JP6653573B2 - シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法 - Google Patents
シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法 Download PDFInfo
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- JP6653573B2 JP6653573B2 JP2015514140A JP2015514140A JP6653573B2 JP 6653573 B2 JP6653573 B2 JP 6653573B2 JP 2015514140 A JP2015514140 A JP 2015514140A JP 2015514140 A JP2015514140 A JP 2015514140A JP 6653573 B2 JP6653573 B2 JP 6653573B2
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- phenyl
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
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- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
Landscapes
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- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
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| US61/757,876 | 2013-01-29 | ||
| PCT/US2013/042148 WO2013177241A1 (en) | 2012-05-22 | 2013-05-22 | Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use |
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| US10526287B2 (en) | 2015-04-23 | 2020-01-07 | Constellation Pharmaceuticals, Inc. | LSD1 inhibitors and uses thereof |
| MX391259B (es) | 2015-10-14 | 2025-03-21 | X Therma Inc | Composiciones y métodos para reducir la formación de cristales de hielo. |
| CN109071456A (zh) | 2016-02-16 | 2018-12-21 | 麻省理工学院 | 作为myc调节剂的max结合剂及其用途 |
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| US11633379B2 (en) | 2017-01-04 | 2023-04-25 | Trustees Of Dartmouth College | Methods of inhibiting PCSK9 |
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| CN120590310B (zh) * | 2025-08-07 | 2025-10-28 | 昆明医科大学 | 一种吲哚-3-芳基酮衍生物及其制备方法和应用 |
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| US3931288A (en) * | 1972-03-13 | 1976-01-06 | Hoffmann-La Roche Inc. | Alkyl esters of 4-chlorophenoxy-4-oxo-cycloalkyl-carboxylic acid |
| US4755505A (en) * | 1987-08-18 | 1988-07-05 | American Home Products Corporation | 1-[2-(dialkylamino)alkyl]-4,5-dihydro-4-(aryl)-1-benzazocine-2,6(1H,3H)-diones as anti-arrhythmic agents |
| AU3840000A (en) | 1999-04-20 | 2000-11-02 | Meiji Seika Kaisha Ltd. | Tricyclic compounds |
| ATE280170T1 (de) * | 2000-11-03 | 2004-11-15 | Wyeth Corp | Cyclopenta(b)(1,4) diazepino(6,7,1-hi)indole als 5ht2c antagonisten |
| TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| JP4484108B2 (ja) | 2002-05-16 | 2010-06-16 | 塩野義製薬株式会社 | Ｐｇｄ２受容体拮抗作用を有する化合物 |
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| WO2004069831A1 (en) * | 2003-02-10 | 2004-08-19 | Glenmark Pharmaceuticals Ltd. | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation |
| WO2004110999A1 (en) | 2003-06-10 | 2004-12-23 | Smithkline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
| US7622494B2 (en) | 2003-08-26 | 2009-11-24 | Smithkline Beecham Corporation | Chemical compounds |
| WO2005094833A1 (en) | 2004-03-31 | 2005-10-13 | Council Of Scientific And Industrial Research | Novel n-substituted dihydrobenzothiepino, dihydrobenzoxepino and tetrahydro benzocyclohepta indoles as selective estrogen receptor modulators |
| ES2446044T3 (es) | 2004-09-20 | 2014-03-06 | Janssen Pharmaceutica Nv | Derivados tetracíclicos novedosos que contienen heteroátomos útiles como moduladores de los receptores de hormonas sexuales esteroideas |
| US7338973B2 (en) | 2004-09-20 | 2008-03-04 | Janssen Pharmaceutica N.V. | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators |
| RS52642B (sr) | 2004-11-18 | 2013-06-28 | Synta Pharmaceuticals Corp. | Jedinjenja triazola koja modulišu aktivnost hsp90 |
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| CL2009000725A1 (es) | 2008-03-24 | 2009-05-29 | Medivation Technologies Inc | Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico. |
| WO2010036998A2 (en) | 2008-09-29 | 2010-04-01 | Abbott Laboratories | Indole and indoline derivatives and methods of use thereof |
| WO2010054382A1 (en) | 2008-11-10 | 2010-05-14 | Elixir Pharmaceuticals, Inc. | Compounds, compositions, and methods for treating malaria or leishmaniasis |
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| NZ595410A (en) | 2009-03-27 | 2013-12-20 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
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| GB201016411D0 (en) * | 2010-09-30 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method for cancer |
| WO2012054526A2 (en) * | 2010-10-19 | 2012-04-26 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
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2013
- 2013-05-22 JP JP2015514140A patent/JP6653573B2/ja active Active
- 2013-05-22 WO PCT/US2013/042148 patent/WO2013177241A1/en not_active Ceased
- 2013-05-22 EP EP13794752.9A patent/EP2887804B1/en not_active Not-in-force
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2014
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2887804B1 (en) | 2021-01-27 |
| JP2015517577A (ja) | 2015-06-22 |
| US9598365B2 (en) | 2017-03-21 |
| US20150057326A1 (en) | 2015-02-26 |
| WO2013177241A1 (en) | 2013-11-28 |
| EP2887804A4 (en) | 2016-10-05 |
| EP2887804A1 (en) | 2015-07-01 |
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