AU2013267435B2 - Cyclosporin A analogs - Google Patents

Cyclosporin A analogs Download PDF

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Publication number
AU2013267435B2
AU2013267435B2 AU2013267435A AU2013267435A AU2013267435B2 AU 2013267435 B2 AU2013267435 B2 AU 2013267435B2 AU 2013267435 A AU2013267435 A AU 2013267435A AU 2013267435 A AU2013267435 A AU 2013267435A AU 2013267435 B2 AU2013267435 B2 AU 2013267435B2
Authority
AU
Australia
Prior art keywords
methyl
compound
methylamino
cyclosporin
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013267435A
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English (en)
Other versions
AU2013267435A1 (en
Inventor
William R. Carling
Catherine Simone V. Frydrych
Michael E. Garst
Andrew D. Jones
Simon N. Pettit
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Allergan Inc
Original Assignee
Allergan Inc
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Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2013267435A1 publication Critical patent/AU2013267435A1/en
Application granted granted Critical
Publication of AU2013267435B2 publication Critical patent/AU2013267435B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013267435A 2012-06-01 2013-05-30 Cyclosporin A analogs Ceased AU2013267435B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654388P 2012-06-01 2012-06-01
US61/654,388 2012-06-01
PCT/US2013/043266 WO2013181339A2 (en) 2012-06-01 2013-05-30 Cyclosporin a analogs

Publications (2)

Publication Number Publication Date
AU2013267435A1 AU2013267435A1 (en) 2014-12-18
AU2013267435B2 true AU2013267435B2 (en) 2017-11-09

Family

ID=48577956

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013267435A Ceased AU2013267435B2 (en) 2012-06-01 2013-05-30 Cyclosporin A analogs

Country Status (8)

Country Link
US (2) US9266927B2 (enExample)
EP (2) EP2855508B1 (enExample)
JP (1) JP2015519368A (enExample)
CN (1) CN104487449A (enExample)
AU (1) AU2013267435B2 (enExample)
CA (1) CA2874548A1 (enExample)
TW (1) TW201408702A (enExample)
WO (1) WO2013181339A2 (enExample)

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WO2014138437A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid conjugates
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
WO2016160362A1 (en) 2015-03-31 2016-10-06 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
US10738084B2 (en) 2015-06-30 2020-08-11 Sentry Therapeutics Limited Macrocycles
CN118324867A (zh) * 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
IL278473A (en) 2020-11-03 2022-06-01 Yeda Res & Dev Methods for diagnosing and determining treatment in multiple myeloma
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
WO2012079172A1 (en) * 2010-12-15 2012-06-21 Isotechnika Pharma Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3

Also Published As

Publication number Publication date
JP2015519368A (ja) 2015-07-09
HK1208874A1 (en) 2016-03-18
EP2855508A2 (en) 2015-04-08
US20160039880A1 (en) 2016-02-11
US20130324480A1 (en) 2013-12-05
CA2874548A1 (en) 2013-12-05
CN104487449A (zh) 2015-04-01
EP2855508B1 (en) 2018-02-14
WO2013181339A3 (en) 2014-03-13
AU2013267435A1 (en) 2014-12-18
US9266927B2 (en) 2016-02-23
TW201408702A (zh) 2014-03-01
WO2013181339A2 (en) 2013-12-05
EP3263587A1 (en) 2018-01-03

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