CN104487449A - 环孢菌素a类似物 - Google Patents

环孢菌素a类似物 Download PDF

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Publication number
CN104487449A
CN104487449A CN201380038907.0A CN201380038907A CN104487449A CN 104487449 A CN104487449 A CN 104487449A CN 201380038907 A CN201380038907 A CN 201380038907A CN 104487449 A CN104487449 A CN 104487449A
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CN
China
Prior art keywords
methyl
methylamino
sar
compound
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380038907.0A
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English (en)
Chinese (zh)
Inventor
S·N·佩蒂特
A·D·琼斯
C·S·V·弗雷德里希
W·R·卡林
M·E·贾斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CN104487449A publication Critical patent/CN104487449A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380038907.0A 2012-06-01 2013-05-30 环孢菌素a类似物 Pending CN104487449A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654388P 2012-06-01 2012-06-01
US61/654,388 2012-06-01
PCT/US2013/043266 WO2013181339A2 (en) 2012-06-01 2013-05-30 Cyclosporin a analogs

Publications (1)

Publication Number Publication Date
CN104487449A true CN104487449A (zh) 2015-04-01

Family

ID=48577956

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380038907.0A Pending CN104487449A (zh) 2012-06-01 2013-05-30 环孢菌素a类似物

Country Status (8)

Country Link
US (2) US9266927B2 (https=)
EP (2) EP3263587A1 (https=)
JP (1) JP2015519368A (https=)
CN (1) CN104487449A (https=)
AU (1) AU2013267435B2 (https=)
CA (1) CA2874548A1 (https=)
TW (1) TW201408702A (https=)
WO (1) WO2013181339A2 (https=)

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US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10077289B2 (en) 2015-03-31 2018-09-18 Allergan, Inc. Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
US10738084B2 (en) 2015-06-30 2020-08-11 Sentry Therapeutics Limited Macrocycles
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WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2020163594A1 (en) 2019-02-07 2020-08-13 The Regents Of The University Of California Immunophilin binding agents and uses thereof
GB202007106D0 (en) * 2020-05-14 2020-07-01 Ucl Business Plc Cyclosporine analogues
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用

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Patent Citations (1)

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Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
CA2874548A1 (en) 2013-12-05
WO2013181339A2 (en) 2013-12-05
TW201408702A (zh) 2014-03-01
AU2013267435B2 (en) 2017-11-09
US9266927B2 (en) 2016-02-23
WO2013181339A3 (en) 2014-03-13
US20130324480A1 (en) 2013-12-05
HK1208874A1 (en) 2016-03-18
JP2015519368A (ja) 2015-07-09
EP3263587A1 (en) 2018-01-03
EP2855508A2 (en) 2015-04-08
US20160039880A1 (en) 2016-02-11
AU2013267435A1 (en) 2014-12-18
EP2855508B1 (en) 2018-02-14

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Application publication date: 20150401