JP2015524427A5 - - Google Patents
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- Publication number
- JP2015524427A5 JP2015524427A5 JP2015524182A JP2015524182A JP2015524427A5 JP 2015524427 A5 JP2015524427 A5 JP 2015524427A5 JP 2015524182 A JP2015524182 A JP 2015524182A JP 2015524182 A JP2015524182 A JP 2015524182A JP 2015524427 A5 JP2015524427 A5 JP 2015524427A5
- Authority
- JP
- Japan
- Prior art keywords
- oxyntomodulin derivative
- seq
- fatty liver
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0081475 | 2012-07-25 | ||
| KR1020120081475A KR101968344B1 (ko) | 2012-07-25 | 2012-07-25 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| PCT/KR2013/006668 WO2014017843A1 (en) | 2012-07-25 | 2013-07-25 | Composition for treating hyperlipidemia comprising oxyntomodulin derivative |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007302A Division JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015524427A JP2015524427A (ja) | 2015-08-24 |
| JP2015524427A5 true JP2015524427A5 (https=) | 2017-03-09 |
Family
ID=49997578
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524182A Pending JP2015524427A (ja) | 2012-07-25 | 2013-07-25 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2018007302A Active JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2019046854A Active JP6903086B2 (ja) | 2012-07-25 | 2019-03-14 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2021063405A Withdrawn JP2021107403A (ja) | 2012-07-25 | 2021-04-02 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007302A Active JP6499333B2 (ja) | 2012-07-25 | 2018-01-19 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2019046854A Active JP6903086B2 (ja) | 2012-07-25 | 2019-03-14 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
| JP2021063405A Withdrawn JP2021107403A (ja) | 2012-07-25 | 2021-04-02 | オキシントモジュリン誘導体を含む高脂血症の治療のための組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20150182593A1 (https=) |
| EP (3) | EP2884994B1 (https=) |
| JP (4) | JP2015524427A (https=) |
| KR (1) | KR101968344B1 (https=) |
| CN (2) | CN104507492B (https=) |
| AR (1) | AR091903A1 (https=) |
| AU (2) | AU2013293714B2 (https=) |
| BR (2) | BR112015001596B1 (https=) |
| CA (2) | CA3121985C (https=) |
| CL (4) | CL2015000177A1 (https=) |
| DK (1) | DK3384925T3 (https=) |
| ES (2) | ES2842881T3 (https=) |
| IL (2) | IL236913B (https=) |
| MX (2) | MX360024B (https=) |
| MY (2) | MY171493A (https=) |
| NZ (2) | NZ705384A (https=) |
| PE (1) | PE20150633A1 (https=) |
| PH (2) | PH12019501131A1 (https=) |
| RU (2) | RU2642267C2 (https=) |
| SG (2) | SG10201700527UA (https=) |
| TW (3) | TWI708614B (https=) |
| UA (2) | UA118177C2 (https=) |
| WO (1) | WO2014017843A1 (https=) |
| ZA (2) | ZA201501238B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11197914B2 (en) | 2016-04-22 | 2021-12-14 | Shenzhen Turier Biotech Co. Ltd. | GLP-1R/GCGR dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis |
Families Citing this family (51)
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| UA126465C2 (uk) | 2011-06-10 | 2022-10-12 | Ханмі Сайенс Ко., Лтд. | Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить |
| RU2607365C2 (ru) | 2011-06-17 | 2017-01-10 | Ханми Сайенс Ко., Лтд. | Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| KR101968344B1 (ko) * | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| WO2014073842A1 (en) | 2012-11-06 | 2014-05-15 | Hanmi Pharm. Co., Ltd. | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
| KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| AU2013366692B2 (en) | 2012-12-21 | 2017-11-23 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| AR098616A1 (es) * | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
| CR20160376A (es) | 2014-01-20 | 2016-10-07 | Hanmi Pharm Ind Co Ltd | Insulina de acción prolongada y uso de la misma |
| MX387560B (es) * | 2014-03-31 | 2025-03-18 | Hanmi Pharmaceutical Co Ltd | Procedimiento para mejorar la solubilidad de proteínas y péptidos usando un enlace del fragmento fc de inmunoglobulina. |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
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| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| TWI802396B (zh) * | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
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| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
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| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
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| EP4523705A3 (en) | 2015-06-30 | 2025-06-11 | Hanmi Pharm. Co., Ltd. | Glucagon derivative and a composition comprising a long acting conjugate of the same |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
| UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
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| JP6937773B2 (ja) * | 2016-03-07 | 2021-09-22 | ハンミ ファーマシューティカル カンパニー リミテッド | ポリエチレングリコール誘導体及びその用途 |
| ES2983409T3 (es) * | 2016-03-10 | 2024-10-23 | Medimmune Ltd | Agonista de Glp-1/glucagón para su uso en el tratamiento de la esteatohepatitis no alcohólica |
| EP3479841A4 (en) | 2016-06-29 | 2020-03-04 | Hanmi Pharm. Co., Ltd. | GLUCAGON DERIVATIVE, CONJUGATE THEREOF, COMPOSITION THEREOF AND THERAPEUTIC USE THEREOF |
| JP7158378B2 (ja) | 2016-09-23 | 2022-10-21 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン受容体との結合力が減少された、インスリンアナログ及びその用途 |
| WO2018069422A1 (en) * | 2016-10-12 | 2018-04-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of non-alcoholic fatty liver disease |
| KR20180091773A (ko) | 2017-02-07 | 2018-08-16 | 한미약품 주식회사 | 비펩티드성 중합체 링커 화합물, 그 링커 화합물을 포함하는 결합체, 및 이들의 제조방법 |
| KR102629006B1 (ko) | 2017-03-23 | 2024-01-25 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도 |
| US11352405B2 (en) * | 2017-08-09 | 2022-06-07 | Sanofi | GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
| SG11202001283PA (en) * | 2017-08-16 | 2020-03-30 | Dong A St Co Ltd | Acylated oxyntomodulin peptide analog |
| US11419918B2 (en) | 2017-11-06 | 2022-08-23 | Shenzhen Turier Biotech Co., Ltd. | Treatment of biliary cirrhosis based on oxyntomodulin analogue GLP-1R/GCGR dual-target agonist peptide |
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| UA126465C2 (uk) * | 2011-06-10 | 2022-10-12 | Ханмі Сайенс Ко., Лтд. | Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить |
| RU2607365C2 (ru) | 2011-06-17 | 2017-01-10 | Ханми Сайенс Ко., Лтд. | Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11197914B2 (en) | 2016-04-22 | 2021-12-14 | Shenzhen Turier Biotech Co. Ltd. | GLP-1R/GCGR dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis |
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