JP2015517305A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015517305A5 JP2015517305A5 JP2015510818A JP2015510818A JP2015517305A5 JP 2015517305 A5 JP2015517305 A5 JP 2015517305A5 JP 2015510818 A JP2015510818 A JP 2015510818A JP 2015510818 A JP2015510818 A JP 2015510818A JP 2015517305 A5 JP2015517305 A5 JP 2015517305A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fxia
- amino acid
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167438.6 | 2012-05-10 | ||
| EP12167438 | 2012-05-10 | ||
| EP12181697.9 | 2012-08-24 | ||
| EP12181697 | 2012-08-24 | ||
| EP13150361.7 | 2013-01-07 | ||
| EP13150361 | 2013-01-07 | ||
| US201361817675P | 2013-04-30 | 2013-04-30 | |
| US61/817,675 | 2013-04-30 | ||
| PCT/EP2013/059618 WO2013167669A1 (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018106275A Division JP2018148920A (ja) | 2012-05-10 | 2018-06-01 | 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517305A JP2015517305A (ja) | 2015-06-22 |
| JP2015517305A5 true JP2015517305A5 (enExample) | 2016-06-23 |
| JP6348900B2 JP6348900B2 (ja) | 2018-06-27 |
Family
ID=49550177
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510818A Active JP6348900B2 (ja) | 2012-05-10 | 2013-05-08 | 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途 |
| JP2018106275A Pending JP2018148920A (ja) | 2012-05-10 | 2018-06-01 | 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018106275A Pending JP2018148920A (ja) | 2012-05-10 | 2018-06-01 | 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9783614B2 (enExample) |
| EP (2) | EP2847228B1 (enExample) |
| JP (2) | JP6348900B2 (enExample) |
| KR (1) | KR102060376B1 (enExample) |
| CN (1) | CN104684932B (enExample) |
| AR (1) | AR091024A1 (enExample) |
| AU (2) | AU2013258043B2 (enExample) |
| BR (1) | BR112014027952B1 (enExample) |
| CA (1) | CA2872926C (enExample) |
| DK (1) | DK2847228T3 (enExample) |
| ES (1) | ES2698950T3 (enExample) |
| HR (1) | HRP20181680T1 (enExample) |
| HU (1) | HUE040580T2 (enExample) |
| IL (1) | IL235238B (enExample) |
| LT (1) | LT2847228T (enExample) |
| MX (1) | MX362454B (enExample) |
| NZ (1) | NZ701121A (enExample) |
| PL (1) | PL2847228T3 (enExample) |
| RS (1) | RS57889B1 (enExample) |
| SG (2) | SG10201609322QA (enExample) |
| SI (1) | SI2847228T1 (enExample) |
| TW (2) | TWI631140B (enExample) |
| WO (1) | WO2013167669A1 (enExample) |
| ZA (1) | ZA201407784B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2705851C (en) | 2007-11-21 | 2016-11-01 | Oregon Health & Science University | Anti-factor xi monoclonal antibodies and methods of use thereof |
| AU2009335643B2 (en) | 2008-12-18 | 2014-05-29 | Oregon Health & Science University | Anti-fXI antibodies and methods of use |
| IN2014CN02805A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| IN2014CN02806A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| LT2766346T (lt) | 2011-10-14 | 2017-06-12 | Bristol-Myers Squibb Company | Pakeistieji tetrahidroizochinolino junginiai, kaip faktoriaus xia inhibitoriai |
| US9783614B2 (en) | 2012-05-10 | 2017-10-10 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor Xia and uses thereof |
| HRP20180465T1 (hr) | 2012-10-12 | 2018-05-04 | Bristol-Myers Squibb Company | Kristalni oblici inhibitora faktora xia |
| US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
| NO2760821T3 (enExample) | 2014-01-31 | 2018-03-10 | ||
| JP6505727B2 (ja) | 2014-01-31 | 2019-04-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロ環式ｐ２’基を有する第ｘｉａ因子阻害剤としてのマクロ環 |
| TW201613977A (en) | 2014-08-07 | 2016-04-16 | Novartis Ag | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |
| EA201790336A1 (ru) | 2014-08-07 | 2017-06-30 | Новартис Аг | Антитела к ангиопоэтинподобному белку 4 и способы применения |
| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| CA2972800A1 (en) | 2015-01-02 | 2016-07-07 | Dyax Corp. | Bispecific antibodies against plasma kallikrein and factor xii |
| JOP20160131B1 (ar) * | 2015-06-26 | 2022-03-14 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| EP3325516B1 (en) | 2015-07-21 | 2021-12-15 | Takeda Pharmaceutical Company Limited | A monoclonal antibody inhibitor of factor xiia |
| US11066481B2 (en) | 2015-07-23 | 2021-07-20 | The Regents Of The University Of California | Antibodies to coagulation factor XIa and uses thereof |
| US10053515B2 (en) | 2016-01-22 | 2018-08-21 | Merck Sharp & Dohme Corp. | Anti-coagulation factor XI antibodies |
| KR102448456B1 (ko) * | 2016-03-23 | 2022-09-28 | 프로틱스 비브이 | 인자 xi의 활성 부위에 대한 모노클로날 항체 및 이의 용도 |
| JP7103950B2 (ja) | 2016-04-22 | 2022-07-20 | アクセレロン ファーマ インコーポレーテッド | Ａｌｋ７結合性タンパク質及びその使用 |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| EA201892716A1 (ru) | 2016-06-14 | 2019-05-31 | Мерк Шарп И Доум Корп. | Антитела к фактору свертывания xi |
| AU2017329645A1 (en) * | 2016-09-20 | 2019-04-04 | Aronora Inc. | Novel antibodies against factor XI and uses thereof |
| WO2018089248A2 (en) * | 2016-11-02 | 2018-05-17 | Tucker Erik L | E-we thrombin analog and fibrinolytic combination |
| CN118320078A (zh) * | 2016-12-23 | 2024-07-12 | 诺华股份有限公司 | 采用抗因子XI/XIa抗体治疗的方法 |
| KR102616666B1 (ko) * | 2016-12-23 | 2023-12-27 | 노파르티스 아게 | 인자 xi 항체 및 사용 방법 |
| PT3570882T (pt) * | 2017-01-19 | 2022-01-11 | Bayer Pharma AG | Nova formulação estável para anticorpos fxia |
| US11958911B2 (en) | 2017-02-10 | 2024-04-16 | Shanghai Benemae Pharmaceutical | Anti-coagulation factor XI antibody |
| CN108409863B (zh) * | 2017-02-10 | 2023-09-26 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| EP3713965A1 (en) | 2017-11-22 | 2020-09-30 | Novartis AG | Reversal binding agents for anti-factor xi/xia antibodies and uses thereof |
| WO2020008022A1 (en) * | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | METHOD FOR THE PRODUCTION OF FREEZE-DRIED PELLETS COMPRISING AN ANTI-COAGULATION FACTOR XIa (FXIa) ANTIBODY |
| PE20211399A1 (es) * | 2018-08-01 | 2021-07-27 | Novo Nordisk As | Anticuerpos procoagulantes mejorados |
| JP7152682B2 (ja) | 2018-08-07 | 2022-10-13 | 日本電信電話株式会社 | 光伝送システム及び伝送モード選択方法 |
| CN113227150B (zh) * | 2018-08-09 | 2023-07-28 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| EP3852820B1 (en) * | 2018-09-17 | 2024-11-20 | Board of Regents, The University of Texas System | Compositions and methods for treating bone injury |
| WO2020089380A1 (en) | 2018-10-31 | 2020-05-07 | Bayer Aktiengesellschaft | REVERSAL AGENTS FOR NEUTRALIZING THE THERAPEUTIC ACTIVITY OF ANTI-FXIa ANTIBODIES |
| US12703762B2 (en) | 2018-12-18 | 2026-08-11 | Novartis Ag | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| AU2020211905A1 (en) | 2019-01-21 | 2021-08-05 | Aronora Inc. | Novel humanized antibodies against factor XI having anti-thrombotic and anti-inflammatory effects and uses thereof |
| EP3957652A4 (en) | 2019-04-16 | 2023-06-21 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Anti-fxi/fxia antibody and use thereof |
| CN110423278B (zh) | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| BR112022026533A2 (pt) * | 2020-07-02 | 2023-01-17 | Beijing Tuo Jie Biopharmaceutical Co Ltd | Anticorpo anti-fxi/fxia, fragmento de ligação do mesmo, e antígenos e uso farmacêutico do mesmo |
| EP4644426A1 (en) * | 2022-12-30 | 2025-11-05 | Gan & Lee Pharmaceuticals Co., Ltd. | Antibody against coagulation factor xi and/or activated form factor xia thereof, and use thereof |
| CN119454938B (zh) * | 2024-11-15 | 2025-07-25 | 广州骐骥生物科技有限公司 | 一种枸橼酸透析浓缩液及其制备方法 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| DE4319041A1 (de) | 1992-10-23 | 1994-04-28 | Bayer Ag | Trisubstituierte Biphenyle |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US20030235587A1 (en) | 1998-08-07 | 2003-12-25 | Feuerstein Giora Z. | Anticoagulant agents useful in treatment of thrombosis |
| ATE431347T1 (de) | 1996-10-14 | 2009-05-15 | Bayer Healthcare Ag | Neue heterocyclylmethyl-substituierte pyrazolderivate und ihre verwendung in der behandlung von herz-kreislauf-erkrankungen |
| DE19642255A1 (de) | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
| DE19649460A1 (de) | 1996-11-26 | 1998-05-28 | Bayer Ag | Neue substituierte Pyrazolderivate |
| GB9701425D0 (en) | 1997-01-24 | 1997-03-12 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834045A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| WO2000007626A1 (en) | 1998-08-07 | 2000-02-17 | Smithkline Beecham Corporation | Use of anti-coagulation factor antibodies as long-lasting protective agents |
| DE19846514A1 (de) | 1998-10-09 | 2000-04-20 | Bayer Ag | Neue Heterocyclyl-methyl-substituierte Pyrazole |
| DE19920352A1 (de) | 1999-05-04 | 2000-11-09 | Bayer Ag | Substituiertes Pyrazolderivat |
| DE19942809A1 (de) | 1999-09-08 | 2001-03-15 | Bayer Ag | Verfahren zur Herstellung substituierter Pyrimidinderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| US20080219998A1 (en) | 2001-12-07 | 2008-09-11 | Andras Gruber | Anti-Thrombotic Agents |
| US20080138837A1 (en) | 2004-07-19 | 2008-06-12 | Robert Greenfield | Methods and kits for detecting and measuring ADAMTS13/FXI complexes |
| US7270976B2 (en) | 2004-07-19 | 2007-09-18 | American Diagnostica, Inc. | Methods for measuring ADAMTS13 activity and protein on platelets and in plasma |
| US7279513B2 (en) | 2004-11-19 | 2007-10-09 | Nalco Company | Preparation of neutralized ethylene-acrylic acid polymer dispersions and use in printing media for improvement of digital toner adhesion |
| DE102005050377A1 (de) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Heterocyclische Verbindungen und ihre Verwendung |
| DE102005050376A1 (de) | 2005-10-21 | 2007-05-31 | Bayer Healthcare Ag | Dicarbonsäure-Derivate und ihre Verwendung |
| DE102005050375A1 (de) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Tetrazol-Derivate und ihre Verwendung |
| DE102005050498A1 (de) | 2005-10-21 | 2007-06-06 | Bayer Healthcare Aktiengesellschaft | Cyclopropylessigsäure-Derivate und ihre Verwendung |
| DE102005050497A1 (de) | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Difluorphenol-Derivate und ihre Verwendung |
| CA2661023C (en) | 2006-08-18 | 2017-08-15 | Novartis Ag | Prlr-specific antibody and uses thereof |
| JP2010526066A (ja) | 2007-04-23 | 2010-07-29 | シェーリング コーポレイション | 抗ｍｄｌ−１抗体 |
| US8574849B2 (en) | 2007-10-03 | 2013-11-05 | The University Of Vermont And State Agriculture College | Methods of detection of factor XIa and tissue factor |
| CA2705851C (en) * | 2007-11-21 | 2016-11-01 | Oregon Health & Science University | Anti-factor xi monoclonal antibodies and methods of use thereof |
| WO2009154461A1 (en) * | 2008-06-19 | 2009-12-23 | Prothix Bv | Use of anti-factors xi antibodies for prevention of thrombus formation |
| CA2743864A1 (en) | 2008-11-25 | 2010-06-10 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| AU2009335643B2 (en) * | 2008-12-18 | 2014-05-29 | Oregon Health & Science University | Anti-fXI antibodies and methods of use |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| UA107112C2 (uk) | 2010-05-27 | 2014-11-25 | Мерк Шарп Енд Доме Корп. | Активатори розчинної гуанілатциклази |
| CA2803688A1 (en) | 2010-06-25 | 2011-12-29 | Bayer Intellectual Property Gmbh | Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes |
| EP2590979A1 (de) | 2010-07-09 | 2013-05-15 | Bayer Intellectual Property GmbH | Annellierte pyrimidine und triazine und ihre verwendung zur behandlung bzw. prophylaxe von herz-kreislauf-erkrankungen |
| DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
| US20140171434A1 (en) | 2011-01-11 | 2014-06-19 | Bayer Pharma Aktiengessellschaft | Substituted imidazopyridines and imidazopyridazines and the use thereof |
| WO2012143510A1 (de) | 2011-04-21 | 2012-10-26 | Bayer Intellectual Property Gmbh | Fluoralkyl-substituierte pyrazolopyridine und ihre verwendung |
| WO2013030138A1 (en) | 2011-09-01 | 2013-03-07 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| BR112014005110A2 (pt) | 2011-09-02 | 2017-04-18 | Bayer Ip Gmbh | pirimidinas aneladas substituídas e utilização das mesmas |
| US9783614B2 (en) * | 2012-05-10 | 2017-10-10 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor Xia and uses thereof |
-
2013
- 2013-05-08 US US14/400,281 patent/US9783614B2/en active Active
- 2013-05-08 EP EP13721746.9A patent/EP2847228B1/en active Active
- 2013-05-08 CN CN201380037161.1A patent/CN104684932B/zh active Active
- 2013-05-08 RS RS20181219A patent/RS57889B1/sr unknown
- 2013-05-08 SG SG10201609322QA patent/SG10201609322QA/en unknown
- 2013-05-08 SI SI201331209T patent/SI2847228T1/sl unknown
- 2013-05-08 HU HUE13721746A patent/HUE040580T2/hu unknown
- 2013-05-08 MX MX2014013568A patent/MX362454B/es active IP Right Grant
- 2013-05-08 LT LTEP13721746.9T patent/LT2847228T/lt unknown
- 2013-05-08 BR BR112014027952-7A patent/BR112014027952B1/pt not_active IP Right Cessation
- 2013-05-08 NZ NZ701121A patent/NZ701121A/en not_active IP Right Cessation
- 2013-05-08 ES ES13721746T patent/ES2698950T3/es active Active
- 2013-05-08 CA CA2872926A patent/CA2872926C/en active Active
- 2013-05-08 DK DK13721746.9T patent/DK2847228T3/en active
- 2013-05-08 KR KR1020147034253A patent/KR102060376B1/ko not_active Expired - Fee Related
- 2013-05-08 AU AU2013258043A patent/AU2013258043B2/en not_active Ceased
- 2013-05-08 EP EP18176293.1A patent/EP3404045A1/en not_active Withdrawn
- 2013-05-08 PL PL13721746T patent/PL2847228T3/pl unknown
- 2013-05-08 HR HRP20181680TT patent/HRP20181680T1/hr unknown
- 2013-05-08 WO PCT/EP2013/059618 patent/WO2013167669A1/en not_active Ceased
- 2013-05-08 JP JP2015510818A patent/JP6348900B2/ja active Active
- 2013-05-08 SG SG11201406719UA patent/SG11201406719UA/en unknown
- 2013-05-09 TW TW102116466A patent/TWI631140B/zh not_active IP Right Cessation
- 2013-05-09 TW TW106143305A patent/TWI644925B/zh not_active IP Right Cessation
- 2013-05-10 AR ARP130101638A patent/AR091024A1/es not_active Application Discontinuation
-
2014
- 2014-10-21 IL IL235238A patent/IL235238B/en active IP Right Grant
- 2014-10-24 ZA ZA2014/07784A patent/ZA201407784B/en unknown
-
2017
- 2017-08-30 US US15/691,731 patent/US10221247B2/en active Active
- 2017-08-30 US US15/691,736 patent/US10040866B2/en active Active
-
2018
- 2018-02-06 AU AU2018200850A patent/AU2018200850C1/en not_active Ceased
- 2018-06-01 JP JP2018106275A patent/JP2018148920A/ja active Pending
-
2019
- 2019-03-04 US US16/292,196 patent/US11046783B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7257374B2 (ja) | Ｔ制御性細胞の増殖または枯渇方法 | |
| Psaila et al. | Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia | |
| Miller et al. | Pulmonary complications of sickle cell disease | |
| Cerny et al. | Why does my patient have leukocytosis? | |
| AU2013329083B2 (en) | Enhancement of the immune response | |
| Daniels et al. | Imatinib treatment for idiopathic pulmonary fibrosis: randomized placebo-controlled trial results | |
| Seth et al. | Surgical stress promotes the development of cancer metastases by a coagulation-dependent mechanism involving natural killer cells in a murine model | |
| Hally et al. | Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction | |
| Jensen et al. | The haematocrit–an important factor causing impaired haemostasis in patients with cyanotic congenital heart disease | |
| Miyashita et al. | A three-phase approach for the early identification of acute lung injury induced by severe sepsis | |
| Ekser et al. | Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation | |
| Pan et al. | GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI | |
| JP2019522974A (ja) | 抗Ｍａｃ−１抗体 | |
| DeLyria et al. | Fatal cryocrystalglobulinemia with intravascular and renal tubular crystalline deposits | |
| Pervaiz et al. | Pulmonary complications of sickle cell disease: a narrative clinical review | |
| Naito et al. | Antithrombotic therapy strategy for cancer-associated ischemic stroke: a case series of 26 patients | |
| Krajewski et al. | Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation | |
| Zhu et al. | Hemostatic function and transfusion efficacy of apheresis platelet concentrates treated with gamma irradiation in use for thrombocytopenic patients | |
| Quinn et al. | Occupancy of the internal and external pools of glycoprotein IIb/IIIa following abciximab bolus and infusion | |
| Laurichesse et al. | Oxaliplatin and methylprednisolone-induced thrombocytopenia and monocytopenia, owing to anti-GPIIbIIIa and-CD36 antibodies in a patient with colorectal cancer | |
| Thomas et al. | First evaluation of the safety, pharmacokinetics and pharmacodynamics of BAY 1213790, a full human IgG1 antibody targeting coagulation factor XIa, in healthy young men | |
| Demirkan et al. | Differential diagnosis and management of acute profound thrombocytopenia by tirofiban: a case report | |
| Johnson | Signaling Between Intraepithelial T Cells and Villous Enterocytes in Celiac Disease | |
| Dumas et al. | Acquired Type II von Willebrand syndrome in locally advanced bladder cancer successfully treated with intravenous immunoglobulin and chemotherapy | |
| JP2011518203A (ja) | Ｇｐｖｉの阻害によるがんの予防及び処置方法 |