PE20150869A1 - Tris-(hetero)aril-pirazoles y su uso - Google Patents

Tris-(hetero)aril-pirazoles y su uso

Info

Publication number
PE20150869A1
PE20150869A1 PE2015000171A PE2015000171A PE20150869A1 PE 20150869 A1 PE20150869 A1 PE 20150869A1 PE 2015000171 A PE2015000171 A PE 2015000171A PE 2015000171 A PE2015000171 A PE 2015000171A PE 20150869 A1 PE20150869 A1 PE 20150869A1
Authority
PE
Peru
Prior art keywords
hetero
tris
pirazoles
aril
preparation
Prior art date
Application number
PE2015000171A
Other languages
English (en)
Inventor
Steffen Wildum
Burkhard Klenke
Astrid Wendt
Original Assignee
Aicuris Gmbh And Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48986151&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20150869(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh And Co Kg filed Critical Aicuris Gmbh And Co Kg
Publication of PE20150869A1 publication Critical patent/PE20150869A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a nuevos tris-(hetero)aril-pirazoles, a procedimientos para su preparacion, a su uso para el tratamiento y/o la profilaxis de enfermedades como tambien a su uso para la preparacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, en especial de enfermedades retrovirales, en humanos y/o animales
PE2015000171A 2012-08-17 2013-08-16 Tris-(hetero)aril-pirazoles y su uso PE20150869A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012016908.6A DE102012016908A1 (de) 2012-08-17 2012-08-17 Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung

Publications (1)

Publication Number Publication Date
PE20150869A1 true PE20150869A1 (es) 2015-05-27

Family

ID=48986151

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015000171A PE20150869A1 (es) 2012-08-17 2013-08-16 Tris-(hetero)aril-pirazoles y su uso

Country Status (27)

Country Link
US (1) US9249148B2 (es)
EP (1) EP2885300A1 (es)
JP (1) JP2015524835A (es)
KR (1) KR20150042841A (es)
CN (1) CN104684913B (es)
AP (1) AP2015008325A0 (es)
AR (1) AR092145A1 (es)
AU (1) AU2013303993A1 (es)
BR (1) BR112015003115A2 (es)
CA (1) CA2881997A1 (es)
CL (1) CL2015000362A1 (es)
CU (1) CU20150015A7 (es)
DE (1) DE102012016908A1 (es)
EA (1) EA201500232A1 (es)
HK (1) HK1212327A1 (es)
IL (1) IL237298A0 (es)
MA (1) MA37928A1 (es)
MX (1) MX2015002046A (es)
NZ (1) NZ704727A (es)
PE (1) PE20150869A1 (es)
PH (1) PH12015500322B1 (es)
SG (1) SG11201501183VA (es)
TN (1) TN2015000045A1 (es)
TW (1) TW201412720A (es)
UA (1) UA112488C2 (es)
WO (1) WO2014027112A1 (es)
ZA (1) ZA201501078B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
WO2015121413A1 (en) * 2014-02-14 2015-08-20 Aicuris Gmbh & Co. Kg New active pharmaceutical ingredient combinations with compounds based on tri(hetero)aryl pyrazoles
EP3263567A1 (en) * 2016-07-01 2018-01-03 AiCuris Anti-infective Cures GmbH Carboxamide-substituted pyrazoles and tri(hetero)aryl-pyrazoles for use in methods of treating and / or preventing cardiovascular diseases and / or comorbidities thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
IL104311A (en) 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6277847B1 (en) 1999-04-02 2001-08-21 Fmc Corporation Herbicidal isoindolinonyl-and 3,4-dihydroisoquinolonyl-substituted heterocycles
US7223782B2 (en) 2001-11-01 2007-05-29 Icagen, Inc. Pyrazole-amides and -sulfonamides
US6649638B1 (en) * 2002-08-14 2003-11-18 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
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CA2555331C (en) 2004-02-20 2011-01-04 Astrazeneca Ab Therapeutic agents
JP4705630B2 (ja) 2004-03-26 2011-06-22 エフ．ホフマン−ラ ロシュ アーゲー テトラヒドロカルバゾール及び誘導体
EP1762568A1 (en) 2004-07-01 2007-03-14 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
GB0417910D0 (en) 2004-08-11 2004-09-15 Novartis Ag Organic compounds
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
WO2007002563A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
EP1743637A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
ES2326723B1 (es) 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazol sustituidos y combinaciones de los mismos para el tratamiento del sindrome metabolico.
GB0516661D0 (en) 2005-08-13 2005-09-21 Astrazeneca Ab Therapeutic agents
NZ566036A (en) 2005-09-13 2010-06-25 Janssen Pharmaceutica Nv 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor
US20090143413A1 (en) 2005-11-29 2009-06-04 Adams Alan D Thiazole Derivatives as CXCR3 Receptor Modulators
WO2007064872A2 (en) 2005-12-01 2007-06-07 Bayer Healthcare Llc Urea compounds useful in the treatment of cancer
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JP4994295B2 (ja) * 2007-04-20 2012-08-08 田辺三菱製薬株式会社 医薬組成物
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WO2015121413A1 (en) 2014-02-14 2015-08-20 Aicuris Gmbh & Co. Kg New active pharmaceutical ingredient combinations with compounds based on tri(hetero)aryl pyrazoles

Also Published As

Publication number Publication date
NZ704727A (en) 2016-07-29
PH12015500322A1 (en) 2015-03-30
SG11201501183VA (en) 2015-05-28
IL237298A0 (en) 2015-04-30
BR112015003115A2 (pt) 2017-07-04
DE102012016908A1 (de) 2014-02-20
AU2013303993A1 (en) 2015-03-12
EA201500232A1 (ru) 2015-07-30
PH12015500322B1 (en) 2015-03-30
WO2014027112A1 (de) 2014-02-20
AP2015008325A0 (en) 2015-03-31
HK1212327A1 (en) 2016-06-10
TW201412720A (zh) 2014-04-01
KR20150042841A (ko) 2015-04-21
MA37928A1 (fr) 2017-11-30
US20150203500A1 (en) 2015-07-23
JP2015524835A (ja) 2015-08-27
CA2881997A1 (en) 2014-02-20
MX2015002046A (es) 2015-06-05
EP2885300A1 (de) 2015-06-24
CN104684913B (zh) 2016-11-23
UA112488C2 (uk) 2016-09-12
AR092145A1 (es) 2015-03-25
ZA201501078B (en) 2017-11-29
TN2015000045A1 (en) 2016-06-29
CN104684913A (zh) 2015-06-03
CU20150015A7 (es) 2015-11-27
CL2015000362A1 (es) 2015-07-10
US9249148B2 (en) 2016-02-02

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