JP2015529656A5 - - Google Patents

Info

Publication number

JP2015529656A5

JP2015529656A5 JP2015525601A JP2015525601A JP2015529656A5 JP 2015529656 A5 JP2015529656 A5 JP 2015529656A5 JP 2015525601 A JP2015525601 A JP 2015525601A JP 2015525601 A JP2015525601 A JP 2015525601A JP 2015529656 A5 JP2015529656 A5 JP 2015529656A5

Authority

JP

Japan

Prior art keywords

seq

immune complex

antibody

hvr

amino acid

Prior art date

2013-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 37
• 125000003275 alpha amino acid group Chemical group 0.000 claims 27
• 229940127089 cytotoxic agent Drugs 0.000 claims 12
• 239000002254 cytotoxic agent Substances 0.000 claims 12
• 231100000599 cytotoxic agent Toxicity 0.000 claims 12
• 229940124597 therapeutic agent Drugs 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 8
• 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 7
• 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 7
• 229940127121 immunoconjugate Drugs 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 201000001441 melanoma Diseases 0.000 claims 4
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical class C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 claims 4
• 239000000427 antigen Substances 0.000 claims 3
• 102000036639 antigens Human genes 0.000 claims 3
• 108091007433 antigens Proteins 0.000 claims 3
• 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims 2
• 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
• 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
• 108010016626 Dipeptides Proteins 0.000 claims 2
• 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 2
• 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 2
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
• 108010014402 tyrosinase-related protein-1 Proteins 0.000 claims 2
• AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• NLMBVBUNULOTNS-HOKPPMCLSA-N [4-[[(2s)-5-(carbamoylamino)-2-[[(2s)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl n-[(2s)-1-[[(2s)-1-[[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-o Chemical compound C1([C@H](O)[C@@H](C)NC(=O)[C@H](C)[C@@H](OC)[C@@H]2CCCN2C(=O)C[C@H]([C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCC=2C=CC(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN3C(C=CC3=O)=O)C(C)C)=CC=2)C(C)C)OC)=CC=CC=C1 NLMBVBUNULOTNS-HOKPPMCLSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000007857 hydrazones Chemical class 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• AMKBTTRWLGVRER-OFVILXPXSA-N n-[(2s)-1-[[(2s)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)NC=1C=CC(CO)=CC=1)C(=O)CCCCCN1C(=O)C=CC1=O AMKBTTRWLGVRER-OFVILXPXSA-N 0.000 claims 1
• 229950010159 nemorubicin Drugs 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 0 C[C@@](CCC1)O[C@]1O[C@@](C[C@@](Cc1c(c(C(c2cccc(OC)c22)=O)c3C2=O)O)(C(NCCN(C(CC2SC(C)(C)*)=O)C2=O)=O)O)c1c3O Chemical compound C[C@@](CCC1)O[C@]1O[C@@](C[C@@](Cc1c(c(C(c2cccc(OC)c22)=O)c3C2=O)O)(C(NCCN(C(CC2SC(C)(C)*)=O)C2=O)=O)O)c1c3O 0.000 description 1
• UQMUIPXTUDIUJD-SCSAIBSYSA-N O[C@H]1NCCOC1 Chemical compound O[C@H]1NCCOC1 UQMUIPXTUDIUJD-SCSAIBSYSA-N 0.000 description 1
• GUDNSPYMGXUOCO-SCSAIBSYSA-N [O-][C@H]1NCCOC1 Chemical compound [O-][C@H]1NCCOC1 GUDNSPYMGXUOCO-SCSAIBSYSA-N 0.000 description 1