JP2015522617A - タンパク質凝集の阻害剤としてのジ−およびトリ−ヘテロアリール誘導体 - Google Patents
タンパク質凝集の阻害剤としてのジ−およびトリ−ヘテロアリール誘導体 Download PDFInfo
- Publication number
- JP2015522617A JP2015522617A JP2015523185A JP2015523185A JP2015522617A JP 2015522617 A JP2015522617 A JP 2015522617A JP 2015523185 A JP2015523185 A JP 2015523185A JP 2015523185 A JP2015523185 A JP 2015523185A JP 2015522617 A JP2015522617 A JP 2015522617A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- compound according
- formula
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UDHMIPNADXWGKM-UHFFFAOYSA-N CCCC[n]1c(C(SC(N2CCN(C)CC2)=N)=N)nnc1Cc1c[n](C)c2ccccc12 Chemical compound CCCC[n]1c(C(SC(N2CCN(C)CC2)=N)=N)nnc1Cc1c[n](C)c2ccccc12 UDHMIPNADXWGKM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672239P | 2012-07-16 | 2012-07-16 | |
| US61/672,239 | 2012-07-16 | ||
| PCT/US2013/050719 WO2014014937A1 (en) | 2012-07-16 | 2013-07-16 | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015522617A true JP2015522617A (ja) | 2015-08-06 |
| JP2015522617A5 JP2015522617A5 (enExample) | 2016-09-01 |
Family
ID=49949212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523185A Pending JP2015522617A (ja) | 2012-07-16 | 2013-07-16 | タンパク質凝集の阻害剤としてのジ−およびトリ−ヘテロアリール誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9284309B2 (enExample) |
| EP (1) | EP2872143B1 (enExample) |
| JP (1) | JP2015522617A (enExample) |
| KR (1) | KR20150031481A (enExample) |
| CN (1) | CN104703604A (enExample) |
| AU (1) | AU2013290361A1 (enExample) |
| BR (1) | BR112015001096A2 (enExample) |
| CA (1) | CA2877983A1 (enExample) |
| ES (1) | ES2661394T3 (enExample) |
| HK (1) | HK1210598A1 (enExample) |
| IL (1) | IL236712A0 (enExample) |
| IN (1) | IN2015DN01171A (enExample) |
| MX (1) | MX2015000618A (enExample) |
| RU (1) | RU2015104962A (enExample) |
| WO (1) | WO2014014937A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017505779A (ja) * | 2014-01-29 | 2017-02-23 | ニューロポア セラピーズ インコーポレイテッド | タンパク質凝集の阻害剤としてのヘテロアリールアミド |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2885049T3 (es) | 2015-07-29 | 2021-12-13 | UCB Biopharma SRL | Derivados de bis-heteroarilo como moduladores de la agregación de proteínas |
| KR20190111080A (ko) * | 2017-01-26 | 2019-10-01 | 유씨비 바이오파마 에스피알엘 | 단백질 응집의 조절제로서의 비스-헤테로아릴 유도체 |
| ES2884145T3 (es) | 2017-01-26 | 2021-12-10 | UCB Biopharma SRL | Derivados bicíclicos de bis-heteroarilo como moduladores de la agregación de proteínas |
| EA201991753A1 (ru) | 2017-01-26 | 2020-01-14 | Юсб Байофарма Спрл | Алкоксибисгетероарильные производные в качестве модуляторов агрегации белков |
| US20190382346A1 (en) | 2017-02-28 | 2019-12-19 | Universitat Autonoma De Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| CN113683598B (zh) * | 2020-05-18 | 2022-10-14 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2025223458A1 (zh) * | 2024-04-23 | 2025-10-30 | 深圳众格生物科技有限公司 | 一种cyp11a1抑制剂、其制备方法及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011084642A1 (en) * | 2009-12-16 | 2011-07-14 | Neuropore Therapies, Inc. | Compound suitable for the treatment of synucleopathies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001056993A2 (en) | 2000-02-05 | 2001-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| ATE335737T1 (de) | 2000-09-15 | 2006-09-15 | Vertex Pharma | Isoxazole und ihre verwendung als erk-inhibitoren |
| WO2004014905A1 (en) * | 2002-08-08 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
| ES2644724T3 (es) | 2009-04-30 | 2017-11-30 | Glaxo Group Limited | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| WO2011146748A1 (en) * | 2010-05-21 | 2011-11-24 | New York University | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase |
-
2013
- 2013-07-16 EP EP13820320.3A patent/EP2872143B1/en active Active
- 2013-07-16 WO PCT/US2013/050719 patent/WO2014014937A1/en not_active Ceased
- 2013-07-16 US US14/415,120 patent/US9284309B2/en active Active
- 2013-07-16 ES ES13820320.3T patent/ES2661394T3/es active Active
- 2013-07-16 CN CN201380038158.1A patent/CN104703604A/zh active Pending
- 2013-07-16 CA CA2877983A patent/CA2877983A1/en not_active Abandoned
- 2013-07-16 HK HK15111382.6A patent/HK1210598A1/xx unknown
- 2013-07-16 MX MX2015000618A patent/MX2015000618A/es unknown
- 2013-07-16 BR BR112015001096A patent/BR112015001096A2/pt not_active Application Discontinuation
- 2013-07-16 JP JP2015523185A patent/JP2015522617A/ja active Pending
- 2013-07-16 KR KR20157004215A patent/KR20150031481A/ko not_active Withdrawn
- 2013-07-16 RU RU2015104962A patent/RU2015104962A/ru not_active Application Discontinuation
- 2013-07-16 AU AU2013290361A patent/AU2013290361A1/en not_active Abandoned
-
2015
- 2015-01-14 IL IL236712A patent/IL236712A0/en unknown
- 2015-02-12 IN IN1171DEN2015 patent/IN2015DN01171A/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011084642A1 (en) * | 2009-12-16 | 2011-07-14 | Neuropore Therapies, Inc. | Compound suitable for the treatment of synucleopathies |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017505779A (ja) * | 2014-01-29 | 2017-02-23 | ニューロポア セラピーズ インコーポレイテッド | タンパク質凝集の阻害剤としてのヘテロアリールアミド |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150183776A1 (en) | 2015-07-02 |
| BR112015001096A2 (pt) | 2017-06-27 |
| AU2013290361A1 (en) | 2015-02-05 |
| CA2877983A1 (en) | 2014-01-23 |
| EP2872143B1 (en) | 2017-12-13 |
| ES2661394T3 (es) | 2018-03-28 |
| IN2015DN01171A (enExample) | 2015-06-26 |
| EP2872143A4 (en) | 2015-12-02 |
| WO2014014937A1 (en) | 2014-01-23 |
| KR20150031481A (ko) | 2015-03-24 |
| US9284309B2 (en) | 2016-03-15 |
| RU2015104962A (ru) | 2016-09-10 |
| MX2015000618A (es) | 2015-04-10 |
| IL236712A0 (en) | 2015-02-26 |
| HK1210598A1 (en) | 2016-04-29 |
| EP2872143A1 (en) | 2015-05-20 |
| CN104703604A (zh) | 2015-06-10 |
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| JP2015522617A (ja) | タンパク質凝集の阻害剤としてのジ−およびトリ−ヘテロアリール誘導体 | |
| US11078196B2 (en) | Heteroaryl amides as inhibitors of protein aggregation | |
| CN110198938B (zh) | 作为蛋白质聚集调节剂的双-杂芳基衍生物 | |
| US10975066B2 (en) | Bis-heteroaryl derivatives as modulators of protein aggregation | |
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| Date | Code | Title | Description |
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| A977 | Report on retrieval |
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| A521 | Request for written amendment filed |
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