JP2015533084A5 - - Google Patents
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- JP2015533084A5 JP2015533084A5 JP2015534816A JP2015534816A JP2015533084A5 JP 2015533084 A5 JP2015533084 A5 JP 2015533084A5 JP 2015534816 A JP2015534816 A JP 2015534816A JP 2015534816 A JP2015534816 A JP 2015534816A JP 2015533084 A5 JP2015533084 A5 JP 2015533084A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- marker
- item
- marker gene
- gene set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003550 marker Substances 0.000 claims description 103
- 238000000034 method Methods 0.000 claims description 96
- 206010028980 Neoplasm Diseases 0.000 claims description 65
- 108090000623 proteins and genes Proteins 0.000 claims description 57
- 102000038427 NEDD8-activating enzyme E1 Human genes 0.000 claims description 52
- 108091007790 NEDD8-activating enzyme E1 Proteins 0.000 claims description 52
- 239000003112 inhibitor Substances 0.000 claims description 48
- 201000011510 cancer Diseases 0.000 claims description 46
- 230000014509 gene expression Effects 0.000 claims description 32
- 238000010238 partial least squares regression Methods 0.000 claims description 17
- 230000037361 pathway Effects 0.000 claims description 13
- 230000035945 sensitivity Effects 0.000 claims description 13
- -1 1- Substituted methyl Chemical group 0.000 claims description 10
- 230000002489 hematologic effect Effects 0.000 claims description 10
- 230000019491 signal transduction Effects 0.000 claims description 8
- 206010005003 Bladder cancer Diseases 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 7
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 7
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 7
- 201000004101 esophageal cancer Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 201000002528 pancreatic cancer Diseases 0.000 claims description 7
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 7
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- 201000000849 skin cancer Diseases 0.000 claims description 6
- 201000001441 melanoma Diseases 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 4
- 102000009096 Proto-Oncogene Proteins c-myb Human genes 0.000 claims description 4
- 108010087776 Proto-Oncogene Proteins c-myb Proteins 0.000 claims description 4
- 102000040945 Transcription factor Human genes 0.000 claims description 4
- 108091023040 Transcription factor Proteins 0.000 claims description 4
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims description 4
- 102000019997 adhesion receptor Human genes 0.000 claims description 4
- 108010013985 adhesion receptor Proteins 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 2
- FIYXUOWXHWJDAM-UHFFFAOYSA-N methyl sulfamate Chemical class COS(N)(=O)=O FIYXUOWXHWJDAM-UHFFFAOYSA-N 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- MPUQHZXIXSTTDU-QXGSTGNESA-N sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester Chemical compound C1[C@H](O)[C@H](COS(=O)(=O)N)C[C@H]1N1C2=NC=NC(N[C@@H]3C4=CC=CC=C4CC3)=C2C=C1 MPUQHZXIXSTTDU-QXGSTGNESA-N 0.000 description 3
- 230000008236 biological pathway Effects 0.000 description 2
- 201000010536 head and neck cancer Diseases 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261708349P | 2012-10-01 | 2012-10-01 | |
| US61/708,349 | 2012-10-01 | ||
| PCT/US2013/062902 WO2014055543A2 (en) | 2012-10-01 | 2013-10-01 | Biomarkers and methods to predict response to inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533084A JP2015533084A (ja) | 2015-11-19 |
| JP2015533084A5 true JP2015533084A5 (enExample) | 2017-02-09 |
| JP6486826B2 JP6486826B2 (ja) | 2019-03-20 |
Family
ID=50435571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534816A Expired - Fee Related JP6486826B2 (ja) | 2012-10-01 | 2013-10-01 | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10662477B2 (enExample) |
| EP (1) | EP2904115B1 (enExample) |
| JP (1) | JP6486826B2 (enExample) |
| CN (1) | CN104822844B (enExample) |
| CA (1) | CA2886783A1 (enExample) |
| WO (1) | WO2014055543A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9827246B2 (en) | 2011-10-28 | 2017-11-28 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to NAE inhibitors |
| US10210312B2 (en) * | 2013-02-03 | 2019-02-19 | Youscript Inc. | Systems and methods for quantification and presentation of medical risk arising from unknown factors |
| CN104820873B (zh) * | 2015-05-13 | 2017-12-26 | 中国环境科学研究院 | 一种基于金属定量构效关系的淡水急性基准预测方法 |
| EP3322987B1 (en) * | 2015-07-13 | 2021-09-08 | Biodesix, Inc. | Predictive test for melanoma patient benefit from pd-1 antibody drug and classifier development methods |
| JP2018525991A (ja) * | 2015-08-12 | 2018-09-13 | セルジーン コーポレイション | 固形腫瘍の治療方法及び免疫調節療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| GB201521481D0 (en) * | 2015-12-04 | 2016-01-20 | Healx Ltd | Prognostic system |
| WO2017136139A1 (en) | 2016-02-01 | 2017-08-10 | Biodesix, Inc. | Predictive test for melanoma patient benefit from interleukin-2 (il2) therapy |
| CA3023265A1 (en) * | 2016-05-05 | 2017-11-09 | Nantomics, Llc | Checkpoint failure and methods therefor |
| WO2018129301A1 (en) | 2017-01-05 | 2018-07-12 | Biodesix, Inc. | Method for identification of cancer patients with durable benefit from immunotherapy in overall poor prognosis subgroups |
| US11124519B2 (en) | 2017-09-21 | 2021-09-21 | Millennium Pharmaceuticals, Inc. | Cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate, formulations and uses thereof |
| WO2019190732A1 (en) | 2018-03-29 | 2019-10-03 | Biodesix, Inc. | Apparatus and method for identification of primary immune resistance in cancer patients |
| CN112639474A (zh) * | 2018-05-14 | 2021-04-09 | 卑尔根生物股份公司 | 血清生物标志物 |
| CN110885830A (zh) * | 2018-09-07 | 2020-03-17 | 安徽华大医学检验所有限公司 | Fn1基因突变及其应用 |
| CN109411015B (zh) * | 2018-09-28 | 2020-12-22 | 深圳裕策生物科技有限公司 | 基于循环肿瘤dna的肿瘤突变负荷检测装置及存储介质 |
| CN109762911B (zh) * | 2019-02-21 | 2020-12-01 | 华中农业大学 | Ptprj基因作为猪免疫相关性状的分子标记及其应用 |
| JP7438693B2 (ja) | 2019-09-02 | 2024-02-27 | キヤノンメディカルシステムズ株式会社 | 診療支援装置 |
| GB2595718A (en) * | 2020-06-04 | 2021-12-08 | Cancer Research Tech Ltd | Methods for predicting treatment response in cancers |
| CA3193688A1 (en) * | 2020-10-09 | 2022-04-14 | Vladimir Lazar | Novel prediction method and gene signatures for the treatment of cancer |
| CN112415206B (zh) * | 2020-10-23 | 2023-08-18 | 上海良润生物医药科技有限公司 | 外泌体中的cd171蛋白作为肿瘤转移诊断标志物的应用 |
| CN113046357B (zh) * | 2021-01-25 | 2023-05-16 | 柳州市柳铁中心医院 | 一种乐伐替尼耐药基因dusp9、其筛选方法及应用 |
| CN114045336B (zh) * | 2021-09-28 | 2024-01-02 | 中国人民解放军空军军医大学 | Cga基因作为靶点在制备用于诊断和治疗耐药实体瘤药物的应用 |
| US12254987B2 (en) * | 2023-03-23 | 2025-03-18 | Certis Oncology Solutions, Inc. | Artificial intelligence for identifying one or more predictive biomarkers |
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-
2013
- 2013-10-01 US US14/432,587 patent/US10662477B2/en not_active Expired - Fee Related
- 2013-10-01 EP EP13843965.8A patent/EP2904115B1/en not_active Not-in-force
- 2013-10-01 WO PCT/US2013/062902 patent/WO2014055543A2/en not_active Ceased
- 2013-10-01 CA CA2886783A patent/CA2886783A1/en not_active Abandoned
- 2013-10-01 CN CN201380061933.5A patent/CN104822844B/zh not_active Expired - Fee Related
- 2013-10-01 JP JP2015534816A patent/JP6486826B2/ja not_active Expired - Fee Related
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| JP2015533084A5 (enExample) | ||
| McKerrow et al. | LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint | |
| Lin et al. | Membrane protein-regulated networks across human cancers | |
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| Wei et al. | Intratumoral and intertumoral genomic heterogeneity of multifocal localized prostate cancer impacts molecular classifications and genomic prognosticators | |
| Gadd et al. | Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets | |
| Alsaleem et al. | A novel prognostic two-gene signature for triple negative breast cancer | |
| Milde et al. | Nestin expression identifies ependymoma patients with poor outcome | |
| Aloraifi et al. | Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer | |
| Dudbridge et al. | Predictive accuracy of combined genetic and environmental risk scores | |
| Golestan et al. | Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification | |
| WO2016074589A1 (zh) | 检测西妥昔单抗治疗转移性结直肠癌耐药的试剂盒 | |
| HRP20191182T1 (hr) | Identifikacija tumorsko-zaštitnih epitopa za liječenje karcinoma | |
| Xiong et al. | A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations | |
| Liu et al. | Heterogeneous expression of tandem‐pore K+ channel genes in adult and embryonic rat heart quantified by real‐time polymerase chain reaction | |
| Tsuru et al. | miR‐424 levels in hair shaft are increased in psoriatic patients | |
| Sokolov et al. | Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression | |
| Worst et al. | The EEF1A2 gene expression as risk predictor in localized prostate cancer | |
| RU2019120046A (ru) | Оценки риска на основе экспрессии варианта 7 фосфодиэстеразы 4d человека | |
| Tai et al. | Evaluation of domain prediction in CASP6 | |
| Chiam et al. | Identification of microRNA biomarkers of response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma using next generation sequencing | |
| Cheng et al. | A signature of nine lncRNA methylated genes predicts survival in patients with glioma | |
| KR102265529B1 (ko) | 복합 유전 정보 네트워크 분석에 기반한 질병 위험도 진단 방법 | |
| Siwo et al. | Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite | |
| Mao et al. | Hypoxia regulated gene network in glioblastoma has special algebraic topology structures and revealed communications involving warburg effect and immune regulation |