JP2012516899A5 - - Google Patents
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- JP2012516899A5 JP2012516899A5 JP2011549263A JP2011549263A JP2012516899A5 JP 2012516899 A5 JP2012516899 A5 JP 2012516899A5 JP 2011549263 A JP2011549263 A JP 2011549263A JP 2011549263 A JP2011549263 A JP 2011549263A JP 2012516899 A5 JP2012516899 A5 JP 2012516899A5
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- JP
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- Prior art keywords
- compound
- hydrogen
- halogen
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical group 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 230000001506 immunosuppresive effect Effects 0.000 claims description 3
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims description 2
- 206010062016 Immunosuppression Diseases 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 125000003700 epoxy group Chemical group 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- -1 hydroxyl compound Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15020709P | 2009-02-05 | 2009-02-05 | |
| US61/150,207 | 2009-02-05 | ||
| PCT/US2010/023220 WO2010091193A2 (en) | 2009-02-05 | 2010-02-04 | Triptolide c-ring derivatives as anticancer agents and immune modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516899A JP2012516899A (ja) | 2012-07-26 |
| JP2012516899A5 true JP2012516899A5 (enExample) | 2013-02-21 |
| JP5653939B2 JP5653939B2 (ja) | 2015-01-14 |
Family
ID=42542652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011549263A Expired - Fee Related JP5653939B2 (ja) | 2009-02-05 | 2010-02-04 | 抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8268882B2 (enExample) |
| EP (1) | EP2393818A4 (enExample) |
| JP (1) | JP5653939B2 (enExample) |
| CN (2) | CN102307881B (enExample) |
| AU (1) | AU2010210594B2 (enExample) |
| CA (1) | CA2750844A1 (enExample) |
| WO (1) | WO2010091193A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI480040B (zh) * | 2012-06-11 | 2015-04-11 | Univ Kaohsiung Medical | 雷公藤甲素用於製備治療與運動神經元存活蛋白質表現相關之疾病的藥物的用途 |
| WO2014031979A1 (en) | 2012-08-23 | 2014-02-27 | Dyer, Cheryl, A. | Reducing the reproductive capacity of mammals |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| AU7570191A (en) | 1990-03-14 | 1991-10-10 | Board Of Regents, The University Of Texas System | Tripterygium wilfordii hook f extracts and components thereof for immunosuppression |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| NZ500762A (en) * | 1997-05-23 | 2001-08-31 | Aventis Pharma Inc | Triptolide derivatives substituted with amino acids, useful in the treatment of autoimmune diseases |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| EP1109789B1 (en) * | 1998-09-02 | 2003-07-16 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| WO2002017931A1 (fr) | 2000-09-01 | 2002-03-07 | Xiaomin Wang | Utilisation d'un ou de plusieurs extraits de tripterygium wilfordii hook.f pour la preparation de medicaments destines a prevenir et a traiter des troubles du systeme nerveux |
| US6620843B2 (en) * | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| US7847109B2 (en) * | 2002-05-31 | 2010-12-07 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| JP2004168713A (ja) * | 2002-11-20 | 2004-06-17 | St Marianna Univ School Of Medicine | アポトーシス誘導剤 |
| CN1726025A (zh) * | 2002-12-17 | 2006-01-25 | 泛华医药公司 | 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 |
| CN100408583C (zh) * | 2003-02-25 | 2008-08-06 | 美国泛华医药公司 | 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| WO2005000291A1 (en) | 2003-06-27 | 2005-01-06 | Pharmagenesis, Inc. | Method for treatment of idiopathic pulmonary fibrosis using triptolide derivatives |
| WO2005062913A2 (en) * | 2003-12-24 | 2005-07-14 | Pharmagenesis, Inc. | Triplide 5,6-derivatives as immunomodulators and anticancer agents |
| US7863464B2 (en) * | 2004-03-02 | 2011-01-04 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| CN100374443C (zh) * | 2004-03-29 | 2008-03-12 | 北京键凯科技有限公司 | 亲水性聚合物-雷公藤提取物的结合物及其药物组合物 |
| WO2009023201A1 (en) * | 2007-08-16 | 2009-02-19 | Myelorx Llc | Rigid derivatives of triptolide as anticancer, immune suppressant, anti-fibrosis, and cns protectant agents |
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2010
- 2010-02-04 US US13/147,587 patent/US8268882B2/en not_active Expired - Fee Related
- 2010-02-04 EP EP10739131.0A patent/EP2393818A4/en not_active Withdrawn
- 2010-02-04 CN CN201080006751.4A patent/CN102307881B/zh not_active Expired - Fee Related
- 2010-02-04 AU AU2010210594A patent/AU2010210594B2/en not_active Ceased
- 2010-02-04 WO PCT/US2010/023220 patent/WO2010091193A2/en not_active Ceased
- 2010-02-04 CA CA2750844A patent/CA2750844A1/en not_active Abandoned
- 2010-02-04 CN CN201410448310.XA patent/CN104387406A/zh active Pending
- 2010-02-04 JP JP2011549263A patent/JP5653939B2/ja not_active Expired - Fee Related