JP2015519403A - 活性剤送達のための粘膜付着性デバイス - Google Patents

活性剤送達のための粘膜付着性デバイス Download PDF

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Publication number
JP2015519403A
JP2015519403A JP2015517461A JP2015517461A JP2015519403A JP 2015519403 A JP2015519403 A JP 2015519403A JP 2015517461 A JP2015517461 A JP 2015517461A JP 2015517461 A JP2015517461 A JP 2015517461A JP 2015519403 A JP2015519403 A JP 2015519403A
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JP
Japan
Prior art keywords
release
active agent
mucoadhesive
layer
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015517461A
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English (en)
Japanese (ja)
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JP2015519403A5 (enExample
Inventor
ハリス，バルック，ゼット．
マーシー，ビジャイ，エム．，ケイ．
スタインバーグ，デービッド，アダム
パールマン，ロドニー
ローゼン，ハワード，ブライアン
ランガー，ロバート，サミュエル
バラシュ，ヒラ，エプスタイン
ベール，ジョナサン，ロバート
ミトラゴトリ，サミル，スレシュ
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University of California
University of California Berkeley
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University of California San Diego UCSD
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Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of JP2015519403A publication Critical patent/JP2015519403A/ja
Publication of JP2015519403A5 publication Critical patent/JP2015519403A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Adhesive Tapes (AREA)
JP2015517461A 2012-06-14 2013-06-14 活性剤送達のための粘膜付着性デバイス Pending JP2015519403A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261659784P 2012-06-14 2012-06-14
US201261659781P 2012-06-14 2012-06-14
US61/659,784 2012-06-14
US61/659,781 2012-06-14
US201261671287P 2012-07-13 2012-07-13
US61/671,287 2012-07-13
PCT/US2013/045976 WO2013188819A2 (en) 2012-06-14 2013-06-14 Mucoadhesive devices for delivery of active agents

Publications (2)

Publication Number Publication Date
JP2015519403A true JP2015519403A (ja) 2015-07-09
JP2015519403A5 JP2015519403A5 (enExample) 2016-07-14

Family

ID=48748504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015517461A Pending JP2015519403A (ja) 2012-06-14 2013-06-14 活性剤送達のための粘膜付着性デバイス

Country Status (5)

Country Link
US (4) US20150174076A1 (enExample)
EP (1) EP2861220A2 (enExample)
JP (1) JP2015519403A (enExample)
CA (1) CA2915358A1 (enExample)
WO (1) WO2013188819A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019004088A1 (ja) * 2017-06-27 2019-01-03 株式会社バイオセレンタック 粘膜付着性経口製剤
JP2019505535A (ja) * 2016-02-05 2019-02-28 エントレガ，インコーポレイテッド 活性剤の送達のための乾燥剤を含む経口製剤

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PL3191083T3 (pl) * 2014-09-11 2021-07-12 Gelita Ag Cząstki żelatyny/pektyny
ES2630106T3 (es) 2014-10-07 2017-08-18 Cyprumed Gmbh Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos
AU2016335287A1 (en) 2015-10-07 2018-04-12 Cyprumed Gmbh Pharmaceutical formulations for the oral delivery of peptide drugs
CA3015172A1 (en) 2016-02-18 2017-08-24 Privo Technologies, Inc. Two-stage microparticle-based therapeutic delivery system and method
ITUA20161822A1 (it) * 2016-03-18 2017-09-18 Indena Spa Composizioni utili nella prevenzione e/o nel trattamento di patologie del cavo orale, delle prime vie aeree e dell’esofago
WO2018065634A1 (en) 2016-10-07 2018-04-12 Cyprumed Gmbh Pharmaceutical compositions for the nasal delivery of peptide or protein drugs
KR102592782B1 (ko) 2017-01-23 2023-10-20 에이에프와이엑스 테라퓨틱스 에스에이 전기방사 섬유에 기반한 2층 제품의 제조 방법
WO2018151849A1 (en) * 2017-02-17 2018-08-23 Privo Technologies, Inc. Particle-based multi-layer therapeutic delivery device and method
US10478403B1 (en) 2017-05-03 2019-11-19 Privo Technologies, Inc. Intraoperative topically-applied non-implantable rapid release patch
JP7045397B2 (ja) 2017-05-17 2022-03-31 マサチューセッツ インスティテュート オブ テクノロジー 自己復元システムおよび関連構成要素
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
EP3773475A1 (en) 2018-04-06 2021-02-17 Cyprumed GmbH Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins
AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN114340615A (zh) * 2019-08-12 2022-04-12 麻省理工学院 用于施用治疗剂的制品和方法
US11793980B2 (en) 2019-08-31 2023-10-24 Celero Systems, Inc. Intestinal attachment device
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
CN116419750A (zh) 2020-09-07 2023-07-11 西普鲁梅有限公司 改进的glp-1受体激动剂的药物制剂
AU2022241157A1 (en) 2021-03-15 2023-09-07 Epitomee Medical Ltd. Expandable devices for delivery of active agents to tissues
CN119156221A (zh) 2022-03-03 2024-12-17 西普鲁梅有限公司 治疗性肽和蛋白质的改进的口服药物制剂
WO2024062466A1 (en) 2022-09-21 2024-03-28 Epitomee Medical Ltd. Controllably disintegrable self-expandable ingestible devices

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPS56100714A (en) * 1980-01-16 1981-08-12 Teijin Ltd Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
JPH11513982A (ja) * 1995-10-23 1999-11-30 セラテック・インコーポレーテッド グルカゴン様インシュリン分泌性ペプチドの経頬送達
US20030017195A1 (en) * 2001-07-20 2003-01-23 Samir Mitragotri Method for oral drug delivery
WO2012068147A1 (en) * 2010-11-15 2012-05-24 The Ohio State University Research Foundation Controlled release mucoadhesive systems

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US6159497A (en) * 1998-10-30 2000-12-12 Noven Pharmaceuticals, Inc. Patch applicator
EP1478618A1 (en) * 2002-02-07 2004-11-24 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
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WO2007125545A2 (en) * 2006-05-02 2007-11-08 Panacea Biotec Ltd Transmucosal composition
JP5005422B2 (ja) * 2007-05-09 2012-08-22 株式会社エンプラス 射出成形ギヤ
EP2694004B1 (en) * 2011-04-04 2015-06-10 Coloplast A/S An adhesive patch

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56100714A (en) * 1980-01-16 1981-08-12 Teijin Ltd Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
JPH11513982A (ja) * 1995-10-23 1999-11-30 セラテック・インコーポレーテッド グルカゴン様インシュリン分泌性ペプチドの経頬送達
US20030017195A1 (en) * 2001-07-20 2003-01-23 Samir Mitragotri Method for oral drug delivery
WO2012068147A1 (en) * 2010-11-15 2012-05-24 The Ohio State University Research Foundation Controlled release mucoadhesive systems

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019505535A (ja) * 2016-02-05 2019-02-28 エントレガ，インコーポレイテッド 活性剤の送達のための乾燥剤を含む経口製剤
JP2021167316A (ja) * 2016-02-05 2021-10-21 エントレガ，インコーポレイテッド 活性剤の送達のための乾燥剤を含む経口製剤
JP2024016193A (ja) * 2016-02-05 2024-02-06 エントレガ，インコーポレイテッド 活性剤の送達のための乾燥剤を含む経口製剤
WO2019004088A1 (ja) * 2017-06-27 2019-01-03 株式会社バイオセレンタック 粘膜付着性経口製剤
JPWO2019004088A1 (ja) * 2017-06-27 2020-04-23 株式会社バイオセレンタック 粘膜付着性経口製剤
US11291629B2 (en) 2017-06-27 2022-04-05 Bioserentach Co., Ltd. Mucoadhesive oral preparation
JP7260913B2 (ja) 2017-06-27 2023-04-19 株式会社バイオセレンタック 粘膜付着性経口製剤

Also Published As

Publication number Publication date
CA2915358A1 (en) 2013-12-19
US20160101056A1 (en) 2016-04-14
US20150174076A1 (en) 2015-06-25
EP2861220A2 (en) 2015-04-22
WO2013188819A3 (en) 2014-02-06
WO2013188819A2 (en) 2013-12-19
US20170196800A1 (en) 2017-07-13
US20180098934A1 (en) 2018-04-12

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