JP2015524836A - 化粧品又は医薬品の保湿成分 - Google Patents
化粧品又は医薬品の保湿成分 Download PDFInfo
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- JP2015524836A JP2015524836A JP2015527017A JP2015527017A JP2015524836A JP 2015524836 A JP2015524836 A JP 2015524836A JP 2015527017 A JP2015527017 A JP 2015527017A JP 2015527017 A JP2015527017 A JP 2015527017A JP 2015524836 A JP2015524836 A JP 2015524836A
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- skin
- cosmetic
- pullulan
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Abstract
Description
- 成分の混合物の総重量に対して乾燥物質で0.0001重量%〜10重量%、より有利には0.001重量%〜5重量%、さらにより有利には0.01重量%〜3重量%、特に0.1重量%〜1重量%、さらにより具体的には0.25重量%〜0.5重量%、非常に具体的には0.25重量%の含量の、本発明による組合せに由来するプルラン、化粧品若しくは医薬品として許容されるその誘導体、及び
- 成分の混合物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.001重量%〜5重量%、より有利には0.01重量%〜3重量%、特に0.1重量%〜1重量%、より具体的には0.1重量%〜1重量%、さらにより具体的には0.25重量%〜0.5重量%、非常に具体的には0.25重量%の含量の、本発明による組合せに由来するヒアルロン酸、化粧品若しくは医薬品として許容されるその塩若しくは誘導体、及び/又は
- 成分の混合物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.001重量%〜5重量%、より有利には0.01重量%〜3重量%、さらにより有利には0.1重量%〜2重量%、さらにより具体的には0.5重量%の含量の、本発明による組合せに由来するアルギン酸、化粧品若しくは医薬品として許容されるその塩若しくは誘導体
を含有する。
- 組成物の総重量に対して乾燥物質で0.0001重量%〜10重量%の量、有利には0.001重量%〜5重量%、より有利には0.001重量%〜3重量%、特に0.005重量%〜0.1重量%、より好ましくは0.007重量%〜0.02重量%の量のプルラン、化粧品又は医薬品として許容されるその誘導体、及び
- 組成物の乾燥物質の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.001重量%〜5重量%、より有利には0.001重量%〜3重量%、特に0.005重量%〜0.1重量%、より好ましくは0.007重量%〜0.02重量%の含量のヒアルロン酸、化粧品又は医薬品として許容されるその塩又は誘導体、及び
- 組成物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.001重量%〜5重量%、より有利には0.001重量%〜1重量%、特に0.007重量%〜0.2重量%、さらにより具体的には0.01重量%〜0.1重量%の含量のアルギン酸、化粧品又は医薬品として許容されるその塩又は誘導体
を含有する。
- メラニン生合成基質、特にL-チロシン及びその誘導体、又はL-ジヒドロフェニルアラニン、
- メラニン合成を刺激することができる薬剤、特に米国特許第5,698,184号に記載されている、銅などの金属イオンとダイズ、コラーゲン又はカゼインに由来するタンパク質加水分解物などのペプトンの複合体、
- チロシナーゼの活性又は発現を、場合により細胞内cAMPのレベルを増大することによって刺激することができる薬剤、例えば特にプロオピオメラノコルチンペプチド、α-MSHs若しくはα-MSH類似体、又はMC1R受容体作動薬(米国特許第5,683,981号又は国際公開第98/25584号)、cAMP類似体、フォルスコリン及びキサンチン塩基(例えばカフェイン又はテオフィリン)、又はタンパク質キナーゼCを活性化することによって刺激することができる薬剤、例えばジアシルグリセロール若しくはソラレン、
- メラノサイトからケラチノサイトへのメラノソームの移動を、例えばPAR-2受容体を刺激することによって刺激することができる薬剤、例えばモノマー又はオリゴマー形態の、カテキンポリフェノール、特にカテキン、エピカテキン、ガロカテキン及びエピガロカテキン、その塩及びエステル、並びにそれらを含有する植物エキス、特に緑茶のエキス。
- セルフタンニング剤、例えばイサチン、アロキサン、ニンヒドリン、グリセルアルデヒド、メソ酒石酸アルデヒド、グルタルアルデヒド、エリトルロース、ジヒドロキシアセトン(DHA)、
- 追加の着色剤、例えばソルガムエキス、及び特にBASF Beauty Care Solutions France SASによって名称QUICKSUNで販売されている、ギムネマ(Gymnema sylvestre)又はムイラプアマ(Muira Puama)のエキスと組み合わせたチコリー(Cichorium intybus)のエキス。
- フィブロネクチンの合成を刺激する薬剤、特に出願人によって名称Deliner(商標)で販売されている、特にトウモロコシエキス、及びSEDERMA社によって商標Matrixil(登録商標)で販売されているパルミトイルペンタペプチド、
- 細胞外マトリックスの線維芽細胞増殖因子(FGF2)が分解及び/若しくは変性しないように保護する薬剤、特にフランス特許出願第0654316号で出願人氏名による特許出願文書に記載されているハイビスカス(Hibiscus abelmoschus)のエキス、並びに/又は線維芽細胞の増殖を刺激する薬剤、例えば欧州特許出願第1 119 344B1号(Laboratoires Expanscience)にも記載されている、出願人によって販売されている名称Phytokine(商標)で公知のペプチドを含有する発酵ダイズエキス、好ましくはこれらうちの2種のエキスの組合せ、
- ラミニンの合成を刺激する薬剤、特に出願人によって名称Basaline(商標)で販売されている、特にバイオテクノロジーによって加工された麦芽エキス、
-ヒアルロナン合成酵素-2(HAS2)の発現及び/又は活性を刺激する薬剤、例えばフランス特許出願第2 893 252A1号に記載の植物エキス、特にガランガル(ナンキョウ(Alpinia galangal))の水性エキス、
- リシルオキシダーゼ様(LOXL)の合成を刺激する薬剤、例えばゲオフィラ・コルディフォリア(Geophila cordifolia)のエキス及びフランス特許出願第2855968号に記載のもの、特にディルのエキス、
-細胞内ATPの合成を刺激する薬剤、特に藻類ラミナリア・ディギタータ(Laminaria digitata)のエキス、
- グリコサミノグリカンの合成を刺激する活性剤、例えば乳の発酵製品、
- コラーゲンを刺激する活性剤、例えばレチノール及び/又はビタミンC、
- メタロプロテイナーゼ(MMP)、例えばより具体的にはMMP1、2、3又は9を抑制する活性剤、例えばレチノイド及び誘導体、オリゴペプチド及びリポペプチド、リポアミノ酸、BASF Beauty Care Solutions Franceによって商標Collalift(登録商標)で販売されている麦芽エキス、BASF Beauty Care solutions France SASによって名称Extracellium(商標)で販売されている加水分解バレイショエキス、リコペン、イソフラボン、ケルセチン、ケンフェロール、アピゲニン。
- 剥脱を促進することによって落屑に直接的に作用することができる任意の化合物、例えばβ-ヒドロキシ酸、特にサリチル酸及びその誘導体、特にエステル誘導体(5-n-オクタノイルサリチル酸を含む)、フルーツ酸、α-ヒドロキシ酸、例えばサリチル酸、グリコール酸、クエン酸、乳酸、酒石酸、リンゴ酸若しくはマンデル酸、ゲンチシン酸若しくはそのエステル、特にゲンチジン酸トコフェリル、オリゴフコース、ケイ皮酸、レスベラトロール及び特定のジャスモン酸誘導体、並びに/又はそれらの誘導体及び/若しくはそれらの混合物、
- 或いはコルネオデスモソーム(corneodesmosome)の落屑又は分解に関与する酵素、グリコシダーゼに作用することができる任意の化合物、無機塩をキレートする薬剤EDTA、アミノスルホン酸化合物、BASFによって商標TRILON(商標)で販売されているメチルグリシン二酢酸ナトリウム、蜂蜜、糖誘導体、例えばO-オクタノイル-6-D-マルトース及びN-アセチルグルコサミン
を意味すると理解される。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- 0.25重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA0.25%)、及び
- 1重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA1%)
によって得られた時間関数としての不感喪失の測定を、対照(活性剤を含まない同量の水で処理した合成皮膚:乾燥皮膚)との比較において比較するグラフである。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- アルギン酸ナトリウムの形態の0.5重量%のアルギン酸を含有する組成物(アルギネート0.5%)、及び
- 1重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート1%)
によって得られた時間関数としての不感喪失の測定を、対照(活性剤を含まない同量の水で処理した合成皮膚:乾燥皮膚)との比較において比較するグラフである。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- 0.25重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA0.25%)、
- 1重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA1%)、
- 0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート0.5%)、
- 1重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート1%)、及び
- 0.5重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸、及び0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(HA0.5%/Algin.0.5%)
によって得られた時間関数としての不感喪失の測定を、対照(活性剤を含まない同量の水で処理した合成皮膚:乾燥皮膚)との比較において比較するグラフである。
A.プルラン、ヒアルロン酸ナトリウム及びアルギン酸ナトリウムの3種類の化合物の組合せによって形成された網状構造のマクロ蛍光による観測:
B.大尺度におけるAによる観測:
C.光学顕微鏡(×10)による網状構造の観測:
D.透過型電子顕微鏡(×60)による網状構造の観測。
プルラン及びヒアルロン酸を含有する本発明による組合せの水分喪失の低減に対する相乗効果の実証(図1)
原則
使用した試験は、蒸発した水の量を時間関数として測定するインビトロ試験である。この試験は、開口シリンダーによる通常の試験から発想を得ているが、オーブン内で乾燥させた後、湿気雰囲気を用いずに実施した。それによって、不感水分喪失を増大し、通常の試験よりもはるかに厳しい条件下での不感水分喪失を模倣する。
プロトコルは以下の通りであった。
- 以下の様々な濃度の構成成分を遊星式撹拌機により脱イオン水中で混合することによって、様々な試験組成物を調製した。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- 0.25重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA0.25%)、
- 1重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA1%)、及び
- 本発明による組合せを含有する組成物(0.5重量%のプルラン、及び0.5重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸:HA0.5%/Pull.0.5%)。
- 各組成物を、合成皮膚(Vitroskin(登録商標))上に200μmの薄層として適用した。負の対照として、合成皮膚(Vitroskin(登録商標))を、この量の水だけを含有する組成物で同様に処理した。
- 処理した合成皮膚を、換気オーブン内で45℃において1時間乾燥させた。
- 半径1cm及び高さ2cmを有する円筒形セルを脱イオン水(およそ6cm3)で満たした。
- 測定される蒸発表面積がおよそ3.14cm2になるように、処理した皮膚をセル上に置いた。
- セルを45℃の換気オーブンに入れた。
- t=0、2時間、4時間、18時間及び24時間においてセルを秤量し、水分喪失を測定した。
図1から明らかに分かる通り、不感水分喪失は、本発明による組合せを1重量%(0.5%のヒアルロン酸ナトリウム及び0.5%のプルラン)の含量で含有する組成物の方が、1重量%のヒアルロン酸ナトリウム又は1重量%のプルランを含有する組成物よりも低い。したがって、構成成分の間には明らかに相乗作用がある。この相乗作用は、特に適用の5時間後に際立っており、組成物の適用の10時間後に非常に著しく、組成物の適用の18時間後にはよりいっそう強力であり、少なくとも24時間継続する。
プルラン及びアルギン酸を含有する本発明による組合せの水分喪失の低減に対する相乗効果の実証(図2)
原則及びプロトコル
実施例1に示したプロトコルを、以下の試験水性組成物を用いて同様に使用する。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- 0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート0.5%)、
- 1重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート1%)、
- 0.5重量%のプルラン、及び0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する本発明による組合せを含有する組成物:Pull.0.5%/Algin.0.5%、並びに
- 活性剤を含まない水から構成された組成物。
図2から明らかに分かる通り、不感水分喪失は、本発明による組合せを1重量%(0.5%のアルギン酸ナトリウム及び0.5%のプルラン)の含量で含有する組成物の方が、1重量%のアルギン酸ナトリウム又は1重量%のプルランを含有する組成物よりも低い。したがって、構成成分の間には明らかに相乗作用がある。この相乗作用は、特に適用の12時間後に際立っており、組成物の適用の15時間後に非常に著しく、さらに組成物の適用の18時間後も強力であり、少なくとも24時間継続する。
プルラン、ヒアルロン酸及びアルギン酸を含有する本発明による組合せの水分喪失の低減に対する相乗効果の実証(図3)
原則及びプロトコル
実施例1に示したプロトコルを、以下の試験水性組成物を用いて同様に使用する。
- 0.25重量%のプルランを含有する組成物(プルラン0.25%)、
- 1重量%のプルランを含有する組成物(プルラン1%)、
- 0.25重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA0.25%)、
- 1重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸を含有する組成物(HA1%)、
- 0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート0.5%)、
- 1重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(アルギネート1%)、
- 0.5重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸、及び0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物(HA0.5%/Algin.0.5%)、
- 0.25重量%のプルラン、0.25重量%のヒアルロン酸ナトリウムの形態のヒアルロン酸、及び0.5重量%のアルギン酸ナトリウムの形態のアルギン酸を含有する組成物:Pull.0.25%/HA0.25%/Algin.0.5%、並びに
- 活性剤を含まない水から構成された組成物。
図3から明らかに分かる通り、不感水分喪失は、本発明による組合せを1重量%(0.5%のアルギン酸、0.25%のヒアルロン酸及び0.5%のプルラン)の含量で含有する組成物の方が、1重量%のアルギン酸又は1重量%のプルラン又は1重量%のヒアルロン酸又はさらには0.5重量%のヒアルロン酸及び0.5重量%のアルギン酸を含有する組成物よりも低い。したがって、3種類の構成成分の間には明らかに相乗作用がある。この相乗作用は、特に組成物の適用の4時間後に際立っており、少なくとも24時間継続する。この相乗作用は、実施例1で示したヒアルロン酸及びプルランの単純な組合せ、又は実施例2で示したアルギン酸及びプルランの単純な組合せを上回っている。
アルギン酸ナトリウム、ヒアルロン酸ナトリウム及びプルランの組合せを含有する本発明による組成物の含水量に関する特性の評価
原則
この研究は、誘電伝導率を測定することによって、本発明による組合せの角層の保湿特性を、この組合せを含まない組成物と比較してエクスビボで評価することからなる。この技術は、水分子の二極性及び角層において誘発される電場に起因して、角層が乾燥するほど角層の電気伝導が低くなることに基づく。この技術は、局所活性剤の保湿力を測定するために従来使用されており、以下の刊行物:OBATA M、TAGAMI H: A rapid in vitro test to assess skin moisturizers、J. Soc. Cosmet. Chem.、vol. 41、235-242、1990、OBATA M、TAGAMI H: Electrical determination of water content and concentration profile in simulation model of in vivo stratum corneum、J. Invest. Dermatol.、vol. 92、854-859、1989に記載されている。
外科廃棄物から生じた正常なのヒト腹部の皮膚の生検材料を取り出し、60℃で2分間加熱した後、上皮層を真皮から分離する。角層、すなわち「角質層」を、刊行物ROCHEFORT A、DROUOT P、LEDUC M、VASSALET R、AGACHE P: A new technique for evaluation of cosmetics effect on mechanical properties of stratum corneum and epidermis in vitro. Int. J. Cosm. Sci.、vol. 8、27-36, 1986に記載のプロトコルに従って酵素的消化によって単離し、それらの適応を以下に言及する。
- 処理なしの角質層(TN1)
- 組成物Aが以下の通りであるプラセボヒドロゲル(TN2)で処理した角質層
組成物B
結果を表4.1に示す。表4.2に示した結果は、いわゆるプラセボ組成物(負の対照2:TN2)で処理した角質により得られた誘電伝導率の測定と比較した、試験生成物を含有する前述の組成物で処理した後の誘電伝導率のパーセント増大率として表されている。
含水量を、角層の水和状態に比例する誘電伝導率を測定することによって評価した。
本発明による組合せを含有する組成物による活性成分の含量の評価
原則
このエクスビボ研究は、Franzセルで実施され、皮膚の生検材料を介して、試験組成物の拡散を時間関数として研究することを可能にする。
外科廃棄物から、正常なヒト腹部の皮膚の完全な生検材料を得、Franzセルのドナー及びレセプター区画の界面に挿入した。試験組成物を、セルのいわゆるドナー/上面に適用した。レセプター流体としてPBS緩衝液を使用した。
- 正の対照:組成物B(それぞれ3%及び10%のセリン及び尿素を含有する)(対照組成物)
- 以下の実施例7による化粧品成分の混合物(本発明による組成物)
この結果によって、本発明による組成物に含有されているセリンが、ポリマーを含有していない対照組成物に含有されている場合よりも、角層において6時間後だけでなく、10、24及び48時間後もはるかに良好に保持されていることが実証される。
本発明による組合せによって形成されたポリマーの網状構造の顕微鏡による可視化
プロトコル
1/1/2の比の0.25重量%プルラン、0.25重量%ヒアルロン酸ナトリウム及び0.5重量%アルギン酸ナトリウムを含有する水溶液を、ホモジナイズし、次に凍結乾燥させる。次に、こうして得られた、脱水された網状構造形態の組合せを、マクロ蛍光又は透過型電子顕微鏡によって観測するために細かく切る(5×10cm)。
結果を図4に示す。
1/1/2の比のプルラン、ヒアルロン酸及びアルギン酸の本発明による組合せは、顕微鏡によって既に観測された通り、多層分子網状構造を形成する。特に、透過型電子顕微鏡による観測(D)では、形成された網状構造のシート構造が明らかに示されている。この分子網状構造が形成されると、本発明による組成物に含有されている活性成分の経皮的拡散に対する遅延効果が誘発され、したがって先の実施例5で実証された通り、活性成分の含量が増大され、それらの含量が留まる時間が延長される。
アルギン酸ナトリウム、ヒアルロン酸ナトリウム及びプルランの組合せを含有する本発明による化粧品又は医薬品成分の混合物
以下の配合(重量パーセント)を有する化粧品又は医薬品成分の混合物を調製する。
化粧品又は医薬品の形態の本発明による組成物の保湿効果のインビボ評価
原則
この研究では、単回適用した後に本発明による組合せによって提供される即時性の水和を、Corneometerを使用してインビボで決定することが可能である。
研究を、年齢18〜65歳の22人の女性で実施した。
本発明による組成物は、プラセボ組成物と比較して、皮膚の含水量を著しく改善した。この改善は、即効性であり、30分後から長時間持続する。
Claims (29)
- プルラン又はその誘導体と、ヒアルロン酸又はその塩若しくは誘導体及びアルギン酸又はその塩若しくは誘導体からなる多糖の混合物との組合せであって、プルラン又は誘導体/ヒアルロン酸、塩又は誘導体/アルギン酸、塩又は誘導体の重量比が、1/0.001/0.001〜1/100/100の範囲である、組合せ。
- プルランが、500kDa未満の分子量を有することを特徴とする、請求項1に記載の組合せ。
- ヒアルロン酸、その塩又はエステル化誘導体が、20kDa超、有利には50〜800kDaの分子量を有することを特徴とする、請求項1又は2に記載の組合せ。
- ヒアルロン酸の誘導体が、エステル化誘導体若しくは有機無機ケイ素系誘導体、又はそれらの混合物であることを特徴とする、請求項1〜3のいずれか一項に記載の組合せ。
- ヒアルロン酸の塩、有利にはヒアルロン酸ナトリウムを含むことを特徴とする、請求項1〜3のいずれか一項に記載の組合せ。
- アルギン酸の塩、有利にはアルギン酸ナトリウムを含むことを特徴とする、請求項1〜5のいずれか一項に記載の組合せ。
- アルギン酸の誘導体が、エステル化誘導体若しくは有機無機ケイ素系誘導体、又はそれらの混合物であることを特徴とする、請求項1〜5のいずれか一項に記載の組合せ。
- プルラン又は誘導体と多糖の混合物との重量比が、1/0.002〜1/200の範囲であることを特徴とする、請求項1〜7のいずれか一項に記載の組合せ。
- プルラン又は誘導体/ヒアルロン酸、塩又は誘導体/アルギン酸、塩又は誘導体の重量比が、1/1/1〜1/10/10、好ましくは1/1/1〜1/2/5の範囲であることを特徴とする、請求項1〜8のいずれか一項に記載の組合せ。
- プルラン又は誘導体/アルギン酸、塩又は誘導体の重量比が、1/1〜1/2の範囲であることを特徴とする、請求項1〜9のいずれか一項に記載の組合せ。
- プルラン又は誘導体/ヒアルロン酸、塩又は誘導体/アルギン酸、塩又は誘導体の重量比が、1/1/2であることを特徴とする、請求項1〜10のいずれか一項に記載の組合せ。
- 不感水分喪失を低減するため、並びに/又は皮膚及び/若しくは粘膜の含水量を増大するため、並びに/又は皮膚及び/若しくは粘膜における化粧品及び/若しくは医薬品活性成分の含量を増大し、及び/若しくはそれらの含量が留まる時間を延長するため、及び/若しくはその状態を長時間維持するための、プルラン又はその誘導体と、ヒアルロン酸、その塩又は誘導体、アルギン酸、その塩又は誘導体、及びこれらの多糖の混合物から選択される多糖との組合せの使用。
- 皮膚及び/又は粘膜の保湿剤としての、プルラン又はその誘導体と、ヒアルロン酸、その塩又は誘導体、アルギン酸、その塩又は誘導体、及びこれらの多糖の混合物から選択される多糖との組合せの使用。
- 組合せが、請求項1〜11のいずれか一項に記載の組合せである、請求項12又は13に記載の使用。
- 化粧品又は医薬組成物に組み込むための化粧品又は医薬品成分の混合物であって、請求項1〜11のいずれか一項に記載の組合せ、及び化粧品又は医薬品用の適切な担体を含む、混合物。
- 成分の混合物の総重量に対して乾燥物質で0.001重量%〜20重量%、有利には0.1重量%〜5重量%の含量の組合せを含むことを特徴とする、請求項15に記載の化粧品又は医薬品成分の混合物。
- 化粧品又は医薬品成分の混合物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.1重量%〜1重量%の含量のプルラン又は化粧品若しくは医薬品として許容されるその誘導体、及び
化粧品又は医薬品成分の混合物の乾燥物質の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.1重量%〜1重量%の含量のヒアルロン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体、及び/又は
化粧品又は医薬品成分の混合物の総重量に対して乾燥物質で0.0001重量%〜10重量%の含量のアルギン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体
を含むことを特徴とする、請求項15又は16に記載の化粧品又は医薬品成分の混合物。 - 特にトレハロース、セリン、尿素及びそれらの混合物から選択される別の保湿剤をさらに含むことを特徴とする、請求項15〜17のいずれか一項に記載の化粧品又は医薬品成分の混合物。
- 化粧品又は医薬品成分の混合物の総重量に対して乾燥物質で0.1重量%〜2重量%の含量のアルギン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体を含有することを特徴とする、請求項15〜18のいずれか一項に記載の化粧品又は医薬品成分の混合物。
- 請求項1〜11のいずれか一項に記載の組合せ、又は請求項15〜19のいずれか一項に記載の化粧品若しくは医薬品成分の混合物、及び化粧品又は医薬品用の適切な担体を含む、局所投与のための化粧品又は医薬組成物。
- 組成物の総重量に対して乾燥物質で0.0001重量%〜20重量%、有利には0.01重量%〜5重量%の含量の組合せを含むことを特徴とする、請求項20に記載の組成物。
- 組成物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.005重量%〜0.1重量%の含量のプルラン又は化粧品若しくは医薬品として許容されるその誘導体、及び
組成物の乾燥物質の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.005重量%〜0.1重量%の含量のヒアルロン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体、及び/又は
組成物の総重量に対して乾燥物質で0.0001重量%〜10重量%、有利には0.007重量%〜0.2重量%の含量のアルギン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体
を含むことを特徴とする、請求項20又は21に記載の組成物。 - 組成物の総重量に対して乾燥物質で0.001重量%〜1重量%の含量のアルギン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体を含有することを特徴とする、請求項20〜22のいずれか一項に記載の組成物。
- 組成物の総重量に対して乾燥物質で0.007重量%〜0.2重量%の含量のアルギン酸又は化粧品若しくは医薬品として許容されるその塩若しくは誘導体を含有することを特徴とする、請求項23に記載の組成物。
- 美容液、ローション、クリーム、ミルク、軟膏、ペースト、フォーム、エマルション、ヒドロゲル、シャワー用ゲル、マスク、スティック、パッチ、又はメーキャップパウダー、有利にはクリーム又はローションの形態であることを特徴とする、請求項20〜24のいずれか一項に記載の組成物。
- 1/1/1〜1/10/10、好ましくは1/1/1〜1/2/5の範囲の比の、プルラン又は誘導体/ヒアルロン酸、塩又は誘導体/アルギン酸、塩又は誘導体の組合せを含有することを特徴とする、請求項20〜25のいずれか一項に記載の組成物。
- 皮膚及び/若しくは粘膜、特に侵襲を受けた、感受性の、感作された、障害性の、不耐性の、老人性の、脆弱性の若しくは反応性の皮膚及び/若しくは粘膜の水和状態を維持若しくは改善するため、並びに/又は皮膚及び/若しくは粘膜の乾燥の徴候の出現を、特に少なくとも10時間にわたって防止する若しくは遅らせるため、並びに/又は乾燥皮膚及び/若しくは粘膜に関連する鱗片状態及び/若しくはそう痒及び/若しくはこわばりなどの皮膚及び/若しくは粘膜の乾燥状態を治療するため、並びに/又は皮膚乾燥に関連する皺の出現を防止若しくは低減するため、並びに/又は乾燥皮膚及び/若しくは粘膜の快適性を改善するため、並びに/又は見た目及び/若しくは感触のざらつきの出現を有する皮膚及び/若しくは粘膜を治療するため、並びに/又は亀裂を治療及び/若しくは防止するための、請求項20〜26のいずれか一項に記載の化粧品組成物の使用。
- ふけ若しくは白色粃糠疹及び/若しくはひび割れ及び/若しくはアトピー性皮膚炎及び/若しくは魚鱗癬並びに/又は皮膚及び/若しくは粘膜の病変、例えば湿疹を伴う皮膚若しくは粘膜の乾燥状態の治療及び/又は防止に使用するための、請求項20〜26のいずれか一項に記載の医薬組成物。
- 請求項1〜11のいずれか一項に記載の組合せを含む、クレンジング組成物、特に洗浄剤組成物。
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CN114767550B (zh) * | 2022-03-30 | 2023-06-23 | 仁和全域(上海)大健康研究院有限公司 | 一种复合补水保湿面膜及其制备方法 |
WO2023203468A1 (en) | 2022-04-22 | 2023-10-26 | Galderma Holding SA | Topical hydration compositions |
IT202200013855A1 (it) * | 2022-06-30 | 2023-12-30 | Eufoton S R L | Procedimento per il trattamento della cute e relative formulazioni cosmetiche in siero |
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- 2013-08-13 JP JP2015527017A patent/JP6679308B2/ja active Active
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- 2013-08-13 CN CN201380052956.XA patent/CN104736136B/zh active Active
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- 2013-08-13 EP EP13773275.6A patent/EP2882415B1/fr active Active
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Also Published As
Publication number | Publication date |
---|---|
BR112015003125A2 (pt) | 2017-07-04 |
WO2014027163A3 (fr) | 2014-04-24 |
EP2882415B1 (fr) | 2020-03-18 |
KR20150070100A (ko) | 2015-06-24 |
BR112015003125B8 (pt) | 2020-02-11 |
FR2994387A1 (fr) | 2014-02-14 |
BR112015003125B1 (pt) | 2020-01-21 |
US20150209264A1 (en) | 2015-07-30 |
JP6679308B2 (ja) | 2020-04-15 |
WO2014027163A2 (fr) | 2014-02-20 |
KR102156007B1 (ko) | 2020-09-15 |
JP2019023191A (ja) | 2019-02-14 |
ES2794005T3 (es) | 2020-11-17 |
EP2882415A2 (fr) | 2015-06-17 |
FR2994387B1 (fr) | 2016-07-29 |
CN104736136B (zh) | 2019-02-15 |
CN104736136A (zh) | 2015-06-24 |
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