JP2015521466A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015521466A5 JP2015521466A5 JP2015516728A JP2015516728A JP2015521466A5 JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5 JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- region
- fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660232P | 2012-06-15 | 2012-06-15 | |
| US61/660,232 | 2012-06-15 | ||
| PCT/IB2013/054810 WO2013186719A1 (en) | 2012-06-15 | 2013-06-12 | Improved antagonist antibodies against gdf-8 and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Division JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521466A JP2015521466A (ja) | 2015-07-30 |
| JP2015521466A5 true JP2015521466A5 (https=) | 2016-07-28 |
| JP6433889B2 JP6433889B2 (ja) | 2018-12-05 |
Family
ID=48914383
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516728A Expired - Fee Related JP6433889B2 (ja) | 2012-06-15 | 2013-06-12 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8992913B2 (https=) |
| EP (1) | EP2861617A1 (https=) |
| JP (3) | JP6433889B2 (https=) |
| KR (1) | KR101704893B1 (https=) |
| CN (1) | CN104487453B (https=) |
| AR (1) | AR093217A1 (https=) |
| AU (1) | AU2013276131B2 (https=) |
| CA (1) | CA2876397C (https=) |
| CO (1) | CO7151524A2 (https=) |
| IL (1) | IL236289A0 (https=) |
| MX (1) | MX364738B (https=) |
| MY (1) | MY177331A (https=) |
| NZ (1) | NZ702269A (https=) |
| PE (1) | PE20150223A1 (https=) |
| PH (1) | PH12014502698B1 (https=) |
| RU (1) | RU2630634C2 (https=) |
| SA (1) | SA113340642B1 (https=) |
| SG (1) | SG11201408042YA (https=) |
| TW (1) | TWI495643B (https=) |
| WO (1) | WO2013186719A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| AU2012339722B2 (en) | 2011-11-14 | 2017-09-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A |
| EP2861617A1 (en) * | 2012-06-15 | 2015-04-22 | Pfizer Inc. | Improved antagonist antibodies against gdf-8 and uses therefor |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| TWI633117B (zh) | 2012-09-13 | 2018-08-21 | 必治妥美雅史谷比公司 | 結合至肌肉生長抑制素（ｍｙｏｓｔａｔｉｎ）以纖維連接蛋白爲主之支架結構域蛋白質 |
| EA201590719A1 (ru) | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US9994641B2 (en) * | 2013-12-25 | 2018-06-12 | Jcr Pharmaceuticals Co., Ltd. | Anti-human transferrin receptor antibody that passes through blood-brain barrier |
| HK1243940A1 (zh) | 2014-11-06 | 2018-07-27 | Scholar Rock, Inc. | 抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途 |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN104829728B (zh) * | 2015-01-21 | 2019-03-12 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体her2xcd3的构建及应用 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| EA201792184A1 (ru) | 2015-04-01 | 2018-04-30 | Анаптисбайо, Инк. | Антитела, направленные против т-клеточного иммуноглобулина и белка муцина 3 (tim-3) |
| WO2016168613A1 (en) * | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| LT3350220T (lt) | 2015-09-15 | 2021-09-27 | Scholar Rock, Inc. | Anti pro/latentinio miostatino antikūnai ir jų panaudojimas |
| TWI605057B (zh) | 2015-12-18 | 2017-11-11 | 中外製藥股份有限公司 | 抗肌抑素抗體、含變異ｆｃ區之多肽及使用方法 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| CN109069638B (zh) | 2016-03-24 | 2022-03-29 | 璟尚生物制药公司 | 用于癌症治疗的三特异性抑制剂 |
| AU2017283546C1 (en) | 2016-06-13 | 2020-11-19 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| KR102306744B1 (ko) | 2016-06-17 | 2021-09-28 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| CA2971303C (en) | 2016-06-21 | 2026-03-03 | Bamboo Therapeutics, Inc. | Optimized mini-dystrophin genes and expression cassettes and their use |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| SG11201903867YA (en) | 2016-11-01 | 2019-05-30 | Anaptysbio Inc | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| CN109071656B (zh) | 2017-01-05 | 2021-05-18 | 璟尚生物制药公司 | 检查点调节物拮抗剂 |
| ES2944357T3 (es) | 2017-01-06 | 2023-06-20 | Scholar Rock Inc | Tratamiento de enfermedades metabólicas inhibiendo la activación de miostatina |
| MX2019008208A (es) | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-tim-3. |
| WO2018156711A1 (en) * | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Il13ra2-binding chimeric antigen receptors |
| CN111787981B (zh) | 2018-03-01 | 2025-12-30 | 瑞泽恩制药公司 | 增加肌肉量和减少脂肪量的方法 |
| CN113101364B (zh) | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| CN112739717B (zh) | 2018-06-29 | 2025-02-11 | 璟尚生物制药公司 | 三特异性拮抗剂 |
| EP3990030A1 (en) | 2019-06-27 | 2022-05-04 | Pfizer Inc. | Methods of treating duchenne muscular dystrophy using aav mini-dystrophin gene therapy |
| US10851157B2 (en) | 2019-07-01 | 2020-12-01 | Gensun Biopharma, Inc. | Antagonists targeting the TGF-β pathway |
| GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| EP4232071A4 (en) * | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| WO2022106976A1 (en) | 2020-11-18 | 2022-05-27 | Pfizer Inc. | Stable pharmaceutical formulations of soluble fgfr3 decoys |
| AU2022275666A1 (en) | 2021-05-19 | 2023-12-07 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| MX2023014840A (es) | 2021-06-23 | 2024-02-12 | Scholar Rock Inc | Un inhibidor de la vía de la miostatina en combinación con un activador de la vía de la glp-1 para su uso en el tratamiento de trastornos metabólicos. |
| US20250257131A1 (en) * | 2022-04-08 | 2025-08-14 | The Wistar Institute Of Anatomy And Biology | Bispecific T Cell Engagers Targeting Tumor Antigens |
| CN120187750A (zh) * | 2022-09-21 | 2025-06-20 | 瑞泽恩制药公司 | 治疗肥胖、糖尿病和肝功能障碍的方法 |
| IL321628A (en) | 2022-12-22 | 2025-08-01 | Scholar Rock Inc | Selective and potent inhibitory antibodies for myostatin activation |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
| WO1990013327A1 (en) | 1989-04-28 | 1990-11-15 | Riker Laboratories, Inc. | Dry powder inhalation device |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| DE69424687T2 (de) | 1993-03-09 | 2000-09-07 | Genzyme Corp., Cambridge | Verfahren zur isolierung von proteinen aus milch |
| US6607884B1 (en) | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US6673534B1 (en) | 1995-10-26 | 2004-01-06 | The Johns Hopkins University School Of Medicine | Methods for detection of mutations in myostatin variants |
| DK0690873T3 (da) | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| US20030074680A1 (en) | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6465239B1 (en) | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US7332575B2 (en) | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
| US6046037A (en) | 1994-12-30 | 2000-04-04 | Hiatt; Andrew C. | Method for producing immunoglobulins containing protection proteins in plants and their use |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| SE9502800D0 (sv) | 1995-08-10 | 1995-08-10 | Astra Ab | Disposable inhaler |
| EP0869815A1 (en) | 1995-09-21 | 1998-10-14 | University Of Utah Research Foundation | Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| DE69841139D1 (de) | 1997-07-14 | 2009-10-22 | Univ Liege | Mutationen im myostatingen steigern muskelmasse in säugetieren |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
| US6372454B2 (en) | 1997-08-29 | 2002-04-16 | Human Genome Sciences, Inc. | Nucleic acid molecules encoding Follistatin-3 |
| WO1999024618A1 (en) | 1997-11-10 | 1999-05-20 | The Johns Hopkins University School Of Medicine | Methods for detection of mutations in myostatin variants |
| WO1999040181A1 (en) | 1998-02-05 | 1999-08-12 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| ES2330062T3 (es) * | 1998-05-06 | 2009-12-03 | Metamorphix, Inc. | Procedimientos para tratar la diabetes por inhibicion de gdf-8. |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| AU772694B2 (en) | 1999-01-21 | 2004-05-06 | Metamorphix International, Inc. | Growth differentiation factor inhibitors and uses therefor |
| US7056512B1 (en) | 1999-07-20 | 2006-06-06 | Pharmexa A/S | Method for down-regulating GDF-8 activity |
| AU1097301A (en) * | 1999-10-22 | 2001-05-08 | Scripps Research Institute, The | Humanization of non-human, mammalian antibodies |
| US7037501B2 (en) | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| CU23007A1 (es) | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| US20040058445A1 (en) | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| CA2476887A1 (en) | 2002-02-21 | 2003-09-04 | Wyeth | Gasp1:a follistatin domain containing protein |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| US20040110933A1 (en) * | 2002-09-13 | 2004-06-10 | Dyax Corporation | CD44-binding ligands |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| BRPI0410927A (pt) * | 2003-06-02 | 2006-06-27 | Wyeth Corp | métodos terapêuticos e profiláticos para distúrbios neuromusculares |
| ATE557042T1 (de) * | 2004-03-23 | 2012-05-15 | Lilly Co Eli | Anti-myostatin-antikörper |
| PE20100251A1 (es) * | 2004-09-10 | 2010-04-10 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina |
| AU2006232914A1 (en) | 2005-03-23 | 2006-10-12 | Wyeth | Detection of an immune response to GDF-8 modulating agents |
| CA2601667A1 (en) | 2005-03-23 | 2006-09-28 | Wyeth | Detection of gdf-8 modulating agents |
| NL1031674C2 (nl) * | 2005-04-25 | 2007-04-26 | Pfizer | Antilichamen tegen myostatine. |
| ES2534760T3 (es) * | 2005-08-19 | 2015-04-28 | Wyeth Llc | Anticuerpos antagonistas contra GDF-8 y sus usos en el tratamiento de ELA y otros trastornos asociados con GDF-8 |
| WO2008073598A2 (en) * | 2006-10-31 | 2008-06-19 | Immunogen, Inc. | Methods for improving antibody production |
| PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| EP2861617A1 (en) * | 2012-06-15 | 2015-04-22 | Pfizer Inc. | Improved antagonist antibodies against gdf-8 and uses therefor |
-
2013
- 2013-06-12 EP EP13744828.8A patent/EP2861617A1/en not_active Withdrawn
- 2013-06-12 MX MX2014014995A patent/MX364738B/es active IP Right Grant
- 2013-06-12 CN CN201380030753.0A patent/CN104487453B/zh not_active Expired - Fee Related
- 2013-06-12 US US13/916,379 patent/US8992913B2/en not_active Expired - Fee Related
- 2013-06-12 SG SG11201408042YA patent/SG11201408042YA/en unknown
- 2013-06-12 MY MYPI2014703762A patent/MY177331A/en unknown
- 2013-06-12 CA CA2876397A patent/CA2876397C/en not_active Expired - Fee Related
- 2013-06-12 KR KR1020147034989A patent/KR101704893B1/ko not_active Expired - Fee Related
- 2013-06-12 JP JP2015516728A patent/JP6433889B2/ja not_active Expired - Fee Related
- 2013-06-12 AU AU2013276131A patent/AU2013276131B2/en not_active Ceased
- 2013-06-12 NZ NZ702269A patent/NZ702269A/en not_active IP Right Cessation
- 2013-06-12 PE PE2014002435A patent/PE20150223A1/es active IP Right Grant
- 2013-06-12 SA SA113340642A patent/SA113340642B1/ar unknown
- 2013-06-12 RU RU2014150433A patent/RU2630634C2/ru active
- 2013-06-12 WO PCT/IB2013/054810 patent/WO2013186719A1/en not_active Ceased
- 2013-06-14 AR ARP130102122A patent/AR093217A1/es unknown
- 2013-06-14 TW TW102121200A patent/TWI495643B/zh not_active IP Right Cessation
-
2014
- 2014-11-27 CO CO14261553A patent/CO7151524A2/es unknown
- 2014-12-03 PH PH12014502698A patent/PH12014502698B1/en unknown
- 2014-12-15 IL IL236289A patent/IL236289A0/en active IP Right Grant
-
2015
- 2015-02-19 US US14/626,321 patent/US9751937B2/en not_active Expired - Fee Related
-
2017
- 2017-08-01 US US15/666,317 patent/US20180057579A1/en not_active Abandoned
-
2018
- 2018-11-07 JP JP2018209932A patent/JP2019059738A/ja active Pending
-
2019
- 2019-11-13 US US16/682,437 patent/US20200277365A1/en not_active Abandoned
-
2020
- 2020-07-21 JP JP2020124373A patent/JP2021001170A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015521466A5 (https=) | ||
| RU2014150433A (ru) | Улучшенные антитела антагонисты против gdf-8 и их применения | |
| JP2019201643A5 (https=) | ||
| JP2017052784A5 (https=) | ||
| RU2015136078A (ru) | Антитело против с5 и способ предупреждения и лечения обусловленных комплементом заболеваний | |
| FI3322727T3 (fi) | Humanisoituja tai kimeerisiä CD3-vasta-aineita | |
| JP2018183173A5 (https=) | ||
| JP2014511179A5 (https=) | ||
| HRP20220405T1 (hr) | Protutijela protiv ngf i njihova upotreba | |
| IL261666B1 (en) | Binding proteins and methods of use thereof | |
| JP2018512138A5 (https=) | ||
| HRP20170568T1 (hr) | Protutijela anti-ox40 i postupci za njihovu uporabu | |
| JP2019530427A5 (https=) | ||
| NZ597996A (en) | Antibodies against human respiratory syncytial virus (rsv) and methods of use | |
| HRP20220787T1 (hr) | Protutijela protiv garp-tgf-beta | |
| HRP20210892T1 (hr) | Terapijska uporaba specifičnog liganda u bolestima povezanim s msrv | |
| PE20120835A1 (es) | Anticuerpos anti-tnf-alfa y sus usos | |
| JP2017535257A5 (https=) | ||
| RU2017126476A (ru) | Новые модуляторы и способы их применения | |
| JP2016529882A5 (https=) | ||
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2015525795A5 (https=) | ||
| RU2017134495A (ru) | Антитела к альфа-рецептору собачьего интерлейкина-4 | |
| EP2377555A3 (en) | Antibodies against vascular endothelial growth factor receptor-1 | |
| JP2014519334A5 (https=) |