JP2015528430A5 - - Google Patents
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- JP2015528430A5 JP2015528430A5 JP2015526007A JP2015526007A JP2015528430A5 JP 2015528430 A5 JP2015528430 A5 JP 2015528430A5 JP 2015526007 A JP2015526007 A JP 2015526007A JP 2015526007 A JP2015526007 A JP 2015526007A JP 2015528430 A5 JP2015528430 A5 JP 2015528430A5
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- JP
- Japan
- Prior art keywords
- acc
- suspension
- weight
- acid
- stabilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 44
- 239000003381 stabilizer Substances 0.000 claims 33
- 239000000725 suspension Substances 0.000 claims 33
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 18
- 238000000034 method Methods 0.000 claims 15
- 239000000243 solution Substances 0.000 claims 15
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 13
- 239000007864 aqueous solution Substances 0.000 claims 13
- 150000001413 amino acids Chemical class 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 150000007524 organic acids Chemical class 0.000 claims 12
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 11
- 239000001110 calcium chloride Substances 0.000 claims 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims 11
- 239000003960 organic solvent Substances 0.000 claims 11
- 239000003513 alkali Substances 0.000 claims 9
- 159000000007 calcium salts Chemical class 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 230000000087 stabilizing effect Effects 0.000 claims 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 6
- 229930006000 Sucrose Natural products 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 239000005720 sucrose Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 5
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 5
- 239000011575 calcium Substances 0.000 claims 5
- 229910052791 calcium Inorganic materials 0.000 claims 5
- 239000000843 powder Substances 0.000 claims 5
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- -1 sulfuric acid ester Chemical class 0.000 claims 4
- 150000003628 tricarboxylic acids Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 150000002894 organic compounds Chemical class 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 claims 2
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims 2
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 238000005119 centrifugation Methods 0.000 claims 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims 2
- 229950006137 dexfosfoserine Drugs 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 229940093915 gynecological organic acid Drugs 0.000 claims 2
- 235000005985 organic acids Nutrition 0.000 claims 2
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims 2
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 235000000346 sugar Nutrition 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- SJSQTARGNAQQKY-GBXIJSLDSA-N (2s,3r)-2-amino-3-sulfooxybutanoic acid Chemical compound OS(=O)(=O)O[C@H](C)[C@H](N)C(O)=O SJSQTARGNAQQKY-GBXIJSLDSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000003862 amino acid derivatives Chemical class 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 150000005323 carbonate salts Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000976 ink Substances 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 claims 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims 1
- 229910052808 lithium carbonate Inorganic materials 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 239000004579 marble Substances 0.000 claims 1
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 1
- 150000004692 metal hydroxides Chemical class 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229950007002 phosphocreatine Drugs 0.000 claims 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-K phosphonatoenolpyruvate Chemical compound [O-]C(=O)C(=C)OP([O-])([O-])=O DTBNBXWJWCWCIK-UHFFFAOYSA-K 0.000 claims 1
- 150000003014 phosphoric acid esters Chemical class 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 150000004043 trisaccharides Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261680322P | 2012-08-07 | 2012-08-07 | |
| US61/680,322 | 2012-08-07 | ||
| US201261736015P | 2012-12-12 | 2012-12-12 | |
| US61/736,015 | 2012-12-12 | ||
| PCT/IL2013/050670 WO2014024191A1 (en) | 2012-08-07 | 2013-08-07 | Method for producing stabilized amorphous calcium carbonate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528430A JP2015528430A (ja) | 2015-09-28 |
| JP2015528430A5 true JP2015528430A5 (https=) | 2016-09-23 |
| JP6263181B2 JP6263181B2 (ja) | 2018-01-17 |
Family
ID=50067495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526007A Active JP6263181B2 (ja) | 2012-08-07 | 2013-08-07 | 安定化させた非晶質炭酸カルシウムの製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9550878B2 (https=) |
| EP (1) | EP2882687B1 (https=) |
| JP (1) | JP6263181B2 (https=) |
| CN (1) | CN104520238B (https=) |
| AU (1) | AU2013301121B2 (https=) |
| BR (1) | BR112015002505B1 (https=) |
| CA (1) | CA2880783C (https=) |
| IL (1) | IL236960A (https=) |
| RU (1) | RU2637019C2 (https=) |
| WO (1) | WO2014024191A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2637019C2 (ru) | 2012-08-07 | 2017-11-29 | Аморфикал Лтд. | Способ получения стабилизированного аморфного карбоната кальция |
| AU2015294869B2 (en) * | 2014-07-31 | 2019-06-06 | Amorphical Ltd. | Non-aqueous liquid and semi-solid formulations of amorphous calcium carbonate |
| US10758565B2 (en) | 2015-06-04 | 2020-09-01 | Amorphical Ltd. | Compositions of amorphous calcium carbonate for inhalation, sublingual or buccal administration |
| US12121538B2 (en) | 2015-06-04 | 2024-10-22 | Amorphical Ltd. | Compositions of amorphous calcium carbonate for inhalation, sublingual or buccal administration |
| RU2757419C2 (ru) | 2016-01-18 | 2021-10-15 | Аморфикал Лтд. | Стабилизированный аморфный карбонат кальция для лечения мышечной дистрофии |
| CN108778295A (zh) | 2016-01-18 | 2018-11-09 | 艾玛菲克有限公司 | 作为细胞培养基补充剂的稳定的无定形碳酸钙 |
| EP3275838A1 (en) | 2016-07-25 | 2018-01-31 | Omya International AG | Production of amorphous calcium carbonate |
| AU2017349921B2 (en) | 2016-10-25 | 2023-06-15 | Amorphical Ltd | Amorphous calcium carbonate for treating a leukemia |
| KR20220038056A (ko) | 2019-07-23 | 2022-03-25 | 아모피컬 리미티드 | 운동 수행능력을 개선시키기 위한 비정질 탄산칼슘 |
| KR102271087B1 (ko) * | 2019-11-25 | 2021-06-30 | 한국세라믹기술원 | 패각류를 이용한 구형 탄산칼슘 입자 제조방법 |
| CN115353137B (zh) * | 2022-06-30 | 2023-10-24 | 福建信息职业技术学院 | 一种无定形碳酸钙的制备方法及其应用 |
| CN116350791B (zh) * | 2023-03-13 | 2024-11-12 | 清华大学 | 利用acc包载金属离子增加药物负载率的通用制备方法 |
| WO2025165296A1 (en) * | 2024-01-31 | 2025-08-07 | Nanyang Technological University | Carbon dioxide-based cementitious product for buildings and soil improvement |
| KR102765553B1 (ko) * | 2024-04-02 | 2025-02-07 | 부산대학교 산학협력단 | 탄산칼슘의 제조방법, 탄산칼슘 및 이를 포함하는 도료 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237147A (en) | 1974-01-04 | 1980-12-02 | Monsanto Company | Stabilized amorphous calcium carbonate |
| JPS56124368A (en) * | 1980-02-25 | 1981-09-30 | Monsanto Co | Stabilized amorphous calcium carbonate |
| JPS5964527A (ja) * | 1982-09-29 | 1984-04-12 | Shiraishi Chuo Kenkyusho:Kk | アモルファス炭酸カルシウムの製造方法 |
| SU1171423A1 (ru) * | 1983-01-04 | 1985-08-07 | Отделение Нефтехимии Института Физико-Органической Химии И Углехимии Ан Усср | Способ получени зол карбоната кальци |
| US6228161B1 (en) * | 1996-12-30 | 2001-05-08 | Minerals Technologies Inc. | Use of calcium carbonate in an acidic aqueous media |
| KR100561231B1 (ko) | 2004-05-18 | 2006-03-15 | 한국지질자원연구원 | 표면개질에 의한 비정질 탄산칼슘 제조방법 |
| CA2567972C (en) | 2004-05-26 | 2015-07-28 | Ben-Gurion University Of The Negev Research And Development Authority | Orally-administrable compositions comprising stable amorphous calcium carbonate |
| FI120032B (fi) * | 2004-07-13 | 2009-06-15 | Fp Pigments Oy | Menetelmä ja laite kalsiumkarbonaattituotteen valmistamiseksi, tuote ja sen käyttö |
| KR20070099571A (ko) * | 2004-12-22 | 2007-10-09 | 솔베이(소시에떼아노님) | 알칼리 토금속 카르보네이트의 내산성 입자 |
| JP2007191453A (ja) * | 2006-01-23 | 2007-08-02 | Gifu Prefecture | 非晶質クエン酸カルシウム・炭酸カルシウム複合体及びその製造方法 |
| IL178495A (en) | 2006-10-05 | 2014-12-31 | Univ Ben Gurion | Use of cancerous gastric components or artificial calcium containing carbonate, chitin and polypeptide preparations to treat calcium metabolism-related or calcium-signaling conditions |
| EP2211873B1 (en) * | 2007-10-22 | 2012-08-08 | Amorphical Ltd. | Stable amorphous calcium carbonate comprising phosphorylated amino acids |
| CN101580260B (zh) | 2009-05-31 | 2011-04-27 | 河南大学 | 一种微乳液法制备无定形碳酸钙的方法 |
| JP5429747B2 (ja) * | 2009-12-04 | 2014-02-26 | 学校法人日本大学 | 微小粉からなる化合物の製造方法、非晶質炭酸カルシウム |
| US8906996B2 (en) * | 2010-07-30 | 2014-12-09 | Schaefer Kalk Gmbh & Co. Kg | Spherical, amorphous calcium carbonate particles |
| JP6327859B2 (ja) * | 2011-03-18 | 2018-05-23 | シェーファー カルク ゲーエムベーハー ウント コー． カーゲー | 微細構造複合粒子 |
| CN103635428B (zh) * | 2011-04-28 | 2017-02-15 | 卡勒拉公司 | 使用碳酸钙和稳定剂的方法和组合物 |
| RU2637019C2 (ru) | 2012-08-07 | 2017-11-29 | Аморфикал Лтд. | Способ получения стабилизированного аморфного карбоната кальция |
-
2013
- 2013-08-07 RU RU2015103192A patent/RU2637019C2/ru active
- 2013-08-07 AU AU2013301121A patent/AU2013301121B2/en active Active
- 2013-08-07 US US14/418,034 patent/US9550878B2/en active Active
- 2013-08-07 EP EP13827551.6A patent/EP2882687B1/en active Active
- 2013-08-07 CN CN201380040013.5A patent/CN104520238B/zh active Active
- 2013-08-07 BR BR112015002505-6A patent/BR112015002505B1/pt active IP Right Grant
- 2013-08-07 WO PCT/IL2013/050670 patent/WO2014024191A1/en not_active Ceased
- 2013-08-07 JP JP2015526007A patent/JP6263181B2/ja active Active
- 2013-08-07 CA CA2880783A patent/CA2880783C/en active Active
-
2015
- 2015-01-28 IL IL236960A patent/IL236960A/en active IP Right Grant
-
2016
- 2016-12-06 US US15/370,623 patent/US10125262B2/en active Active
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