JP2015519368A - シクロスポリンａ類似体 - Google Patents

シクロスポリンａ類似体 Download PDF

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Publication number
JP2015519368A
JP2015519368A JP2015515175A JP2015515175A JP2015519368A JP 2015519368 A JP2015519368 A JP 2015519368A JP 2015515175 A JP2015515175 A JP 2015515175A JP 2015515175 A JP2015515175 A JP 2015515175A JP 2015519368 A JP2015519368 A JP 2015519368A
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JP
Japan
Prior art keywords
methyl
compound
methylamino
cyclosporin
sar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2015515175A
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English (en)
Japanese (ja)
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JP2015519368A5 (https=
Inventor
サイモン エヌ ペティット
サイモン エヌ ペティット
アンドリュー ディー ジョーンズ
アンドリュー ディー ジョーンズ
キャサリン シモーネ ヴィ フライドライヒ
キャサリン シモーネ ヴィ フライドライヒ
ウィリアム アール カーリング
ウィリアム アール カーリング
ガースト　マイケル　イー
マイケル イー ガースト
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Allergan Inc
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Allergan Inc
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Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2015519368A publication Critical patent/JP2015519368A/ja
Publication of JP2015519368A5 publication Critical patent/JP2015519368A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015515175A 2012-06-01 2013-05-30 シクロスポリンａ類似体 Pending JP2015519368A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654388P 2012-06-01 2012-06-01
US61/654,388 2012-06-01
PCT/US2013/043266 WO2013181339A2 (en) 2012-06-01 2013-05-30 Cyclosporin a analogs

Publications (2)

Publication Number Publication Date
JP2015519368A true JP2015519368A (ja) 2015-07-09
JP2015519368A5 JP2015519368A5 (https=) 2016-07-28

Family

ID=48577956

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015515175A Pending JP2015519368A (ja) 2012-06-01 2013-05-30 シクロスポリンａ類似体

Country Status (8)

Country Link
US (2) US9266927B2 (https=)
EP (2) EP3263587A1 (https=)
JP (1) JP2015519368A (https=)
CN (1) CN104487449A (https=)
AU (1) AU2013267435B2 (https=)
CA (1) CA2874548A1 (https=)
TW (1) TW201408702A (https=)
WO (1) WO2013181339A2 (https=)

Families Citing this family (11)

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US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
WO2014138425A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10077289B2 (en) 2015-03-31 2018-09-18 Allergan, Inc. Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
US10738084B2 (en) 2015-06-30 2020-08-11 Sentry Therapeutics Limited Macrocycles
CN109476705B (zh) * 2016-05-17 2024-02-27 美国科技环球有限公司 新型环孢菌素衍生物及其用途
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2020163594A1 (en) 2019-02-07 2020-08-13 The Regents Of The University Of California Immunophilin binding agents and uses thereof
GB202007106D0 (en) * 2020-05-14 2020-07-01 Ucl Business Plc Cyclosporine analogues
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用

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Also Published As

Publication number Publication date
CA2874548A1 (en) 2013-12-05
WO2013181339A2 (en) 2013-12-05
TW201408702A (zh) 2014-03-01
AU2013267435B2 (en) 2017-11-09
US9266927B2 (en) 2016-02-23
WO2013181339A3 (en) 2014-03-13
US20130324480A1 (en) 2013-12-05
HK1208874A1 (en) 2016-03-18
CN104487449A (zh) 2015-04-01
EP3263587A1 (en) 2018-01-03
EP2855508A2 (en) 2015-04-08
US20160039880A1 (en) 2016-02-11
AU2013267435A1 (en) 2014-12-18
EP2855508B1 (en) 2018-02-14

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