JP2015519368A - シクロスポリンａ類似体 - Google Patents

シクロスポリンａ類似体 Download PDF

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Publication number
JP2015519368A
JP2015519368A JP2015515175A JP2015515175A JP2015519368A JP 2015519368 A JP2015519368 A JP 2015519368A JP 2015515175 A JP2015515175 A JP 2015515175A JP 2015515175 A JP2015515175 A JP 2015515175A JP 2015519368 A JP2015519368 A JP 2015519368A
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JP
Japan
Prior art keywords
methyl
compound
methylamino
cyclosporin
sar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015515175A
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English (en)
Japanese (ja)
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JP2015519368A5 (enExample
Inventor
サイモン エヌ ペティット
サイモン エヌ ペティット
アンドリュー ディー ジョーンズ
アンドリュー ディー ジョーンズ
キャサリン シモーネ ヴィ フライドライヒ
キャサリン シモーネ ヴィ フライドライヒ
ウィリアム アール カーリング
ウィリアム アール カーリング
ガースト　マイケル　イー
マイケル イー ガースト
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Allergan Inc
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Allergan Inc
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Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2015519368A publication Critical patent/JP2015519368A/ja
Publication of JP2015519368A5 publication Critical patent/JP2015519368A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015515175A 2012-06-01 2013-05-30 シクロスポリンａ類似体 Pending JP2015519368A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654388P 2012-06-01 2012-06-01
US61/654,388 2012-06-01
PCT/US2013/043266 WO2013181339A2 (en) 2012-06-01 2013-05-30 Cyclosporin a analogs

Publications (2)

Publication Number Publication Date
JP2015519368A true JP2015519368A (ja) 2015-07-09
JP2015519368A5 JP2015519368A5 (enExample) 2016-07-28

Family

ID=48577956

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015515175A Pending JP2015519368A (ja) 2012-06-01 2013-05-30 シクロスポリンａ類似体

Country Status (8)

Country Link
US (2) US9266927B2 (enExample)
EP (2) EP3263587A1 (enExample)
JP (1) JP2015519368A (enExample)
CN (1) CN104487449A (enExample)
AU (1) AU2013267435B2 (enExample)
CA (1) CA2874548A1 (enExample)
TW (1) TW201408702A (enExample)
WO (1) WO2013181339A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
WO2014138359A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid antibiotic conjugates
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
EP3277704A1 (en) 2015-03-31 2018-02-07 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
CN108025039B (zh) * 2015-06-30 2022-07-29 西普拉里斯有限公司 新颖的大环化合物
AU2017267560B2 (en) * 2016-05-17 2022-03-24 S&T Global Inc. Novel cyclosporin derivatives and uses thereof
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
US12594275B2 (en) 2019-02-07 2026-04-07 The Regents Of The University Of California Immunophilin binding agents and uses thereof
GB202007106D0 (en) * 2020-05-14 2020-07-01 Ucl Business Plc Cyclosporine analogues
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541207A (ja) * 1999-04-13 2002-12-03 アラーガン・セイルズ・インコーポレイテッド シクロスポリンａ誘導体を使用する眼の処置
US20040157768A1 (en) * 2003-02-07 2004-08-12 Or Yat Sun Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
WO2011020596A2 (de) * 2009-08-17 2011-02-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Cyclosporinderivate
WO2011070364A1 (en) * 2009-12-09 2011-06-16 Scynexis, Inc. Novel cyclic peptides
JP2011529451A (ja) * 2008-07-30 2011-12-08 アイソテクニカ ファーマ インク． 非免疫抑制性シクロスポリン類似体分子

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4885276A (en) 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
US5227467A (en) 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US5214130A (en) 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
EP0569487A1 (en) 1991-01-31 1993-11-18 Abbott Laboratories Endothelin converting enzyme inhibitors
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
PT1150999E (pt) 1999-02-05 2006-10-31 Debiopharm Sa Derivados da ciclosporina em que a sequencia peptidica contem pelo menos um aminoacido nao natural do tipo pseudo-prolina e metodo para preparacao dos mesmos
NZ526622A (en) 2000-12-11 2006-07-28 Amgen Sf Llc CXCR3 antagonists
US6784156B2 (en) 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
US6809077B2 (en) * 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
HRP20070058B1 (hr) 2001-10-19 2014-05-23 Isotechnika Inc. Sinteza ciklosporinskih analoga
US20030165545A1 (en) 2002-01-30 2003-09-04 Allergan, Inc. Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
US20040110666A1 (en) 2002-12-04 2004-06-10 Or Yat Sun Cyclosporins for the treatment of immune disorders
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US20050277584A1 (en) 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
PT1802650E (pt) 2004-10-01 2011-12-30 Scynexis Inc Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7135455B2 (en) 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US8288348B2 (en) 2005-07-13 2012-10-16 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
EP3103468B1 (en) 2005-10-14 2020-07-15 Allergan, Inc. Prevention of drug-associated keratoconjunctivitis with a cyclosporin
US20070087962A1 (en) 2005-10-17 2007-04-19 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7655625B2 (en) 2006-02-13 2010-02-02 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en) 2006-03-03 2009-07-07 Allergan, Inc. Treatment with cyclosporin A
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US20070232532A1 (en) 2006-03-28 2007-10-04 Amr Technology, Inc. Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders
CA2652662C (en) 2006-05-19 2015-11-03 Scynexis, Inc. Methods for the treatment and prevention of ocular disorders
US20080146497A1 (en) 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
US9561178B2 (en) 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
CN101687013A (zh) 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途
WO2008143996A1 (en) 2007-05-18 2008-11-27 Scynexis, Inc. New chemical processes
US20090306033A1 (en) 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
JP5820722B2 (ja) 2008-06-06 2015-11-24 スシネキス インク シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
US8716238B2 (en) 2008-07-10 2014-05-06 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
US8536114B2 (en) 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
JP2012514645A (ja) 2009-01-08 2012-06-28 アラーガン インコーポレイテッド 爪成長の増進用組成物
RU2492181C2 (ru) 2009-01-30 2013-09-10 Энанта Фармасьютикалс, Инк. Аналоги циклоспорина для предупреждения или лечения инфекции гепатита с
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US20110009339A1 (en) 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
WO2010127301A1 (en) 2009-05-01 2010-11-04 Allergan, Inc. Method of treating allergic conjunctivitis with cyclosporin compositions
JP2012528163A (ja) 2009-05-27 2012-11-12 アラーガン、インコーポレイテッド 炎症性疾患および状態を処置するためのシクロスポリン誘導体
US20100305047A1 (en) 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8405658B2 (en) 2009-09-14 2013-03-26 Autodesk, Inc. Estimation of light color and direction for augmented reality applications
EP3078385A1 (en) 2010-05-25 2016-10-12 Allergan, Inc. Cyclosporin emulsions
US9217015B2 (en) 2010-07-16 2015-12-22 S&T Global Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
AU2011316690C1 (en) 2010-10-12 2017-01-19 Allergan, Inc. Cyclosporin analogs
EP2627663B1 (en) 2010-10-12 2018-02-21 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
MX350746B (es) 2010-12-03 2017-09-14 Hebei Kunxiangjishi Pharmaceutical Tech Co Ltd Derivados de ciclosporina novedosos para el tratamiento y la prevención de una infección viral.
AU2011342284C1 (en) * 2010-12-15 2017-07-13 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
AU2012209184B2 (en) 2011-01-26 2017-06-15 Allergan, Inc. Androgen composition for treating an opthalmic condition
UA113627C2 (xx) 2011-05-27 2017-02-27 Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
CN103987370A (zh) 2011-10-05 2014-08-13 阿勒根公司 用于增进指甲健康的组合物
CN104039813B (zh) 2011-11-15 2017-08-29 阿勒根公司 环孢菌素a形式2及其制备方法
JP6363506B2 (ja) 2011-11-15 2018-07-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ２型の懸濁剤
KR102029513B1 (ko) 2011-11-15 2019-10-07 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형
CN108714137B (zh) 2011-11-15 2022-02-01 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
BR112015023669A2 (pt) 2013-03-15 2017-07-18 Yang Suizhou novos derivados de ciclosporina e suas utilizações

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541207A (ja) * 1999-04-13 2002-12-03 アラーガン・セイルズ・インコーポレイテッド シクロスポリンａ誘導体を使用する眼の処置
US20040157768A1 (en) * 2003-02-07 2004-08-12 Or Yat Sun Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
JP2011529451A (ja) * 2008-07-30 2011-12-08 アイソテクニカ ファーマ インク． 非免疫抑制性シクロスポリン類似体分子
WO2011020596A2 (de) * 2009-08-17 2011-02-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Cyclosporinderivate
WO2011070364A1 (en) * 2009-12-09 2011-06-16 Scynexis, Inc. Novel cyclic peptides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, JPN6017011429, 2008, pages 3995 - 3998, ISSN: 0003533477 *
CHEMBIOCHEM, vol. 6, JPN6017011436, 2005, pages 890 - 899, ISSN: 0003533481 *
INTERNATIONAL JOURNAL OF PEPTIDE & PROTEIN RESEARCH, vol. 31(2), JPN6017011428, 1988, pages 173 - 185, ISSN: 0003533476 *
ORGANIC LETTERS, vol. 4(12), JPN6017011426, 2002, pages 2051 - 2054, ISSN: 0003533475 *
ORGANIC LETTERS, vol. 5, no. 5, JPN6017011434, 2003, pages 693 - 696, ISSN: 0003533480 *
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, vol. 88, no. 3, JPN6017011433, 1995, pages 317 - 326, ISSN: 0003533479 *
SYNLETT, JPN6017011431, 2009, pages 2935 - 2938, ISSN: 0003533478 *

Also Published As

Publication number Publication date
CN104487449A (zh) 2015-04-01
US9266927B2 (en) 2016-02-23
EP3263587A1 (en) 2018-01-03
US20130324480A1 (en) 2013-12-05
EP2855508B1 (en) 2018-02-14
CA2874548A1 (en) 2013-12-05
WO2013181339A2 (en) 2013-12-05
HK1208874A1 (en) 2016-03-18
WO2013181339A3 (en) 2014-03-13
TW201408702A (zh) 2014-03-01
AU2013267435A1 (en) 2014-12-18
US20160039880A1 (en) 2016-02-11
AU2013267435B2 (en) 2017-11-09
EP2855508A2 (en) 2015-04-08

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