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533084A JP2015533084A (ja) | 2015-11-19 |
| JP2015533084A5 true JP2015533084A5 (enExample) | 2017-02-09 |
| JP6486826B2 JP6486826B2 (ja) | 2019-03-20 |
Family
ID=50435571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534816A Expired - Fee Related JP6486826B2 (ja) | 2012-10-01 | 2013-10-01 | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10662477B2 (enExample) |
| EP (1) | EP2904115B1 (enExample) |
| JP (1) | JP6486826B2 (enExample) |
| CN (1) | CN104822844B (enExample) |
| CA (1) | CA2886783A1 (enExample) |
| WO (1) | WO2014055543A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2862580A1 (en) | 2011-10-28 | 2013-05-02 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to nae inhibitors |
| EP2951741A2 (en) * | 2013-02-03 | 2015-12-09 | Genelex Corporation | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
| CN104820873B (zh) * | 2015-05-13 | 2017-12-26 | 中国环境科学研究院 | 一种基于金属定量构效关系的淡水急性基准预测方法 |
| US10007766B2 (en) | 2015-07-13 | 2018-06-26 | Biodesix, Inc. | Predictive test for melanoma patient benefit from antibody drug blocking ligand activation of the T-cell programmed cell death 1 (PD-1) checkpoint protein and classifier development methods |
| WO2017027672A1 (en) * | 2015-08-12 | 2017-02-16 | Celgene Corporation | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| GB201521481D0 (en) * | 2015-12-04 | 2016-01-20 | Healx Ltd | Prognostic system |
| US11710539B2 (en) | 2016-02-01 | 2023-07-25 | Biodesix, Inc. | Predictive test for melanoma patient benefit from interleukin-2 (IL2) therapy |
| KR20180126085A (ko) * | 2016-05-05 | 2018-11-26 | 난토믹스, 엘엘씨 | 체크포인트 부전 및 그 방법(checkpoint failure and methods therefor) |
| CN110383069A (zh) | 2017-01-05 | 2019-10-25 | 佰欧迪塞克斯公司 | 用于鉴定总体不良预后亚组中持久受益于免疫疗法的癌症患者的方法 |
| US11124519B2 (en) | 2017-09-21 | 2021-09-21 | Millennium Pharmaceuticals, Inc. | Cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate, formulations and uses thereof |
| US12094587B2 (en) | 2018-03-29 | 2024-09-17 | Biodesix, Inc. | Apparatus and method for identification of primary immune resistance in cancer patients |
| US20210215697A1 (en) * | 2018-05-14 | 2021-07-15 | Bergenbio Asa | Serum Biomarkers |
| CN110885830A (zh) * | 2018-09-07 | 2020-03-17 | 安徽华大医学检验所有限公司 | Fn1基因突变及其应用 |
| CN109411015B (zh) * | 2018-09-28 | 2020-12-22 | 深圳裕策生物科技有限公司 | 基于循环肿瘤dna的肿瘤突变负荷检测装置及存储介质 |
| CN109762911B (zh) * | 2019-02-21 | 2020-12-01 | 华中农业大学 | Ptprj基因作为猪免疫相关性状的分子标记及其应用 |
| JP7438693B2 (ja) * | 2019-09-02 | 2024-02-27 | キヤノンメディカルシステムズ株式会社 | 診療支援装置 |
| GB2595718A (en) * | 2020-06-04 | 2021-12-08 | Cancer Research Tech Ltd | Methods for predicting treatment response in cancers |
| EP4226377A1 (en) | 2020-10-09 | 2023-08-16 | Worldwide Innovative Network | Novel prediction method and gene signatures for the treatment of cancer |
| CN112415206B (zh) * | 2020-10-23 | 2023-08-18 | 上海良润生物医药科技有限公司 | 外泌体中的cd171蛋白作为肿瘤转移诊断标志物的应用 |
| CN113046357B (zh) * | 2021-01-25 | 2023-05-16 | 柳州市柳铁中心医院 | 一种乐伐替尼耐药基因dusp9、其筛选方法及应用 |
| CN114045336B (zh) * | 2021-09-28 | 2024-01-02 | 中国人民解放军空军军医大学 | Cga基因作为靶点在制备用于诊断和治疗耐药实体瘤药物的应用 |
| US12254987B2 (en) * | 2023-03-23 | 2025-03-18 | Certis Oncology Solutions, Inc. | Artificial intelligence for identifying one or more predictive biomarkers |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
| EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| HUT62312A (en) | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| WO1992010588A1 (en) | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2087413A1 (en) | 1992-01-17 | 1993-07-18 | Joseph R. Lakowicz | Fluorescent energy transfer immunoassay |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| DE69322266T2 (de) | 1992-04-03 | 1999-06-02 | Perkin-Elmer Corp., Foster City, Calif. | Proben zusammensetzung und verfahren |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| DE4311230C2 (de) | 1993-04-02 | 1996-12-19 | Mannesmann Ag | Nicht-spurgebundenes Fahrzeug mit Elektromotor |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
| US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
| US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| WO1995030774A1 (en) | 1994-05-05 | 1995-11-16 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
| US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
| US6096778A (en) | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
| US6075150A (en) | 1998-01-26 | 2000-06-13 | Cv Therapeutics, Inc. | α-ketoamide inhibitors of 20S proteasome |
| US7045610B2 (en) | 1998-04-03 | 2006-05-16 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
| US6831099B1 (en) | 1999-05-12 | 2004-12-14 | Yale University | Enzyme inhibition |
| US7013221B1 (en) | 1999-07-16 | 2006-03-14 | Rosetta Inpharmatics Llc | Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays |
| US6077674A (en) | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
| FR2828884B1 (fr) | 2001-08-27 | 2005-09-09 | Centre Nat Rech Scient | Hydrazinopeptoides et leurs utilisations dans le traitement des cancers |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| MX272108B (es) | 2003-02-14 | 2009-11-25 | Bayer Healthcare Ag | Heterociclos sustituidos. |
| KR20060026052A (ko) | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| TW589273B (en) | 2003-07-31 | 2004-06-01 | Quanta Comp Inc | Packaging carton |
| FR2859995A1 (fr) | 2003-09-23 | 2005-03-25 | Centre Nat Rech Scient | Hydrazinopeptoides reduits et leurs utilisations dans le traitement des cancers |
| WO2005099687A2 (en) | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| WO2005105826A1 (ja) | 2004-04-28 | 2005-11-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | チロペプチンａ類縁体 |
| BRPI0510802A (pt) | 2004-05-10 | 2007-11-06 | Proteolix Inc | compostos para inibição de enzima |
| US20070249540A1 (en) | 2004-05-24 | 2007-10-25 | Adonia Papathanassiu | Methods for Inhibiting Proteasome and Heat Shock Protein 90 |
| GB0412301D0 (en) | 2004-06-02 | 2004-07-07 | Diagenic As | Product and method |
| EP1805208A2 (en) | 2004-10-20 | 2007-07-11 | Proteolix, Inc. | Labeled compounds for proteasome inhibition |
| JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| US8624027B2 (en) * | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| SG169369A1 (en) | 2006-02-02 | 2011-03-30 | Millennium Pharm Inc | Inhibitors of e1 activating enzymes |
| ATE485276T1 (de) | 2006-08-08 | 2010-11-15 | Millennium Pharm Inc | Heteroarylverbindungen als hemmer der e1- aktivierenden enzyme |
| WO2009099991A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
| UA108986C2 (uk) * | 2009-05-14 | 2015-07-10 | Мілленніум Фармасьютікалз, Інк. | Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти) |
| BRPI1015179A2 (pt) * | 2009-06-19 | 2016-04-19 | Merck Patent Gmbh | biomarcadores e métodos para a determinação de eficácia de anticorpos anti-egfr em terapia de câncer |
| CN102713606A (zh) * | 2009-11-13 | 2012-10-03 | 无限制药股份有限公司 | 用于鉴定、评估、预防和治疗癌症的组合物、试剂盒和方法 |
| JP5968871B2 (ja) * | 2010-04-13 | 2016-08-10 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | フォワードプログラミングによる肝細胞の産生 |
| EP3699915A1 (en) * | 2010-04-29 | 2020-08-26 | The Regents of The University of California | Pathway recognition algorithm using data integration on genomic models (paradigm) |
| US8945847B2 (en) * | 2010-05-24 | 2015-02-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for ascertaining biosafety of an agent |
| WO2012006589A2 (en) * | 2010-07-08 | 2012-01-12 | Infinity Pharmaceuticals, Inc. | Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling |
| US9506926B2 (en) * | 2011-02-18 | 2016-11-29 | The Regents Of The University Of California | Molecular predictors of therapeutic response to specific anti-cancer agents |
| CA2862580A1 (en) | 2011-10-28 | 2013-05-02 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to nae inhibitors |
-
2013
- 2013-10-01 JP JP2015534816A patent/JP6486826B2/ja not_active Expired - Fee Related
- 2013-10-01 CN CN201380061933.5A patent/CN104822844B/zh not_active Expired - Fee Related
- 2013-10-01 EP EP13843965.8A patent/EP2904115B1/en not_active Not-in-force
- 2013-10-01 WO PCT/US2013/062902 patent/WO2014055543A2/en not_active Ceased
- 2013-10-01 US US14/432,587 patent/US10662477B2/en not_active Expired - Fee Related
- 2013-10-01 CA CA2886783A patent/CA2886783A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| McKerrow et al. | LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint | |
| Karmodiya et al. | A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation and identifies H3K36me2 as a global mark of gene suppression | |
| Drew et al. | Improved inherited peripheral neuropathy genetic diagnosis by whole‐exome sequencing | |
| Borisov et al. | Signaling pathways activation profiles make better markers of cancer than expression of individual genes | |
| Alsaleem et al. | A novel prognostic two-gene signature for triple negative breast cancer | |
| JP2010500565A5 (enExample) | ||
| Dudbridge et al. | Predictive accuracy of combined genetic and environmental risk scores | |
| Golestan et al. | Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification | |
| Li et al. | Modeling microRNA-mRNA interactions using PLS regression in human colon cancer | |
| Sun et al. | OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer | |
| HRP20191182T1 (hr) | Identifikacija tumorsko-zaštitnih epitopa za liječenje karcinoma | |
| Liu et al. | Heterogeneous expression of tandem‐pore K+ channel genes in adult and embryonic rat heart quantified by real‐time polymerase chain reaction | |
| Worst et al. | The EEF1A2 gene expression as risk predictor in localized prostate cancer | |
| JP2024111161A (ja) | 気分障害検査用バイオマーカーとしてのｒｎａ編集 | |
| Weng et al. | Poly (A) code analyses reveal key determinants for tissue-specific mRNA alternative polyadenylation | |
| KR102265529B1 (ko) | 복합 유전 정보 네트워크 분석에 기반한 질병 위험도 진단 방법 | |
| Che et al. | A new explained-variance based genetic risk score for predictive modeling of disease risk | |
| Zhong et al. | MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia | |
| Siwo et al. | Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite | |
| Hong et al. | Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population‐based adult twin study | |
| Laborde et al. | Transcriptional profiling by sequencing of oropharyngeal cancer | |
| Haase et al. | Identification and validation of selective upregulation of ventricular myosin light chain type 2 mRNA in idiopathic dilated cardiomyopathy | |
| Antonini et al. | Research techniques made simple: identification and characterization of long noncoding RNA in dermatological research | |
| Yue et al. | RETRACTED: The predictive efficacy of programmed cell death in immunotherapy of melanoma: A comprehensive analysis of gene expression data for programmed cell death biomarker and therapeutic target discovery | |
| Song | A two-stage patient enrichment adaptive design in phase II oncology trials |