JP2015526487A5 - - Google Patents
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- JP2015526487A5 JP2015526487A5 JP2015528857A JP2015528857A JP2015526487A5 JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5 JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- pharmaceutically acceptable
- mesomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210323870.3 | 2012-09-04 | ||
| CN201210323870 | 2012-09-04 | ||
| PCT/CN2013/082273 WO2014036897A1 (zh) | 2012-09-04 | 2013-08-26 | 咪唑啉类衍生物、其制备方法及其在医药上的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526487A JP2015526487A (ja) | 2015-09-10 |
| JP2015526487A5 true JP2015526487A5 (https=) | 2017-12-21 |
| JP6262733B2 JP6262733B2 (ja) | 2018-01-17 |
Family
ID=50236528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528857A Active JP6262733B2 (ja) | 2012-09-04 | 2013-08-26 | イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9586947B2 (https=) |
| EP (1) | EP2894151B1 (https=) |
| JP (1) | JP6262733B2 (https=) |
| KR (1) | KR102189940B1 (https=) |
| CN (1) | CN103958480B (https=) |
| AU (1) | AU2013312587B2 (https=) |
| BR (1) | BR112015004637B1 (https=) |
| CA (1) | CA2883545C (https=) |
| CY (1) | CY1123649T1 (https=) |
| DK (1) | DK2894151T3 (https=) |
| ES (1) | ES2835248T3 (https=) |
| HR (1) | HRP20202050T1 (https=) |
| HU (1) | HUE052904T2 (https=) |
| LT (1) | LT2894151T (https=) |
| MX (1) | MX368844B (https=) |
| PT (1) | PT2894151T (https=) |
| RS (1) | RS61242B1 (https=) |
| RU (1) | RU2639145C2 (https=) |
| SI (1) | SI2894151T1 (https=) |
| SM (1) | SMT202000672T1 (https=) |
| TW (1) | TWI617546B (https=) |
| WO (1) | WO2014036897A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS61242B1 (sr) * | 2012-09-04 | 2021-01-29 | Shanghai hengrui pharmaceutical co ltd | Derivati imidazolina, postupci njihove pripreme i njihove primene u medicini |
| JP6817962B2 (ja) * | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2017011371A1 (en) | 2015-07-10 | 2017-01-19 | Arvinas, Inc | Mdm2-based modulators of proteolysis and associated methods of use |
| CA2988436A1 (en) * | 2015-07-13 | 2017-01-19 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
| SI3348546T1 (sl) * | 2015-09-10 | 2020-09-30 | Jiangsu Hengrui Medicine Co., Ltd. | Kristalinična oblika zaviralca androgenega receptorja in postopek priprave le-tega |
| CN106518773A (zh) * | 2015-09-10 | 2017-03-22 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的结晶形式及其制备方法 |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| US9963433B2 (en) * | 2016-01-29 | 2018-05-08 | Wayne State University | Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor |
| AU2017220970B2 (en) * | 2016-02-19 | 2021-12-16 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition containing imidazoline derivative |
| EP3481394A1 (en) * | 2016-07-08 | 2019-05-15 | Janssen Pharmaceutica N.V. | Thiohydantoin androgen receptor antagonists for the treatment of cancer |
| CN110023297A (zh) * | 2016-07-08 | 2019-07-16 | 詹森药业有限公司 | 作为雄性激素受体拮抗剂的取代的乙内酰脲和硫代己内酰脲衍生物 |
| AU2017202864B2 (en) | 2017-02-13 | 2020-04-23 | Kangpu Biopharmaceuticals, Ltd. | Combination treating prostate cancer, pharmaceutical composition and treatment method |
| CN112300076B (zh) * | 2017-12-13 | 2022-10-25 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的晶型及其制备方法 |
| CN110684046B (zh) * | 2018-07-06 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 一种新的咪唑啉类衍生物的制备方法 |
| CN108976171B (zh) * | 2018-08-27 | 2020-06-16 | 长沙泽达医药科技有限公司 | 化合物、组合物及其在药物制备中的用途 |
| JP7542538B2 (ja) | 2018-09-18 | 2024-08-30 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体 |
| WO2020083187A1 (zh) * | 2018-10-22 | 2020-04-30 | 江苏恒瑞医药股份有限公司 | 一种ar拮抗剂联合parp抑制剂在制备治疗前列腺癌的药物中的用途 |
| US11325889B2 (en) * | 2018-12-19 | 2022-05-10 | Celgene Corporation | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
| PL3897636T3 (pl) | 2018-12-19 | 2025-04-28 | Celgene Corporation | Podstawione związki 3-((3-aminofenylo)amino)piperydyno-2,6-dionu, ich kompozycje i sposoby leczenia nimi |
| GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
| CN113929628A (zh) * | 2020-06-29 | 2022-01-14 | 江苏恒瑞医药股份有限公司 | 一种咪唑啉衍生物的制备方法 |
| CN113024513A (zh) * | 2021-03-22 | 2021-06-25 | 中国药科大学 | 新型雄激素受体降解剂、制备方法和医药用途 |
| CN117327019A (zh) * | 2022-06-23 | 2024-01-02 | 南京思聚生物医药有限公司 | 一种局部作用的雄激素受体拮抗剂的应用 |
| CN115850186B (zh) * | 2023-02-07 | 2024-04-09 | 长沙泽达医药科技有限公司 | 一种乙撑硫脲衍生物的晶型及用途 |
| CN118993935B (zh) * | 2024-10-23 | 2025-02-14 | 江苏恒瑞医药股份有限公司 | 咪唑啉衍生物或其盐的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| CN100562516C (zh) | 2001-12-27 | 2009-11-25 | 第一制药株式会社 | β-淀粉样蛋白产生和分泌的抑制剂 |
| US20060025589A1 (en) * | 2002-10-01 | 2006-02-02 | Jean Binet | 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
| TW200621723A (en) * | 2004-09-09 | 2006-07-01 | Chugai Pharmaceutical Co Ltd | Novel imidazolidine derivative and use thereof |
| US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US7709517B2 (en) * | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| JP4644737B2 (ja) * | 2005-05-13 | 2011-03-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ジアリールヒダントイン化合物 |
| BRPI0713378A8 (pt) | 2006-06-27 | 2018-01-02 | Takeda Pharmaceutical | composto, pró-droga, modulador da função do receptor gpr40, agente farmacêutico uso do composto, e, método de produção de uma forma opticamente ativa de um composto |
| ES2427917T3 (es) | 2009-02-10 | 2013-11-04 | Astrazeneca Ab | Derivados de triazolo [4,3-b] piridazina y sus usos para el cáncer de próstata |
| CN101817787B (zh) | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
| EP2416657A4 (en) * | 2009-04-09 | 2012-09-05 | Medivation Prostate Therapeutics Inc | COMPOUNDS COMPRISING SUBSTITUTED DI-ARYLHYDANTOIDS AND DI-ARYLTHIOHYDANTOINES AND METHODS OF USE THEREOF |
| US8450374B2 (en) | 2009-06-29 | 2013-05-28 | University Of Delaware | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal |
| JP2013505295A (ja) | 2009-09-22 | 2013-02-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節する化合物 |
| MX2012009561A (es) | 2010-02-17 | 2012-11-23 | Amgen Inc | Carboxamidas como inhibidores de canales de sodio dependientes del voltaje. |
| RU2434851C1 (ru) | 2010-07-22 | 2011-11-27 | Александр Васильевич Иващенко | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
| CN103209960A (zh) | 2010-07-26 | 2013-07-17 | 百时美施贵宝公司 | 用作cyp17抑制剂的磺酰胺化合物 |
| WO2012050868A1 (en) * | 2010-09-28 | 2012-04-19 | Georgia Tech Research Corporation | Histone deacetylase (hdac) inhibitors targeting prostate tumors and methods of making and using thereof |
| RU2576316C2 (ru) | 2010-11-03 | 2016-02-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидная композиция, способ контроля вредителей, способ контроля эндопаразитов, эктопаразитов или обоих и способ усиления жизнестойкости растений |
| DK2683694T3 (en) | 2011-03-10 | 2016-07-18 | Suzhou Kintor Pharmaceuticals Inc | ANDROGEN RECEPTOR ANTAGONISTS AND APPLICATIONS THEREOF |
| RS61242B1 (sr) * | 2012-09-04 | 2021-01-29 | Shanghai hengrui pharmaceutical co ltd | Derivati imidazolina, postupci njihove pripreme i njihove primene u medicini |
-
2013
- 2013-08-26 RS RS20201565A patent/RS61242B1/sr unknown
- 2013-08-26 HU HUE13835193A patent/HUE052904T2/hu unknown
- 2013-08-26 MX MX2015002602A patent/MX368844B/es active IP Right Grant
- 2013-08-26 HR HRP20202050TT patent/HRP20202050T1/hr unknown
- 2013-08-26 DK DK13835193.7T patent/DK2894151T3/da active
- 2013-08-26 SI SI201331826T patent/SI2894151T1/sl unknown
- 2013-08-26 LT LTEP13835193.7T patent/LT2894151T/lt unknown
- 2013-08-26 CA CA2883545A patent/CA2883545C/en active Active
- 2013-08-26 ES ES13835193T patent/ES2835248T3/es active Active
- 2013-08-26 SM SM20200672T patent/SMT202000672T1/it unknown
- 2013-08-26 RU RU2015110122A patent/RU2639145C2/ru active
- 2013-08-26 CN CN201380004069.5A patent/CN103958480B/zh active Active
- 2013-08-26 PT PT138351937T patent/PT2894151T/pt unknown
- 2013-08-26 JP JP2015528857A patent/JP6262733B2/ja active Active
- 2013-08-26 KR KR1020157007651A patent/KR102189940B1/ko active Active
- 2013-08-26 US US14/425,207 patent/US9586947B2/en active Active
- 2013-08-26 WO PCT/CN2013/082273 patent/WO2014036897A1/zh not_active Ceased
- 2013-08-26 EP EP13835193.7A patent/EP2894151B1/en active Active
- 2013-08-26 AU AU2013312587A patent/AU2013312587B2/en active Active
- 2013-08-26 BR BR112015004637-1A patent/BR112015004637B1/pt active IP Right Grant
- 2013-08-30 TW TW102131223A patent/TWI617546B/zh active
-
2017
- 2017-01-20 US US15/411,517 patent/US9895355B2/en active Active
-
2020
- 2020-12-18 CY CY20201101202T patent/CY1123649T1/el unknown
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