JP2012516899A5 - - Google Patents
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- JP2012516899A5 JP2012516899A5 JP2011549263A JP2011549263A JP2012516899A5 JP 2012516899 A5 JP2012516899 A5 JP 2012516899A5 JP 2011549263 A JP2011549263 A JP 2011549263A JP 2011549263 A JP2011549263 A JP 2011549263A JP 2012516899 A5 JP2012516899 A5 JP 2012516899A5
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- JP
- Japan
- Prior art keywords
- compound
- hydrogen
- halogen
- composition
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical group 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 230000001506 immunosuppresive effect Effects 0.000 claims description 3
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims description 2
- 206010062016 Immunosuppression Diseases 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 125000003700 epoxy group Chemical group 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- -1 hydroxyl compound Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15020709P | 2009-02-05 | 2009-02-05 | |
| US61/150,207 | 2009-02-05 | ||
| PCT/US2010/023220 WO2010091193A2 (en) | 2009-02-05 | 2010-02-04 | Triptolide c-ring derivatives as anticancer agents and immune modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516899A JP2012516899A (ja) | 2012-07-26 |
| JP2012516899A5 true JP2012516899A5 (enExample) | 2013-02-21 |
| JP5653939B2 JP5653939B2 (ja) | 2015-01-14 |
Family
ID=42542652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011549263A Expired - Fee Related JP5653939B2 (ja) | 2009-02-05 | 2010-02-04 | 抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8268882B2 (enExample) |
| EP (1) | EP2393818A4 (enExample) |
| JP (1) | JP5653939B2 (enExample) |
| CN (2) | CN104387406A (enExample) |
| AU (1) | AU2010210594B2 (enExample) |
| CA (1) | CA2750844A1 (enExample) |
| WO (1) | WO2010091193A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI480040B (zh) * | 2012-06-11 | 2015-04-11 | 高雄醫學大學 | 雷公藤甲素用於製備治療與運動神經元存活蛋白質表現相關之疾病的藥物的用途 |
| MX368417B (es) | 2012-08-23 | 2019-10-02 | Senestech Inc | Reduccion de la capacidad reproductiva de mamiferos. |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| AU7570191A (en) | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| EP0983275B1 (en) * | 1997-05-23 | 2002-08-28 | Aventis Pharmaceuticals Inc. | Novel triptolide derivatives useful in the treatment of autoimmune diseases |
| DE69932649T2 (de) * | 1998-09-02 | 2007-08-09 | Pharmagenesis, Inc., Palo Alto | Triptolid-Prodrugs mit hoher Wasserlöslichkeit |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| WO2002017931A1 (fr) | 2000-09-01 | 2002-03-07 | Xiaomin Wang | Utilisation d'un ou de plusieurs extraits de tripterygium wilfordii hook.f pour la preparation de medicaments destines a prevenir et a traiter des troubles du systeme nerveux |
| US6620843B2 (en) | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| JP4680589B2 (ja) * | 2002-05-31 | 2011-05-11 | ファーマジェネシス， インコーポレイテッド | アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体 |
| JP2004168713A (ja) * | 2002-11-20 | 2004-06-17 | St Marianna Univ School Of Medicine | アポトーシス誘導剤 |
| JP2006513209A (ja) * | 2002-12-17 | 2006-04-20 | ファーマジェネシス， インコーポレイテッド | 免疫調節因子および抗癌剤としてのトリプトライド誘導体 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| CN100408583C (zh) * | 2003-02-25 | 2008-08-06 | 美国泛华医药公司 | 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物 |
| WO2005020887A2 (en) | 2003-06-27 | 2005-03-10 | Pharmagenesis, Inc. | Method for treatment of severe acute respiratory syndrome |
| US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| ES2385716T3 (es) * | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| CN100374443C (zh) * | 2004-03-29 | 2008-03-12 | 北京键凯科技有限公司 | 亲水性聚合物-雷公藤提取物的结合物及其药物组合物 |
| WO2009023201A1 (en) * | 2007-08-16 | 2009-02-19 | Myelorx Llc | Rigid derivatives of triptolide as anticancer, immune suppressant, anti-fibrosis, and cns protectant agents |
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2010
- 2010-02-04 AU AU2010210594A patent/AU2010210594B2/en not_active Ceased
- 2010-02-04 JP JP2011549263A patent/JP5653939B2/ja not_active Expired - Fee Related
- 2010-02-04 EP EP10739131.0A patent/EP2393818A4/en not_active Withdrawn
- 2010-02-04 CN CN201410448310.XA patent/CN104387406A/zh active Pending
- 2010-02-04 US US13/147,587 patent/US8268882B2/en not_active Expired - Fee Related
- 2010-02-04 CA CA2750844A patent/CA2750844A1/en not_active Abandoned
- 2010-02-04 CN CN201080006751.4A patent/CN102307881B/zh not_active Expired - Fee Related
- 2010-02-04 WO PCT/US2010/023220 patent/WO2010091193A2/en not_active Ceased