JP2015517535A - 改善された合成 - Google Patents

改善された合成 Download PDF

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Publication number
JP2015517535A
JP2015517535A JP2015512969A JP2015512969A JP2015517535A JP 2015517535 A JP2015517535 A JP 2015517535A JP 2015512969 A JP2015512969 A JP 2015512969A JP 2015512969 A JP2015512969 A JP 2015512969A JP 2015517535 A JP2015517535 A JP 2015517535A
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JP
Japan
Prior art keywords
group
formula
compound
protecting group
acid
Prior art date
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Ceased
Application number
JP2015512969A
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English (en)
Japanese (ja)
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JP2015517535A5 (https=
Inventor
クライヴ ムスクロフト−テイラー，アンドリュー
クライヴ ムスクロフト−テイラー，アンドリュー
アンドリュー マーシャル，フィリップ
アンドリュー マーシャル，フィリップ
メアリー メイスン，ジェニファー
メアリー メイスン，ジェニファー
ミラー ウォーカー，デーヴィット
ミラー ウォーカー，デーヴィット
Original Assignee
オンコロジー リサーチ インターナショナル リミテッド
オンコロジー リサーチ インターナショナル リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012902119A external-priority patent/AU2012902119A0/en
Application filed by オンコロジー リサーチ インターナショナル リミテッド, オンコロジー リサーチ インターナショナル リミテッド filed Critical オンコロジー リサーチ インターナショナル リミテッド
Publication of JP2015517535A publication Critical patent/JP2015517535A/ja
Publication of JP2015517535A5 publication Critical patent/JP2015517535A5/ja
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015512969A 2012-05-23 2013-04-24 改善された合成 Ceased JP2015517535A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012902119 2012-05-23
AU2012902119A AU2012902119A0 (en) 2012-05-23 Improved synthesis
AU2013204005 2013-04-11
AU2013204005A AU2013204005B2 (en) 2012-05-23 2013-04-11 Improved synthesis
PCT/AU2013/000416 WO2013173862A1 (en) 2012-05-23 2013-04-24 Improved synthesis

Publications (2)

Publication Number Publication Date
JP2015517535A true JP2015517535A (ja) 2015-06-22
JP2015517535A5 JP2015517535A5 (https=) 2016-07-14

Family

ID=49622929

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015512969A Ceased JP2015517535A (ja) 2012-05-23 2013-04-24 改善された合成

Country Status (13)

Country Link
US (1) US20150105543A1 (https=)
EP (1) EP2852607B1 (https=)
JP (1) JP2015517535A (https=)
CN (1) CN104395333B (https=)
AU (1) AU2013204005B2 (https=)
BR (1) BR112014029189A2 (https=)
CA (1) CA2874030A1 (https=)
EA (1) EA201492194A1 (https=)
HK (1) HK1202876A1 (https=)
IN (1) IN2014DN10846A (https=)
MX (1) MX356853B (https=)
TW (1) TWI609025B (https=)
WO (1) WO2013173862A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193858B (zh) * 2013-04-12 2016-08-03 中国海洋大学 螺甾碱烷型糖苷生物碱的合成方法
AU2018217439B2 (en) * 2017-02-10 2021-11-25 Oncology Research International Limited Steroid saponins with anti-cancer activity
CN110790811A (zh) * 2019-10-10 2020-02-14 华南农业大学 双相体系氯化铝水解制备薯蓣皂素方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1115346C (zh) * 2000-10-20 2003-07-23 中国科学院上海有机化学研究所 鼠李糖取代的β－D－葡萄糖基－薯蓣皂甙的皂甙库、制备方法和用途
CN101130568B (zh) * 2007-09-07 2011-06-15 中国科学院上海有机化学研究所 一类喷脑皂甙类化合物、合成方法及其用途
JP5706815B2 (ja) * 2008-04-08 2015-04-22 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ トリテルペンであるサポニン、その合成法および使用
CN101635335B (zh) * 2008-07-25 2013-02-27 深圳市比克电池有限公司 圆柱电池卷芯入壳机

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, JPN6017009062, 2006, pages 2454 - 2458, ISSN: 0003972870 *
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, JPN6017009059, 2012, pages 2690 - 2700, ISSN: 0003972868 *
CARBOHYDRATE RESEARCH, vol. 317, JPN6017009057, 1999, pages 53 - 62, ISSN: 0003972866 *
CARBOHYDRATE RESEARCH, vol. 338, JPN6017009060, 2003, pages 721 - 727, ISSN: 0003972869 *
CHEMISTRY LETTERS, vol. 34, no. 9, JPN6017009058, 2005, pages 1220 - 1221, ISSN: 0003972867 *
CHINESE CHEMICAL LETTERS, vol. 14, no. 4, JPN6017009065, 2003, pages 361 - 364, ISSN: 0003972871 *
STUDIES IN PLANT SCIENCE, vol. 6, JPN6017009069, 1999, pages 196 - 200, ISSN: 0003972872 *

Also Published As

Publication number Publication date
EA201492194A1 (ru) 2015-04-30
TWI609025B (zh) 2017-12-21
EP2852607A4 (en) 2016-02-24
BR112014029189A2 (pt) 2017-06-27
AU2013204005B2 (en) 2015-04-16
MX2014014056A (es) 2015-08-14
EP2852607A1 (en) 2015-04-01
IN2014DN10846A (https=) 2015-09-04
HK1202876A1 (zh) 2015-10-09
TW201350497A (zh) 2013-12-16
AU2013204005A1 (en) 2013-12-12
CA2874030A1 (en) 2013-11-28
MX356853B (es) 2018-06-18
CN104395333B (zh) 2018-01-02
CN104395333A (zh) 2015-03-04
WO2013173862A1 (en) 2013-11-28
EP2852607B1 (en) 2018-10-24
US20150105543A1 (en) 2015-04-16

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