JP2015521592A5 - - Google Patents

Info

Publication number

JP2015521592A5

JP2015521592A5 JP2015516648A JP2015516648A JP2015521592A5 JP 2015521592 A5 JP2015521592 A5 JP 2015521592A5 JP 2015516648 A JP2015516648 A JP 2015516648A JP 2015516648 A JP2015516648 A JP 2015516648A JP 2015521592 A5 JP2015521592 A5 JP 2015521592A5

Authority

JP

Japan

Prior art keywords

polypeptide

item

isolated polypeptide

seq

immunogenic

Prior art date

2013-06-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims description 64
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 64
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 64
• 230000002163 immunogen Effects 0.000 claims description 31
• 239000012634 fragment Substances 0.000 claims description 20
• 102000037865 fusion proteins Human genes 0.000 claims description 16
• 108020001507 fusion proteins Proteins 0.000 claims description 16
• 108091033319 polynucleotide Proteins 0.000 claims description 15
• 102000040430 polynucleotide Human genes 0.000 claims description 15
• 239000002157 polynucleotide Substances 0.000 claims description 15
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 239000010410 layer Substances 0.000 claims description 12
• 239000013638 trimer Substances 0.000 claims description 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 6
• 208000030507 AIDS Diseases 0.000 claims description 5
• 239000011229 interlayer Substances 0.000 claims description 5
• 208000015181 infectious disease Diseases 0.000 claims description 4
• -1 and V59 and S109 Chemical compound 0.000 claims description 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 239000002671 adjuvant Substances 0.000 claims description 2
• 235000001014 amino acid Nutrition 0.000 claims description 2
• 150000001413 amino acids Chemical class 0.000 claims description 2
• 235000018417 cysteine Nutrition 0.000 claims description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
• 230000028993 immune response Effects 0.000 claims description 2
• 150000007523 nucleic acids Chemical group 0.000 claims description 2
• 229960005486 vaccine Drugs 0.000 claims description 2
• 230000005847 immunogenicity Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 6
• 208000031886 HIV Infections Diseases 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1
• 238000010845 search algorithm Methods 0.000 description 1