JP2015522535A5 - - Google Patents
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- Publication number
- JP2015522535A5 JP2015522535A5 JP2015511694A JP2015511694A JP2015522535A5 JP 2015522535 A5 JP2015522535 A5 JP 2015522535A5 JP 2015511694 A JP2015511694 A JP 2015511694A JP 2015511694 A JP2015511694 A JP 2015511694A JP 2015522535 A5 JP2015522535 A5 JP 2015522535A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- docosa
- hydroxy
- eicosa
- hexaenoic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003110 anti-inflammatory effect Effects 0.000 claims description 8
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 8
- 239000002243 precursor Substances 0.000 claims 8
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 6
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- LRWYBGFSVUBWMO-UAAZXLHOSA-N 18(R)-HEPE Chemical compound CC[C@@H](O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O LRWYBGFSVUBWMO-UAAZXLHOSA-N 0.000 claims 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- OIWTWACQMDFHJG-CCFUIAGSSA-N resolvin D1 Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)C\C=C/CCC(O)=O OIWTWACQMDFHJG-CCFUIAGSSA-N 0.000 claims 4
- JBRPFYYLEQERPG-XTIXYJHRSA-N resolvin d5 Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C\C=C/C=C/[C@@H](O)\C=C/CCCC(O)=O JBRPFYYLEQERPG-XTIXYJHRSA-N 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- SWTYBBUBEPPYCX-VIIQGJSXSA-N (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid Chemical compound CC\C=C/CC(O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O SWTYBBUBEPPYCX-VIIQGJSXSA-N 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 235000020667 long-chain omega-3 fatty acid Nutrition 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- CRDZYJSQHCXHEG-SFVBTVKNSA-N protectin D1 Chemical compound CC\C=C/C[C@H](O)\C=C/C=C/C=C/[C@H](O)C\C=C/C\C=C/CCC(O)=O CRDZYJSQHCXHEG-SFVBTVKNSA-N 0.000 claims 3
- IKFAUGXNBOBQDM-XFMPMKITSA-N resolvin D2 Chemical compound CC\C=C/C[C@H](O)[C@H](O)\C=C\C=C\C=C/C=C/[C@@H](O)C\C=C/CCC(O)=O IKFAUGXNBOBQDM-XFMPMKITSA-N 0.000 claims 3
- QBTJOLCUKWLTIC-UZAFJXHNSA-N resolvin D3 Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCC(O)=O QBTJOLCUKWLTIC-UZAFJXHNSA-N 0.000 claims 3
- YKPLJNOOLKUEBS-RIYRYSNMSA-N resolvin D4 Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCC(O)=O YKPLJNOOLKUEBS-RIYRYSNMSA-N 0.000 claims 3
- JKPUWSZSJINVLB-OSKNXYPTSA-N resolvin D6 Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCC(O)=O JKPUWSZSJINVLB-OSKNXYPTSA-N 0.000 claims 3
- AOPOCGPBAIARAV-JJVMZPRHSA-N (18S)-resolvin E1 Chemical compound CC[C@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O AOPOCGPBAIARAV-JJVMZPRHSA-N 0.000 claims 2
- HLHYXXBCQOUTGK-FHCQLJOMSA-N (7R,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid Chemical compound CC\C=C/C\C=C/C[C@H](O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCC(O)=O HLHYXXBCQOUTGK-FHCQLJOMSA-N 0.000 claims 2
- MCRJLMXYVFDXLS-IHWYZUJNSA-N 12S-HEPE Natural products CC\C=C/C\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O MCRJLMXYVFDXLS-IHWYZUJNSA-N 0.000 claims 2
- TUXFWOHFPFBNEJ-GJGHEGAFSA-N 13,14-dihydro-Delta(12)-prostaglandin J2 Chemical compound CCCCC[C@H](O)C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O TUXFWOHFPFBNEJ-GJGHEGAFSA-N 0.000 claims 2
- IXAQOQZEOGMIQS-JEWNPAEBSA-N 15-epi-lipoxin A4 Chemical compound CCCCC[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O IXAQOQZEOGMIQS-JEWNPAEBSA-N 0.000 claims 2
- XLYRHVKBJYDBOS-HXSPUPMESA-N 16,17-Epoxy-DHA Chemical compound CC\C=C/CC1OC1\C=C\C=C\C=C/C\C=C/C\C=C/CCC(O)=O XLYRHVKBJYDBOS-HXSPUPMESA-N 0.000 claims 2
- LRWYBGFSVUBWMO-OKIFYYRFSA-N 18(S)-HEPE Chemical compound CC[C@H](O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O LRWYBGFSVUBWMO-OKIFYYRFSA-N 0.000 claims 2
- WYCMUVNNXSREQB-BBJRFLMCSA-N 18S-Resolvin E3 Chemical compound CC[C@H](O)[C@H](O)\C=C\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WYCMUVNNXSREQB-BBJRFLMCSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 2
- 239000001569 carbon dioxide Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- IXAQOQZEOGMIQS-SSQFXEBMSA-N lipoxin A4 Chemical compound CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O IXAQOQZEOGMIQS-SSQFXEBMSA-N 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- AOPOCGPBAIARAV-OTBJXLELSA-N resolvin E1 Chemical compound CC[C@@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O AOPOCGPBAIARAV-OTBJXLELSA-N 0.000 claims 2
- KPRHYAOSTOHNQA-NNQKPOSRSA-N resolvin E2 Chemical compound CC[C@@H](O)\C=C\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O KPRHYAOSTOHNQA-NNQKPOSRSA-N 0.000 claims 2
- WYCMUVNNXSREQB-AZOGICFMSA-N resolvin E3 Chemical compound CC[C@H](O)C(O)\C=C\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WYCMUVNNXSREQB-AZOGICFMSA-N 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- FRJZMMUVPROLHN-PXDZPDTHSA-N (4Z,7Z,10Z,12E,14R,16Z,19Z,21R)-dihydroxydocosahexaenoic acid Chemical compound C[C@@H](O)\C=C/C\C=C/C[C@@H](O)\C=C\C=C/C\C=C/C\C=C/CCC(O)=O FRJZMMUVPROLHN-PXDZPDTHSA-N 0.000 claims 1
- FRJZMMUVPROLHN-XEGNPPHTSA-N (4Z,7Z,10Z,12E,14R,16Z,19Z,21S)-dihydroxydocosahexaenoic acid Chemical compound C[C@H](O)\C=C/C\C=C/C[C@@H](O)\C=C\C=C/C\C=C/C\C=C/CCC(O)=O FRJZMMUVPROLHN-XEGNPPHTSA-N 0.000 claims 1
- FRJZMMUVPROLHN-KZPAZRNKSA-N (4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoic acid Chemical compound C[C@@H](O)\C=C/C\C=C/C[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCC(O)=O FRJZMMUVPROLHN-KZPAZRNKSA-N 0.000 claims 1
- FRJZMMUVPROLHN-PPFGPZQYSA-N (4Z,7Z,10Z,12E,14S,16Z,19Z,21S)-dihydroxydocosahexaenoic acid Chemical compound C[C@H](O)\C=C/C\C=C/C[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCC(O)=O FRJZMMUVPROLHN-PPFGPZQYSA-N 0.000 claims 1
- IKFAUGXNBOBQDM-FYSWCGKBSA-N (4z,7s,8e,10z,12e,14e,16r,17r,19z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid Chemical compound CC\C=C/C[C@@H](O)[C@H](O)\C=C\C=C\C=C/C=C/[C@@H](O)C\C=C/CCC(O)=O IKFAUGXNBOBQDM-FYSWCGKBSA-N 0.000 claims 1
- ZCNGLMJKKCHIMQ-RTWYPSNKSA-N (4z,8e,10z,12z,16z)-7,14-dihydroxydocosa-4,8,10,12,16-pentaenoic acid Chemical compound CCCCC\C=C/CC(O)\C=C/C=C\C=C\C(O)C\C=C/CCC(O)=O ZCNGLMJKKCHIMQ-RTWYPSNKSA-N 0.000 claims 1
- HLHYXXBCQOUTGK-NVFVPEJPSA-N (7S,14S)-dihydroxy-(4Z,8E,10E,12Z,16Z,19Z)-docosahexaenoic acid Chemical compound CC\C=C/C\C=C/C[C@H](O)\C=C/C=C/C=C/[C@@H](O)C\C=C/CCC(O)=O HLHYXXBCQOUTGK-NVFVPEJPSA-N 0.000 claims 1
- VHRUMKCAEVRUBK-WKELIDJCSA-N (z)-7-[(1s,5e)-5-[(z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid Chemical compound CCCCC\C=C/C=C1\[C@@H](C\C=C/CCCC(O)=O)C=CC1=O VHRUMKCAEVRUBK-WKELIDJCSA-N 0.000 claims 1
- IDEHSDHMEMMYIR-HODZVVMCSA-N 11S-HEPE Chemical compound CC\C=C/C\C=C/C=C/[C@@H](O)C\C=C/C\C=C/CCCC(O)=O IDEHSDHMEMMYIR-HODZVVMCSA-N 0.000 claims 1
- MCRJLMXYVFDXLS-UOLHMMFFSA-N 12(S)-HEPE Chemical compound CC\C=C/C\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O MCRJLMXYVFDXLS-UOLHMMFFSA-N 0.000 claims 1
- JSFATNQSLKRBCI-UDQWCNDOSA-N 15(R)-HETE Chemical compound CCCCC[C@@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O JSFATNQSLKRBCI-UDQWCNDOSA-N 0.000 claims 1
- WLKCSMCLEKGITB-DBVSHIMFSA-N 15(S)-HEPE Chemical compound CC\C=C/C[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WLKCSMCLEKGITB-DBVSHIMFSA-N 0.000 claims 1
- JSFATNQSLKRBCI-VAEKSGALSA-N 15(S)-HETE Chemical compound CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O JSFATNQSLKRBCI-VAEKSGALSA-N 0.000 claims 1
- VHRUMKCAEVRUBK-GODQJPCRSA-N 15-deoxy-Delta(12,14)-prostaglandin J2 Chemical compound CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O VHRUMKCAEVRUBK-GODQJPCRSA-N 0.000 claims 1
- JTGJRDREFMAMJA-MPPNEBGGSA-N 20-Hydroxy-Resolvin E1 Chemical compound OCC[C@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O JTGJRDREFMAMJA-MPPNEBGGSA-N 0.000 claims 1
- FTAGQROYQYQRHF-GHWNLOBHSA-N 5S-HEPE Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O FTAGQROYQYQRHF-GHWNLOBHSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010003062 Apraxia Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
- 206010008635 Cholestasis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 241000238424 Crustacea Species 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 208000004930 Fatty Liver Diseases 0.000 claims 1
- 206010019708 Hepatic steatosis Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- ZZMKOZNTEJVKRY-MCPYMSAWSA-N Lipoxin A5 Chemical compound CC\C=C/C[C@H](O)\C=C/C=C\C=C\C=C\[C@H](O)[C@@H](O)CCCC(O)=O ZZMKOZNTEJVKRY-MCPYMSAWSA-N 0.000 claims 1
- ZZMKOZNTEJVKRY-RFMHRSAXSA-N Lipoxin A5 Natural products CCC=C/CC(O)C=CC=C/C=C/C=C/C(O)C(O)CCCC(=O)O ZZMKOZNTEJVKRY-RFMHRSAXSA-N 0.000 claims 1
- 241000237852 Mollusca Species 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 241001303601 Rosacea Species 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 208000030961 allergic reaction Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- OIWTWACQMDFHJG-BJEBZIPWSA-N aspirin-triggered resolvin D1 Chemical compound CC\C=C/C[C@@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)C\C=C/CCC(O)=O OIWTWACQMDFHJG-BJEBZIPWSA-N 0.000 claims 1
- QBTJOLCUKWLTIC-AXRBAIMGSA-N aspirin-triggered resolvin D3 Chemical compound CC\C=C/C[C@@H](O)\C=C\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCC(O)=O QBTJOLCUKWLTIC-AXRBAIMGSA-N 0.000 claims 1
- YKPLJNOOLKUEBS-MMOUQCFBSA-N aspirin-triggered resolvin D4 Chemical compound CC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCC(O)=O YKPLJNOOLKUEBS-MMOUQCFBSA-N 0.000 claims 1
- JBRPFYYLEQERPG-RIVVZJRMSA-N aspirin-triggered resolvin D5 Chemical compound CC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/C=C/[C@@H](O)\C=C/CCCC(O)=O JBRPFYYLEQERPG-RIVVZJRMSA-N 0.000 claims 1
- JKPUWSZSJINVLB-VDOHSOROSA-N aspirin-triggered resolvin D6 Chemical compound CC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCC(O)=O JKPUWSZSJINVLB-VDOHSOROSA-N 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000007870 cholestasis Effects 0.000 claims 1
- 231100000359 cholestasis Toxicity 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000004808 supercritical fluid chromatography Methods 0.000 claims 1
- 238000000194 supercritical-fluid extraction Methods 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645281P | 2012-05-10 | 2012-05-10 | |
| US61/645,281 | 2012-05-10 | ||
| PCT/US2013/040314 WO2013170006A2 (en) | 2012-05-10 | 2013-05-09 | Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131272A Division JP6821626B2 (ja) | 2012-05-10 | 2018-07-11 | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522535A JP2015522535A (ja) | 2015-08-06 |
| JP2015522535A5 true JP2015522535A5 (enExample) | 2016-06-30 |
| JP6370775B2 JP6370775B2 (ja) | 2018-08-08 |
Family
ID=49551457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511694A Active JP6370775B2 (ja) | 2012-05-10 | 2013-05-09 | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
| JP2018131272A Active JP6821626B2 (ja) | 2012-05-10 | 2018-07-11 | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131272A Active JP6821626B2 (ja) | 2012-05-10 | 2018-07-11 | 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10568858B2 (enExample) |
| EP (2) | EP2858496B9 (enExample) |
| JP (2) | JP6370775B2 (enExample) |
| CN (3) | CN110478342A (enExample) |
| AU (1) | AU2013259503B2 (enExample) |
| CA (1) | CA2873055C (enExample) |
| DK (1) | DK2858496T3 (enExample) |
| ES (1) | ES2946109T3 (enExample) |
| NZ (1) | NZ702325A (enExample) |
| PL (1) | PL2858496T3 (enExample) |
| PT (1) | PT2858496T (enExample) |
| WO (1) | WO2013170006A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| CN110478342A (zh) | 2012-05-10 | 2019-11-22 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
| GB201301626D0 (en) * | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| US9902681B2 (en) | 2013-05-30 | 2018-02-27 | The Brigham And Women's Hospital, Inc. | N-3 immunoresolvents: structures and actions |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| MX2016008953A (es) * | 2014-01-10 | 2017-02-02 | Dignity Sciences Ltd | Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas. |
| JP6315536B2 (ja) * | 2014-01-29 | 2018-04-25 | 岩手県 | Ｐｐａｒ活性化剤 |
| JP6604529B2 (ja) * | 2014-01-29 | 2019-11-13 | 岩手県 | ヒドロキシエイコサペンタエン酸の取得方法 |
| CN106687113B (zh) | 2014-06-06 | 2021-09-03 | 海洋原料公司 | ω-3组合物、剂型及使用方法 |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| JP2018502163A (ja) * | 2015-01-16 | 2018-01-25 | アフィミューン リミテッド | １５−ｈｅｐｅを含む組成物及びそれを使用する方法 |
| WO2016130522A1 (en) * | 2015-02-09 | 2016-08-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases |
| US9682034B2 (en) | 2015-03-10 | 2017-06-20 | Elc Management Llc | Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways |
| JP2018520197A (ja) | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| WO2017041094A1 (en) | 2015-09-03 | 2017-03-09 | Solutex Na Llc | Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same |
| ES2607715B1 (es) | 2015-10-01 | 2018-01-17 | Solutex Na, Lcc | Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa |
| CN113230244A (zh) * | 2015-12-18 | 2021-08-10 | 艾菲穆恩有限公司 | 包含15-hepe的组合物及其使用方法 |
| JP6906047B2 (ja) | 2016-06-03 | 2021-07-21 | テティス・ファーマシューティカルズ・エルエルシー | 特異的炎症収束性メディエーターの塩に関連する組成物及び方法 |
| US11484520B2 (en) * | 2017-01-18 | 2022-11-01 | Universitat Autonoma De Barcelona | Specialized pro-resolving lipid mediators for use in the treatment of neurodegenerative diseases and/or autoimmune diseases |
| WO2019016580A1 (en) | 2017-07-20 | 2019-01-24 | Universitat Autonoma De Barcelona | MARESINS FOR USE IN THE TREATMENT OF CNS INJURIES |
| KR101981534B1 (ko) * | 2017-09-01 | 2019-05-23 | (주)솔빛피앤에프 | 프로텍틴 dx를 유효성분으로 함유하는 고지혈증 또는 지방간 질환 예방 또는 치료용 조성물 |
| KR102003153B1 (ko) * | 2018-01-17 | 2019-07-23 | 연세대학교 산학협력단 | 레졸빈 d2를 유효성분으로 함유하는 피부 염증 치료용 조성물 |
| WO2019203540A2 (ko) * | 2018-04-16 | 2019-10-24 | 한국생명공학연구원 | 다중불포화지방산의 멀티-하이드록시 유도체 생산 방법 |
| CN108578398A (zh) * | 2018-06-11 | 2018-09-28 | 温州医科大学 | 巨噬素在制备预防或治疗类风湿性关节炎的药物中的应用 |
| NO345574B1 (en) * | 2018-06-19 | 2021-04-26 | Epax Norway As | Composition for treatment of dry eye disease and meibomianitis |
| WO2019243887A1 (en) | 2018-06-22 | 2019-12-26 | Ambiotis | Method for restoration of the natural capacity of the body to end inflammation by personalization of the food supplementation and objectification of its effect |
| WO2020076578A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
| KR102673270B1 (ko) * | 2018-10-15 | 2024-06-07 | (주)아모레퍼시픽 | 피부장벽 강화용 조성물 |
| US11400057B2 (en) | 2018-10-19 | 2022-08-02 | University Of Rochester | Treatment of vulvar pain |
| KR102704402B1 (ko) * | 2018-10-24 | 2024-09-06 | (주)아모레퍼시픽 | 피부장벽 강화용 조성물 |
| WO2020109480A1 (en) * | 2018-11-30 | 2020-06-04 | Evonik Operations Gmbh | Preparation for use to increase the formation of one or more specialized pro-resolving lipid mediators (spm) |
| WO2020252413A1 (en) * | 2019-06-13 | 2020-12-17 | The Regents Of The University Of California | Methods and compositions for determination liver fibrosis |
| CN110420224A (zh) * | 2019-07-25 | 2019-11-08 | 江苏华豚药业有限公司 | 河豚肝油皂化物的应用及其制备方法 |
| WO2021019037A1 (en) * | 2019-08-01 | 2021-02-04 | Evonik Operations Gmbh | Preparation comprising omega-3 fatty acid salts and extracts of gum resins from boswellia species |
| US11607623B2 (en) | 2019-08-08 | 2023-03-21 | Cornerstone Technologies Llc | Dynamic interface system and its application in supercritical fluid extraction and chromatography |
| GB201913383D0 (en) * | 2019-09-17 | 2019-10-30 | Univ London Queen Mary | Methods for predicting patient response to DMARDs |
| KR102870005B1 (ko) * | 2019-09-25 | 2025-10-17 | (주)아모레퍼시픽 | 피부장벽 강화용 조성물 |
| EP4071241A4 (en) * | 2019-12-06 | 2023-10-18 | Korea Research Institute of Bioscience and Biotechnology | MONO-HYDROXY OR DI-HYDROXY DERIVATIVES OF POLYUNSATURATED FATTY ACIDS, PROCESS FOR THEIR PRODUCTION AND USE |
| KR102256823B1 (ko) * | 2019-12-06 | 2021-05-26 | 한국생명공학연구원 | 도코사헥사노엔산 유도체를 함유하는 주름 개선, 아토피피부염 개선 및 피부 장벽 강화용 복합 조성물 |
| BR112022011276A2 (pt) * | 2019-12-09 | 2022-09-06 | Univ Louisiana State | Biomolécula para tratamento de patologias da córnea |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| US20230273228A1 (en) | 2020-07-17 | 2023-08-31 | Solutex Gc, S.L. | Diagnostic Method and Compounds for the Treatment of Infections Caused by a Pathogen |
| WO2022049168A1 (en) * | 2020-09-04 | 2022-03-10 | Dsm Ip Assets B.V. | 17(s)-hdpa for metabolic-syndrome related disorders |
| EP4255412A1 (en) | 2020-12-04 | 2023-10-11 | Chemo Research, S.L. | Specialized pro-resolving lipid mediators for treating pcos |
| KR20220159751A (ko) | 2021-05-26 | 2022-12-05 | (주)아모레퍼시픽 | 미백용 조성물 및 이를 이용한 피부 미백방법 |
| KR102662544B1 (ko) * | 2021-10-19 | 2024-05-03 | 서울대학교산학협력단 | 참문어 추출물을 유효성분으로 포함하는 만성 폐쇄성 폐질환 예방 또는 치료용 약학적 조성물 |
| EP4499060A1 (en) | 2022-03-25 | 2025-02-05 | Chemo Research, S.L. | Specialized pro-resolving lipid mediators for treating long covid-19 |
| CN115466776B (zh) * | 2022-09-26 | 2025-06-27 | 中国医学科学院基础医学研究所 | 检测嗜酸性粒细胞的试剂、嗜酸性粒细胞及其胞质内容物和羟基二十二碳六烯酸的应用 |
| CN116139122B (zh) * | 2023-02-28 | 2025-11-07 | 武汉大学人民医院（湖北省人民医院） | 消退素d2在制备缓解和/或治疗心肌梗死及其相关疾病的药物中的应用 |
| WO2025023183A1 (ja) * | 2023-07-21 | 2025-01-30 | 国立大学法人大阪大学 | 炎症性腸疾患を抑制する脂肪酸代謝産物 |
| WO2025233510A1 (en) | 2024-05-10 | 2025-11-13 | Chemo Research, S.L. | Specialized pro-resolving lipid mediators for treating depression, anxiety, and/or stress |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH01169354A (ja) * | 1987-12-25 | 1989-07-04 | Hitachi Ltd | 超臨界炭酸ガス抽出物の分取方法 |
| US5133902A (en) | 1989-08-22 | 1992-07-28 | Viswanatha Sankaran | Transesterification of triglycerides |
| US4966876A (en) | 1989-08-22 | 1990-10-30 | Viswanatha Sankaran | Transesterification of triglycerides |
| IT1274734B (it) | 1994-08-25 | 1997-07-24 | Prospa Bv | Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti |
| KR100234947B1 (ko) | 1997-06-05 | 1999-12-15 | 이형도 | 멀티 탭 고주파 모듈레이터 |
| ATE497384T1 (de) | 1997-12-10 | 2011-02-15 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| JP4175698B2 (ja) * | 1998-06-19 | 2008-11-05 | サントリー株式会社 | 新規なトリグリセリド及びそれを含む組成物 |
| IL151299A0 (en) * | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| PT1243262E (pt) * | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| JPWO2002102364A1 (ja) * | 2001-06-18 | 2004-09-30 | 山田 幸子 | ＰＰＡＲγ作動性医薬組成物 |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| KR20110053281A (ko) | 2002-11-22 | 2011-05-19 | 니폰스이산가부시키가이샤 | 산화 안정성이 향상된 이중결합을 가진 유기물을 함유하는 조성물 |
| JP4280158B2 (ja) | 2002-12-27 | 2009-06-17 | 富士フイルム株式会社 | ドコサヘキサエン酸生産能を有する微生物及びその利用 |
| US20090318394A1 (en) | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| KR20070090928A (ko) * | 2004-11-19 | 2007-09-06 | 마텍 바이오싸이언스스 코포레이션 | 장쇄 다가불포화 지방산으로부터의 옥시리핀, 및 이의 제조방법 및 사용 방법 |
| JP2009051732A (ja) * | 2005-12-13 | 2009-03-12 | Meiji Seika Kaisha Ltd | Ｐｐａｒリガンド活性を有する組成物 |
| US20110190389A1 (en) | 2007-02-20 | 2011-08-04 | Linda Arterburn | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| AU2008269989B2 (en) * | 2007-06-29 | 2014-02-27 | Dsm Ip Assets B.V. | Production and purification of esters of polyunsaturated fatty acids |
| KR101650680B1 (ko) | 2007-08-31 | 2016-08-23 | 디에스엠 아이피 어셋츠 비.브이. | 다중불포화된 지방산 함유 고체 지방 조성물 및 그의 용도 및 생산 |
| US8927747B2 (en) * | 2008-09-16 | 2015-01-06 | The Brigham And Women's Hospital, Inc. | 14-hydroxy-docosahexaenoic acid compounds |
| WO2010095706A1 (ja) | 2009-02-20 | 2010-08-26 | 国立大学法人東京大学 | 新規抗炎症性化合物 |
| US20110071090A1 (en) | 2009-03-11 | 2011-03-24 | Stable Solutions Llc | Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle |
| CL2009001343A1 (es) * | 2009-06-02 | 2009-07-10 | Golden Omega S A | Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar. |
| US8479921B2 (en) | 2009-12-09 | 2013-07-09 | Amcor Flexibles, Inc. | Child resistant blister package |
| WO2011087981A2 (en) | 2010-01-15 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Clinical benefits of eicosapentaenoic acid in humans |
| WO2012023254A1 (ja) | 2010-08-19 | 2012-02-23 | 国立大学法人 東京大学 | オメガ３系脂肪酸由来の新規抗炎症性代謝物 |
| US8865685B2 (en) | 2011-06-30 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| WO2013096993A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
| CN110478342A (zh) * | 2012-05-10 | 2019-11-22 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
| AU2014299410B2 (en) | 2013-06-27 | 2017-12-21 | Smartfish As | Use of a composition comprising fish oil and juice for the treatment of inflammation |
| MX2016008953A (es) | 2014-01-10 | 2017-02-02 | Dignity Sciences Ltd | Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas. |
| WO2017041094A1 (en) | 2015-09-03 | 2017-03-09 | Solutex Na Llc | Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same |
-
2013
- 2013-05-09 CN CN201910864506.XA patent/CN110478342A/zh active Pending
- 2013-05-09 WO PCT/US2013/040314 patent/WO2013170006A2/en not_active Ceased
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- 2013-05-09 EP EP23157714.9A patent/EP4205546A1/en active Pending
- 2013-05-09 DK DK13788058.9T patent/DK2858496T3/da active
- 2013-05-09 NZ NZ702325A patent/NZ702325A/en unknown
- 2013-05-09 CN CN201380036376.1A patent/CN104684389A/zh active Pending
- 2013-05-09 CN CN202310172271.4A patent/CN116173001A/zh active Pending
- 2013-05-09 ES ES13788058T patent/ES2946109T3/es active Active
- 2013-05-09 AU AU2013259503A patent/AU2013259503B2/en active Active
- 2013-05-09 PT PT137880589T patent/PT2858496T/pt unknown
- 2013-05-09 US US14/400,198 patent/US10568858B2/en active Active
- 2013-05-09 CA CA2873055A patent/CA2873055C/en active Active
- 2013-05-09 PL PL13788058.9T patent/PL2858496T3/pl unknown
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- 2018-07-11 JP JP2018131272A patent/JP6821626B2/ja active Active
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- 2022-02-22 US US17/677,158 patent/US11865096B2/en active Active
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