JP2015528463A5 - - Google Patents
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- Publication number
- JP2015528463A5 JP2015528463A5 JP2015529881A JP2015529881A JP2015528463A5 JP 2015528463 A5 JP2015528463 A5 JP 2015528463A5 JP 2015529881 A JP2015529881 A JP 2015529881A JP 2015529881 A JP2015529881 A JP 2015529881A JP 2015528463 A5 JP2015528463 A5 JP 2015528463A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- compound according
- hydroxyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261693437P | 2012-08-27 | 2012-08-27 | |
| US61/693,437 | 2012-08-27 | ||
| PCT/US2013/056418 WO2014035827A1 (en) | 2012-08-27 | 2013-08-23 | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528463A JP2015528463A (ja) | 2015-09-28 |
| JP2015528463A5 true JP2015528463A5 (enExample) | 2016-10-13 |
| JP6270848B2 JP6270848B2 (ja) | 2018-01-31 |
Family
ID=49117974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529881A Expired - Fee Related JP6270848B2 (ja) | 2012-08-27 | 2013-08-23 | ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中央部肥厚の低下 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9024042B2 (enExample) |
| EP (1) | EP2888239B1 (enExample) |
| JP (1) | JP6270848B2 (enExample) |
| KR (2) | KR20200110820A (enExample) |
| CN (1) | CN104684904B (enExample) |
| AU (1) | AU2013309124B2 (enExample) |
| CA (1) | CA2882743C (enExample) |
| DK (1) | DK2888239T3 (enExample) |
| ES (1) | ES2711425T3 (enExample) |
| TR (1) | TR201900863T4 (enExample) |
| WO (1) | WO2014035827A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2711425T3 (es) | 2012-08-27 | 2019-05-03 | Allergan Inc | Espesamiento de la córnea central reducido mediante el uso de profármacos de éster hidrófilos de beta-clorociclopentanos |
| KR20160124835A (ko) * | 2014-02-20 | 2016-10-28 | 알러간, 인코포레이티드 | 베타-클로로시클로펜탄의 친수성 에스테르 프로드럭의 사용에 의해 감소된 중앙 각막 비후 |
| WO2015175544A1 (en) * | 2014-05-12 | 2015-11-19 | Allergan, Inc. | Quaternary ammonium alkyl esters of prostanoid derivatives as stable prodrugs |
| US9573926B2 (en) | 2014-05-22 | 2017-02-21 | Allergan, Inc. | Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for their use |
| US10329284B2 (en) | 2014-10-02 | 2019-06-25 | Allergan, Inc. | Ester prodrugs of gamma-lactams and their use |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
| CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| AU5436198A (en) * | 1996-11-12 | 1998-06-03 | Alcon Laboratories, Inc. | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension |
| DE10322843A1 (de) | 2003-05-19 | 2004-12-16 | Clariant Gmbh | Verfahren zur Herstellung von Anilinboronsäuren und ihren Derivaten |
| WO2006047466A2 (en) | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US20070254920A1 (en) | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
| BRPI0714885B8 (pt) * | 2006-07-11 | 2021-05-25 | Allergan Inc | compostos terapêuticos e seu uso |
| US7947732B2 (en) * | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
| US7737140B2 (en) * | 2008-04-24 | 2010-06-15 | Allergan, Inc. | Therapeutic compounds |
| EP2291346A2 (en) * | 2008-05-15 | 2011-03-09 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| NZ628266A (en) | 2009-11-09 | 2016-02-26 | Allergan Inc | Compositions and methods for stimulating hair growth |
| US20110136872A1 (en) | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| ES2711425T3 (es) | 2012-08-27 | 2019-05-03 | Allergan Inc | Espesamiento de la córnea central reducido mediante el uso de profármacos de éster hidrófilos de beta-clorociclopentanos |
| US9090595B2 (en) | 2012-08-27 | 2015-07-28 | Allergan, Inc. | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
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2013
- 2013-08-23 ES ES13759081T patent/ES2711425T3/es active Active
- 2013-08-23 CA CA2882743A patent/CA2882743C/en active Active
- 2013-08-23 EP EP13759081.6A patent/EP2888239B1/en active Active
- 2013-08-23 KR KR1020207026858A patent/KR20200110820A/ko not_active Ceased
- 2013-08-23 US US13/974,975 patent/US9024042B2/en active Active
- 2013-08-23 KR KR1020157007444A patent/KR102304111B1/ko not_active Expired - Fee Related
- 2013-08-23 AU AU2013309124A patent/AU2013309124B2/en not_active Ceased
- 2013-08-23 DK DK13759081.6T patent/DK2888239T3/en active
- 2013-08-23 JP JP2015529881A patent/JP6270848B2/ja not_active Expired - Fee Related
- 2013-08-23 CN CN201380051147.7A patent/CN104684904B/zh not_active Expired - Fee Related
- 2013-08-23 WO PCT/US2013/056418 patent/WO2014035827A1/en not_active Ceased
- 2013-08-23 TR TR2019/00863T patent/TR201900863T4/tr unknown
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2015
- 2015-04-13 US US14/685,414 patent/US9427401B2/en active Active