AU2013309124B2 - Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes - Google Patents
Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes Download PDFInfo
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- AU2013309124B2 AU2013309124B2 AU2013309124A AU2013309124A AU2013309124B2 AU 2013309124 B2 AU2013309124 B2 AU 2013309124B2 AU 2013309124 A AU2013309124 A AU 2013309124A AU 2013309124 A AU2013309124 A AU 2013309124A AU 2013309124 B2 AU2013309124 B2 AU 2013309124B2
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- Prior art keywords
- unsubstituted
- substituted
- compound
- alkyl
- hydroxyl
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- 206010071164 Corneal thickening Diseases 0.000 title claims abstract description 10
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- 239000000651 prodrug Substances 0.000 title abstract description 15
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- 238000000034 method Methods 0.000 claims abstract description 42
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- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
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- 125000006684 polyhaloalkyl group Polymers 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
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- 150000003892 tartrate salts Chemical class 0.000 description 1
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- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| US201261693437P | 2012-08-27 | 2012-08-27 | |
| US61/693,437 | 2012-08-27 | ||
| PCT/US2013/056418 WO2014035827A1 (en) | 2012-08-27 | 2013-08-23 | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
Publications (2)
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| AU2013309124A1 AU2013309124A1 (en) | 2015-03-12 |
| AU2013309124B2 true AU2013309124B2 (en) | 2018-03-01 |
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| EP (1) | EP2888239B1 (enExample) |
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| TR (1) | TR201900863T4 (enExample) |
| WO (1) | WO2014035827A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104684904B (zh) | 2012-08-27 | 2017-10-13 | 阿勒根公司 | 通过使用β‑氯环戊烷的亲水性酯前药减轻中央角膜增厚 |
| CA2939569A1 (en) * | 2014-02-20 | 2015-11-19 | Allergan, Inc. | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
| WO2015175544A1 (en) * | 2014-05-12 | 2015-11-19 | Allergan, Inc. | Quaternary ammonium alkyl esters of prostanoid derivatives as stable prodrugs |
| US9573926B2 (en) | 2014-05-22 | 2017-02-21 | Allergan, Inc. | Amidoalkylenyl and amidoaryl esters, compositions thereof, and methods for their use |
| WO2016054596A1 (en) * | 2014-10-02 | 2016-04-07 | Allergan, Inc. | Ester prodrugs of gamma-lactams and their use |
| SI3752501T1 (sl) | 2018-02-13 | 2023-08-31 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| SI3820572T1 (sl) | 2018-07-13 | 2023-12-29 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080015231A1 (en) * | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Therapeutic compounds |
| US20090239869A1 (en) * | 2008-03-18 | 2009-09-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US20090270396A1 (en) * | 2008-04-24 | 2009-10-29 | Allergan, Inc. | Therapeutic compounds |
| US20100210689A1 (en) * | 2007-07-13 | 2010-08-19 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6353000B1 (en) | 1996-11-12 | 2002-03-05 | Alcon Laboratories, Inc. | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension |
| DE10322843A1 (de) | 2003-05-19 | 2004-12-16 | Clariant Gmbh | Verfahren zur Herstellung von Anilinboronsäuren und ihren Derivaten |
| WO2006047466A2 (en) * | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US20070254920A1 (en) | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
| AU2009246573B2 (en) * | 2008-05-15 | 2014-04-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US20110124736A1 (en) | 2009-11-09 | 2011-05-26 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US20110136872A1 (en) | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| CN104684904B (zh) | 2012-08-27 | 2017-10-13 | 阿勒根公司 | 通过使用β‑氯环戊烷的亲水性酯前药减轻中央角膜增厚 |
| US9090595B2 (en) | 2012-08-27 | 2015-07-28 | Allergan, Inc. | Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes |
-
2013
- 2013-08-23 CN CN201380051147.7A patent/CN104684904B/zh not_active Expired - Fee Related
- 2013-08-23 JP JP2015529881A patent/JP6270848B2/ja not_active Expired - Fee Related
- 2013-08-23 WO PCT/US2013/056418 patent/WO2014035827A1/en not_active Ceased
- 2013-08-23 KR KR1020207026858A patent/KR20200110820A/ko not_active Ceased
- 2013-08-23 AU AU2013309124A patent/AU2013309124B2/en not_active Ceased
- 2013-08-23 DK DK13759081.6T patent/DK2888239T3/en active
- 2013-08-23 CA CA2882743A patent/CA2882743C/en active Active
- 2013-08-23 TR TR2019/00863T patent/TR201900863T4/tr unknown
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- 2013-08-23 KR KR1020157007444A patent/KR102304111B1/ko not_active Expired - Fee Related
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- 2015-04-13 US US14/685,414 patent/US9427401B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080015231A1 (en) * | 2006-07-11 | 2008-01-17 | Allergan, Inc. | Therapeutic compounds |
| US20100210689A1 (en) * | 2007-07-13 | 2010-08-19 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| US20090239869A1 (en) * | 2008-03-18 | 2009-09-24 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US20090270396A1 (en) * | 2008-04-24 | 2009-10-29 | Allergan, Inc. | Therapeutic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2888239T3 (en) | 2019-03-04 |
| CA2882743C (en) | 2021-11-30 |
| US9024042B2 (en) | 2015-05-05 |
| KR102304111B1 (ko) | 2021-09-23 |
| US20140057975A1 (en) | 2014-02-27 |
| KR20150046269A (ko) | 2015-04-29 |
| US20150322036A1 (en) | 2015-11-12 |
| KR20200110820A (ko) | 2020-09-25 |
| JP2015528463A (ja) | 2015-09-28 |
| CN104684904B (zh) | 2017-10-13 |
| JP6270848B2 (ja) | 2018-01-31 |
| EP2888239B1 (en) | 2018-11-28 |
| WO2014035827A1 (en) | 2014-03-06 |
| HK1211031A1 (en) | 2016-05-13 |
| AU2013309124A1 (en) | 2015-03-12 |
| US9427401B2 (en) | 2016-08-30 |
| CN104684904A (zh) | 2015-06-03 |
| EP2888239A1 (en) | 2015-07-01 |
| CA2882743A1 (en) | 2014-03-06 |
| ES2711425T3 (es) | 2019-05-03 |
| TR201900863T4 (tr) | 2019-02-21 |
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Legal Events
| Date | Code | Title | Description |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |