MX2015000618A - Derivados de di- y tri-heteroarilo como inhibidores de la agregacion de proteinas. - Google Patents
Derivados de di- y tri-heteroarilo como inhibidores de la agregacion de proteinas.Info
- Publication number
- MX2015000618A MX2015000618A MX2015000618A MX2015000618A MX2015000618A MX 2015000618 A MX2015000618 A MX 2015000618A MX 2015000618 A MX2015000618 A MX 2015000618A MX 2015000618 A MX2015000618 A MX 2015000618A MX 2015000618 A MX2015000618 A MX 2015000618A
- Authority
- MX
- Mexico
- Prior art keywords
- protein aggregation
- tri
- inhibitors
- heteroaryl derivatives
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672239P | 2012-07-16 | 2012-07-16 | |
| PCT/US2013/050719 WO2014014937A1 (en) | 2012-07-16 | 2013-07-16 | Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015000618A true MX2015000618A (es) | 2015-04-10 |
Family
ID=49949212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015000618A MX2015000618A (es) | 2012-07-16 | 2013-07-16 | Derivados de di- y tri-heteroarilo como inhibidores de la agregacion de proteinas. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9284309B2 (enExample) |
| EP (1) | EP2872143B1 (enExample) |
| JP (1) | JP2015522617A (enExample) |
| KR (1) | KR20150031481A (enExample) |
| CN (1) | CN104703604A (enExample) |
| AU (1) | AU2013290361A1 (enExample) |
| BR (1) | BR112015001096A2 (enExample) |
| CA (1) | CA2877983A1 (enExample) |
| ES (1) | ES2661394T3 (enExample) |
| HK (1) | HK1210598A1 (enExample) |
| IL (1) | IL236712A0 (enExample) |
| IN (1) | IN2015DN01171A (enExample) |
| MX (1) | MX2015000618A (enExample) |
| RU (1) | RU2015104962A (enExample) |
| WO (1) | WO2014014937A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ722487A (en) | 2014-01-29 | 2022-04-29 | Ucb Biopharma Sprl | Heteroaryl amides as inhibitors of protein aggregation |
| EP3328379B1 (en) | 2015-07-29 | 2021-07-28 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| JP7073385B2 (ja) | 2017-01-26 | 2022-05-23 | ユーシービー バイオファルマ エスアールエル | タンパク質凝集のモジュレーターとしての二環式ビス－ヘテロアリール誘導体 |
| RU2019126170A (ru) * | 2017-01-26 | 2021-02-26 | Юсб Байофарма Спрл | Бисгетероарильные производные в качестве модуляторов агрегации белков |
| EP3573981B1 (en) * | 2017-01-26 | 2022-03-16 | UCB Biopharma SRL | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| US20190382346A1 (en) | 2017-02-28 | 2019-12-19 | Universitat Autonoma De Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| CN113683598B (zh) * | 2020-05-18 | 2022-10-14 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2025223458A1 (zh) * | 2024-04-23 | 2025-10-30 | 深圳众格生物科技有限公司 | 一种cyp11a1抑制剂、其制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU782878B2 (en) | 2000-02-05 | 2005-09-08 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| JP4052573B2 (ja) | 2000-09-15 | 2008-02-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | イソオキサゾールおよびｅｒｋのインヒビターとしてのその使用 |
| AU2003257094A1 (en) * | 2002-08-08 | 2004-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
| AU2010243613B2 (en) * | 2009-04-30 | 2015-05-07 | Glaxo Group Limited | Oxazole substituted indazoles as PI3-kinase inhibitors |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| JP5922031B2 (ja) * | 2009-12-16 | 2016-05-24 | ニューロポア セラピーズ，インコーポレイティド | 化合物 |
| US9198891B2 (en) | 2010-05-21 | 2015-12-01 | New York University | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase |
-
2013
- 2013-07-16 JP JP2015523185A patent/JP2015522617A/ja active Pending
- 2013-07-16 CN CN201380038158.1A patent/CN104703604A/zh active Pending
- 2013-07-16 AU AU2013290361A patent/AU2013290361A1/en not_active Abandoned
- 2013-07-16 KR KR20157004215A patent/KR20150031481A/ko not_active Withdrawn
- 2013-07-16 BR BR112015001096A patent/BR112015001096A2/pt not_active Application Discontinuation
- 2013-07-16 HK HK15111382.6A patent/HK1210598A1/xx unknown
- 2013-07-16 US US14/415,120 patent/US9284309B2/en active Active
- 2013-07-16 MX MX2015000618A patent/MX2015000618A/es unknown
- 2013-07-16 ES ES13820320.3T patent/ES2661394T3/es active Active
- 2013-07-16 CA CA2877983A patent/CA2877983A1/en not_active Abandoned
- 2013-07-16 EP EP13820320.3A patent/EP2872143B1/en active Active
- 2013-07-16 WO PCT/US2013/050719 patent/WO2014014937A1/en not_active Ceased
- 2013-07-16 RU RU2015104962A patent/RU2015104962A/ru not_active Application Discontinuation
-
2015
- 2015-01-14 IL IL236712A patent/IL236712A0/en unknown
- 2015-02-12 IN IN1171DEN2015 patent/IN2015DN01171A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL236712A0 (en) | 2015-02-26 |
| EP2872143A4 (en) | 2015-12-02 |
| HK1210598A1 (en) | 2016-04-29 |
| EP2872143A1 (en) | 2015-05-20 |
| ES2661394T3 (es) | 2018-03-28 |
| EP2872143B1 (en) | 2017-12-13 |
| BR112015001096A2 (pt) | 2017-06-27 |
| US20150183776A1 (en) | 2015-07-02 |
| AU2013290361A1 (en) | 2015-02-05 |
| JP2015522617A (ja) | 2015-08-06 |
| US9284309B2 (en) | 2016-03-15 |
| WO2014014937A1 (en) | 2014-01-23 |
| CN104703604A (zh) | 2015-06-10 |
| KR20150031481A (ko) | 2015-03-24 |
| IN2015DN01171A (enExample) | 2015-06-26 |
| CA2877983A1 (en) | 2014-01-23 |
| RU2015104962A (ru) | 2016-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015000618A (es) | Derivados de di- y tri-heteroarilo como inhibidores de la agregacion de proteinas. | |
| PH12016501493A1 (en) | Heteroaryl amides as inhibitors of protein aggregation | |
| PH12015500983A1 (en) | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections | |
| PH12014501738A1 (en) | Piperidino-pyrimidine derivatives for the treatment of viral infections | |
| SG10201808102WA (en) | Bicyclic heterocycle compounds and their uses in therapy | |
| PH12015500724B1 (en) | 1, 2, 4-triazine derivatives for the treatment of viral infections | |
| MX370792B (es) | Composiciones para usarse en el tratamiento de cáncer. | |
| MX2019008256A (es) | Derivados de bis-heteroarilo biciclicos como moduladores de agregacion de proteinas. | |
| MX2019007053A (es) | Derivados de bis-heteroarilo como moduladores de la agregacion de proteinas. | |
| MX369952B (es) | Derivados de 1,4-dihidrodioxina fusionada como inhibidores del factor de transcripción de choque térmico 1. | |
| IN2014MN02056A (enExample) | ||
| EA032271B9 (ru) | Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний | |
| MX2018004109A (es) | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. | |
| HK1202452A1 (en) | Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation | |
| AU2012280776B2 (en) | Compounds and pharmaceutical combinations for the treatment of neurodegenerative and ischemic brain diseases | |
| MX2019007054A (es) | Derivados de alcoxi bis-heteroarilo como moduladores de la agregacion de proteinas. | |
| JO3483B1 (ar) | 4-هيدروكسي -2- مثيل -5- (بروبان-2-يليدين) هكس - 3- ين حلقي كربالدهيد للوقاية من ومعالجة مرض معرفي أو تنكسي عصبي أو عصبي | |
| IN2014DN08443A (enExample) | ||
| MX2016004094A (es) | Composicion farmaceutica que comprende capecitabina y ciclofosfamida. | |
| EP3881845A3 (en) | Combination of trazodone and gabapentin for the treatment of pain | |
| MX377759B (es) | Actividad antimicrobiana "in vitro" de la combinacion de peptidos antibiocidas de alacran con antibioticos de uso comun. |