CN104395333B - 改进的合成 - Google Patents

改进的合成 Download PDF

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Publication number
CN104395333B
CN104395333B CN201380034397.XA CN201380034397A CN104395333B CN 104395333 B CN104395333 B CN 104395333B CN 201380034397 A CN201380034397 A CN 201380034397A CN 104395333 B CN104395333 B CN 104395333B
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China
Prior art keywords
formula
compounds
compound
acid
group
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CN201380034397.XA
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English (en)
Chinese (zh)
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CN104395333A (zh
Inventor
安德鲁·克莱夫·穆斯克罗夫-泰勒
菲利普·安德鲁·马歇尔
珍妮弗·玛丽·马松
大卫·米拉尔·沃克
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ONCOLOGY RESEARCH INTERNATIONAL Ltd
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ONCOLOGY RESEARCH INTERNATIONAL Ltd
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Priority claimed from AU2012902119A external-priority patent/AU2012902119A0/en
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Publication of CN104395333A publication Critical patent/CN104395333A/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380034397.XA 2012-05-23 2013-04-24 改进的合成 Active CN104395333B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012902119 2012-05-23
AU2012902119A AU2012902119A0 (en) 2012-05-23 Improved synthesis
AU2013204005 2013-04-11
AU2013204005A AU2013204005B2 (en) 2012-05-23 2013-04-11 Improved synthesis
PCT/AU2013/000416 WO2013173862A1 (en) 2012-05-23 2013-04-24 Improved synthesis

Publications (2)

Publication Number Publication Date
CN104395333A CN104395333A (zh) 2015-03-04
CN104395333B true CN104395333B (zh) 2018-01-02

Family

ID=49622929

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380034397.XA Active CN104395333B (zh) 2012-05-23 2013-04-24 改进的合成

Country Status (13)

Country Link
US (1) US20150105543A1 (https=)
EP (1) EP2852607B1 (https=)
JP (1) JP2015517535A (https=)
CN (1) CN104395333B (https=)
AU (1) AU2013204005B2 (https=)
BR (1) BR112014029189A2 (https=)
CA (1) CA2874030A1 (https=)
EA (1) EA201492194A1 (https=)
HK (1) HK1202876A1 (https=)
IN (1) IN2014DN10846A (https=)
MX (1) MX356853B (https=)
TW (1) TWI609025B (https=)
WO (1) WO2013173862A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193858B (zh) * 2013-04-12 2016-08-03 中国海洋大学 螺甾碱烷型糖苷生物碱的合成方法
AU2018217439B2 (en) * 2017-02-10 2021-11-25 Oncology Research International Limited Steroid saponins with anti-cancer activity
CN110790811A (zh) * 2019-10-10 2020-02-14 华南农业大学 双相体系氯化铝水解制备薯蓣皂素方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293199A (zh) * 2000-10-20 2001-05-02 中国科学院上海有机化学研究所 鼠李糖取代的β－D－葡萄糖基－薯蓣皂甙的皂甙库、制备方法和用途
CN101130568A (zh) * 2007-09-07 2008-02-27 中国科学院上海有机化学研究所 一类喷脑皂甙类化合物、合成方法及其用途
WO2009126737A2 (en) * 2008-04-08 2009-10-15 Sloan-Kettering Institute For Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
CN101635335A (zh) * 2008-07-25 2010-01-27 深圳市比克电池有限公司 圆柱电池卷芯入壳机

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293199A (zh) * 2000-10-20 2001-05-02 中国科学院上海有机化学研究所 鼠李糖取代的β－D－葡萄糖基－薯蓣皂甙的皂甙库、制备方法和用途
CN101130568A (zh) * 2007-09-07 2008-02-27 中国科学院上海有机化学研究所 一类喷脑皂甙类化合物、合成方法及其用途
WO2009126737A2 (en) * 2008-04-08 2009-10-15 Sloan-Kettering Institute For Cancer Research Triterpene saponins, methods of synthesis, and uses thereof
CN101635335A (zh) * 2008-07-25 2010-01-27 深圳市比克电池有限公司 圆柱电池卷芯入壳机

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Synthesis and cytotoxicities of icogenin analogues with disaccharide residues;Haixing Wang 等;《Bioorganic & Medicinal Chemistry Letters》;20090326;第19卷(第10期);第2796-2800页 *
Synthesis of novel spirostanic saponins and their cytotoxic activity;Juan C. Hernandez 等;《Bioorganic & Medicinal Chemistry》;20071104;第16卷(第4期);第2063-2076页，尤其是第2065页图1中化合物4a的制备以及第2066页表1中化合物18的制备 *
一种天然三萜皂苷的化学合成和抗肿瘤活性研究;任丽 等;《中国药物化学杂志》;20110831;第21卷(第4期);第280-285页 *

Also Published As

Publication number Publication date
EA201492194A1 (ru) 2015-04-30
TWI609025B (zh) 2017-12-21
EP2852607A4 (en) 2016-02-24
BR112014029189A2 (pt) 2017-06-27
AU2013204005B2 (en) 2015-04-16
MX2014014056A (es) 2015-08-14
EP2852607A1 (en) 2015-04-01
IN2014DN10846A (https=) 2015-09-04
HK1202876A1 (zh) 2015-10-09
TW201350497A (zh) 2013-12-16
AU2013204005A1 (en) 2013-12-12
CA2874030A1 (en) 2013-11-28
MX356853B (es) 2018-06-18
CN104395333A (zh) 2015-03-04
WO2013173862A1 (en) 2013-11-28
EP2852607B1 (en) 2018-10-24
US20150105543A1 (en) 2015-04-16
JP2015517535A (ja) 2015-06-22

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