DK2858496T3 - Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere - Google Patents

Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere Download PDF

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Publication number
DK2858496T3
DK2858496T3 DK13788058.9T DK13788058T DK2858496T3 DK 2858496 T3 DK2858496 T3 DK 2858496T3 DK 13788058 T DK13788058 T DK 13788058T DK 2858496 T3 DK2858496 T3 DK 2858496T3
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Denmark
Prior art keywords
reseal
mediators
precursors
oils
inflammatory activity
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DK13788058.9T
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Danish (da)
English (en)
Inventor
Gerhardus Lucas Bannenberg
Charles Nicholas Serhan
Egea Fernando Moreno
Original Assignee
Solutex Na Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49551457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2858496(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of DK2858496T3 publication Critical patent/DK2858496T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK13788058.9T 2012-05-10 2013-05-09 Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere DK2858496T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261645281P 2012-05-10 2012-05-10
PCT/US2013/040314 WO2013170006A2 (en) 2012-05-10 2013-05-09 Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors

Publications (1)

Publication Number Publication Date
DK2858496T3 true DK2858496T3 (da) 2023-07-24

Family

ID=49551457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13788058.9T DK2858496T3 (da) 2012-05-10 2013-05-09 Olier med anti-inflammatorisk aktivitet, som indeholder naturlige specialiserede pro-afhjælpningsmediatorer og deres forløbere

Country Status (12)

Country Link
US (6) US10568858B2 (enExample)
EP (2) EP2858496B9 (enExample)
JP (2) JP6370775B2 (enExample)
CN (3) CN110478342A (enExample)
AU (1) AU2013259503B2 (enExample)
CA (1) CA2873055C (enExample)
DK (1) DK2858496T3 (enExample)
ES (1) ES2946109T3 (enExample)
NZ (1) NZ702325A (enExample)
PL (1) PL2858496T3 (enExample)
PT (1) PT2858496T (enExample)
WO (1) WO2013170006A2 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
CN110478342A (zh) 2012-05-10 2019-11-22 索卢泰克斯Na有限责任公司 含有天然专门促消退介质及其前体的具有抗炎活性的油
GB201301626D0 (en) * 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
US9902681B2 (en) 2013-05-30 2018-02-27 The Brigham And Women's Hospital, Inc. N-3 immunoresolvents: structures and actions
EP3068757B1 (en) 2013-11-15 2019-02-27 DS Biopharma Limited Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid
MX2016008953A (es) * 2014-01-10 2017-02-02 Dignity Sciences Ltd Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas.
JP6315536B2 (ja) * 2014-01-29 2018-04-25 岩手県 Ｐｐａｒ活性化剤
JP6604529B2 (ja) * 2014-01-29 2019-11-13 岩手県 ヒドロキシエイコサペンタエン酸の取得方法
CN106687113B (zh) 2014-06-06 2021-09-03 海洋原料公司 ω-3组合物、剂型及使用方法
MA41120A (fr) 2014-12-02 2017-10-10 Afimmune Ltd Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci
JP2018502163A (ja) * 2015-01-16 2018-01-25 アフィミューン リミテッド １５−ｈｅｐｅを含む組成物及びそれを使用する方法
WO2016130522A1 (en) * 2015-02-09 2016-08-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases
US9682034B2 (en) 2015-03-10 2017-06-20 Elc Management Llc Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways
JP2018520197A (ja) 2015-07-21 2018-07-26 アフィミューン リミテッド 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物
WO2017041094A1 (en) 2015-09-03 2017-03-09 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same
ES2607715B1 (es) 2015-10-01 2018-01-17 Solutex Na, Lcc Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa
CN113230244A (zh) * 2015-12-18 2021-08-10 艾菲穆恩有限公司 包含15-hepe的组合物及其使用方法
JP6906047B2 (ja) 2016-06-03 2021-07-21 テティス・ファーマシューティカルズ・エルエルシー 特異的炎症収束性メディエーターの塩に関連する組成物及び方法
US11484520B2 (en) * 2017-01-18 2022-11-01 Universitat Autonoma De Barcelona Specialized pro-resolving lipid mediators for use in the treatment of neurodegenerative diseases and/or autoimmune diseases
WO2019016580A1 (en) 2017-07-20 2019-01-24 Universitat Autonoma De Barcelona MARESINS FOR USE IN THE TREATMENT OF CNS INJURIES
KR101981534B1 (ko) * 2017-09-01 2019-05-23 (주)솔빛피앤에프 프로텍틴 dx를 유효성분으로 함유하는 고지혈증 또는 지방간 질환 예방 또는 치료용 조성물
KR102003153B1 (ko) * 2018-01-17 2019-07-23 연세대학교 산학협력단 레졸빈 d2를 유효성분으로 함유하는 피부 염증 치료용 조성물
WO2019203540A2 (ko) * 2018-04-16 2019-10-24 한국생명공학연구원 다중불포화지방산의 멀티-하이드록시 유도체 생산 방법
CN108578398A (zh) * 2018-06-11 2018-09-28 温州医科大学 巨噬素在制备预防或治疗类风湿性关节炎的药物中的应用
NO345574B1 (en) * 2018-06-19 2021-04-26 Epax Norway As Composition for treatment of dry eye disease and meibomianitis
WO2019243887A1 (en) 2018-06-22 2019-12-26 Ambiotis Method for restoration of the natural capacity of the body to end inflammation by personalization of the food supplementation and objectification of its effect
WO2020076578A1 (en) 2018-10-09 2020-04-16 University Of Rochester Treatment of vulvovaginal disorders
KR102673270B1 (ko) * 2018-10-15 2024-06-07 (주)아모레퍼시픽 피부장벽 강화용 조성물
US11400057B2 (en) 2018-10-19 2022-08-02 University Of Rochester Treatment of vulvar pain
KR102704402B1 (ko) * 2018-10-24 2024-09-06 (주)아모레퍼시픽 피부장벽 강화용 조성물
WO2020109480A1 (en) * 2018-11-30 2020-06-04 Evonik Operations Gmbh Preparation for use to increase the formation of one or more specialized pro-resolving lipid mediators (spm)
WO2020252413A1 (en) * 2019-06-13 2020-12-17 The Regents Of The University Of California Methods and compositions for determination liver fibrosis
CN110420224A (zh) * 2019-07-25 2019-11-08 江苏华豚药业有限公司 河豚肝油皂化物的应用及其制备方法
WO2021019037A1 (en) * 2019-08-01 2021-02-04 Evonik Operations Gmbh Preparation comprising omega-3 fatty acid salts and extracts of gum resins from boswellia species
US11607623B2 (en) 2019-08-08 2023-03-21 Cornerstone Technologies Llc Dynamic interface system and its application in supercritical fluid extraction and chromatography
GB201913383D0 (en) * 2019-09-17 2019-10-30 Univ London Queen Mary Methods for predicting patient response to DMARDs
KR102870005B1 (ko) * 2019-09-25 2025-10-17 (주)아모레퍼시픽 피부장벽 강화용 조성물
EP4071241A4 (en) * 2019-12-06 2023-10-18 Korea Research Institute of Bioscience and Biotechnology MONO-HYDROXY OR DI-HYDROXY DERIVATIVES OF POLYUNSATURATED FATTY ACIDS, PROCESS FOR THEIR PRODUCTION AND USE
KR102256823B1 (ko) * 2019-12-06 2021-05-26 한국생명공학연구원 도코사헥사노엔산 유도체를 함유하는 주름 개선, 아토피피부염 개선 및 피부 장벽 강화용 복합 조성물
BR112022011276A2 (pt) * 2019-12-09 2022-09-06 Univ Louisiana State Biomolécula para tratamento de patologias da córnea
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases
US20230273228A1 (en) 2020-07-17 2023-08-31 Solutex Gc, S.L. Diagnostic Method and Compounds for the Treatment of Infections Caused by a Pathogen
WO2022049168A1 (en) * 2020-09-04 2022-03-10 Dsm Ip Assets B.V. 17(s)-hdpa for metabolic-syndrome related disorders
EP4255412A1 (en) 2020-12-04 2023-10-11 Chemo Research, S.L. Specialized pro-resolving lipid mediators for treating pcos
KR20220159751A (ko) 2021-05-26 2022-12-05 (주)아모레퍼시픽 미백용 조성물 및 이를 이용한 피부 미백방법
KR102662544B1 (ko) * 2021-10-19 2024-05-03 서울대학교산학협력단 참문어 추출물을 유효성분으로 포함하는 만성 폐쇄성 폐질환 예방 또는 치료용 약학적 조성물
EP4499060A1 (en) 2022-03-25 2025-02-05 Chemo Research, S.L. Specialized pro-resolving lipid mediators for treating long covid-19
CN115466776B (zh) * 2022-09-26 2025-06-27 中国医学科学院基础医学研究所 检测嗜酸性粒细胞的试剂、嗜酸性粒细胞及其胞质内容物和羟基二十二碳六烯酸的应用
CN116139122B (zh) * 2023-02-28 2025-11-07 武汉大学人民医院（湖北省人民医院） 消退素d2在制备缓解和/或治疗心肌梗死及其相关疾病的药物中的应用
WO2025023183A1 (ja) * 2023-07-21 2025-01-30 国立大学法人大阪大学 炎症性腸疾患を抑制する脂肪酸代謝産物
WO2025233510A1 (en) 2024-05-10 2025-11-13 Chemo Research, S.L. Specialized pro-resolving lipid mediators for treating depression, anxiety, and/or stress

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH01169354A (ja) * 1987-12-25 1989-07-04 Hitachi Ltd 超臨界炭酸ガス抽出物の分取方法
US5133902A (en) 1989-08-22 1992-07-28 Viswanatha Sankaran Transesterification of triglycerides
US4966876A (en) 1989-08-22 1990-10-30 Viswanatha Sankaran Transesterification of triglycerides
IT1274734B (it) 1994-08-25 1997-07-24 Prospa Bv Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti
KR100234947B1 (ko) 1997-06-05 1999-12-15 이형도 멀티 탭 고주파 모듈레이터
ATE497384T1 (de) 1997-12-10 2011-02-15 Cyclosporine Therapeutics Ltd Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen
JP4175698B2 (ja) * 1998-06-19 2008-11-05 サントリー株式会社 新規なトリグリセリド及びそれを含む組成物
IL151299A0 (en) * 2000-02-16 2003-04-10 Brigham & Womens Hospital Aspirin-triggered lipid mediators
PT1243262E (pt) * 2001-03-20 2006-10-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica
JPWO2002102364A1 (ja) * 2001-06-18 2004-09-30 山田　幸子 ＰＰＡＲγ作動性医薬組成物
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
KR20110053281A (ko) 2002-11-22 2011-05-19 니폰스이산가부시키가이샤 산화 안정성이 향상된 이중결합을 가진 유기물을 함유하는 조성물
JP4280158B2 (ja) 2002-12-27 2009-06-17 富士フイルム株式会社 ドコサヘキサエン酸生産能を有する微生物及びその利用
US20090318394A1 (en) 2004-11-19 2009-12-24 Julie Nauroth Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
KR20070090928A (ko) * 2004-11-19 2007-09-06 마텍 바이오싸이언스스 코포레이션 장쇄 다가불포화 지방산으로부터의 옥시리핀, 및 이의 제조방법 및 사용 방법
JP2009051732A (ja) * 2005-12-13 2009-03-12 Meiji Seika Kaisha Ltd Ｐｐａｒリガンド活性を有する組成物
US20110190389A1 (en) 2007-02-20 2011-08-04 Linda Arterburn Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
AU2008269989B2 (en) * 2007-06-29 2014-02-27 Dsm Ip Assets B.V. Production and purification of esters of polyunsaturated fatty acids
KR101650680B1 (ko) 2007-08-31 2016-08-23 디에스엠 아이피 어셋츠 비.브이. 다중불포화된 지방산 함유 고체 지방 조성물 및 그의 용도 및 생산
US8927747B2 (en) * 2008-09-16 2015-01-06 The Brigham And Women's Hospital, Inc. 14-hydroxy-docosahexaenoic acid compounds
WO2010095706A1 (ja) 2009-02-20 2010-08-26 国立大学法人東京大学 新規抗炎症性化合物
US20110071090A1 (en) 2009-03-11 2011-03-24 Stable Solutions Llc Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle
CL2009001343A1 (es) * 2009-06-02 2009-07-10 Golden Omega S A Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.
US8479921B2 (en) 2009-12-09 2013-07-09 Amcor Flexibles, Inc. Child resistant blister package
WO2011087981A2 (en) 2010-01-15 2011-07-21 E. I. Du Pont De Nemours And Company Clinical benefits of eicosapentaenoic acid in humans
WO2012023254A1 (ja) 2010-08-19 2012-02-23 国立大学法人 東京大学 オメガ３系脂肪酸由来の新規抗炎症性代謝物
US8865685B2 (en) 2011-06-30 2014-10-21 Johnson & Johnson Vision Care, Inc. Esters for treatment of ocular inflammatory conditions
WO2013096993A1 (en) 2011-12-27 2013-07-04 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
CN110478342A (zh) * 2012-05-10 2019-11-22 索卢泰克斯Na有限责任公司 含有天然专门促消退介质及其前体的具有抗炎活性的油
AU2014299410B2 (en) 2013-06-27 2017-12-21 Smartfish As Use of a composition comprising fish oil and juice for the treatment of inflammation
MX2016008953A (es) 2014-01-10 2017-02-02 Dignity Sciences Ltd Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas.
WO2017041094A1 (en) 2015-09-03 2017-03-09 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same

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Publication number Publication date
EP2858496A4 (en) 2016-03-23
US20190201363A1 (en) 2019-07-04
WO2013170006A3 (en) 2014-01-03
CN104684389A (zh) 2015-06-03
CN110478342A (zh) 2019-11-22
ES2946109T3 (es) 2023-07-12
US11285126B2 (en) 2022-03-29
US20150126602A1 (en) 2015-05-07
EP2858496A2 (en) 2015-04-15
EP2858496B9 (en) 2023-11-29
CN116173001A (zh) 2023-05-30
WO2013170006A2 (en) 2013-11-14
PL2858496T3 (pl) 2023-09-11
NZ702325A (en) 2016-09-30
JP6370775B2 (ja) 2018-08-08
US20220175711A1 (en) 2022-06-09
CA2873055C (en) 2023-10-10
JP6821626B2 (ja) 2021-01-27
EP2858496B1 (en) 2023-04-12
US10568858B2 (en) 2020-02-25
EP4205546A1 (en) 2023-07-05
US20210154163A1 (en) 2021-05-27
AU2013259503B2 (en) 2017-03-16
JP2015522535A (ja) 2015-08-06
CA2873055A1 (en) 2013-11-14
JP2018193378A (ja) 2018-12-06
US20200281883A1 (en) 2020-09-10
US11865096B2 (en) 2024-01-09
US20180271818A1 (en) 2018-09-27
US11077084B2 (en) 2021-08-03
WO2013170006A4 (en) 2014-02-20
US11077083B2 (en) 2021-08-03
AU2013259503A1 (en) 2014-12-18
PT2858496T (pt) 2023-07-20

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