JP2015524427A5 - - Google Patents
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- Publication number
- JP2015524427A5 JP2015524427A5 JP2015524182A JP2015524182A JP2015524427A5 JP 2015524427 A5 JP2015524427 A5 JP 2015524427A5 JP 2015524182 A JP2015524182 A JP 2015524182A JP 2015524182 A JP2015524182 A JP 2015524182A JP 2015524427 A5 JP2015524427 A5 JP 2015524427A5
- Authority
- JP
- Japan
- Prior art keywords
- oxyntomodulin derivative
- seq
- fatty liver
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0081475 | 2012-07-25 | ||
| KR1020120081475A KR101968344B1 (ko) | 2012-07-25 | 2012-07-25 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| PCT/KR2013/006668 WO2014017843A1 (en) | 2012-07-25 | 2013-07-25 | Composition for treating hyperlipidemia comprising oxyntomodulin derivative |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007302A Division JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524427A JP2015524427A (ja) | 2015-08-24 |
| JP2015524427A5 true JP2015524427A5 (https=) | 2017-03-09 |
Family
ID=49997578
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524182A Pending JP2015524427A (ja) | 2012-07-25 | 2013-07-25 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2018007302A Active JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2019046854A Active JP6903086B2 (ja) | 2012-07-25 | 2019-03-14 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2021063405A Withdrawn JP2021107403A (ja) | 2012-07-25 | 2021-04-02 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007302A Active JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2019046854A Active JP6903086B2 (ja) | 2012-07-25 | 2019-03-14 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2021063405A Withdrawn JP2021107403A (ja) | 2012-07-25 | 2021-04-02 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20150182593A1 (https=) |
| EP (3) | EP3384925B1 (https=) |
| JP (4) | JP2015524427A (https=) |
| KR (1) | KR101968344B1 (https=) |
| CN (2) | CN107854691B (https=) |
| AR (1) | AR091903A1 (https=) |
| AU (2) | AU2013293714B2 (https=) |
| BR (2) | BR112015001596B1 (https=) |
| CA (2) | CA3121985C (https=) |
| CL (4) | CL2015000177A1 (https=) |
| DK (1) | DK3384925T3 (https=) |
| ES (2) | ES2942187T3 (https=) |
| IL (2) | IL236913B (https=) |
| MX (2) | MX360024B (https=) |
| MY (2) | MY171493A (https=) |
| NZ (2) | NZ731657A (https=) |
| PE (1) | PE20150633A1 (https=) |
| PH (2) | PH12019501131A1 (https=) |
| RU (2) | RU2642267C2 (https=) |
| SG (2) | SG10201700527UA (https=) |
| TW (3) | TWI708614B (https=) |
| UA (2) | UA118177C2 (https=) |
| WO (1) | WO2014017843A1 (https=) |
| ZA (2) | ZA201501238B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11197914B2 (en) | 2016-04-22 | 2021-12-14 | Shenzhen Turier Biotech Co. Ltd. | GLP-1R/GCGR dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis |
Families Citing this family (51)
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| PE20240686A1 (es) | 2011-06-10 | 2024-04-10 | Hanmi Science Co Ltd | Peptidos derivados de oxintomodulina con actividad sobre el receptor de glucagon y el receptor de peptido similar a glucagon de tipo 1 (glp-1) |
| PE20230404A1 (es) | 2011-06-17 | 2023-03-07 | Hanmi Science Co Ltd | Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y uso del mismo |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| PE20151421A1 (es) | 2012-11-06 | 2015-09-24 | Hanmi Pharm Ind Co Ltd | Formulacion liquida del conjugado de proteina que comprende la oxintomodulina y un fragmento de inmunoglobulina |
| KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| HK1211232A1 (en) | 2012-12-21 | 2016-05-20 | Sanofi | Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| AR098616A1 (es) * | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
| EP3098235A4 (en) | 2014-01-20 | 2017-10-18 | Hanmi Pharm. Co., Ltd. | Long-acting insulin and use thereof |
| AU2015242657B2 (en) * | 2014-03-31 | 2020-05-21 | Hanmi Pharm. Co., Ltd. | Method for improving solubility of protein and peptide by using immunoglobulin Fc fragment linkage |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| TWI684458B (zh) * | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| TWI802396B (zh) * | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| MY185334A (en) | 2014-12-30 | 2021-05-06 | Hanmi Pharm Ind Co Ltd | Glucagon derivatives with improved stability |
| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| EA201890058A1 (ru) * | 2015-06-30 | 2018-07-31 | Ханми Фарм. Ко., Лтд. | Производное глюкагона и композиция, содержащая длительно действующий конъюгат этого производного |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| WO2017116204A1 (ko) * | 2015-12-31 | 2017-07-06 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 |
| JP6937773B2 (ja) * | 2016-03-07 | 2021-09-22 | ハンミ ファーマシューティカル カンパニー リミテッド | ポリエチレングリコール誘導体及びその用途 |
| AR107890A1 (es) * | 2016-03-10 | 2018-06-28 | Medimmune Ltd | Co-agonistas de glucagón y de glp-1 para el tratamiento de la obesidad |
| KR102005457B1 (ko) * | 2016-06-29 | 2019-07-30 | 한미약품 주식회사 | 글루카곤 유도체, 이의 결합체, 및 이를 포함하는 조성물, 및 이의 치료적 용도 |
| RU2764197C1 (ru) | 2016-09-23 | 2022-01-14 | Ханми Фарм. Ко., Лтд. | Аналоги инсулина с пониженной аффинностью к рецептору инсулина и их применение |
| WO2018069422A1 (en) * | 2016-10-12 | 2018-04-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non-alcoholic fatty liver disease |
| CN110545852B (zh) | 2017-02-07 | 2023-05-26 | 韩美药品株式会社 | 非肽聚合物接头化合物、包含该接头化合物的缀合物及制备该接头化合物和缀合物的方法 |
| AR111341A1 (es) | 2017-03-23 | 2019-07-03 | Hanmi Pharm Ind Co Ltd | Un conjugado del análogo de insulina con afinidad reducida para el receptor de insulina y uso del mismo |
| AU2018314773A1 (en) * | 2017-08-09 | 2020-03-26 | Sanofi | GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
| PL3670529T3 (pl) * | 2017-08-16 | 2024-06-10 | Dong-A St Co., Ltd. | Acylowany analog peptydowy oksyntomoduliny |
| US11419918B2 (en) | 2017-11-06 | 2022-08-23 | Shenzhen Turier Biotech Co., Ltd. | Treatment of biliary cirrhosis based on oxyntomodulin analogue GLP-1R/GCGR dual-target agonist peptide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11197914B2 (en) | 2016-04-22 | 2021-12-14 | Shenzhen Turier Biotech Co. Ltd. | GLP-1R/GCGR dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis |
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