JP2015518463A5 - - Google Patents
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- JP2015518463A5 JP2015518463A5 JP2014561310A JP2014561310A JP2015518463A5 JP 2015518463 A5 JP2015518463 A5 JP 2015518463A5 JP 2014561310 A JP2014561310 A JP 2014561310A JP 2014561310 A JP2014561310 A JP 2014561310A JP 2015518463 A5 JP2015518463 A5 JP 2015518463A5
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- Japan
- Prior art keywords
- unsaturated
- saturated
- bond
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- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12001803 | 2012-03-16 | ||
| EP12001803.1 | 2012-03-16 | ||
| PCT/EP2013/000698 WO2013135359A1 (en) | 2012-03-16 | 2013-03-11 | Targeting aminoacid lipids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018102256A Division JP2018141015A (ja) | 2012-03-16 | 2018-05-29 | 標的指向アミノ酸脂質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518463A JP2015518463A (ja) | 2015-07-02 |
| JP2015518463A5 true JP2015518463A5 (https=) | 2016-04-28 |
| JP6527331B2 JP6527331B2 (ja) | 2019-06-05 |
Family
ID=47901004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561310A Active JP6527331B2 (ja) | 2012-03-16 | 2013-03-11 | 標的指向アミノ酸脂質 |
| JP2018102256A Pending JP2018141015A (ja) | 2012-03-16 | 2018-05-29 | 標的指向アミノ酸脂質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018102256A Pending JP2018141015A (ja) | 2012-03-16 | 2018-05-29 | 標的指向アミノ酸脂質 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9878044B2 (https=) |
| EP (1) | EP2825156B1 (https=) |
| JP (2) | JP6527331B2 (https=) |
| KR (2) | KR102208586B1 (https=) |
| CN (1) | CN104168888A (https=) |
| AU (2) | AU2013231638B2 (https=) |
| BR (1) | BR112014022451B1 (https=) |
| CA (1) | CA2867169C (https=) |
| DK (1) | DK2825156T3 (https=) |
| ES (1) | ES2644778T3 (https=) |
| HK (1) | HK1198924A1 (https=) |
| IL (1) | IL234550A (https=) |
| MX (1) | MX354811B (https=) |
| NO (1) | NO2825156T3 (https=) |
| NZ (1) | NZ631034A (https=) |
| PT (1) | PT2825156T (https=) |
| RU (1) | RU2654210C2 (https=) |
| SG (2) | SG10201610401XA (https=) |
| TW (1) | TWI586370B (https=) |
| WO (1) | WO2013135359A1 (https=) |
| ZA (1) | ZA201407490B (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| DK2838515T3 (da) | 2012-04-16 | 2020-02-24 | Harvard College | Mesoporøse siliciumdioxidsammensætninger til modulering af immunresponser |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| BR112015032713B1 (pt) | 2013-09-17 | 2023-03-21 | Obi Pharma, Inc | Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| WO2016164705A1 (en) | 2015-04-10 | 2016-10-13 | Omar Abdel-Rahman Ali | Immune cell trapping devices and methods for making and using the same |
| US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| CN105505382B (zh) * | 2015-12-04 | 2017-06-27 | 安徽师范大学 | 一种铜纳米簇溶液的制备方法及应用 |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| US11752238B2 (en) | 2016-02-06 | 2023-09-12 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| BR112018070097A2 (pt) | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| KR20230110820A (ko) | 2016-04-22 | 2023-07-25 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법 |
| IL263079B2 (en) | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| CN109789092A (zh) * | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| CN110072545A (zh) | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性聚糖组合物及其用途 |
| US11643456B2 (en) | 2016-07-29 | 2023-05-09 | Obi Pharma, Inc. | Human antibodies, pharmaceutical compositions and methods |
| IL264557B2 (en) | 2016-08-02 | 2024-01-01 | Harvard College | Biological agents for regulating immune responses |
| EP4485466A3 (en) * | 2016-08-17 | 2025-04-02 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| WO2018035387A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2018038549A1 (ko) * | 2016-08-24 | 2018-03-01 | 울산대학교 산학협력단 | Dtbp를 이용한 미생물 농축 또는 핵산 추출 방법 |
| CN109996875B (zh) | 2016-08-24 | 2023-11-28 | 注入技术公司 | 使用dtbp浓缩微生物或提取核酸的方法 |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| TWI822055B (zh) | 2016-11-21 | 2023-11-11 | 台灣浩鼎生技股份有限公司 | 共軛生物分子、醫藥組成物及方法 |
| DE17829597T1 (de) * | 2016-11-30 | 2019-12-05 | Noxxon Pharma Ag | Verfahren zur polyalkoxylierung von nukleinsäuren zur rückgewinnung und wiederverwendung einer überschüssigen polyalkoxylierungsreagenz |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| AU2017438994A1 (en) * | 2017-11-09 | 2020-05-28 | Immunovaccine Technologies Inc. | Pharmaceutical compositions, methods for preparation comprising sizing of lipid vesicle particles, and uses thereof |
| TW202504930A (zh) | 2018-06-27 | 2025-02-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
| WO2020061367A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061295A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| CN113518923B (zh) | 2019-03-13 | 2025-01-24 | 默克专利股份公司 | 用于脂质化蛋白质结构的制备的方法 |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
| WO2021061837A1 (en) | 2019-09-23 | 2021-04-01 | President And Fellows Of Harvard College | Biomaterial-based antigen free vaccine and the use thereof |
| GB2613225B (en) * | 2020-03-04 | 2024-01-03 | Verve Therapeutics Inc | Compositions and methods for targeted RNA delivery |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| WO2023015223A2 (en) | 2021-08-03 | 2023-02-09 | Verve Therapeutics, Inc. | Compositions and methods for targeted rna delivery |
| CN118388586A (zh) * | 2024-04-15 | 2024-07-26 | 北京化工大学 | 一类基于氨基酸结构的脂质维生素及其合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55500053A (https=) | 1978-01-16 | 1980-01-31 | ||
| US4144034A (en) * | 1978-03-27 | 1979-03-13 | Texaco Inc. | Polyether-maleic anhydride reaction product containing motor fuel composition |
| EP0142010B1 (de) | 1983-11-10 | 1987-12-23 | Hoesch Aktiengesellschaft | Verfahren und Vorrichtung zum elektrolytischen Abscheiden von Metallen |
| US5512439A (en) | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6030954A (en) | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| IT1254135B (it) | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| CN1263473A (zh) | 1997-05-21 | 2000-08-16 | 利兰·斯坦福青年大学托管委员会 | 增加跨生物膜转运的组合物和方法 |
| JP5117648B2 (ja) * | 1999-04-20 | 2013-01-16 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | カチオン性ｐｅｇ脂質および使用方法。 |
| AU7404800A (en) | 1999-09-30 | 2001-04-30 | Novo Nordisk A/S | A method for preparing conjugates between an antigen and mucosal binding component |
| JP4678967B2 (ja) * | 2001-03-08 | 2011-04-27 | 本田技研工業株式会社 | ゲル化性有機化合物及びそれを用いるゲル |
| GB0106041D0 (en) * | 2001-03-12 | 2001-05-02 | Cancer Res Ventures Ltd | Lipids and liposomes |
| EP2415486B1 (en) | 2001-05-18 | 2017-02-22 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| JP5093547B2 (ja) * | 2001-08-24 | 2012-12-12 | 日本ケミカルリサーチ株式会社 | 両イオン性脂質およびその用途 |
| WO2003022910A1 (en) | 2001-09-08 | 2003-03-20 | Access Pharmaceuticals, Inc. | Synthesis and uses of polymer gel nanoparticle networks |
| EP1308167A1 (de) | 2001-11-06 | 2003-05-07 | Pickl, Winfried, Ao. Univ. Prof. Dr. | Antigenpräsentierende Vesikel |
| JP4331927B2 (ja) * | 2002-08-29 | 2009-09-16 | 協立化学産業株式会社 | 無機ナノ粒子−有機化合物複合体およびそれの一次元配列集積構造体 |
| AU2004248138B2 (en) * | 2003-05-29 | 2009-09-03 | The Scripps Research Institute | Targeted delivery to legumain-expressing cells |
| US20070292354A1 (en) | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| WO2007087341A2 (en) | 2006-01-25 | 2007-08-02 | The Board Of Trustees Of The University Of Illinois | Tolerogenic biodegradable artificial antigen presenting system |
| US20090285881A1 (en) * | 2008-04-16 | 2009-11-19 | Abbott Laboratories | Cationic lipids and uses thereof |
| WO2009129387A2 (en) * | 2008-04-16 | 2009-10-22 | Abbott Laboratories | Cationic lipids and uses thereof |
| US20100104629A1 (en) | 2008-04-16 | 2010-04-29 | Abbott Laboratories | Cationic lipids and uses thereof |
| RU2409587C2 (ru) * | 2009-03-04 | 2011-01-20 | Государственное образовательное учреждение высшего профессионального образования "Московская государственная академия тонкой химической технологии имени М.В. Ломоносова" | 1-гексадецил-5-(1-пиренбутил)-n-(l-орнитил)-l-глутамат бисхлорид |
| CN103179952B (zh) | 2010-09-02 | 2015-06-03 | 斯克里普斯研究学院 | 基于纳米颗粒的肿瘤靶向药物递送 |
| WO2012148891A1 (en) * | 2011-04-29 | 2012-11-01 | Evonik Degussa Corporation | Peptide-lipid conjugates and uses thereof |
| AU2013231819B2 (en) * | 2012-03-16 | 2017-07-20 | Merck Patent Gmbh | Aminoacid lipids |
-
2013
- 2013-03-11 AU AU2013231638A patent/AU2013231638B2/en active Active
- 2013-03-11 KR KR1020147028906A patent/KR102208586B1/ko active Active
- 2013-03-11 PT PT137102935T patent/PT2825156T/pt unknown
- 2013-03-11 SG SG10201610401XA patent/SG10201610401XA/en unknown
- 2013-03-11 RU RU2014141545A patent/RU2654210C2/ru active
- 2013-03-11 CN CN201380013774.1A patent/CN104168888A/zh active Pending
- 2013-03-11 JP JP2014561310A patent/JP6527331B2/ja active Active
- 2013-03-11 MX MX2014010808A patent/MX354811B/es active IP Right Grant
- 2013-03-11 NZ NZ631034A patent/NZ631034A/en unknown
- 2013-03-11 HK HK14112479.9A patent/HK1198924A1/xx unknown
- 2013-03-11 US US14/384,702 patent/US9878044B2/en active Active
- 2013-03-11 NO NO13710293A patent/NO2825156T3/no unknown
- 2013-03-11 SG SG11201405552VA patent/SG11201405552VA/en unknown
- 2013-03-11 EP EP13710293.5A patent/EP2825156B1/en active Active
- 2013-03-11 DK DK13710293.5T patent/DK2825156T3/en active
- 2013-03-11 BR BR112014022451-0A patent/BR112014022451B1/pt active IP Right Grant
- 2013-03-11 CA CA2867169A patent/CA2867169C/en active Active
- 2013-03-11 WO PCT/EP2013/000698 patent/WO2013135359A1/en not_active Ceased
- 2013-03-11 KR KR1020207008113A patent/KR20200036033A/ko not_active Ceased
- 2013-03-11 ES ES13710293.5T patent/ES2644778T3/es active Active
- 2013-03-15 TW TW102109381A patent/TWI586370B/zh active
-
2014
- 2014-09-09 IL IL234550A patent/IL234550A/en active IP Right Grant
- 2014-10-15 ZA ZA2014/07490A patent/ZA201407490B/en unknown
-
2018
- 2018-01-11 US US15/867,985 patent/US11510988B2/en active Active
- 2018-01-12 AU AU2018200293A patent/AU2018200293B2/en active Active
- 2018-05-29 JP JP2018102256A patent/JP2018141015A/ja active Pending
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