JP2015531378A5 - - Google Patents

Info

Publication number

JP2015531378A5

JP2015531378A5 JP2015534749A JP2015534749A JP2015531378A5 JP 2015531378 A5 JP2015531378 A5 JP 2015531378A5 JP 2015534749 A JP2015534749 A JP 2015534749A JP 2015534749 A JP2015534749 A JP 2015534749A JP 2015531378 A5 JP2015531378 A5 JP 2015531378A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

amino

lactam compound

arginine

Prior art date

2013-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 16
• -1 β-lactam compound Chemical class 0.000 claims 12
• 239000004475 Arginine Substances 0.000 claims 10
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 10
• 235000009697 arginine Nutrition 0.000 claims 10
• LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 claims 10
• 229960003865 tazobactam Drugs 0.000 claims 10
• 238000000034 method Methods 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 7
• 208000035143 Bacterial infection Diseases 0.000 claims 6
• 208000022362 bacterial infectious disease Diseases 0.000 claims 6
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 3
• 229930064664 L-arginine Natural products 0.000 claims 3
• 235000014852 L-arginine Nutrition 0.000 claims 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
• 238000000634 powder X-ray diffraction Methods 0.000 claims 3
• UJDQGRLTPBVSFN-TVNHLQOTSA-N 2-[(z)-[2-[[(6r,7r)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene]amino]oxy-2-methylpropanoate;sulfuric acid Chemical compound OS(O)(=O)=O.CN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)C(=N/OC(C)(C)C([O-])=O)\C=3N=C(N)SN=3)[C@H]2SC1 UJDQGRLTPBVSFN-TVNHLQOTSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 238000001757 thermogravimetry curve Methods 0.000 claims 2
• SCNWTQPZTZMXBG-UHFFFAOYSA-N 2-methyloct-2-enoic acid Chemical compound CCCCCC=C(C)C(O)=O SCNWTQPZTZMXBG-UHFFFAOYSA-N 0.000 claims 1
• 108090000204 Dipeptidase 1 Proteins 0.000 claims 1
• 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 102000006635 beta-lactamase Human genes 0.000 claims 1
• 238000000113 differential scanning calorimetry Methods 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 208000019206 urinary tract infection Diseases 0.000 claims 1