JP2015524835A - トリ(ヘテロ)アリールピラゾール及びその使用 - Google Patents

トリ(ヘテロ)アリールピラゾール及びその使用 Download PDF

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JP2015524835A
JP2015524835A JP2015527004A JP2015527004A JP2015524835A JP 2015524835 A JP2015524835 A JP 2015524835A JP 2015527004 A JP2015527004 A JP 2015527004A JP 2015527004 A JP2015527004 A JP 2015527004A JP 2015524835 A JP2015524835 A JP 2015524835A
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alkyl
alkoxy
substituted
halogen
substituents
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Japanese (ja)
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JP2015524835A5 (https=
Inventor
ビルドゥム シュテファン
ビルドゥム シュテファン
クレンケ ブルクハルト
クレンケ ブルクハルト
ベント アストリット
ベント アストリット
Original Assignee
アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48986151&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2015524835(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト, アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト filed Critical アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Publication of JP2015524835A publication Critical patent/JP2015524835A/ja
Publication of JP2015524835A5 publication Critical patent/JP2015524835A5/ja
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015527004A 2012-08-17 2013-08-16 トリ(ヘテロ)アリールピラゾール及びその使用 Ceased JP2015524835A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012016908.6A DE102012016908A1 (de) 2012-08-17 2012-08-17 Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
DE102012016908.6 2012-08-17
PCT/EP2013/067201 WO2014027112A1 (de) 2012-08-17 2013-08-16 Tris-(hetero)aryl-pyrazole und ihre verwendung

Publications (2)

Publication Number Publication Date
JP2015524835A true JP2015524835A (ja) 2015-08-27
JP2015524835A5 JP2015524835A5 (https=) 2016-08-12

Family

ID=48986151

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015527004A Ceased JP2015524835A (ja) 2012-08-17 2013-08-16 トリ(ヘテロ)アリールピラゾール及びその使用

Country Status (27)

Country Link
US (1) US9249148B2 (https=)
EP (1) EP2885300A1 (https=)
JP (1) JP2015524835A (https=)
KR (1) KR20150042841A (https=)
CN (1) CN104684913B (https=)
AP (1) AP2015008325A0 (https=)
AR (1) AR092145A1 (https=)
AU (1) AU2013303993A1 (https=)
BR (1) BR112015003115A2 (https=)
CA (1) CA2881997A1 (https=)
CL (1) CL2015000362A1 (https=)
CU (1) CU20150015A7 (https=)
DE (1) DE102012016908A1 (https=)
EA (1) EA201500232A1 (https=)
HK (1) HK1212327A1 (https=)
IL (1) IL237298A0 (https=)
MA (1) MA37928A1 (https=)
MX (1) MX2015002046A (https=)
NZ (1) NZ704727A (https=)
PE (1) PE20150869A1 (https=)
PH (1) PH12015500322B1 (https=)
SG (1) SG11201501183VA (https=)
TN (1) TN2015000045A1 (https=)
TW (1) TW201412720A (https=)
UA (1) UA112488C2 (https=)
WO (1) WO2014027112A1 (https=)
ZA (1) ZA201501078B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024050645A (ja) * 2018-04-04 2024-04-10 日本たばこ産業株式会社 ヘテロアリールで置換されたピラゾール化合物及びその医薬用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
AR099428A1 (es) * 2014-02-14 2016-07-20 Aicuris Gmbh & Co Kg Combinaciones de principios activos farmacéuticos con compuestos basados en tri(hetero)aril pirazoles
EP3263567A1 (en) * 2016-07-01 2018-01-03 AiCuris Anti-infective Cures GmbH Carboxamide-substituted pyrazoles and tri(hetero)aryl-pyrazoles for use in methods of treating and / or preventing cardiovascular diseases and / or comorbidities thereof

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US20070149549A1 (en) * 2002-08-14 2007-06-28 Li Francine F Prenylation Inhibitors and Methods of Their Synthesis and Use
JP2008285481A (ja) * 2007-04-20 2008-11-27 Mitsubishi Tanabe Pharma Corp 医薬組成物
JP2011514367A (ja) * 2008-03-17 2011-05-06 アイクリス ゲーエムベーハー ウント コー.カーゲー 置換ピラゾールアミドおよびその使用
WO2012009009A2 (en) * 2010-07-14 2012-01-19 Addex Pharma S.A. Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors

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FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
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AR099428A1 (es) 2014-02-14 2016-07-20 Aicuris Gmbh & Co Kg Combinaciones de principios activos farmacéuticos con compuestos basados en tri(hetero)aril pirazoles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070149549A1 (en) * 2002-08-14 2007-06-28 Li Francine F Prenylation Inhibitors and Methods of Their Synthesis and Use
JP2008285481A (ja) * 2007-04-20 2008-11-27 Mitsubishi Tanabe Pharma Corp 医薬組成物
JP2011514367A (ja) * 2008-03-17 2011-05-06 アイクリス ゲーエムベーハー ウント コー.カーゲー 置換ピラゾールアミドおよびその使用
WO2012009009A2 (en) * 2010-07-14 2012-01-19 Addex Pharma S.A. Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024050645A (ja) * 2018-04-04 2024-04-10 日本たばこ産業株式会社 ヘテロアリールで置換されたピラゾール化合物及びその医薬用途

Also Published As

Publication number Publication date
PH12015500322B1 (en) 2019-03-25
UA112488C2 (uk) 2016-09-12
MA37928A1 (fr) 2017-11-30
CN104684913B (zh) 2016-11-23
CA2881997A1 (en) 2014-02-20
DE102012016908A1 (de) 2014-02-20
MX2015002046A (es) 2015-06-05
EA201500232A1 (ru) 2015-07-30
TN2015000045A1 (en) 2016-06-29
EP2885300A1 (de) 2015-06-24
AU2013303993A1 (en) 2015-03-12
AP2015008325A0 (en) 2015-03-31
PE20150869A1 (es) 2015-05-27
WO2014027112A1 (de) 2014-02-20
CU20150015A7 (es) 2015-11-27
ZA201501078B (en) 2017-11-29
CN104684913A (zh) 2015-06-03
CL2015000362A1 (es) 2015-07-10
NZ704727A (en) 2016-07-29
TW201412720A (zh) 2014-04-01
AR092145A1 (es) 2015-03-25
US20150203500A1 (en) 2015-07-23
US9249148B2 (en) 2016-02-02
HK1212327A1 (en) 2016-06-10
IL237298A0 (en) 2015-04-30
PH12015500322A1 (en) 2015-03-30
SG11201501183VA (en) 2015-05-28
BR112015003115A2 (pt) 2017-07-04
KR20150042841A (ko) 2015-04-21

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