MX370792B - Composiciones para usarse en el tratamiento de cáncer. - Google Patents

Composiciones para usarse en el tratamiento de cáncer.

Info

Publication number
MX370792B
MX370792B MX2015015518A MX2015015518A MX370792B MX 370792 B MX370792 B MX 370792B MX 2015015518 A MX2015015518 A MX 2015015518A MX 2015015518 A MX2015015518 A MX 2015015518A MX 370792 B MX370792 B MX 370792B
Authority
MX
Mexico
Prior art keywords
cancer
treatment
compositions
methods
omomyc
Prior art date
Application number
MX2015015518A
Other languages
English (en)
Other versions
MX2015015518A (es
Inventor
Soucek Laura
Beaulieu Marie-Eve
Original Assignee
Fundacio Privada Inst D´Investigacio Oncologica De Vall Hebron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacio Privada Inst D´Investigacio Oncologica De Vall Hebron filed Critical Fundacio Privada Inst D´Investigacio Oncologica De Vall Hebron
Publication of MX2015015518A publication Critical patent/MX2015015518A/es
Publication of MX370792B publication Critical patent/MX370792B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a un polipéptido que consiste en la SEQ ID NO: 1, o una variante funcionalmente equivalente del mismo, que tiene un grado de identidad con respecto a la SEQ ID NO: 1 mayor que 70%, en donde la variante funcionalmente equivalentemente es un polipéptido resultante de la inserción o de la adición de un aminoácido y/o de la eliminación de uno o más aminoácidos y/o de la sustitución conservativa de uno o más aminoácidos con respecto al polipéptido de la SEQ ID NO: 1 y en donde la variante funcionalmente equivalente del mismo puede dimerizar con Myc e inhibir su actividad una vez que se encuentra en el núcleo, siendo capaz de trastocarse a través de la membrana celular y a través de la envoltura nuclear, para usarse en medicina, en donde el polipéptido o la variante funcionalmente equivalente del mismo es para ser administrable.
MX2015015518A 2013-05-07 2014-05-07 Composiciones para usarse en el tratamiento de cáncer. MX370792B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20130382167 EP2801370A1 (en) 2013-05-07 2013-05-07 Methods and compositions for the treatment of cancer
PCT/EP2014/059315 WO2014180889A1 (en) 2013-05-07 2014-05-07 Methods and compositions for the treatment of cancer

Publications (2)

Publication Number Publication Date
MX2015015518A MX2015015518A (es) 2016-07-21
MX370792B true MX370792B (es) 2020-01-08

Family

ID=48366303

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015518A MX370792B (es) 2013-05-07 2014-05-07 Composiciones para usarse en el tratamiento de cáncer.

Country Status (26)

Country Link
US (2) US10370434B2 (es)
EP (4) EP2801370A1 (es)
JP (2) JP6722103B2 (es)
KR (1) KR102324116B1 (es)
CN (1) CN105378084B (es)
AU (1) AU2014264642B2 (es)
BR (2) BR122020017819B1 (es)
CA (1) CA2911863A1 (es)
CY (1) CY1121849T1 (es)
DK (1) DK2994533T3 (es)
EA (2) EA035463B1 (es)
ES (1) ES2733515T3 (es)
HK (1) HK1251494A1 (es)
HR (1) HRP20191330T1 (es)
HU (1) HUE045615T2 (es)
IL (2) IL242483B (es)
LT (1) LT2994533T (es)
ME (1) ME03509B (es)
MX (1) MX370792B (es)
PL (1) PL2994533T3 (es)
PT (1) PT2994533T (es)
RS (1) RS59276B1 (es)
SG (2) SG10201709101VA (es)
SI (1) SI2994533T1 (es)
SM (1) SMT201900423T1 (es)
WO (1) WO2014180889A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2801370A1 (en) 2013-05-07 2014-11-12 Fundació Privada Institut d'Investigació Oncològica de Vall Hebron Methods and compositions for the treatment of cancer
WO2017136534A1 (en) 2016-02-03 2017-08-10 Kennesaw State University Researcha And Service Foundation, Inc. Signal molecules as cell penetration agents
WO2017190061A1 (en) * 2016-04-29 2017-11-02 The University Of Chicago Synthetic dna binding domain peptides and uses thereof
EP3269734A1 (en) 2016-07-15 2018-01-17 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Methods and compositions for the treatment of cancer
CN106591335A (zh) * 2016-11-08 2017-04-26 安徽省农业科学院水稻研究所 一种密码子植物化改造的LbCpf1基因及其应用
EP3678679A1 (en) * 2017-09-08 2020-07-15 IDP Discovery Pharma, S.L. New treatments of multiple myeloma
US20200354411A1 (en) * 2017-11-29 2020-11-12 Agency For Science, Technology And Research Chimeric Molecule for Targeting c-Myc in Cells
CN112513297B (zh) 2018-03-28 2024-10-22 得克萨斯州大学系统董事会 鉴定从外排体分离的dna中的表观遗传改变
WO2019199803A1 (en) * 2018-04-09 2019-10-17 Board Of Regents, The University Of Texas System Therapeutic targeting of oncogenes using exosomes
CN113557035B (zh) * 2019-01-12 2025-09-05 卫理公会医院 自组装肽纳米颗粒和其用途
TWI829893B (zh) * 2019-03-19 2024-01-21 瓦爾希伯倫私人腫瘤研究基金會 診斷肺癌的方法
WO2020187998A1 (en) * 2019-03-19 2020-09-24 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer
CN114174313A (zh) 2019-04-09 2022-03-11 芝加哥大学 采用狄尔斯-阿尔德环加成反应的通用型肽和蛋白质的大环化和多聚化
KR102221227B1 (ko) 2019-05-07 2021-03-03 김영화 공급자 연동과 다국어 지원 기능을 구비한 쇼핑몰 플랫폼 제공 장치 및 그 방법
WO2021041953A1 (en) * 2019-08-30 2021-03-04 The Regents Of The University Of California Gene fragment overexpression screening methodologies, and uses thereof
CN115925975B (zh) * 2022-08-03 2024-09-17 山东大学 一种靶向肿瘤干细胞的car-mφ体内外编辑制备方法以及其应用
EP4361633A1 (en) 2022-10-25 2024-05-01 Peptomyc, S.L. Method for predicting response to a cancer treatment
EP4446742A1 (en) 2023-04-14 2024-10-16 Peptomyc, S.L. Method for assessing or monitoring the response to a cancer treatment
WO2025064985A1 (en) * 2023-09-22 2025-03-27 Ohio State Innovation Foundation Myc INHIBITOR PROTEINS AND USES THEREOF
CN118557561A (zh) * 2024-05-16 2024-08-30 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 9-十六烯酸在制备防治结直肠肿瘤的产品及其作为化疗药物的增效剂中的应用

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Also Published As

Publication number Publication date
EA035463B1 (ru) 2020-06-19
IL273090B (en) 2022-06-01
EA202090683A2 (ru) 2020-06-30
EP3338789A1 (en) 2018-06-27
SI2994533T1 (sl) 2019-09-30
JP6790148B2 (ja) 2020-11-25
ME03509B (me) 2020-04-20
EP2994533A1 (en) 2016-03-16
CN105378084B (zh) 2019-07-05
BR112015028115A2 (pt) 2017-10-17
MX2015015518A (es) 2016-07-21
JP2019147792A (ja) 2019-09-05
US11339205B2 (en) 2022-05-24
WO2014180889A8 (en) 2015-06-18
US20190382468A1 (en) 2019-12-19
IL273090A (en) 2020-04-30
AU2014264642B2 (en) 2020-09-17
LT2994533T (lt) 2019-08-12
US10370434B2 (en) 2019-08-06
HK1219756A1 (en) 2017-04-13
RS59276B1 (sr) 2019-10-31
HK1251494A1 (en) 2019-02-01
US20160122415A1 (en) 2016-05-05
SG11201509131VA (en) 2015-12-30
CN105378084A (zh) 2016-03-02
EA201690159A1 (ru) 2016-05-31
BR122020017819B1 (pt) 2023-11-21
SMT201900423T1 (it) 2019-09-09
EA202090683A3 (ru) 2020-09-30
PT2994533T (pt) 2019-08-05
KR20160013058A (ko) 2016-02-03
EP3545966A1 (en) 2019-10-02
CY1121849T1 (el) 2020-07-31
JP6722103B2 (ja) 2020-07-15
DK2994533T3 (da) 2019-07-01
SG10201709101VA (en) 2017-12-28
ES2733515T3 (es) 2019-11-29
EP2994533B1 (en) 2019-05-01
PL2994533T3 (pl) 2020-03-31
IL242483B (en) 2020-03-31
JP2016520056A (ja) 2016-07-11
HUE045615T2 (hu) 2020-01-28
EP2801370A1 (en) 2014-11-12
BR112015028115B1 (pt) 2023-11-21
KR102324116B1 (ko) 2021-11-11
WO2014180889A1 (en) 2014-11-13
HRP20191330T1 (hr) 2019-10-18
AU2014264642A1 (en) 2015-11-19
CA2911863A1 (en) 2014-11-13

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