JP2015522246A5 - - Google Patents
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- JP2015522246A5 JP2015522246A5 JP2015503288A JP2015503288A JP2015522246A5 JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5 JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5
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- acid sequence
- antibody
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616394P | 2012-03-27 | 2012-03-27 | |
| US61/616,394 | 2012-03-27 | ||
| US201261707411P | 2012-09-28 | 2012-09-28 | |
| US61/707,411 | 2012-09-28 | ||
| PCT/US2013/031178 WO2013148232A1 (en) | 2012-03-27 | 2013-03-14 | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522246A JP2015522246A (ja) | 2015-08-06 |
| JP2015522246A5 true JP2015522246A5 (cg-RX-API-DMAC10.html) | 2016-05-12 |
| JP6404208B2 JP6404208B2 (ja) | 2018-10-10 |
Family
ID=49261043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503288A Active JP6404208B2 (ja) | 2012-03-27 | 2013-03-14 | 特発性肺線維症の予後予測、診断および処置の方法 |
Country Status (16)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| EP3360978A3 (en) | 2009-05-07 | 2018-09-26 | Veracyte, Inc. | Methods for diagnosis of thyroid conditions |
| WO2013035799A1 (ja) | 2011-09-06 | 2013-03-14 | 株式会社シノテスト | ペリオスチンの特定領域に結合する抗体及びこれを用いたペリオスチンの測定方法 |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| WO2018048960A1 (en) * | 2016-09-07 | 2018-03-15 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| CA3280124A1 (en) | 2013-07-31 | 2025-10-31 | Avalyn Pharma Inc. | Aerosol imatinib compounds and uses thereof |
| JP6715767B2 (ja) * | 2013-10-23 | 2020-07-01 | ジェネンテック, インコーポレイテッド | 好酸球性疾患の診断及び治療方法 |
| JP6312054B2 (ja) * | 2013-11-06 | 2018-04-18 | 学校法人日本大学 | 間質性肺炎のバイオマーカー |
| EP3068409A4 (en) * | 2013-11-14 | 2017-08-23 | Proterris, Inc. | Treatment or prevention of pulmonary conditions with carbon monoxide |
| WO2015138034A2 (en) * | 2013-12-20 | 2015-09-17 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
| US9970935B2 (en) | 2014-02-06 | 2018-05-15 | The Brigham And Women's Hospital, Inc. | Uses of GLI1 in detecting tissue fibrosis |
| TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
| WO2015164716A1 (en) * | 2014-04-25 | 2015-10-29 | Brown University | Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome |
| US9913819B2 (en) | 2014-06-12 | 2018-03-13 | Yale University | Methods of treating or preventing fibrotic lung diseases |
| EP2957634A1 (en) | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| CN114606309A (zh) | 2014-11-05 | 2022-06-10 | 威拉赛特公司 | 使用机器学习和高维转录数据的诊断系统和方法 |
| CN104792998B (zh) * | 2015-03-09 | 2016-06-08 | 中国人民解放军第四军医大学 | Loxl2抗原用于制备甲状腺癌预示、侵袭、转移试剂盒的应用 |
| CN111718413A (zh) * | 2015-06-26 | 2020-09-29 | 上海市肿瘤研究所 | Cthrc1在肝硬化诊断和治疗中的应用 |
| WO2017044752A1 (en) * | 2015-09-10 | 2017-03-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Anti-fibrotic effect of cd70 |
| HRP20240306T1 (hr) | 2015-10-27 | 2024-05-10 | Taipei Medical University | Derivati indolina za liječenje i/ili prevenciju fibroznih bolesti |
| CN105400870B (zh) * | 2015-11-11 | 2018-09-25 | 南方医科大学 | CD1c在菌阴肺结核诊断中的应用 |
| HK1254295A1 (zh) | 2015-11-23 | 2019-07-19 | 默克专利股份有限公司 | 用於治疗纤维化和/或纤维化病症的抗-αV整合素抗体 |
| MX2018006269A (es) * | 2015-11-23 | 2018-09-05 | Merck Patent Gmbh | Anticuerpo anti-alfa-v-integrina para el tratamiento de fibrosis y/o trastornos fibroticos. |
| JP2019522638A (ja) * | 2016-05-27 | 2019-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ニンテダニブ及びピルフェニドンによる治療開始を判定するためのecmバイオマーカーの使用 |
| CN106319058B (zh) * | 2016-08-31 | 2019-09-10 | 汪道文 | 一种检测特发性肺纤维化致病基因的dna文库及其应用 |
| US11397178B2 (en) | 2016-10-28 | 2022-07-26 | Cedars-Sinai Medical Center | Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy |
| US20200017913A1 (en) * | 2017-03-02 | 2020-01-16 | President And Fellows Of Harvard College | Methods and systems for predicting treatment responses in subjects |
| IT201700026858A1 (it) * | 2017-03-10 | 2018-09-10 | Univ Degli Studi Padova | Uso di inibitori delle serin proteasi, in particolare di serpinb3 |
| US20190127456A1 (en) * | 2017-10-31 | 2019-05-02 | Fibrogen, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| CN108931645A (zh) * | 2018-07-26 | 2018-12-04 | 北京大学第医院 | 一种hcv清除后肝纤维化评估系统及评估方法 |
| KR102958241B1 (ko) | 2018-09-10 | 2026-04-30 | 레인 테라퓨틱스, 인크. | Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도 |
| CN112969921B (zh) * | 2018-10-29 | 2024-06-07 | 国立大学法人东京医科齿科大学 | 取得间质性肺炎患者的呼吸功能的降低风险相关信息的方法及其利用 |
| US12480960B2 (en) | 2019-01-11 | 2025-11-25 | University Of Virginia Patent Foundation | Compositions and methods for predicting lung function decline in idiopathic pulmonary fibrosis |
| WO2022026922A2 (en) * | 2020-07-31 | 2022-02-03 | Genentech, Inc. | Methods for treating exacerbations of inflammatory respiratory diseases |
| EP4297768A4 (en) | 2021-02-25 | 2025-01-15 | Lung Therapeutics, LLC | Biomarkers for the treatment of interstitial lung disease |
| JP2024523034A (ja) * | 2021-06-18 | 2024-06-25 | エフ. ホフマン-ラ ロシュ アーゲー | 二重特異性抗ccl2抗体 |
| ES2957479B2 (es) * | 2022-06-07 | 2025-07-28 | Baigene S L | Metodo de obtencion de datos utiles para la prediccion del riesgo de un sujeto de sufrir fibrosis |
| KR20250025381A (ko) | 2022-06-17 | 2025-02-21 | 아포지 바이오로직스, 인크. | 인터류킨 13에 결합하는 항체 및 사용 방법 |
| CN115925920B (zh) * | 2022-08-04 | 2023-07-25 | 瑞因细胞工程科技(广州)有限公司 | 一种基因增强型免疫细胞治疗肝硬化的方法 |
| US20260008845A1 (en) * | 2022-11-14 | 2026-01-08 | Alentis Therapeutics Ag | Biomarkers for fibrosis treatment using anti-claudin-1 antibodies |
| CN117747093B (zh) * | 2024-02-20 | 2024-06-07 | 神州医疗科技股份有限公司 | 一种特发性肺纤维化诊断模型的构建方法及诊断系统 |
| CN118583834B (zh) * | 2024-07-30 | 2024-11-22 | 上海交通大学医学院附属仁济医院 | 一种慢性肝纤维化性疾病的诊断系统 |
| CN119162300A (zh) * | 2024-09-12 | 2024-12-20 | 中国人民解放军陆军军医大学第一附属医院 | 用于预测肺纤维化程度及预后情况的标志物、模型及应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| ATE182651T1 (de) | 1992-06-09 | 1999-08-15 | Hoppe Ag | Riegel und türschloss |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1972194A1 (en) | 1996-12-03 | 2008-09-24 | Amgen Fremont Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| AR045614A1 (es) * | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
| MX361174B (es) * | 2003-12-23 | 2018-11-29 | Genentech Inc | Anticuerpos anti-il13 novedosos y sus usos. |
| US20080044420A1 (en) | 2005-05-11 | 2008-02-21 | Heavner George A | Anti-IL-13 antibodies, compositions, methods and uses |
| KR101363777B1 (ko) | 2005-09-30 | 2014-02-14 | 메디뮨 리미티드 | 인터루킨―13 항체 조성물 |
| EP2532677A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| AU2007238533C1 (en) * | 2006-01-13 | 2013-08-15 | Indiana University Research & Technology Corporation | Molecules for the treatment of lung disease involving an immune reaction to connective tissue found in the lung |
| TWI395754B (zh) * | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
| BRPI0718225A2 (pt) * | 2006-10-05 | 2013-11-12 | Centocor Ortho Biotech Inc | Antagonistas de ccr2 para tratamento de fibrose |
| WO2008083695A1 (de) | 2006-12-20 | 2008-07-17 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Vorrichtung und verfahren zur messung der intensität des lichtes einer ersten gruppe von lichtquellen einer beleuchtungseinheit |
| US20090068195A1 (en) * | 2007-04-23 | 2009-03-12 | Wyeth | Methods and compositions for treating and monitoring treatment of il-13-associated disorders |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| CA2705486C (en) * | 2007-11-19 | 2019-04-02 | Celera Corporation | Lung cancer markers and uses thereof |
| NZ601815A (en) * | 2008-03-31 | 2014-10-31 | Genentech Inc | Compositions and methods for treating and diagnosing asthma |
| WO2010028274A1 (en) * | 2008-09-05 | 2010-03-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation |
| CA2744588A1 (en) * | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Ligands that bind il-13 |
| US8911960B2 (en) * | 2009-06-01 | 2014-12-16 | Case Western Reserve University | Method for identifying idiopathic pneumonia progression by measuring the level of mannose-binding protein C |
| KR101615420B1 (ko) * | 2010-12-16 | 2016-04-26 | 제넨테크, 인크. | Th2 억제에 관한 진단 및 치료 |
-
2013
- 2013-03-14 WO PCT/US2013/031178 patent/WO2013148232A1/en not_active Ceased
- 2013-03-14 HK HK15107420.8A patent/HK1206796A1/xx unknown
- 2013-03-14 AU AU2013240344A patent/AU2013240344A1/en not_active Abandoned
- 2013-03-14 JP JP2015503288A patent/JP6404208B2/ja active Active
- 2013-03-14 CA CA2864884A patent/CA2864884A1/en not_active Abandoned
- 2013-03-14 EP EP20153153.0A patent/EP3725892A1/en not_active Withdrawn
- 2013-03-14 CN CN201380027564.8A patent/CN104334744A/zh active Pending
- 2013-03-14 NZ NZ628458A patent/NZ628458A/en not_active IP Right Cessation
- 2013-03-14 KR KR1020147029554A patent/KR102197524B1/ko not_active Expired - Fee Related
- 2013-03-14 CN CN201611178102.8A patent/CN107099581B/zh active Active
- 2013-03-14 SG SG11201405830VA patent/SG11201405830VA/en unknown
- 2013-03-14 RU RU2014139546A patent/RU2014139546A/ru not_active Application Discontinuation
- 2013-03-14 SG SG10201702842SA patent/SG10201702842SA/en unknown
- 2013-03-14 EP EP13768451.0A patent/EP2831280B1/en active Active
- 2013-03-14 MX MX2014011503A patent/MX370486B/es active IP Right Grant
- 2013-03-14 AR ARP130100827A patent/AR090339A1/es unknown
- 2013-03-14 BR BR112014023348-9A patent/BR112014023348A2/pt not_active IP Right Cessation
-
2014
- 2014-09-23 US US14/493,649 patent/US20160230226A1/en not_active Abandoned
- 2014-09-25 MX MX2019015159A patent/MX2019015159A/es unknown
-
2017
- 2017-12-18 IL IL256396A patent/IL256396A/en unknown
-
2018
- 2018-03-16 US US15/924,114 patent/US20190062836A1/en not_active Abandoned
- 2018-10-16 AU AU2018250393A patent/AU2018250393A1/en not_active Abandoned
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