JP2015531750A5 - - Google Patents

Info

Publication number

JP2015531750A5

JP2015531750A5 JP2015521677A JP2015521677A JP2015531750A5 JP 2015531750 A5 JP2015531750 A5 JP 2015531750A5 JP 2015521677 A JP2015521677 A JP 2015521677A JP 2015521677 A JP2015521677 A JP 2015521677A JP 2015531750 A5 JP2015531750 A5 JP 2015531750A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

hvr

sequence

Prior art date

2013-07-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090001123 antibodies Proteins 0.000 claims description 22
• 102000004965 antibodies Human genes 0.000 claims description 22
• 108010047814 Antigen-Antibody Complex Proteins 0.000 claims description 13
• 239000003814 drug Substances 0.000 claims description 11
• 108010027440 Immunoconjugates Proteins 0.000 claims description 4
• 102000018748 Immunoconjugates Human genes 0.000 claims description 4
• 208000009899 Burkitt Lymphoma Diseases 0.000 claims description 3
• 206010026798 Mantle cell lymphomas Diseases 0.000 claims description 3
• 102000033147 ERVK-25 Human genes 0.000 claims description 2
• 108091005771 Peptidases Proteins 0.000 claims description 2
• 239000004365 Protease Substances 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 24
• 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims 7
• 239000002254 cytotoxic agent Substances 0.000 claims 5
• 231100000599 cytotoxic agent Toxicity 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 3
• 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 2
• 206010024324 Leukaemias Diseases 0.000 claims 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
• 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 2
• 239000000825 pharmaceutical preparation Substances 0.000 claims 2
• 102100000189 CD22 Human genes 0.000 claims 1
• 101700020617 CD22 Proteins 0.000 claims 1
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
• DASWEROEPLKSEI-UIJRFTGLSA-N Monomethyl auristatin E Chemical group CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 DASWEROEPLKSEI-UIJRFTGLSA-N 0.000 claims 1
• 206010025310 Other lymphomas Diseases 0.000 claims 1
• 102000018075 Subfamily B ATP Binding Cassette Transporter Human genes 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000002768 hair cell Anatomy 0.000 claims 1
• 150000007857 hydrazones Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229940079593 drugs Drugs 0.000 description 6
• VHJLVAABSRFDPM-UHFFFAOYSA-N 1,4-dimercaptobutane-2,3-diol Chemical compound SCC(O)C(O)CS VHJLVAABSRFDPM-UHFFFAOYSA-N 0.000 description 4
• 229920002574 CR-39 Polymers 0.000 description 4
• SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 description 4
• XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
• 230000000903 blocking Effects 0.000 description 4
• 230000021615 conjugation Effects 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• 235000020960 dehydroascorbic acid Nutrition 0.000 description 4
• 239000011615 dehydroascorbic acid Substances 0.000 description 4
• SLURUCSFDHKXFR-WWMWMSKMSA-N (7S,9S)-7-[[(1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyl-3,4,4a,6,7,9,9a,10a-octahydro-1H-pyrano[1,2][1,3]oxazolo[3,4-b][1,4]oxazin-3-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC(OC)=C2C(=O)C(C(O)=C23)=C1C(O)=C3C[C@@](O)(C(=O)CO)C[C@@H]2O[C@H]1C[C@@H]2N3CCO[C@H](OC)[C@H]3O[C@@H]2[C@H](C)O1 SLURUCSFDHKXFR-WWMWMSKMSA-N 0.000 description 2
• 229960004308 ACETYLCYSTEINE Drugs 0.000 description 2
• 206010012818 Diffuse large B-cell lymphoma Diseases 0.000 description 2
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
• 150000002019 disulfides Chemical class 0.000 description 2
• 125000005647 linker group Chemical group 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 125000000446 sulfanediyl group Chemical group *S* 0.000 description 2
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical group C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 description 1