JP2015524798A5 - - Google Patents
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- Publication number
- JP2015524798A5 JP2015524798A5 JP2015521836A JP2015521836A JP2015524798A5 JP 2015524798 A5 JP2015524798 A5 JP 2015524798A5 JP 2015521836 A JP2015521836 A JP 2015521836A JP 2015521836 A JP2015521836 A JP 2015521836A JP 2015524798 A5 JP2015524798 A5 JP 2015524798A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- cyano
- imidazo
- chloro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(**)c(nc1N*)n[n]2c1ncc2N Chemical compound CN(**)c(nc1N*)n[n]2c1ncc2N 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671179P | 2012-07-13 | 2012-07-13 | |
| US61/671,179 | 2012-07-13 | ||
| US201361790511P | 2013-03-15 | 2013-03-15 | |
| US61/790,511 | 2013-03-15 | ||
| PCT/US2013/050247 WO2014011974A1 (en) | 2012-07-13 | 2013-07-12 | Imidazotriazinecarbonitriles useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524798A JP2015524798A (ja) | 2015-08-27 |
| JP2015524798A5 true JP2015524798A5 (https=) | 2016-07-21 |
| JP6228199B2 JP6228199B2 (ja) | 2017-11-08 |
Family
ID=48833089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521836A Expired - Fee Related JP6228199B2 (ja) | 2012-07-13 | 2013-07-12 | キナーゼ阻害剤として有用であるイミダゾトリアジンカルボニトリル |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8940736B2 (https=) |
| EP (1) | EP2872514B1 (https=) |
| JP (1) | JP6228199B2 (https=) |
| KR (1) | KR20150059647A (https=) |
| CN (1) | CN104470925B (https=) |
| AR (1) | AR092349A1 (https=) |
| AU (1) | AU2013290054A1 (https=) |
| BR (1) | BR112015000704A2 (https=) |
| CA (1) | CA2878852A1 (https=) |
| CL (1) | CL2015000094A1 (https=) |
| CO (1) | CO7180199A2 (https=) |
| EA (1) | EA201590224A1 (https=) |
| HK (1) | HK1210775A1 (https=) |
| IL (1) | IL236605A0 (https=) |
| MX (1) | MX2015000310A (https=) |
| PE (1) | PE20150332A1 (https=) |
| PH (1) | PH12015500064A1 (https=) |
| SG (1) | SG11201500158RA (https=) |
| TN (1) | TN2015000002A1 (https=) |
| TW (1) | TW201414737A (https=) |
| WO (1) | WO2014011974A1 (https=) |
| ZA (1) | ZA201501009B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009008916A2 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of Californina | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US9000131B2 (en) * | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| US9243057B2 (en) | 2010-08-31 | 2016-01-26 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| SI2841437T1 (sl) | 2012-04-26 | 2017-09-29 | Bristol-Myers Squibb Company | Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| TW201414737A (zh) | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| EA201690458A1 (ru) | 2013-08-23 | 2016-07-29 | Инсайт Корпорейшн | Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| DE102014111834A1 (de) * | 2014-08-19 | 2016-02-25 | Illinois Tool Works Inc. | Einfülleinrichtung für einen Betriebsstofftank |
| ES2898765T3 (es) | 2015-04-10 | 2022-03-08 | Araxes Pharma Llc | Compuestos de quinazolina sustituidos y métodos de uso de los mismos |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Ｐｉｍ激酶抑制劑之鹽 |
| EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356349A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356359B1 (en) | 2015-09-28 | 2021-10-20 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2017070135A1 (en) * | 2015-10-20 | 2017-04-27 | Bristol-Myers Squibb Company | Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer |
| WO2017070137A1 (en) * | 2015-10-20 | 2017-04-27 | Bristol-Myers Squibb Company | Combination of ck2 inhibitors and immune checkpoint modulators for cancer treatment |
| KR20180081596A (ko) | 2015-11-16 | 2018-07-16 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| CN109562111B (zh) * | 2016-06-24 | 2023-04-04 | 北极星药业股份有限公司 | Ck2抑制剂，其组合物及方法 |
| US10138248B2 (en) | 2016-06-24 | 2018-11-27 | Incyte Corporation | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| JP7447002B2 (ja) * | 2017-09-11 | 2024-03-11 | クルーゾン・ファーマシューティカルズ・インコーポレイテッド | ＳＨＰ２のオクタヒドロシクロペンタ［ｃ］ピロールのアロステリック阻害剤 |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| MX2021000887A (es) | 2018-08-01 | 2021-03-31 | Araxes Pharma Llc | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. |
| CN113207291A (zh) * | 2018-10-24 | 2021-08-03 | 亚瑞克西斯制药公司 | 2-(2-丙烯酰基-2,6-二氮杂螺[3.4]辛-6-基)-6-(1h-吲唑-4-基)苄腈衍生物及相关化合物作为用于抑制肿瘤转移的g12c突变kras蛋白的抑制剂 |
| MX2021009439A (es) * | 2019-02-07 | 2021-11-12 | Beigene Ltd | Derivados de imidazo [2,1-f] [1,2,4] triazin-4-amina como agonista de tlr7. |
| AR119494A1 (es) * | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
| EP4041399A1 (en) * | 2019-10-02 | 2022-08-17 | Tolremo Therapeutics AG | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer |
| KR20230028798A (ko) | 2020-06-25 | 2023-03-02 | 톨레모 테라퓨틱스 아게 | 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물 |
| IL307402A (en) | 2021-04-07 | 2023-12-01 | Tolremo Therapeutics Ag | The tercyclic derivatives, pharmaceutical compounds and their use in the treatment or amelioration of cancer |
| EP4611890A1 (en) * | 2022-11-03 | 2025-09-10 | BioSplice Therapeutics, Inc. | 4-aminopyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof |
| WO2024220399A1 (en) * | 2023-04-17 | 2024-10-24 | Bristol-Myers Squibb Company | Pyrazolotriazinecarbonitriles useful as kinase inhibitors |
| WO2025074096A1 (en) * | 2023-10-02 | 2025-04-10 | Turbine Simulated Cell Technologies Ltd | P97 (vcp) atpase inhibitors |
| WO2025193691A1 (en) * | 2024-03-12 | 2025-09-18 | Casma Therapeutics, Inc. | Bicyclic heteroaromatic compounds as trpml modulators |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4327027A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| WO2006065755A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists |
| WO2006065788A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Novel muscarinic acetylcholine receptor antagonists |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| CN101312977B (zh) * | 2005-09-22 | 2012-06-13 | 布里斯托尔-迈尔斯.斯奎布公司 | 用作激酶调节剂的稠合杂环化合物 |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| WO2008057402A2 (en) | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| CN101730699A (zh) * | 2007-03-21 | 2010-06-09 | 百时美施贵宝公司 | 可用于治疗增殖性、变应性、自身免疫性和炎症性疾病的稠合杂环化合物 |
| US8476430B2 (en) | 2008-07-24 | 2013-07-02 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| TWI491610B (zh) * | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
| WO2010068810A2 (en) | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| SG179083A1 (en) * | 2009-09-11 | 2012-04-27 | Cylene Pharmaceuticals Inc | Pharmaceutically useful heterocycle-substituted lactams |
| JP5802676B2 (ja) * | 2009-12-04 | 2015-10-28 | センワ バイオサイエンシズ インコーポレイテッド | Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物 |
| US9073927B2 (en) | 2010-01-22 | 2015-07-07 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Inhibitors of PI3 kinase |
| WO2011141713A1 (en) | 2010-05-13 | 2011-11-17 | Centro Nacional De Investigaciones Oncologicas (Cnio) | New bicyclic compounds as pi3-k and mtor inhibitors |
| TW201414737A (zh) | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
-
2013
- 2013-07-11 TW TW102125007A patent/TW201414737A/zh unknown
- 2013-07-12 KR KR1020157003512A patent/KR20150059647A/ko not_active Withdrawn
- 2013-07-12 US US13/940,619 patent/US8940736B2/en active Active
- 2013-07-12 WO PCT/US2013/050247 patent/WO2014011974A1/en not_active Ceased
- 2013-07-12 SG SG11201500158RA patent/SG11201500158RA/en unknown
- 2013-07-12 EP EP13739922.6A patent/EP2872514B1/en not_active Not-in-force
- 2013-07-12 EA EA201590224A patent/EA201590224A1/ru unknown
- 2013-07-12 MX MX2015000310A patent/MX2015000310A/es unknown
- 2013-07-12 BR BR112015000704A patent/BR112015000704A2/pt not_active IP Right Cessation
- 2013-07-12 CN CN201380037444.6A patent/CN104470925B/zh not_active Expired - Fee Related
- 2013-07-12 PE PE2015000038A patent/PE20150332A1/es not_active Application Discontinuation
- 2013-07-12 US US14/414,152 patent/US9273057B2/en active Active
- 2013-07-12 AU AU2013290054A patent/AU2013290054A1/en not_active Abandoned
- 2013-07-12 AR ARP130102495A patent/AR092349A1/es unknown
- 2013-07-12 HK HK15111498.7A patent/HK1210775A1/xx unknown
- 2013-07-12 JP JP2015521836A patent/JP6228199B2/ja not_active Expired - Fee Related
- 2013-07-12 CA CA2878852A patent/CA2878852A1/en not_active Abandoned
-
2014
- 2014-11-04 US US14/532,218 patent/US9556178B2/en active Active
-
2015
- 2015-01-05 TN TNP2015000002A patent/TN2015000002A1/fr unknown
- 2015-01-06 IL IL236605A patent/IL236605A0/en unknown
- 2015-01-12 PH PH12015500064A patent/PH12015500064A1/en unknown
- 2015-01-13 CL CL2015000094A patent/CL2015000094A1/es unknown
- 2015-01-26 CO CO15014912A patent/CO7180199A2/es unknown
- 2015-02-12 ZA ZA2015/01009A patent/ZA201501009B/en unknown
- 2015-12-21 US US14/976,476 patent/US20160108050A1/en not_active Abandoned
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