JP2015521466A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015521466A5 JP2015521466A5 JP2015516728A JP2015516728A JP2015521466A5 JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5 JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015516728 A JP2015516728 A JP 2015516728A JP 2015521466 A5 JP2015521466 A5 JP 2015521466A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- region
- fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660232P | 2012-06-15 | 2012-06-15 | |
| US61/660,232 | 2012-06-15 | ||
| PCT/IB2013/054810 WO2013186719A1 (en) | 2012-06-15 | 2013-06-12 | Improved antagonist antibodies against gdf-8 and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Division JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521466A JP2015521466A (ja) | 2015-07-30 |
| JP2015521466A5 true JP2015521466A5 (https=) | 2016-07-28 |
| JP6433889B2 JP6433889B2 (ja) | 2018-12-05 |
Family
ID=48914383
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516728A Expired - Fee Related JP6433889B2 (ja) | 2012-06-15 | 2013-06-12 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209932A Pending JP2019059738A (ja) | 2012-06-15 | 2018-11-07 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| JP2020124373A Withdrawn JP2021001170A (ja) | 2012-06-15 | 2020-07-21 | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8992913B2 (https=) |
| EP (1) | EP2861617A1 (https=) |
| JP (3) | JP6433889B2 (https=) |
| KR (1) | KR101704893B1 (https=) |
| CN (1) | CN104487453B (https=) |
| AR (1) | AR093217A1 (https=) |
| AU (1) | AU2013276131B2 (https=) |
| CA (1) | CA2876397C (https=) |
| CO (1) | CO7151524A2 (https=) |
| IL (1) | IL236289A0 (https=) |
| MX (1) | MX364738B (https=) |
| MY (1) | MY177331A (https=) |
| NZ (1) | NZ702269A (https=) |
| PE (1) | PE20150223A1 (https=) |
| PH (1) | PH12014502698A1 (https=) |
| RU (1) | RU2630634C2 (https=) |
| SA (1) | SA113340642B1 (https=) |
| SG (1) | SG11201408042YA (https=) |
| TW (1) | TWI495643B (https=) |
| WO (1) | WO2013186719A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| DK2780368T3 (en) | 2011-11-14 | 2018-02-05 | Regeneron Pharma | COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A |
| KR101704893B1 (ko) * | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| ES2984405T3 (es) | 2012-09-13 | 2024-10-29 | Bristol Myers Squibb Co | Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina |
| ES2715710T3 (es) | 2013-01-25 | 2019-06-05 | Shire Human Genetic Therapies | Folistatina en el tratamiento de la distrofía muscular de Duchenne |
| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
| RS61778B1 (sr) | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| EP3088518A4 (en) * | 2013-12-25 | 2017-09-20 | JCR Pharmaceuticals Co., Ltd. | Novel anti-transferrin receptor antibody that passes through blood-brain barrier |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN104829728B (zh) * | 2015-01-21 | 2019-03-12 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体her2xcd3的构建及应用 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| FI3277321T3 (fi) | 2015-04-01 | 2024-10-31 | Anaptysbio Inc | T-soluimmunoglobuliinia ja musiiniproteiini 3:a (tim-3) vastaan suunnattuja vasta-aineita |
| KR20170135967A (ko) | 2015-04-15 | 2017-12-08 | 리제너론 파마슈티칼스 인코포레이티드 | Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법 |
| HRP20211081T1 (hr) | 2015-09-15 | 2021-10-15 | Scholar Rock, Inc. | Anti-pro/latentna miostatinska protutijela i njihove uporabe |
| AR107078A1 (es) | 2015-12-18 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Anticuerpo antimiostatina, polipéptidos que contienen regiones fc variantes así como métodos de uso |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| US10894823B2 (en) | 2016-03-24 | 2021-01-19 | Gensun Biopharma Inc. | Trispecific inhibitors for cancer treatment |
| NZ789269A (en) | 2016-06-13 | 2026-01-30 | Scholar Rock Inc | Use of myostatin inhibitors and combination therapies |
| KR102376582B1 (ko) | 2016-06-17 | 2022-03-18 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| CA2971303C (en) | 2016-06-21 | 2026-03-03 | Bamboo Therapeutics, Inc. | Optimized mini-dystrophin genes and expression cassettes and their use |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| MX2019005116A (es) | 2016-11-01 | 2019-11-12 | Anaptysbio Inc | Anticuerpos dirigidos contra la proteina de inmunoglobulina de linfocitos t y de mucina 3 (tim-3). |
| WO2018128939A1 (en) * | 2017-01-05 | 2018-07-12 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| EP4218817A3 (en) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
| WO2018129553A1 (en) | 2017-01-09 | 2018-07-12 | Tesaro, Inc. | Methods of treating cancer with anti-tim-3 antibodies |
| US12083148B2 (en) | 2017-02-22 | 2024-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | IL13Ra2-binding chimeric antigen receptors |
| MX2020008991A (es) | 2018-03-01 | 2020-12-10 | Regeneron Pharma | Metodos para alterar la composicion corporal. |
| CN110540590B (zh) * | 2018-05-29 | 2023-08-18 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制物的开发和应用 |
| US10597453B2 (en) | 2018-06-29 | 2020-03-24 | Gensun Biopharma, Inc. | Antitumor immune checkpoint regulator antagonists |
| EP3990030A1 (en) | 2019-06-27 | 2022-05-04 | Pfizer Inc. | Methods of treating duchenne muscular dystrophy using aav mini-dystrophin gene therapy |
| CN114340735B (zh) | 2019-06-28 | 2024-11-12 | 璟尚生物制药公司 | 突变的TGFβ1-RII胞外域和免疫球蛋白支架组成的抗肿瘤拮抗剂 |
| GB2595299B (en) | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| KR20230112632A (ko) | 2020-10-23 | 2023-07-27 | 애셔 바이오테라퓨틱스, 인크. | 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합 |
| WO2022106976A1 (en) | 2020-11-18 | 2022-05-27 | Pfizer Inc. | Stable pharmaceutical formulations of soluble fgfr3 decoys |
| IL308609A (en) | 2021-05-19 | 2024-01-01 | Asher Biotherapeutics Inc | IL-21 polypeptides and target constructs |
| CA3221555A1 (en) | 2021-06-23 | 2022-12-29 | Kimberly LONG | A myostatin pathway inhibitor in combination with a glp-1 pathway activator for use in treating metabolic disorders |
| US20250257131A1 (en) * | 2022-04-08 | 2025-08-14 | The Wistar Institute Of Anatomy And Biology | Bispecific T Cell Engagers Targeting Tumor Antigens |
| WO2024064842A1 (en) * | 2022-09-21 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating obesity, diabetes, and liver dysfunction |
| EP4638496A1 (en) | 2022-12-22 | 2025-10-29 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
| CA2058764A1 (en) | 1989-04-28 | 1990-10-29 | Peter D. Hodson | Dry powder inhalation device |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| WO1994019935A1 (en) | 1993-03-09 | 1994-09-15 | Genzyme Corporation | Isolation of components of interest from milk |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US6607884B1 (en) | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| US6673534B1 (en) | 1995-10-26 | 2004-01-06 | The Johns Hopkins University School Of Medicine | Methods for detection of mutations in myostatin variants |
| DK0690873T3 (da) | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| US6465239B1 (en) | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| US20030074680A1 (en) | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US7332575B2 (en) | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
| US6046037A (en) | 1994-12-30 | 2000-04-04 | Hiatt; Andrew C. | Method for producing immunoglobulins containing protection proteins in plants and their use |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| SE9502800D0 (sv) | 1995-08-10 | 1995-08-10 | Astra Ab | Disposable inhaler |
| CA2232834A1 (en) | 1995-09-21 | 1997-03-27 | University Of Utah | Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells |
| AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| AU756620B2 (en) | 1997-07-14 | 2003-01-16 | University Of Liege | Mutations in the myostation gene cause double-muscling in mammals |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
| JP2001513982A (ja) | 1997-08-29 | 2001-09-11 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | フォリスタチン−３ |
| AU1390999A (en) | 1997-11-10 | 1999-05-31 | Johns Hopkins University School Of Medicine, The | Methods for detection of mutations in myostatin variants |
| CA2319703C (en) | 1998-02-05 | 2005-09-20 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| JP4544742B2 (ja) | 1998-05-06 | 2010-09-15 | メタモーフイクス・インコーポレーテツド | Ｇｄｆ−８の阻害による糖尿病の処置法 |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| MXPA01007366A (es) | 1999-01-21 | 2002-06-04 | Metamorphix Inc | Inhibidores de factores de crecimiento y diferenciacion y usos de los mismos. |
| TR200400621T2 (tr) | 1999-07-20 | 2004-08-23 | Pharmexa A/S | GDF-8 aktivitesinin aşağı doğru düzenlenmesi için bir yöntem. |
| AU1102401A (en) * | 1999-10-22 | 2001-05-08 | Ludwig Institute For Cancer Research | Methods for reducing the effects of cancers that express a33 antigen using a33 antigen specific immunoglobulin products |
| US7037501B2 (en) | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| CU23007A1 (es) | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| US20040058445A1 (en) | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| EP1572909A4 (en) | 2002-02-21 | 2007-06-06 | Wyeth Corp | PROTEIN CONTAINING A DOMAINE OF FOLLISTATIN |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| US20040110933A1 (en) * | 2002-09-13 | 2004-06-10 | Dyax Corporation | CD44-binding ligands |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| RU2322261C2 (ru) | 2003-06-02 | 2008-04-20 | Уайт | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний |
| ATE557042T1 (de) * | 2004-03-23 | 2012-05-15 | Lilly Co Eli | Anti-myostatin-antikörper |
| SV2007002227A (es) * | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
| EP1864138A2 (en) | 2005-03-23 | 2007-12-12 | Wyeth | Detection of gdf-8 modulating agents |
| JP2008537777A (ja) | 2005-03-23 | 2008-09-25 | ワイス | Ｇｄｆ−８調節剤に対する免疫応答の検出 |
| EP1877075A4 (en) * | 2005-04-25 | 2008-07-30 | Pfizer | ANTIBODY TO MYOSTATIN |
| PL2407486T3 (pl) | 2005-08-19 | 2018-05-30 | Wyeth Llc | Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8 |
| CN101535332A (zh) * | 2006-10-31 | 2009-09-16 | 免疫基因公司 | 用于提高抗体产量的方法 |
| PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| KR101704893B1 (ko) * | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
-
2013
- 2013-06-12 KR KR1020147034989A patent/KR101704893B1/ko not_active Expired - Fee Related
- 2013-06-12 RU RU2014150433A patent/RU2630634C2/ru active
- 2013-06-12 NZ NZ702269A patent/NZ702269A/en not_active IP Right Cessation
- 2013-06-12 JP JP2015516728A patent/JP6433889B2/ja not_active Expired - Fee Related
- 2013-06-12 CA CA2876397A patent/CA2876397C/en not_active Expired - Fee Related
- 2013-06-12 SA SA113340642A patent/SA113340642B1/ar unknown
- 2013-06-12 EP EP13744828.8A patent/EP2861617A1/en not_active Withdrawn
- 2013-06-12 US US13/916,379 patent/US8992913B2/en not_active Expired - Fee Related
- 2013-06-12 CN CN201380030753.0A patent/CN104487453B/zh not_active Expired - Fee Related
- 2013-06-12 MY MYPI2014703762A patent/MY177331A/en unknown
- 2013-06-12 AU AU2013276131A patent/AU2013276131B2/en not_active Ceased
- 2013-06-12 PE PE2014002435A patent/PE20150223A1/es active IP Right Grant
- 2013-06-12 MX MX2014014995A patent/MX364738B/es active IP Right Grant
- 2013-06-12 SG SG11201408042YA patent/SG11201408042YA/en unknown
- 2013-06-12 WO PCT/IB2013/054810 patent/WO2013186719A1/en not_active Ceased
- 2013-06-14 AR ARP130102122A patent/AR093217A1/es unknown
- 2013-06-14 TW TW102121200A patent/TWI495643B/zh not_active IP Right Cessation
-
2014
- 2014-11-27 CO CO14261553A patent/CO7151524A2/es unknown
- 2014-12-03 PH PH12014502698A patent/PH12014502698A1/en unknown
- 2014-12-15 IL IL236289A patent/IL236289A0/en active IP Right Grant
-
2015
- 2015-02-19 US US14/626,321 patent/US9751937B2/en not_active Expired - Fee Related
-
2017
- 2017-08-01 US US15/666,317 patent/US20180057579A1/en not_active Abandoned
-
2018
- 2018-11-07 JP JP2018209932A patent/JP2019059738A/ja active Pending
-
2019
- 2019-11-13 US US16/682,437 patent/US20200277365A1/en not_active Abandoned
-
2020
- 2020-07-21 JP JP2020124373A patent/JP2021001170A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015521466A5 (https=) | ||
| RU2014150433A (ru) | Улучшенные антитела антагонисты против gdf-8 и их применения | |
| ME02678B (me) | Antitijela na ox-40 i postupci njihove primjene | |
| JP2019201643A5 (https=) | ||
| JP2017052784A5 (https=) | ||
| JP2017507652A5 (https=) | ||
| RU2015136078A (ru) | Антитело против с5 и способ предупреждения и лечения обусловленных комплементом заболеваний | |
| FI3322727T3 (fi) | Humanisoituja tai kimeerisiä CD3-vasta-aineita | |
| JP2018183173A5 (https=) | ||
| JP2014511179A5 (https=) | ||
| HRP20220405T1 (hr) | Protutijela protiv ngf i njihova upotreba | |
| IL261666B1 (en) | Binding proteins and methods of use thereof | |
| JP2020519308A5 (https=) | ||
| JP2019530427A5 (https=) | ||
| HRP20220787T1 (hr) | Protutijela protiv garp-tgf-beta | |
| HRP20210892T1 (hr) | Terapijska uporaba specifičnog liganda u bolestima povezanim s msrv | |
| PE20120835A1 (es) | Anticuerpos anti-tnf-alfa y sus usos | |
| JP2017535257A5 (https=) | ||
| RU2017126476A (ru) | Новые модуляторы и способы их применения | |
| JP2016529882A5 (https=) | ||
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2015525795A5 (https=) | ||
| EP2377555A3 (en) | Antibodies against vascular endothelial growth factor receptor-1 | |
| JP2014519334A5 (https=) | ||
| JP2020514277A5 (https=) |