JP2015528463A5 - - Google Patents
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- JP2015528463A5 JP2015528463A5 JP2015529881A JP2015529881A JP2015528463A5 JP 2015528463 A5 JP2015528463 A5 JP 2015528463A5 JP 2015529881 A JP2015529881 A JP 2015529881A JP 2015529881 A JP2015529881 A JP 2015529881A JP 2015528463 A5 JP2015528463 A5 JP 2015528463A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- compound according
- hydroxyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261693437P | 2012-08-27 | 2012-08-27 | |
| US61/693,437 | 2012-08-27 | ||
| PCT/US2013/056418 WO2014035827A1 (en) | 2012-08-27 | 2013-08-23 | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528463A JP2015528463A (ja) | 2015-09-28 |
| JP2015528463A5 true JP2015528463A5 (enExample) | 2016-10-13 |
| JP6270848B2 JP6270848B2 (ja) | 2018-01-31 |
Family
ID=49117974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529881A Expired - Fee Related JP6270848B2 (ja) | 2012-08-27 | 2013-08-23 | ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中央部肥厚の低下 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9024042B2 (enExample) |
| EP (1) | EP2888239B1 (enExample) |
| JP (1) | JP6270848B2 (enExample) |
| KR (2) | KR20200110820A (enExample) |
| CN (1) | CN104684904B (enExample) |
| AU (1) | AU2013309124B2 (enExample) |
| CA (1) | CA2882743C (enExample) |
| DK (1) | DK2888239T3 (enExample) |
| ES (1) | ES2711425T3 (enExample) |
| TR (1) | TR201900863T4 (enExample) |
| WO (1) | WO2014035827A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104684904B (zh) | 2012-08-27 | 2017-10-13 | 阿勒根公司 | 通过使用β‑氯环戊烷的亲水性酯前药减轻中央角膜增厚 |
| CA2939569A1 (en) * | 2014-02-20 | 2015-11-19 | Allergan, Inc. | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
| WO2015175544A1 (en) * | 2014-05-12 | 2015-11-19 | Allergan, Inc. | Quaternary ammonium alkyl esters of prostanoid derivatives as stable prodrugs |
| US9573926B2 (en) | 2014-05-22 | 2017-02-21 | Allergan, Inc. | Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for their use |
| WO2016054596A1 (en) * | 2014-10-02 | 2016-04-07 | Allergan, Inc. | Ester prodrugs of gamma-lactams and their use |
| SI3752501T1 (sl) | 2018-02-13 | 2023-08-31 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| SI3820572T1 (sl) | 2018-07-13 | 2023-12-29 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6353000B1 (en) | 1996-11-12 | 2002-03-05 | Alcon Laboratories, Inc. | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension |
| DE10322843A1 (de) | 2003-05-19 | 2004-12-16 | Clariant Gmbh | Verfahren zur Herstellung von Anilinboronsäuren und ihren Derivaten |
| WO2006047466A2 (en) * | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US20070254920A1 (en) | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
| BRPI0714885B8 (pt) * | 2006-07-11 | 2021-05-25 | Allergan Inc | compostos terapêuticos e seu uso |
| US7947732B2 (en) | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
| US7737140B2 (en) * | 2008-04-24 | 2010-06-15 | Allergan, Inc. | Therapeutic compounds |
| AU2009246573B2 (en) * | 2008-05-15 | 2014-04-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US20110124736A1 (en) | 2009-11-09 | 2011-05-26 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US20110136872A1 (en) | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| CN104684904B (zh) | 2012-08-27 | 2017-10-13 | 阿勒根公司 | 通过使用β‑氯环戊烷的亲水性酯前药减轻中央角膜增厚 |
| US9090595B2 (en) | 2012-08-27 | 2015-07-28 | Allergan, Inc. | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
-
2013
- 2013-08-23 CN CN201380051147.7A patent/CN104684904B/zh not_active Expired - Fee Related
- 2013-08-23 JP JP2015529881A patent/JP6270848B2/ja not_active Expired - Fee Related
- 2013-08-23 WO PCT/US2013/056418 patent/WO2014035827A1/en not_active Ceased
- 2013-08-23 KR KR1020207026858A patent/KR20200110820A/ko not_active Ceased
- 2013-08-23 AU AU2013309124A patent/AU2013309124B2/en not_active Ceased
- 2013-08-23 DK DK13759081.6T patent/DK2888239T3/en active
- 2013-08-23 CA CA2882743A patent/CA2882743C/en active Active
- 2013-08-23 TR TR2019/00863T patent/TR201900863T4/tr unknown
- 2013-08-23 ES ES13759081T patent/ES2711425T3/es active Active
- 2013-08-23 EP EP13759081.6A patent/EP2888239B1/en active Active
- 2013-08-23 US US13/974,975 patent/US9024042B2/en active Active
- 2013-08-23 KR KR1020157007444A patent/KR102304111B1/ko not_active Expired - Fee Related
-
2015
- 2015-04-13 US US14/685,414 patent/US9427401B2/en active Active
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