JP2015526472A5 - - Google Patents

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Publication number
JP2015526472A5
JP2015526472A5 JP2015528615A JP2015528615A JP2015526472A5 JP 2015526472 A5 JP2015526472 A5 JP 2015526472A5 JP 2015528615 A JP2015528615 A JP 2015528615A JP 2015528615 A JP2015528615 A JP 2015528615A JP 2015526472 A5 JP2015526472 A5 JP 2015526472A5
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JP
Japan
Prior art keywords
lower alkyl
cancer
formula
membered heteroaryl
group
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JP2015528615A
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English (en)
Japanese (ja)
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JP2015526472A (ja
JP6371284B2 (ja
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Priority claimed from PCT/US2013/055965 external-priority patent/WO2014031732A2/en
Publication of JP2015526472A publication Critical patent/JP2015526472A/ja
Publication of JP2015526472A5 publication Critical patent/JP2015526472A5/ja
Application granted granted Critical
Publication of JP6371284B2 publication Critical patent/JP6371284B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015528615A 2012-08-22 2013-08-21 ファスシンを阻害する方法 Active JP6371284B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261692177P 2012-08-22 2012-08-22
US61/692,177 2012-08-22
US201361778015P 2013-03-12 2013-03-12
US61/778,015 2013-03-12
PCT/US2013/055965 WO2014031732A2 (en) 2012-08-22 2013-08-21 Methods for inhibiting fascin

Publications (3)

Publication Number Publication Date
JP2015526472A JP2015526472A (ja) 2015-09-10
JP2015526472A5 true JP2015526472A5 (OSRAM) 2016-10-13
JP6371284B2 JP6371284B2 (ja) 2018-08-08

Family

ID=50150480

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015528615A Active JP6371284B2 (ja) 2012-08-22 2013-08-21 ファスシンを阻害する方法

Country Status (8)

Country Link
US (5) US10208043B2 (OSRAM)
EP (1) EP2888010B1 (OSRAM)
JP (1) JP6371284B2 (OSRAM)
CN (2) CN113679717A (OSRAM)
CA (2) CA2881554C (OSRAM)
DK (1) DK2888010T3 (OSRAM)
ES (1) ES2877570T3 (OSRAM)
WO (1) WO2014031732A2 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3107902T3 (da) * 2014-02-20 2021-05-03 Cornell Univ Cornell Center For Technology Enterprise & Commercialization Cctec Forbindelser og fremgangsmåder til at hæmme fascin
CN106668008A (zh) * 2015-11-10 2017-05-17 河南省锐达医药科技有限公司 基于stat3蛋白靶点的靶向抗癌药物的发明
CA3010445A1 (en) 2016-01-05 2017-07-13 The Regents Of The University Of California Benzothiazole amphiphiles
US20190016680A1 (en) 2016-01-14 2019-01-17 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
CN108498503A (zh) * 2017-02-24 2018-09-07 河南省锐达医药科技有限公司 一类新型细胞信号传导和基因转录激活因子3型(stat3)抑制剂的制备和用途
JP7168650B2 (ja) 2017-08-02 2022-11-09 スピノジェニックス, インコーポレイテッド ベンゾチアゾールおよび関連化合物
AU2019329835B2 (en) * 2018-08-27 2025-05-29 Spinogenix, Inc. Fascin binding compounds for spinogenesis
RS67123B1 (sr) 2019-01-31 2025-09-30 Spinogenix Inc Čvrsti oblici promotera spinogeneze
CN114014824B (zh) * 2020-12-09 2023-06-13 上海科技大学 一种杂环化合物的应用
CN115894317B (zh) * 2021-09-22 2024-09-03 杭州天玑济世生物科技有限公司 一类具有萘硫酚醚结构的小分子化合物及其应用
WO2025001864A1 (en) * 2023-06-30 2025-01-02 Beijing Double-Crane Runchuang Technology Co., Ltd. Fascin inhibitors

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244696A (en) 1968-06-20 1971-09-02 Fuji Photo Film Co Ltd Improvements in colour developer compositions
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
KR20040068613A (ko) 1994-03-25 2004-07-31 이소테크니카 인코포레이티드 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
WO2000024725A1 (en) 1998-10-26 2000-05-04 Vertex Pharmaceuticals Incorporated Pentacyclic compounds useful as inhibitors of hepatitis c virus ns3 helicase
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
US20040009613A1 (en) 2001-02-16 2004-01-15 Ming-Ming Zhou Methods of identifying modulators of bromodomains
TWI262920B (en) 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
WO2003035005A2 (en) 2001-10-26 2003-05-01 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
EP1446394B1 (en) 2001-11-08 2006-11-02 Ortho-McNeil Pharmaceutical, Inc. Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators
US20050209252A1 (en) 2002-03-29 2005-09-22 Che-Ming Teng Cancer treatment
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
BRPI0415437A (pt) 2003-10-14 2006-12-05 Oxagen Ltd composto, processo para a preparação e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, produto
EP1680431A1 (en) * 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
CA2557144A1 (en) * 2004-02-23 2005-09-09 Prolexys Pharmaceuticals Inc. Non-peptidyl agents with phsp20-like activity, and uses thereof
US20070043057A1 (en) * 2005-02-09 2007-02-22 Threshold Pharmaceuticals, Inc. Lonidamine analogs
TW200612918A (en) 2004-07-29 2006-05-01 Threshold Pharmaceuticals Inc Lonidamine analogs
EP1802297B1 (en) * 2004-10-21 2011-03-30 The Burnham Institute Compositions and methods for treatment of disease caused by yersinia spp infection
EP2079466B1 (en) 2006-09-29 2014-01-15 GlaxoSmithKline LLC Substituted indole compounds
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
US7858645B2 (en) 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
EA017852B1 (ru) 2006-12-20 2013-03-29 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Производные замещенных индазолов, активные в качестве ингибиторов киназ
WO2008089310A2 (en) 2007-01-18 2008-07-24 Lexicon Pharmaceuticals, Inc. Delta 5 desaturase inhibitors for the treatment of obesity
WO2008129276A1 (en) * 2007-04-19 2008-10-30 Boehringer Ingelheim International Gmbh Disulfonamides useful in the treatment of inflammation
WO2009070244A2 (en) 2007-11-21 2009-06-04 Cornell University Methods for inhibiting fascin
CN101919145B (zh) 2007-12-21 2013-07-17 桑迪士克科技股份有限公司 可自配置的多调压器专用集成电路核电力输送
JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
CU20080028A6 (es) 2008-02-29 2011-02-24 Ct Ingenieria Genetica Biotech Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus
US20100305120A1 (en) 2008-04-04 2010-12-02 Biomarin Iga Limited Compounds for treating muscular dystrophy
SI2299999T1 (sl) * 2008-06-04 2017-12-29 Baylor Collega Of Medicine Stat3 inhibitorji
US8673910B2 (en) 2008-06-30 2014-03-18 H. Lee Moffitt Cancer Center And Research Institute Proteasome inhibitors for selectively inducing apoptosis in cancer cells
WO2010033986A2 (en) * 2008-09-22 2010-03-25 Regents Of The University Of Minnesota Dna cytosine deaminase inhibitors
JO3101B1 (ar) 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
WO2010102286A2 (en) * 2009-03-06 2010-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome inhibitors having chymotrypsin-like activity
US8785499B2 (en) 2009-07-10 2014-07-22 University Of Maryland, Baltimore Targeting NAD biosynthesis in bacterial pathogens
ES2360783B1 (es) * 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
KR101632318B1 (ko) 2009-11-05 2016-06-27 재단법인 의약바이오컨버젼스연구단 벤조헤테로사이클 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 암 예방 및 치료용 조성물
EP2528893B1 (en) * 2010-01-29 2018-10-10 Dana-Farber Cancer Institute, Inc. Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders
WO2011133862A1 (en) * 2010-04-23 2011-10-27 Oregon Health And Science University Methods and compositions for promoting myelination
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
ES2650744T3 (es) * 2010-12-14 2018-01-22 Electrophoretics Limited Inhibidores de la caseína quinasa 1 delta (CK1delta)
CA2824344A1 (en) 2011-01-20 2012-07-26 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
US9617242B2 (en) 2012-12-19 2017-04-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors

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