JP2015522569A5 - - Google Patents
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- JP2015522569A5 JP2015522569A5 JP2015518611A JP2015518611A JP2015522569A5 JP 2015522569 A5 JP2015522569 A5 JP 2015522569A5 JP 2015518611 A JP2015518611 A JP 2015518611A JP 2015518611 A JP2015518611 A JP 2015518611A JP 2015522569 A5 JP2015522569 A5 JP 2015522569A5
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- Prior art keywords
- composition
- antigen
- allergen
- particles
- protein
- Prior art date
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- 239000002245 particle Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000013566 allergen Substances 0.000 claims 8
- 102000008214 Glutamate decarboxylase Human genes 0.000 claims 2
- 108091022930 Glutamate decarboxylase Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 1
- 102000009366 Alpha-s1 casein Human genes 0.000 claims 1
- 108050000244 Alpha-s1 casein Proteins 0.000 claims 1
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- 244000205479 Bertholletia excelsa Species 0.000 claims 1
- 235000012284 Bertholletia excelsa Nutrition 0.000 claims 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 240000009226 Corylus americana Species 0.000 claims 1
- 235000001543 Corylus americana Nutrition 0.000 claims 1
- 235000007466 Corylus avellana Nutrition 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102000009093 Dihydrolipoyllysine-residue acetyltransferase Human genes 0.000 claims 1
- 108010073112 Dihydrolipoyllysine-residue acetyltransferase Proteins 0.000 claims 1
- 101800001467 Envelope glycoprotein E2 Proteins 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 102000047918 Myelin Basic Human genes 0.000 claims 1
- 101710107068 Myelin basic protein Proteins 0.000 claims 1
- 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 claims 1
- 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 claims 1
- 102000007999 Nuclear Proteins Human genes 0.000 claims 1
- 108010089610 Nuclear Proteins Proteins 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 241001330451 Paspalum notatum Species 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 102000016202 Proteolipids Human genes 0.000 claims 1
- 108010010974 Proteolipids Proteins 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 101800001271 Surface protein Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 102000005937 Tropomyosin Human genes 0.000 claims 1
- 108010030743 Tropomyosin Proteins 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012645 endogenous antigen Substances 0.000 claims 1
- 102000005525 fibrillarin Human genes 0.000 claims 1
- 108020002231 fibrillarin Proteins 0.000 claims 1
- -1 fp130-RAPS Proteins 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 102000054350 human CHI3L1 Human genes 0.000 claims 1
- 230000000521 hyperimmunizing effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662687P | 2012-06-21 | 2012-06-21 | |
| US61/662,687 | 2012-06-21 | ||
| PCT/US2013/047079 WO2013192532A2 (en) | 2012-06-21 | 2013-06-21 | Peptide conjugated particles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016132A Division JP7210306B2 (ja) | 2012-06-21 | 2019-01-31 | ペプチドコンジュゲート粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522569A JP2015522569A (ja) | 2015-08-06 |
| JP2015522569A5 true JP2015522569A5 (https=) | 2017-11-09 |
| JP6557140B2 JP6557140B2 (ja) | 2019-08-07 |
Family
ID=49769721
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518611A Active JP6557140B2 (ja) | 2012-06-21 | 2013-06-21 | ペプチドコンジュゲート粒子 |
| JP2019016132A Active JP7210306B2 (ja) | 2012-06-21 | 2019-01-31 | ペプチドコンジュゲート粒子 |
| JP2021095735A Active JP7491869B2 (ja) | 2012-06-21 | 2021-06-08 | ペプチドコンジュゲート粒子 |
| JP2023118971A Pending JP2023153869A (ja) | 2012-06-21 | 2023-07-21 | ペプチドコンジュゲート粒子 |
| JP2025116638A Pending JP2025163048A (ja) | 2012-06-21 | 2025-07-10 | ペプチドコンジュゲート粒子 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016132A Active JP7210306B2 (ja) | 2012-06-21 | 2019-01-31 | ペプチドコンジュゲート粒子 |
| JP2021095735A Active JP7491869B2 (ja) | 2012-06-21 | 2021-06-08 | ペプチドコンジュゲート粒子 |
| JP2023118971A Pending JP2023153869A (ja) | 2012-06-21 | 2023-07-21 | ペプチドコンジュゲート粒子 |
| JP2025116638A Pending JP2025163048A (ja) | 2012-06-21 | 2025-07-10 | ペプチドコンジュゲート粒子 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10201596B2 (https=) |
| EP (2) | EP2863942B1 (https=) |
| JP (5) | JP6557140B2 (https=) |
| KR (5) | KR20250052503A (https=) |
| CN (2) | CN104684578B (https=) |
| AU (5) | AU2013278056B2 (https=) |
| BR (1) | BR112014032207B1 (https=) |
| CA (2) | CA3211102A1 (https=) |
| DK (1) | DK2863942T3 (https=) |
| ES (1) | ES2738481T3 (https=) |
| HR (1) | HRP20191178T1 (https=) |
| IL (4) | IL290884B2 (https=) |
| MX (1) | MX363889B (https=) |
| PL (1) | PL2863942T3 (https=) |
| PT (1) | PT2863942T (https=) |
| RU (1) | RU2669346C2 (https=) |
| TR (1) | TR201909998T4 (https=) |
| WO (1) | WO2013192532A2 (https=) |
| ZA (1) | ZA201409305B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
| US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
| WO2013192532A2 (en) | 2012-06-21 | 2013-12-27 | Northwestern University | Peptide conjugated particles |
| EP2928500B1 (en) | 2012-12-04 | 2019-03-06 | Phosphorex Inc. | Microparticles and nanoparticles having negative surface charges |
| CN105263476A (zh) * | 2013-03-13 | 2016-01-20 | 库尔制药开发公司 | 用于治疗炎症的免疫修饰性颗粒 |
| CN105188741A (zh) | 2013-04-03 | 2015-12-23 | 阿勒丁医疗公司 | 新型纳米颗粒组合物 |
| IL292567B2 (en) | 2013-08-13 | 2025-06-01 | Univ Northwestern | Peptide conjugated particles |
| IL260074B2 (en) * | 2015-12-23 | 2026-01-01 | Cour Pharmaceuticals Dev Company Inc | Covalent polymer-antigen particle conjugates |
| US20190365656A1 (en) * | 2016-01-04 | 2019-12-05 | Cour Pharmaceuticals Development Company, Inc. | Particles encapsulating fusion proteins containing linked epitopes |
| GB2550586A (en) | 2016-05-23 | 2017-11-29 | A-Fax Ltd | Racking protection device |
| WO2019217661A1 (en) * | 2018-05-09 | 2019-11-14 | Yale University | Compositions and systems for ex vivo cell modulation and methods of use thereof |
| JP2021523151A (ja) * | 2018-05-11 | 2021-09-02 | ホスホレックス、インコーポレイテッド | 負の表面電荷を有するマイクロ粒子及びナノ粒子 |
| WO2020028909A1 (en) * | 2018-08-03 | 2020-02-06 | Brown University | Oral formulations with increased uptake |
| US20220031632A1 (en) * | 2020-05-14 | 2022-02-03 | Op-T Llc | Nanoparticle compositions and uses thereof |
| EP4182438A1 (en) * | 2020-07-14 | 2023-05-24 | Corning Incorporated | Rapidly dissolving cell culture media powder and methods of making the same |
| EP4419149A1 (en) | 2021-10-21 | 2024-08-28 | Cour Pharmaceuticals Development Company Inc. | Treatment of primary biliary cholangitis (pbc) with tolerizing nanoparticles |
| US20260041747A1 (en) | 2022-07-29 | 2026-02-12 | Repertoire Immune Medicines, Inc. | T cell epitopes associated with type 1 diabetes |
| AU2024275807A1 (en) | 2023-05-23 | 2025-12-11 | Cour Pharmaceuticals Development Company Inc. | Preparation of tolerizing nanoparticles for the treatment of primary biliary cholangitis |
| WO2024243524A1 (en) | 2023-05-25 | 2024-11-28 | Cour Pharmaceuticals Development Company Inc. | Treatment of type 1 diabetes (t1d) with tolerizing nanoparticles |
| WO2025072849A1 (en) | 2023-09-29 | 2025-04-03 | Repertoire Immune Medicines, Inc. | Mhc-presentable peptides associated with type 1 diabetes |
| WO2026019942A2 (en) | 2024-07-16 | 2026-01-22 | Cour Pharmaceuticals Development Company Inc. | Tolerizing immune modifying nanoparticles for treatment of narcolepsy |
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