JP2015517577A5 - - Google Patents

Download PDF

Info

Publication number
JP2015517577A5
JP2015517577A5 JP2015514140A JP2015514140A JP2015517577A5 JP 2015517577 A5 JP2015517577 A5 JP 2015517577A5 JP 2015514140 A JP2015514140 A JP 2015514140A JP 2015514140 A JP2015514140 A JP 2015514140A JP 2015517577 A5 JP2015517577 A5 JP 2015517577A5
Authority
JP
Japan
Prior art keywords
aryl
het
nhr
cycloalkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015514140A
Other languages
English (en)
Japanese (ja)
Other versions
JP6653573B2 (ja
JP2015517577A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/042148 external-priority patent/WO2013177241A1/en
Publication of JP2015517577A publication Critical patent/JP2015517577A/ja
Publication of JP2015517577A5 publication Critical patent/JP2015517577A5/ja
Application granted granted Critical
Publication of JP6653573B2 publication Critical patent/JP6653573B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015514140A 2012-05-22 2013-05-22 シクロアルカニル[b]インドール、シクロアルカニル[b]ベンゾフラン、シクロアルカニル[b]ベンゾチオフェンを合成するための方法、化合物および使用の方法 Active JP6653573B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650039P 2012-05-22 2012-05-22
US61/650,039 2012-05-22
US201361757876P 2013-01-29 2013-01-29
US61/757,876 2013-01-29
PCT/US2013/042148 WO2013177241A1 (en) 2012-05-22 2013-05-22 Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2015517577A JP2015517577A (ja) 2015-06-22
JP2015517577A5 true JP2015517577A5 (enExample) 2016-07-07
JP6653573B2 JP6653573B2 (ja) 2020-02-26

Family

ID=49624309

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514140A Active JP6653573B2 (ja) 2012-05-22 2013-05-22 シクロアルカニル[b]インドール、シクロアルカニル[b]ベンゾフラン、シクロアルカニル[b]ベンゾチオフェンを合成するための方法、化合物および使用の方法

Country Status (4)

Country Link
US (1) US9598365B2 (enExample)
EP (1) EP2887804B1 (enExample)
JP (1) JP6653573B2 (enExample)
WO (1) WO2013177241A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016094688A1 (en) 2014-12-10 2016-06-16 Massachusetts Institute Of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
MX391259B (es) 2015-10-14 2025-03-21 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo.
EP3416950A1 (en) 2016-02-16 2018-12-26 Massachusetts Institute of Technology Max binders as myc modulators and uses thereof
HUE063848T2 (hu) 2016-10-26 2024-02-28 Constellation Pharmaceuticals Inc LSD1 gátlók és gyógyászati alkalmazásaik
WO2018129205A1 (en) * 2017-01-04 2018-07-12 The Trustees Of Dartmouth College Methods of inhibiting pcsk9
KR20230031322A (ko) 2020-06-27 2023-03-07 크레센타 바이오사이언시즈 세포 물질대사를 조정하는 화합물의 조성물 및 사용 방법
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds
CN120590310B (zh) * 2025-08-07 2025-10-28 昆明医科大学 一种吲哚-3-芳基酮衍生物及其制备方法和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3696118A (en) * 1970-04-22 1972-10-03 Marcel K Eberle SPIRO NORBORNANE 6,9-METHANOCYCLOHEPT(b)INDOLES
US3931288A (en) * 1972-03-13 1976-01-06 Hoffmann-La Roche Inc. Alkyl esters of 4-chlorophenoxy-4-oxo-cycloalkyl-carboxylic acid
US4755505A (en) * 1987-08-18 1988-07-05 American Home Products Corporation 1-[2-(dialkylamino)alkyl]-4,5-dihydro-4-(aryl)-1-benzazocine-2,6(1H,3H)-diones as anti-arrhythmic agents
AU3840000A (en) 1999-04-20 2000-11-02 Meiji Seika Kaisha Ltd. Tricyclic compounds
EP1330457B1 (en) * 2000-11-03 2004-10-20 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
WO2003097598A1 (en) 2002-05-16 2003-11-27 Shionogi & Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
WO2004063156A1 (en) 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2004069831A1 (en) * 2003-02-10 2004-08-19 Glenmark Pharmaceuticals Ltd. Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation
US7351733B2 (en) 2003-06-10 2008-04-01 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
WO2005023245A1 (en) 2003-08-26 2005-03-17 Smithkline Beecham Corporation Novel cycloalkyl’b! condensed indoles
WO2005094833A1 (en) 2004-03-31 2005-10-13 Council Of Scientific And Industrial Research Novel n-substituted dihydrobenzothiepino, dihydrobenzoxepino and tetrahydro benzocyclohepta indoles as selective estrogen receptor modulators
SI1796664T1 (sl) 2004-09-20 2014-02-28 Janssen Pharmaceutica N.V. Novi tetraciklični derivati, ki vsebujejo heteroatome, in so uporabni kot modulatorji receptorja spolnega steoidnega hormona
CN101072780B (zh) 2004-09-20 2010-06-23 詹森药业有限公司 用作类固醇性激素受体调节剂的新的含杂原子的四环衍生物
EP1817295B1 (en) 2004-11-18 2012-11-07 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
WO2006121466A2 (en) 2004-11-22 2006-11-16 Smithkline Beecham Corporation Hcv inhibitors
WO2006121467A2 (en) 2004-11-22 2006-11-16 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
RU2008108903A (ru) 2005-08-12 2009-09-20 Джинентех, Инк. (US) Пентациклический ингибитор киназы
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
CA2659425C (en) 2006-08-17 2017-06-20 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
BRPI0906245A2 (pt) 2008-03-24 2015-06-30 Medivation Technologies Inc Composto, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissor ou um distúrbio neuronal em indivíduo, uso de um composto, composição farmacêutica e kit
AR073701A1 (es) 2008-09-29 2010-11-24 Abbott Lab Derivados de indol y de indolicina, metodos para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades neurodegenerativas.
WO2010054382A1 (en) 2008-11-10 2010-05-14 Elixir Pharmaceuticals, Inc. Compounds, compositions, and methods for treating malaria or leishmaniasis
JP5497284B2 (ja) * 2008-12-08 2014-05-21 ユー・ディー・シー アイルランド リミテッド 白色有機電界発光素子
JP5913091B2 (ja) 2009-03-27 2016-04-27 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. C型肝炎ウイルス複製の阻害剤
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011044134A1 (en) 2009-10-05 2011-04-14 Albany Molecular Research, Inc. Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof
US8778959B2 (en) 2009-12-17 2014-07-15 Abbvie Inc. AZA-bridged ring-fused indoles and indolines
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
WO2012054526A2 (en) * 2010-10-19 2012-04-26 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies

Similar Documents

Publication Publication Date Title
JP2015517577A5 (enExample)
TWI767410B (zh) 作為lpa受體拮抗劑之三唑胺基甲酸酯吡啶基磺醯胺及其用途
RU2488584C2 (ru) Новые имидазолидиновые соединения как модуляторы андрогенных рецепторов
JP5260489B2 (ja) ベンズイミダゾール誘導体、及びgabaa受容体複合体をモジュレートするためのその使用
AU2016245278B2 (en) Process for the preparation of androgen receptor antagonists and intermediates thereof
JP6854386B2 (ja) リゾホスファチジン酸受容体1(lpar1)阻害剤化合物
JP5827407B2 (ja) 4−[5−(ピリジン−4−イル)−1h−1,2,4−トリアゾール−3−イル]ピリジン−2−カルボニトリルの製造方法および中間体
JP2020517707A5 (enExample)
JP2015181191A5 (enExample)
EP2960234A1 (en) Trk-INHIBITING COMPOUND
JP2010513494A5 (enExample)
AR074676A1 (es) Derivados de isooxazol como antagonistas de receptores de acido lisofosfatidico, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad fisiologica de lpa.
Zhou et al. Nucleophilic addition of tertiary propargylic amines to arynes followed by a [2, 3]-sigmatropic rearrangement
JP2019500322A (ja) Gpr84に対してアゴニスト作用を有する化合物及びその製造方法、並びに使用
JP2010537994A5 (enExample)
WO2019241796A1 (en) Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma
JP2011510026A5 (enExample)
TW200526646A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
JP2018009003A5 (enExample)
CA3247345A1 (en) Novel processes for preparation of soluble guanylate cyclase stimulators
JP2018523644A5 (enExample)
Wang et al. Synthesis, Characterization, and Reactivity of N-Acyl Chloroformamidines: Useful Building Blocks for the Construction of N-Acyl-Substituted 1, 1-Diaminoethylenes, Amidines, Ureas, and Thioureas
JP2012516899A5 (enExample)
Ning et al. Synthesis, structure and N–N bonding character of 1, 1-disubstituted indazolium hexafluorophosphate
JP2006176509A5 (enExample)