JP2015527302A5 - - Google Patents
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- Publication number
- JP2015527302A5 JP2015527302A5 JP2015518360A JP2015518360A JP2015527302A5 JP 2015527302 A5 JP2015527302 A5 JP 2015527302A5 JP 2015518360 A JP2015518360 A JP 2015518360A JP 2015518360 A JP2015518360 A JP 2015518360A JP 2015527302 A5 JP2015527302 A5 JP 2015527302A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- functional fragment
- mgo
- isolated
- royal jelly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229940109850 royal jelly Drugs 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 230000005764 inhibitory process Effects 0.000 claims description 3
- 102000004225 Cathepsin B Human genes 0.000 claims description 2
- 108090000712 Cathepsin B Proteins 0.000 claims description 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical group CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 claims 38
- 239000012634 fragment Substances 0.000 claims 29
- 235000012907 honey Nutrition 0.000 claims 13
- 238000000034 method Methods 0.000 claims 8
- 239000004472 Lysine Substances 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 240000003553 Leptospermum scoparium Species 0.000 claims 3
- 235000016887 Leptospermum scoparium Nutrition 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 238000003306 harvesting Methods 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003389 potentiating effect Effects 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- VQVUBYASAICPFU-UHFFFAOYSA-N (6'-acetyloxy-2',7'-dichloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Cl)=C(OC(C)=O)C=C1OC1=C2C=C(Cl)C(OC(=O)C)=C1 VQVUBYASAICPFU-UHFFFAOYSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ600847 | 2012-06-22 | ||
| NZ60084712 | 2012-06-22 | ||
| PCT/NZ2013/000110 WO2013191569A1 (en) | 2012-06-22 | 2013-06-24 | Anti-inflammatory proteins and peptides and methods of preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527302A JP2015527302A (ja) | 2015-09-17 |
| JP2015527302A5 true JP2015527302A5 (https=) | 2016-08-04 |
Family
ID=49769069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518360A Ceased JP2015527302A (ja) | 2012-06-22 | 2013-06-24 | 抗炎症性タンパク質及びペプチド並びにそれらの調製方法及び使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9580464B2 (https=) |
| EP (1) | EP2874642B1 (https=) |
| JP (1) | JP2015527302A (https=) |
| CN (1) | CN104540516B (https=) |
| AU (2) | AU2013277858B2 (https=) |
| WO (1) | WO2013191569A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ590143A (en) | 2010-12-22 | 2013-12-20 | Manukamed Ltd | Anti-inflammatory proteins and methods of preparation and use thereof |
| CN105536041A (zh) * | 2016-01-21 | 2016-05-04 | 常州陀谱生物医学技术有限公司 | 一种含王浆酸的抗菌生物敷料、制备方法及其用途 |
| US9744143B1 (en) | 2016-12-06 | 2017-08-29 | Links Medical Products, Inc. | Honey fortified with dihydroxyacetone and methods of making same |
| CN110573526B (zh) * | 2017-04-13 | 2022-03-01 | 威尔科学公司 | 蜂王浆主蛋白的抗体及其用途 |
| WO2018137748A2 (en) * | 2017-07-19 | 2018-08-02 | El Fiky Salem | Antiviral, antifibrotic and anticancer activities of royal-jelly proteins |
| US10842827B2 (en) * | 2018-08-22 | 2020-11-24 | José Manuel Aguilar Yáñez | Treatment and compound for epithelial wounds |
| WO2018188714A2 (en) * | 2018-09-06 | 2018-10-18 | El Fiky Salem Ismaeil Salem | Anti-leukemic, anti-hiv, and sialidase activities of royal-jelly proteins |
| KR102116185B1 (ko) * | 2018-10-24 | 2020-05-27 | 동아대학교 산학협력단 | 신규한 토종벌 유래 로열 젤리 단백질 4-c 말단 펩타이드 및 이의 용도 |
| KR102022118B1 (ko) * | 2019-01-07 | 2019-09-18 | 주식회사 아스트로젠 | 중추신경계 질환의 예방 또는 치료용 세린 유도체 화합물 |
| SG10201902000YA (en) * | 2019-03-06 | 2020-10-29 | Nat Univ Singapore | Isthmin 1 for treatment of lung inflammation |
| US20220280605A1 (en) * | 2019-05-01 | 2022-09-08 | Manukamed Functional Foods Ltd. | A Composition And Method For Improving The Profile Of Blood |
| JP7606478B2 (ja) * | 2019-07-04 | 2024-12-25 | コンビタ リミテッド | Ｍｍｐ－９関連状態及び炎症を予防、改善又は治療するための３，６，７－トリメチルルマジンを含む組成物の使用 |
| KR102380162B1 (ko) * | 2019-07-24 | 2022-03-29 | (주) 바이텍 | 효소처리 로얄젤리 분말을 포함하는 염증성 골관절질환 예방 또는 치료용 약학적 조성물 |
| CN110596262A (zh) * | 2019-08-14 | 2019-12-20 | 中国农业科学院蜜蜂研究所 | 利用液相色谱串联质谱测定蜂蜜中意蜂mrjp1蛋白含量的方法 |
| CN110850001B (zh) * | 2019-12-10 | 2020-12-25 | 中国农业科学院蜜蜂研究所 | 液相色谱串联质谱定量意蜂蜜mrjp3的方法 |
| CN111303282B (zh) * | 2020-03-30 | 2022-07-12 | 中国农业科学院蜜蜂研究所 | 配对的抗mrjp2单克隆抗体及其在定性或定量检测mrjp2中的应用 |
| CN111735966B (zh) * | 2020-07-23 | 2021-01-15 | 中国农业科学院蜜蜂研究所 | 一种液相色谱串联质谱法检测意蜂蜜和中蜂蜜中王浆主蛋白5的方法 |
| AU2021325604A1 (en) * | 2020-08-11 | 2023-03-09 | Quantum Technologies Limited | Bee product extracts, methods of production and uses thereof |
| JP7768775B2 (ja) * | 2021-01-14 | 2025-11-12 | 出光興産株式会社 | ペプチドタグおよびそれを含むタグ付加タンパク質 |
| US12419917B2 (en) | 2021-04-23 | 2025-09-23 | Ndal Mfg Inc | Compositions and methods for treatment of conditions using fractionated honey |
| WO2024054928A1 (en) * | 2022-09-09 | 2024-03-14 | Koliber Biosciences Inc. | Peptides with cytokine-releasing activity and methods for characterizing cytokine-releasing profiles of peptides |
| CN115991760B (zh) * | 2022-11-24 | 2025-06-20 | 福建农林大学 | 一种西方蜜蜂mrjp3 c端重组蛋白及其制备方法及其应用 |
| WO2024144786A1 (en) * | 2022-12-30 | 2024-07-04 | Bee-Io Honey Technologies Ltd. | Royal jelly production methods, systems, compositions and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7230079B2 (en) | 2002-08-29 | 2007-06-12 | Ken Hayashibara | Antiallergic agent |
| JP4384981B2 (ja) | 2002-09-06 | 2009-12-16 | 林原 健 | 精製ローヤルゼリー |
| NZ533368A (en) | 2004-06-08 | 2008-06-30 | Univ Waikato | Isolation process |
| JP2008137968A (ja) | 2006-12-04 | 2008-06-19 | Yamada Bee Farm Corp | ローヤルゼリーアレルゲンタンパク質のエピトープ、その検出用キット、該アレルゲンフリーのローヤルゼリーとその製法 |
| NZ547946A (en) | 2006-12-14 | 2009-10-30 | Waikatolink Ltd | Treatment composition |
| GB0810404D0 (en) | 2008-06-06 | 2008-07-09 | Manuka Medical Ltd | Compositions |
| JP2010095454A (ja) | 2008-10-14 | 2010-04-30 | Cyclochem:Kk | 抗菌組成物 |
| US20120021061A1 (en) | 2008-12-24 | 2012-01-26 | Comvita New Zealand Limited | Medical and nutritional formulations |
| CA2748230C (en) * | 2008-12-24 | 2020-02-18 | Comvita New Zealand Limited | Honey analysis |
| CA2761629A1 (en) * | 2009-05-29 | 2010-12-02 | Ruprecht-Karls-Universitaet Heidelberg | Methylglyoxal-scavenging compounds and their use for the prevention and treatment of pain and/or hyperalgesia |
| NZ590143A (en) * | 2010-12-22 | 2013-12-20 | Manukamed Ltd | Anti-inflammatory proteins and methods of preparation and use thereof |
| CA2917458A1 (en) | 2013-07-09 | 2015-01-15 | Manukamed Limited | A wound dressing |
-
2013
- 2013-06-24 AU AU2013277858A patent/AU2013277858B2/en active Active
- 2013-06-24 JP JP2015518360A patent/JP2015527302A/ja not_active Ceased
- 2013-06-24 CN CN201380038465.XA patent/CN104540516B/zh not_active Expired - Fee Related
- 2013-06-24 WO PCT/NZ2013/000110 patent/WO2013191569A1/en not_active Ceased
- 2013-06-24 US US14/410,227 patent/US9580464B2/en active Active
- 2013-06-24 EP EP13806248.4A patent/EP2874642B1/en active Active
-
2017
- 2017-01-11 US US15/403,767 patent/US20170190748A1/en not_active Abandoned
-
2018
- 2018-03-19 AU AU2018201945A patent/AU2018201945A1/en not_active Abandoned
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