JP2015523553A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523553A5 JP2015523553A5 JP2015512185A JP2015512185A JP2015523553A5 JP 2015523553 A5 JP2015523553 A5 JP 2015523553A5 JP 2015512185 A JP2015512185 A JP 2015512185A JP 2015512185 A JP2015512185 A JP 2015512185A JP 2015523553 A5 JP2015523553 A5 JP 2015523553A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- benzoflavone
- concentration
- weight
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 33
- OUGIDAPQYNCXRA-UHFFFAOYSA-N beta-naphthoflavone Chemical compound O1C2=CC=C3C=CC=CC3=C2C(=O)C=C1C1=CC=CC=C1 OUGIDAPQYNCXRA-UHFFFAOYSA-N 0.000 claims description 18
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 11
- 230000000699 topical effect Effects 0.000 claims description 10
- 206010039792 Seborrhoea Diseases 0.000 claims description 7
- 208000017520 skin disease Diseases 0.000 claims description 7
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 4
- 241001303601 Rosacea Species 0.000 claims description 4
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 4
- 206010000496 acne Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 201000004700 rosacea Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 239000000126 substance Substances 0.000 description 9
- 102000008142 Cytochrome P-450 CYP1A1 Human genes 0.000 description 6
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 210000001732 sebaceous gland Anatomy 0.000 description 5
- 239000003446 ligand Substances 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 239000000556 agonist Substances 0.000 description 2
- 238000011532 immunohistochemical staining Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 101150055214 cyp1a1 gene Proteins 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12168121.7 | 2012-05-15 | ||
| EP12168121.7A EP2664919A1 (fr) | 2012-05-15 | 2012-05-15 | Une méthode pour identifier les ligands du récepteur AhR possédant une activité sebosuppressive thérapeutique |
| PCT/IB2013/053979 WO2013171696A1 (en) | 2012-05-15 | 2013-05-15 | Method for identifying ligands of the ahr receptor having therapeutic sebosuppressive activity, and said ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523553A JP2015523553A (ja) | 2015-08-13 |
| JP2015523553A5 true JP2015523553A5 (https=) | 2016-07-07 |
| JP6254580B2 JP6254580B2 (ja) | 2017-12-27 |
Family
ID=46801377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512185A Expired - Fee Related JP6254580B2 (ja) | 2012-05-15 | 2013-05-15 | 治療用皮脂抑制活性を有するＡｈＲ受容体のリガンドを同定する方法、および前記リガンド |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9480674B2 (https=) |
| EP (2) | EP2664919A1 (https=) |
| JP (1) | JP6254580B2 (https=) |
| KR (1) | KR20150022827A (https=) |
| CN (1) | CN104471391B (https=) |
| AU (1) | AU2013261093A1 (https=) |
| BR (1) | BR112014028307A2 (https=) |
| CA (1) | CA2873191A1 (https=) |
| CO (1) | CO7240392A2 (https=) |
| HK (1) | HK1205252A1 (https=) |
| IL (1) | IL235449A (https=) |
| IN (1) | IN2014DN10283A (https=) |
| MX (1) | MX2014013925A (https=) |
| NZ (1) | NZ702357A (https=) |
| PH (1) | PH12014502548A1 (https=) |
| RU (1) | RU2014150505A (https=) |
| SG (1) | SG11201407405VA (https=) |
| WO (1) | WO2013171696A1 (https=) |
| ZA (1) | ZA201408826B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2082736A1 (fr) | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Composition pharmaceutique à usage topique |
| CN104364394B (zh) * | 2012-03-17 | 2019-02-22 | 加州大学评议会 | 痤疮的快速诊断和个体化治疗 |
| EP2664919A1 (fr) | 2012-05-15 | 2013-11-20 | Jean Hilaire Saurat | Une méthode pour identifier les ligands du récepteur AhR possédant une activité sebosuppressive thérapeutique |
| WO2016022703A1 (en) * | 2014-08-06 | 2016-02-11 | Thesan Pharmaceuticals, Inc. | Agonists of the ahr receptor pathway having sebosuppressive activity and a method for identifying said agonists |
| JP2016150916A (ja) * | 2015-02-17 | 2016-08-22 | 株式会社マンダム | 皮脂分泌抑制剤 |
| EP3167892A1 (en) | 2015-11-10 | 2017-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases |
| EP3448398A4 (en) | 2016-04-21 | 2019-12-18 | Naked Biome, Inc. | COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES |
| WO2018065132A1 (en) | 2016-10-04 | 2018-04-12 | Institut National De La Recherche Agronomique | Use of ahr agonist for the preventive or curative treatment of metabolic syndrome and the associated disorders. |
| EP3715471A1 (en) | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ahr signature marker set |
| EP3875098A1 (en) | 2020-03-04 | 2021-09-08 | Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement | Use of coprococcus bacteria for the treatment of metabolic syndrome and inflammatory bowel diseases |
| US20240417400A1 (en) * | 2021-10-14 | 2024-12-19 | Galileo Biosystems, Inc. | Aryl hydrocarbon receptor (ahr) modulators and therapeutic uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2122923C (en) * | 1991-11-25 | 1999-01-19 | Roy L. Blank | Compositions for regulating skin wrinkles and/or skin atrophy |
| EP1063966A1 (en) * | 1998-03-16 | 2001-01-03 | The Procter & Gamble Company | Methods for regulating skin appearance |
| JP2004515453A (ja) * | 2000-05-05 | 2004-05-27 | ウィスコンシン・アルムナイ・リサーチ・ファウンデーション | 癌を化学療法および放射線療法に付する間に細胞を保護するための組成物および方法 |
| US6902881B2 (en) * | 2000-10-13 | 2005-06-07 | President And Fellows Of Harvard College | Compounds and methods for regulating cell differentiation |
| US20030166583A1 (en) * | 2002-02-22 | 2003-09-04 | Oliver Yoa-Pu Hu | Dermal cytochrome P450 1A inhibitors and enhancers |
| EP1418164A1 (en) | 2002-11-07 | 2004-05-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists |
| FR2849597B1 (fr) * | 2003-01-08 | 2006-12-08 | Oreal | Composition cosmetique pour le soin des peaux grasses, contenant un acide gras carboxylique ou l'un de ses derives |
| WO2006072203A1 (fr) * | 2005-01-05 | 2006-07-13 | Oliver Yoa-Pu Hu | Inhibiteur ou promoteur de l’uridinediphosphate-glucuronosyltransferase2b (ugt2b) |
| US20060210524A1 (en) * | 2005-03-18 | 2006-09-21 | Mower Thomas E | Skin care composition |
| US20060210515A1 (en) * | 2005-03-18 | 2006-09-21 | Mower Thomas E | Hair growth formula |
| DE102005056890A1 (de) | 2005-11-28 | 2007-05-31 | Institut für Umweltmedizinische Forschung gGmbH | Kosmetisches Verfahren zur Beeinflussung der Melaninbildung in der Haut |
| KR100798252B1 (ko) * | 2006-01-18 | 2008-01-24 | 주식회사 엘지생활건강 | ｃ-Ｋｉｔ 활성 저해제, 피부미백제 및 이를 함유하는피부미백용 조성물 |
| DE102006011747A1 (de) * | 2006-03-13 | 2007-09-27 | Symrise Gmbh & Co. Kg | Dermatologische und/oder kosmetische Zubereitungen |
| EP1842541A1 (en) * | 2006-03-29 | 2007-10-10 | G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg | Plant components and extracts and uses thereof |
| US20090208432A1 (en) | 2006-05-03 | 2009-08-20 | Symrise Gmbh & Co., Kg | AH Receptor Antagonists |
| US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
| EP2082736A1 (fr) | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Composition pharmaceutique à usage topique |
| WO2011069860A1 (en) * | 2009-12-08 | 2011-06-16 | Chr. Hansen A/S | Novel use for the treatment of metabolic endotoxemia |
| KR20110139397A (ko) * | 2010-06-23 | 2011-12-29 | 건국대학교 산학협력단 | 다약제 내성 저해 활성을 갖는 5,6-벤조플라본 화합물, 그의 제조 방법 및 이를 유효성분으로 포함하는 다약제 내성 저해용 조성물 |
| CN101953838A (zh) * | 2010-08-13 | 2011-01-26 | 李岱 | 吴茱萸次碱用于治疗银屑病的应用 |
| EP2664919A1 (fr) | 2012-05-15 | 2013-11-20 | Jean Hilaire Saurat | Une méthode pour identifier les ligands du récepteur AhR possédant une activité sebosuppressive thérapeutique |
-
2012
- 2012-05-15 EP EP12168121.7A patent/EP2664919A1/fr not_active Withdrawn
-
2013
- 2013-05-15 JP JP2015512185A patent/JP6254580B2/ja not_active Expired - Fee Related
- 2013-05-15 KR KR20147035211A patent/KR20150022827A/ko not_active Withdrawn
- 2013-05-15 IN IN10283DEN2014 patent/IN2014DN10283A/en unknown
- 2013-05-15 SG SG11201407405VA patent/SG11201407405VA/en unknown
- 2013-05-15 CA CA2873191A patent/CA2873191A1/en not_active Abandoned
- 2013-05-15 NZ NZ702357A patent/NZ702357A/en not_active IP Right Cessation
- 2013-05-15 WO PCT/IB2013/053979 patent/WO2013171696A1/en not_active Ceased
- 2013-05-15 RU RU2014150505A patent/RU2014150505A/ru not_active Application Discontinuation
- 2013-05-15 EP EP13734844.7A patent/EP2850429A1/en not_active Withdrawn
- 2013-05-15 BR BR112014028307A patent/BR112014028307A2/pt not_active IP Right Cessation
- 2013-05-15 CN CN201380025088.6A patent/CN104471391B/zh not_active Expired - Fee Related
- 2013-05-15 MX MX2014013925A patent/MX2014013925A/es unknown
- 2013-05-15 HK HK15105467.6A patent/HK1205252A1/xx unknown
- 2013-05-15 AU AU2013261093A patent/AU2013261093A1/en not_active Abandoned
-
2014
- 2014-11-02 IL IL235449A patent/IL235449A/en not_active IP Right Cessation
- 2014-11-07 US US14/536,507 patent/US9480674B2/en not_active Expired - Fee Related
- 2014-11-14 PH PH12014502548A patent/PH12014502548A1/en unknown
- 2014-12-02 ZA ZA2014/08826A patent/ZA201408826B/en unknown
- 2014-12-12 CO CO14273924A patent/CO7240392A2/es unknown
-
2016
- 2016-10-26 US US15/334,987 patent/US20170042856A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015523553A5 (https=) | ||
| Zhang et al. | Glioblastoma therapy using codelivery of cisplatin and glutathione peroxidase targeting siRNA from iron oxide nanoparticles | |
| Bouhy et al. | Inhibition of the Ca2+-dependent K+ channel, KCNN4/KCa3. 1, improves tissue protection and locomotor recovery after spinal cord injury | |
| US20210077625A1 (en) | Ray tracing technique for wireless channel measurements | |
| US10813919B2 (en) | Use of histone deacetylase inhibitors for enhancing immunotherapies | |
| JP6254580B2 (ja) | 治療用皮脂抑制活性を有するＡｈＲ受容体のリガンドを同定する方法、および前記リガンド | |
| Koenig et al. | Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile | |
| CN111479575A (zh) | 包含化疗剂和检查点抑制剂的组合物及使用方法 | |
| JP2016500698A5 (https=) | ||
| McCarthy et al. | In vivo anticancer synergy mechanism of doxorubicin and verapamil combination treatment is impaired in BALB/c mice with metastatic breast cancer | |
| EP3917489A1 (en) | Methods and compositions for developing target specific exosome and growth factor products | |
| JP6009791B2 (ja) | Ｈｄｃ活性化阻害剤、ｈｄｃ活性化阻害剤組成物、鎮痒剤及び鎮痒剤組成物 | |
| JP2015500820A (ja) | Ｅｇｆｒ阻害の有害反応を予防または処置するための組成物 | |
| Guo et al. | Acceleration of diabetic wound healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells | |
| Li et al. | A nanocapsule system combats aging by inhibiting age-related angiogenesis deficiency and glucolipid metabolism disorders | |
| WO2020023389A1 (en) | Reduced exposure compositions modulating therapeutic targets | |
| Wang et al. | Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation | |
| US12233087B2 (en) | Palladium hyaluronic acid particles and methods of managing cancer or angiogenic conditions | |
| Hayashi et al. | A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice | |
| US20230218589A1 (en) | Compound for prevention or treatment of a skin cancer or skin precancer | |
| JP2017088559A (ja) | フィラグリン産生促進剤 | |
| Maguire et al. | Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions | |
| CN112955162A (zh) | 脂肪细胞介导的抗癌治疗剂的递送 | |
| KR20160016475A (ko) | Tslp 발현을 억제하는 올리고뉴클레오타이드 및 이를 포함하는 미용 또는 약제학적 조성물 | |
| Sumeer et al. | Rheumatoid Arthritis and novel carrier systems in diagnosis and treatment: An AI generated review |